Muscle Biopsy showing Inclusion Bodies: Causes & Reasons

Possible Causes for Muscle Biopsy showing Inclusion Bodies

We performed a muscle biopsy that showed inclusion body myositis (IBM). [ncbi.nlm.nih.gov]

A review of the previously performed muscle biopsy showed most of the cardinal myopathologic features of sporadic inclusion body myositis, in addition to the granuloma. [ncbi.nlm.nih.gov]

The muscle biopsy of inclusion body myositis shows mild to moderate inflammation, atrophic denervated fibers, and most characteristically "rimmed vacuoles" as well as some [bcm.edu]

Other specified deforming dorsopathies

Thoracic paraspinal muscle biopsy showed canonical features of inclusion body myositis. [mayoclinic.pure.elsevier.com]

Neurologic examination revealed no limb weakness. magnetic resonance imaging studies showed atrophy and findings, suggesting fatty replacement of paraspinal muscles. [mayoclinic.pure.elsevier.com]

Granulomatous Myositis

A review of the previously performed muscle biopsy showed most of the cardinal myopathologic features of sporadic inclusion body myositis, in addition to the granuloma. [ncbi.nlm.nih.gov]

Muscle biopsy reveals inclusion bodies i.e. rimmed vacuoles formed due to the collection of abnormal proteins. [kenhub.com]

In inclusion body myositis, findings on muscle biopsy may show the presence of vacuolated muscle fibers with basophilic granular deposits, the presence of varying degrees [rheumatologyadvisor.com]

Inclusion Body Myopathy

The muscle biopsy of inclusion body myositis shows mild to moderate inflammation, atrophic denervated fibers, and most characteristically "rimmed vacuoles" as well as some [bcm.edu]

Muscle biopsy will show rimmed vacuoles (inclusion bodies), amyloid deposits, and endomysial inflammation around muscle fibers. [hss.edu]

One sibling also showed PDB. Light and electron microscopy performed on muscle biopsies demonstrated degenerative changes with inclusion bodies and abnormal aggregates. [ncbi.nlm.nih.gov]

Reducing Body Myopathy

In both girls, serum creatine kinase was increased, and skeletal muscle biopsies showed inclusion bodies that stained with NBT. [omim.org]

Muscle biopsy will show rimmed vacuoles (inclusion bodies), amyloid deposits, and endomysial inflammation around muscle fibers. [hss.edu]

The origin of these inclusions has not been determined. Here we show that reducing bodies bear characteristics of nucleoli. [ncbi.nlm.nih.gov]

Carcinomatous Myopathic Syndrome

Muscle biopsy shows inflammation of muscle, fibre necrosis and the presence of vacuoles and filamentous inclusions in fibres (seen by electron microscopy). [somalidoc.com]

Muscle biopsy shows lymphocytic infiltration of muscle with fibre necrosis. Disease may respond to immunosuppressive treatment with steroids or azathioprine. [somalidoc.com]

Inclusion body myositis is clinically similar to polymyositis, but occurs mainly in elderly patients. [somalidoc.com]

Autosomal Dominant Myosin Storage Myopathy

These findings should alert physicians to the possibility that patients with MYH7 mutations may have muscle biopsies showing pathologic findings similar to inclusion body [gooa.las.ac.cn]

Interestingly, this biopsy specimen contained TDP‐43, p62, and SMI‐31‐positive protein aggregates typical of inclusion body myositis. [gooa.las.ac.cn]

Spheroid Body Myopathy

Compared to an earlier muscle biopsy specimen his plastic-embedded biopsy specimen revealed fewer Mallory body-like inclusions. [coek.info]

The younger brother, now 19 years old, also showed facial proximal muscle weakness as well as progressive scoliosis, but no cardiac or respiratory functional impairment. [coek.info]

Myopathy, Endocrine

Muscle biopsy shows inflammation of muscle, fibre necrosis and the presence of vacuoles and filamentous inclusions in fibres (seen by electron microscopy). [somalidoc.com]

Muscle biopsy shows lymphocytic infiltration of muscle with fibre necrosis. Disease may respond to immunosuppressive treatment with steroids or azathioprine. [somalidoc.com]

Adult Polyglucosan Body Disease

Some muscle biopsies show these inclusions in intramuscular nerve branches. [ncbi.nlm.nih.gov]

METHODS: Fifteen muscle biopsies from adults between the ages of 36 and 84 years, all showing polyglucosan bodies in intramuscular peripheral nerve twigs, were tested by sequencing [ncbi.nlm.nih.gov]

INTRODUCTION: Adult polyglucosan body disease (APBD) is associated with formation of polyglucosan bodies in peripheral nerve branches. [ncbi.nlm.nih.gov]

Acquired Amyloid Myopathy

The clinical phenotype of this patient was characteristic of inclusion body myositis, yet biopsies from two separate muscles performed at the same time did not show the characteristic [hopkinsarthritis.org]

A repeat biopsy from the deltoid muscle (bottom panels) showed characteristic changes of IBM, not evident on the initial biopsies. [hopkinsarthritis.org]

A third biopsy from a muscle less severely affected secured the diagnosis. [hopkinsarthritis.org]

Myopathy and Diabetes mellitus

It was decided to take a muscle biopsy that showed an inclusion body myopathy, explaining the initial treatment failure. [scienceopen.com]

Oculopharyngeal Muscular Dystrophy

Histological and histochemical studies of muscle biopsy showed nonspecific myopathic changes; no "ragged-red" fibers were seen. [ncbi.nlm.nih.gov]

A muscle biopsy specimen in Case 2 showed abundant rimmed vacuoles and abnormal filaments 13-19 nm in diameter in the sarcoplasm, usually reported to occur in inclusion body [ncbi.nlm.nih.gov]

Electron microscopy demonstrated bizarre large mitochondria with abnormal cristae, but no intranuclear inclusion bodies. [ncbi.nlm.nih.gov]

Infantile Symmetrical Thalamic Degeneration

Skin biopsy for electron microscope showed lipofuscine inclusion bodies. Muscle biopsy showed nonspecific changes. [alliedacademies.org]

Brain MRI showed deep white matter changes with mild cerebellar atrophy. Skin biopsy for electron microscopy showed lipofuscine inclusion bodies. [alliedacademies.org]

Muscle biopsy showed non-specific changes. He had the slowest regression in developmental milestones in comparison to his sisters. [alliedacademies.org]

Fingerprint Body Myopathy

Muscle biopsy revealed inflammatory infiltrates and rimmed vacuoles, similar to those found in inclusion-body myositis. [pure.unic.ac.cy]

Laboratory investigations showed anti-gliadin antibodies and severe vitamin E deficiency. [pure.unic.ac.cy]

Polymyositis

Furthermore, the muscle biopsy in sIBM often shows the presence of inclusion bodies and/or mitochondrial alterations by modified Gomori trichrome staining or electron microscopy [empendium.com]

Muscle biopsies showing rimmed vacuoles, whose histology suggests cytoplasm inclusion bodies were excluded intending to exclude the cases of inclusion-bodies myositis 14. [doi.org]

Muscle biopsies showing rimmed vacuoles, whose histology suggests cytoplasm inclusion bodies were excluded intending to exclude the cases of inclusion-bodies myositis14. [scielo.br]

Labor

Although classified as an inflammatory myopathy, inclusion body myositis shows minimal evidence of inflammation. [emedicine.medscape.com]

Moreover, both conditions may be associated with malignancies. [5] Despite these similarities, muscle biopsy findings and characteristic skin findings of dermatomyositis reveal [emedicine.medscape.com]

Birth

Although classified as an inflammatory myopathy, inclusion body myositis shows minimal evidence of inflammation. [emedicine.medscape.com]

Puerperium

Although classified as an inflammatory myopathy, inclusion body myositis shows minimal evidence of inflammation. [emedicine.medscape.com]

Distal Spinal Muscular Atrophy Type 5

Electromyography (EMG) and occasionally muscle biopsy are needed to confirm the diagnosis. Inclusion body myositis has a more benign prognosis than MND. [patient.info]

The list below shows further conditions that may have similar clinical features: Diabetic amyotrophy. Guillain-Barré syndrome. Post-polio syndrome. [patient.info]

Myositis

Muscle biopsy reveals inclusion bodies i.e. rimmed vacuoles formed due to the collection of abnormal proteins. [kenhub.com]

Possible inclusion body myositis If the muscle shows only inflammation (invasion of nonnecrotic muscle fibers by mononuclear cells)—without other pathologic features of inclusion [ncbi.nlm.nih.gov]

Limb-Girdle Muscular Dystrophy Type 1E

A muscle biopsy will show ragged-red fibers which contain accumulations of glycogen and neutral lipids. [lecturio.com]

Muscle biopsy of myofibrillar myopathies See the list below. [emedicine.medscape.com]

Inflammatory Myopathies These are a group of diseases including polymyositis, dermatomyositis, inclusion body myositis and necrotizing autoimmune myopathy. [lecturio.com]

Muscular Dystrophy-Dystroglycanopathy Type C14

A muscle biopsy will show ragged-red fibers which contain accumulations of glycogen and neutral lipids. [lecturio.com]

Inflammatory Myopathies These are a group of diseases including polymyositis, dermatomyositis, inclusion body myositis and necrotizing autoimmune myopathy. [lecturio.com]

Zebra Body Myopathy

A sporadic inclusion body myopathy was suspected clinically and a muscle biopsy was performed. [nmd-journal.com]

EMG showed a mixed neurogenic–myopathic picture; fatty degeneration of the flexors of the thighs was seen on MRI. [nmd-journal.com]

Lower Motor Neuron Syndrome with Late-Adult Onset

Electromyography (EMG) and occasionally muscle biopsy are needed to confirm the diagnosis. Inclusion body myositis has a more benign prognosis than MND. [patient.info]

In these cases muscle biopsy is likely to provide diagnostically useful information. [journals.plos.org]

The list below shows further conditions that may have similar clinical features: Diabetic amyotrophy. Guillain-Barré syndrome. Post-polio syndrome. [patient.info]

Bilateral Leg Weakness

Electromyography (EMG) and occasionally muscle biopsy are needed to confirm the diagnosis. Inclusion body myositis has a more benign prognosis than MND. [patient.info]

The list below shows further conditions that may have similar clinical features: Diabetic amyotrophy. Guillain-Barré syndrome. Post-polio syndrome. [patient.info]

Limb-Girdle Muscular Dystrophy Type 2E

A muscle biopsy will show ragged-red fibers which contain accumulations of glycogen and neutral lipids. [lecturio.com]

Muscle biopsy of myofibrillar myopathies See the list below. [emedicine.medscape.com]

Inflammatory Myopathies These are a group of diseases including polymyositis, dermatomyositis, inclusion body myositis and necrotizing autoimmune myopathy. [lecturio.com]

Neuronal Ceroid Lipofuscinosis Type 3

Skin and muscle biopsy for inclusion bodies were negative and blood film showed no vacuolated lymphocytes. [pediatricneurosciences.com]

Muscular Dystrophy-Dystroglycanopathy Type C3

A muscle biopsy will show ragged-red fibers which contain accumulations of glycogen and neutral lipids. [lecturio.com]

Muscle biopsy of myofibrillar myopathies See the list below. [emedicine.medscape.com]

Inflammatory Myopathies These are a group of diseases including polymyositis, dermatomyositis, inclusion body myositis and necrotizing autoimmune myopathy. [lecturio.com]

Muscular Dystrophy-Dystroglycanopathy Type C9

A muscle biopsy will show ragged-red fibers which contain accumulations of glycogen and neutral lipids. [lecturio.com]

Inflammatory Myopathies These are a group of diseases including polymyositis, dermatomyositis, inclusion body myositis and necrotizing autoimmune myopathy. [lecturio.com]