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73 Possible Causes for Muscle Biopsy showing Inflammatory Changes, Vacuolization

  • Inclusion Body Myositis

    The coexistence of ring fibres, rimmed vacuoles and inclusion-body myositis-type inclusions in a child with congenital myopathy has not been previously reported.[ncbi.nlm.nih.gov] Muscle biopsy shows inflammatory reaction in association with degenerative changes of the muscle fibers.[scielo.br] Abstract OBJECTIVE: Sporadic inclusion body myositis (sIBM) pathogenesis is unknown; however, rimmed vacuoles (RVs) are a constant feature.[ncbi.nlm.nih.gov]

  • Polymyositis

    KEYWORDS: anti-Ku antibody; dropped head syndrome; rimmed vacuole; scleroderma-polymyositis overlap syndrome[ncbi.nlm.nih.gov] Muscle biopsy shows chronic inflammatory changes consistent with polymyositis.[emedicine.medscape.com] […] may be difficult to find or not be "classic" Presence of occasional granular staining suggestive for vacuoles using LC3 or ubiquitin requires clinical correlation to determine[pathologyoutlines.com]

  • Tropical Myositis

    Sixteen showed changes of suppurative myositis i.e. non-specific acute inflammatory reaction, muscle necrosis with myocytolysis, vacuolation of cytoplasm and loss of striations[ncbi.nlm.nih.gov] Sixteen showed changes of suppurative myositis i.e. non-specific acute inflammatory reaction, muscle necrosis with myocytolysis, vacuolation of cytoplasm and loss of striations[ncbi.nlm.nih.gov] Twenty four muscle biopsies were taken.[ncbi.nlm.nih.gov]

  • Dermatomyositis

    Vacuoles in small & intermediate-sized muscle fibers GT stain Congo red stain Abnormal internal architecture in dermatomyositis muscle fibers is more apparent on Gomori trichrome[neuromuscular.wustl.edu] Representative muscle biopsy micrograph (from another patient) shows inflammatory myopathic changes seen in dermatomyositis. (From Reference 3 , with permission.)[rc.rcjournal.com] However in this picture ( Figure 4a ), the white spaces or vacuoles were interspersed between the keratinocytes.[omicsonline.org]

  • Childhood Dermatomyositis

    Numerous dark-stained fibers and vacuoles were observed in periodic acid-Schiff (PAS) staining.[ijdvl.com] Vacuoles in small & intermediate-sized muscle fibers GT stain Congo red stain Abnormal internal architecture in dermatomyositis muscle fibers is more apparent on Gomori trichrome[neuromuscular.wustl.edu] Notably, muscle biopsy from JDM patients can present with striking patterns of vacuoles that are similar to those in GSD.[ijdvl.com]

  • Oculopharyngeal Muscular Dystrophy

    In contrast, patients with distal myopathy with rimmed vacuoles revealed many rimmed vacuoles, on average in 20% of the fibers, and their oculopharyngeal muscles were spared[ncbi.nlm.nih.gov] The first muscle biopsy appeared normal except for some round-cell collections, whereas the second one, 5 years later, showed marked dystrophic changes.[ncbi.nlm.nih.gov] Innervated cultures had large cytoplasmic vacuoles in a number of muscle fibers.[ncbi.nlm.nih.gov]

  • Inclusion Body Myopathy

    The most significant muscle pathology is the presence of rimmed vacuoles, which appear to play a major role in muscle atrophy and weakness.[ncbi.nlm.nih.gov] Muscle Pathology Muscle biopsy from patient III-1 showed myopathic and neuropathic changes with marked fiber size variation, scattered or clusters of small atrophic angulated[journals.plos.org] HIBM was originally described as rimmed vacuole myopathy sparing the quadriceps; therefore, the two diseases have been suspected to be allelic.[ncbi.nlm.nih.gov]

  • Sarcotubular Myopathy

    The vacuoles are similar to those described in sarcotubular myopathy. TRIM32 sequencing revealed the common c.1459G A mutation at homozygosity.[ncbi.nlm.nih.gov] Muscle biopsy may show inflammatory changes. No brain or eye abnormalities are present. Intellect is normal.[emedicine.medscape.com] Myriad small spaces appeared in abnormal fibers in the transverse sections, while in longitudinal sections the vacuolation was segmental in distribution.[mayoclinic.pure.elsevier.com]

  • Trichinellosis

    […] invasion H&E stain Inclusions in Muscle fibers Inclusions in muscle fibers: Possible trichina larva within muscle fibers Muscle fibers: Other pathology Muscle Fibers Necrosis Vacuolation[neuromuscular.wustl.edu]

  • Limb-Girdle Muscular Dystrophy

    […] pathology Vacuoles/ultrastructure Substances Chromatin LMNA protein, human Lamin Type A MyoD Protein MyoD1 myogenic differentiation protein PAX7 Transcription Factor PAX7[ncbi.nlm.nih.gov] Dystrophies are a group of non-inflammatory hereditary conditions which show dystrophic changes (increased connective tissue, fiber splitting) on biopsy without degeneration[lecturio.com] Our case suggests that posterior-dominant lower limb muscle impairment with gluteus and truncal muscle involvement and the detection of rimmed vacuoles on a muscle biopsy[ncbi.nlm.nih.gov]

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