Possible Causes for muscle biopsy showing inclusion bodies Inclusion Body Myositis We performed a muscle biopsy that showed inclusion body myositis (IBM). [ncbi.nlm.nih.gov] A review of the previously performed muscle biopsy showed most of the cardinal myopathologic features of sporadic inclusion body myositis, in addition to the granuloma. [ncbi.nlm.nih.gov] The muscle biopsy of inclusion body myositis shows mild to moderate inflammation, atrophic denervated fibers, and most characteristically "rimmed vacuoles" as well as some [bcm.edu] Labor Although classified as an inflammatory myopathy, inclusion body myositis shows minimal evidence of inflammation. [emedicine.medscape.com] Moreover, both conditions may be associated with malignancies. [5] Despite these similarities, muscle biopsy findings and characteristic skin findings of dermatomyositis reveal [emedicine.medscape.com] Birth Although classified as an inflammatory myopathy, inclusion body myositis shows minimal evidence of inflammation. [emedicine.medscape.com] Moreover, both conditions may be associated with malignancies. [5] Despite these similarities, muscle biopsy findings and characteristic skin findings of dermatomyositis reveal [emedicine.medscape.com] Puerperium Although classified as an inflammatory myopathy, inclusion body myositis shows minimal evidence of inflammation. [emedicine.medscape.com] Moreover, both conditions may be associated with malignancies. [5] Despite these similarities, muscle biopsy findings and characteristic skin findings of dermatomyositis reveal [emedicine.medscape.com] Radiculomyelopathy Electromyography (EMG) and occasionally muscle biopsy are needed to confirm the diagnosis. Inclusion body myositis has a more benign prognosis than MND. [patient.info] The list below shows further conditions that may have similar clinical features: Diabetic amyotrophy. Guillain-Barré syndrome. Post-polio syndrome. [patient.info] Granulomatous Myositis A review of the previously performed muscle biopsy showed most of the cardinal myopathologic features of sporadic inclusion body myositis, in addition to the granuloma. [ncbi.nlm.nih.gov] Muscle biopsy reveals inclusion bodies i.e. rimmed vacuoles formed due to the collection of abnormal proteins. [kenhub.com] In inclusion body myositis, findings on muscle biopsy may show the presence of vacuolated muscle fibers with basophilic granular deposits, the presence of varying degrees [rheumatologyadvisor.com] Benign Adult Familial Myoclonic Epilepsy The diagnosis is made by biopsy (skin, muscle, liver, brain) showing periodic acid-Schiff positive glycogen-like intracellular inclusion bodies (Lafora bodies). [neuroweb.us] Brain MRI shows often cerebellar atrophy. [neuroweb.us] Celiac Disease Muscle biopsy showed inflammatory changes in five. One patient had evidence of inclusion body myositis. [dx.doi.org] Myositis Muscle biopsy reveals inclusion bodies i.e. rimmed vacuoles formed due to the collection of abnormal proteins. [kenhub.com] Possible inclusion body myositis If the muscle shows only inflammation (invasion of nonnecrotic muscle fibers by mononuclear cells)—without other pathologic features of inclusion [ncbi.nlm.nih.gov] In inclusion body myositis, findings on muscle biopsy may show the presence of vacuolated muscle fibers with basophilic granular deposits, the presence of varying degrees [rheumatologyadvisor.com] Distal Spinal Muscular Atrophy Type 5 Electromyography (EMG) and occasionally muscle biopsy are needed to confirm the diagnosis. Inclusion body myositis has a more benign prognosis than MND. [patient.info] The list below shows further conditions that may have similar clinical features: Diabetic amyotrophy. Guillain-Barré syndrome. Post-polio syndrome. [patient.info] Amyotrophic Lateral Sclerosis Type 1 Electromyography (EMG) and occasionally muscle biopsy are needed to confirm the diagnosis. Inclusion body myositis has a more benign prognosis than MND. [patient.info] The list below shows further conditions that may have similar clinical features: Diabetic amyotrophy. Guillain-Barré syndrome. Post-polio syndrome. [patient.info] Progressive Bulbar Paralysis Electromyography (EMG) and occasionally muscle biopsy are needed to confirm the diagnosis. Inclusion body myositis has a more benign prognosis than MND. [patient.info] The list below shows further conditions that may have similar clinical features: Diabetic amyotrophy. Guillain-Barré syndrome. Post-polio syndrome. [patient.info] Upper Motor Neuron Disease Electromyography (EMG) and occasionally muscle biopsy are needed to confirm the diagnosis. Inclusion body myositis has a more benign prognosis than MND. [patient.info] The list below shows further conditions that may have similar clinical features: Diabetic amyotrophy. Guillain-Barré syndrome. Post-polio syndrome. [patient.info] Motor Neuron Disease Electromyography (EMG) and occasionally muscle biopsy are needed to confirm the diagnosis. Inclusion body myositis has a more benign prognosis than MND. [patient.info] The list below shows further conditions that may have similar clinical features: Diabetic amyotrophy. Guillain-Barré syndrome. Post-polio syndrome. [patient.info] Amyotrophic Lateral Sclerosis Electromyography (EMG) and occasionally muscle biopsy are needed to confirm the diagnosis. Inclusion body myositis has a more benign prognosis than MND. [patient.info] The list below shows further conditions that may have similar clinical features: Diabetic amyotrophy. Guillain-Barré syndrome. Post-polio syndrome. [patient.info] Primary Lateral Sclerosis Electromyography (EMG) and occasionally muscle biopsy are needed to confirm the diagnosis. Inclusion body myositis has a more benign prognosis than MND. [patient.info] The list below shows further conditions that may have similar clinical features: Diabetic amyotrophy. Guillain-Barré syndrome. Post-polio syndrome. [patient.info] Idiopathic Camptocormia Thoracic paraspinal muscle biopsy showed canonical features of inclusion body myositis. [mayoclinic.pure.elsevier.com] Thoracic paraspinal muscle biopsy showed canonical features of inclusion body myositis. The current patient broadens the clinical presentation of inclusion body myositis. [mayoclinic.pure.elsevier.com] Neurologic examination revealed no limb weakness. magnetic resonance imaging studies showed atrophy and findings, suggesting fatty replacement of paraspinal muscles. [mayoclinic.pure.elsevier.com] Inclusion Body Myopathy The muscle biopsy of inclusion body myositis shows mild to moderate inflammation, atrophic denervated fibers, and most characteristically "rimmed vacuoles" as well as some [bcm.edu] One sibling also showed PDB. Light and electron microscopy performed on muscle biopsies demonstrated degenerative changes with inclusion bodies and abnormal aggregates. [ncbi.nlm.nih.gov] The clinical features and histological characteristics of the muscle biopsies showed the typical pattern of predominantly distal vacuolar myopathy with quadriceps sparing. [ncbi.nlm.nih.gov] Bilateral Leg Weakness Electromyography (EMG) and occasionally muscle biopsy are needed to confirm the diagnosis. Inclusion body myositis has a more benign prognosis than MND. [patient.info] The list below shows further conditions that may have similar clinical features: Diabetic amyotrophy. Guillain-Barré syndrome. Post-polio syndrome. [patient.info] Renal Injury Although classified as an inflammatory myopathy, inclusion body myositis shows minimal evidence of inflammation. [emedicine.medscape.com] Moreover, both conditions may be associated with malignancies. [5] Despite these similarities, muscle biopsy findings and characteristic skin findings of dermatomyositis reveal [emedicine.medscape.com] Adult Polyglucosan Body Disease Some muscle biopsies show these inclusions in intramuscular nerve branches. [ncbi.nlm.nih.gov] METHODS: Fifteen muscle biopsies from adults between the ages of 36 and 84 years, all showing polyglucosan bodies in intramuscular peripheral nerve twigs, were tested by sequencing [ncbi.nlm.nih.gov] INTRODUCTION: Adult polyglucosan body disease (APBD) is associated with formation of polyglucosan bodies in peripheral nerve branches. [ncbi.nlm.nih.gov] Alcoholic Hepatitis Liver biopsy in these patients shows steatosis, swollen hepatocytes containing eosinophilic inclusion (Mallory) bodies, and a prominent neutrophilic inflammatory cell infiltrate [the-hospitalist.org] […] average consumption in one study was 100 g/day (the equivalent of 10 drinks per day). 1 The typical patient presents with recent onset of jaundice, ascites, and proximal muscle [the-hospitalist.org] Bacterial Myositis Muscle biopsy reveals inclusion bodies i.e. rimmed vacuoles formed due to the collection of abnormal proteins. [kenhub.com] The muscle biopsy specimen demonstrated an inflammatory infiltrate. No inclusion bodies or viral particles were seen. [atmph.org] T1 W magnetic resonance imaging show fatty replacement of hamstring muscles. [kenhub.com] Left Ventricular Noncompaction Muscle biopsy of myofibrillar myopathies See the list below. [emedicine.medscape.com] Light microscopy: Trichrome-stained tissue shows single or multiple areas of blue-red amorphous material described as hyaline structures, cytoplasmic bodies, or inclusions [emedicine.medscape.com] Oculopharyngeal Muscular Dystrophy Histological and histochemical studies of muscle biopsy showed nonspecific myopathic changes; no "ragged-red" fibers were seen. [ncbi.nlm.nih.gov] A muscle biopsy specimen in Case 2 showed abundant rimmed vacuoles and abnormal filaments 13-19 nm in diameter in the sarcoplasm, usually reported to occur in inclusion body [ncbi.nlm.nih.gov] Electron microscopy demonstrated bizarre large mitochondria with abnormal cristae, but no intranuclear inclusion bodies. [ncbi.nlm.nih.gov] Secondary Myopathy […] to the ones seen in inclusion body myositis (IBM). [sites.google.com] CK and aldolase levels are normal Muscle biopsy is not necessary for the diagnosis, but if obtained, it would show chronic myopathic features and red-rimmed vacuoles similar [sites.google.com] MELAS Syndrome There were no ragged-red fibers, but paracrystalline inclusion bodies were shown in the muscle biopsies under electron microscopic examination. [ncbi.nlm.nih.gov] Brain magnetic resonance images showed multiple increased signal intensities over the left frontal, parietal and temporal areas. [ncbi.nlm.nih.gov] Polymyositis Furthermore, the muscle biopsy in sIBM often shows the presence of inclusion bodies and/or mitochondrial alterations by modified Gomori trichrome staining or electron microscopy [empendium.com] Muscle biopsies showing rimmed vacuoles, whose histology suggests cytoplasm inclusion bodies were excluded intending to exclude the cases of inclusion-bodies myositis 14. [doi.org] The muscle biopsy specimen demonstrated an inflammatory infiltrate. No inclusion bodies or viral particles were seen. [atmph.org] Muscular Dystrophy-Dystroglycanopathy Type C14 A muscle biopsy will show ragged-red fibers which contain accumulations of glycogen and neutral lipids. [lecturio.com] Inflammatory Myopathies These are a group of diseases including polymyositis, dermatomyositis, inclusion body myositis and necrotizing autoimmune myopathy. [lecturio.com] Limb-Girdle Muscular Dystrophy Type 2F A muscle biopsy will show ragged-red fibers which contain accumulations of glycogen and neutral lipids. [lecturio.com] Muscle biopsy of myofibrillar myopathies See the list below. [emedicine.medscape.com] Inflammatory Myopathies These are a group of diseases including polymyositis, dermatomyositis, inclusion body myositis and necrotizing autoimmune myopathy. [lecturio.com]
