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99 Possible Causes for Muscle Biopsy showing Variation In Fiber Size, No Muscle Weakness

  • Muscular Dystrophy

    Muscle biopsies of the proband showed large variations in muscle fiber size, necrotic and regenerating fibers and an increase in endomysial collagen tissue.[ncbi.nlm.nih.gov] It causes progressive weakness in muscles of the face, arms, legs, and around the shoulders and chest.[ninds.nih.gov] variation in muscle fiber size not segregated by motor unit.[merckmanuals.com]

  • Duchenne Muscular Dystrophy

    Occasionally, however, females who carry a DMD gene mutation may have muscle weakness and cramping.[ghr.nlm.nih.gov] Generally, proximal muscle weakness is noticed earlier followed by distal muscle weakness.[symptoma.com] Muscular dystrophies are a group of genetic conditions characterized by progressive muscle weakness and wasting (atrophy).[ghr.nlm.nih.gov]

  • Becker Muscular Dystrophy

    The muscle biopsy was myopathic with increased fiber size variation and many internal nuclei, but no dystrophy. No comorbidity was found.[ncbi.nlm.nih.gov] Later symptoms Muscle weakness: Affects the proximal muscles of the limbs mainly.[patient.info] Muscle biopsy revealed mild myopathic features including variation in fiber size and a few necrotic and regenerating muscle fibers.[doi.org]

  • Limb-Girdle Muscular Dystrophy

    Muscle biopsy can show diffuse variation in fiber size, necrosis, regeneration and fibrosis.[dnatesting.uchicago.edu] However, most patients in the current family showed distal as well as proximal limb weakness rather than weakness of toe and finger flexor muscles that were typical features[ncbi.nlm.nih.gov] Muscle biopsy shows evidence of a dystrophy with random variation in fiber size and evidence of degeneration and regeneration. Type one fibers may predominate.[ncbi.nlm.nih.gov]

  • Limb-Girdle Muscular Dystrophy Type 2B

    EMG showed myopathic changes and skeletal muscle biopsies showed severe myopathic changes with variation of fiber size, fiber splitting, increased connective tissue, and some[checkorphan.org] Moreover, polymyositis (PM) is manifested as symmetrical proximal muscle weakness of the four limbs, accompanied by an increased level of serum CK.[ncbi.nlm.nih.gov] Muscle weakness affecting the heart muscles or muscles necessary for breathing is uncommon in people with LGMD2B.[rarediseases.info.nih.gov]

  • Congenital Merosin-Positive Muscular Dystrophy

    (Top) Muscle biopsy showing variation in muscle fiber size with atrophic and hypertrophic fibers.[myslide.es] weakness and contractures, associated with dystrophic changes on skeletal muscle biopsy.[ncbi.nlm.nih.gov] Three alpha-actinin-3-deficient patients had pure CMD and presented in the newborn period with muscle weakness, hypotonia and arthrogryposis.[ncbi.nlm.nih.gov]

  • Rigid Spine Syndrome

    Muscle biopsy performed in the older brother showed increase in fibrosis, variation in fiber size, type I fibre predominance, and the presence of central and eccentric cores[cags.org.ae] Diseases related with Edema and Generalized muscle weakness In the following list you will find some of the most common rare diseases related to Edema and Generalized muscle[mendelian.co] In some individuals with CMD, muscle biopsy may only show fiber size variation with absence of or only mild manifestations of fibrosis, necrosis, or regeneration [ Wang et[ncbi.nlm.nih.gov]

  • Limb-Girdle Muscular Dystrophy Type 2G

    weakness and atrophy.[malacards.org] Foot drop 0009027 Increased connective tissue 0009025 Increased variability in muscle fiber diameter 0003557 Muscular dystrophy 0003560 Proximal muscle weakness in lower[rarediseases.info.nih.gov] A rare autosomal recessive degenerative myopathy (OMIM:601954) characterised by proximal and distal muscle weakness and atrophy in the limbs, dystrophic changes on muscle[medical-dictionary.thefreedictionary.com]

  • Multicore Myopathy with External Ophthalmoplegia

    muscle weakness ; High palate ; Hydrops fetalis ; Increased connective tissue ; Increased variability in muscle fiber diameter ; Joint laxity ; Motor delay ; Muscular dystrophy[mousephenotype.org] Overview A rare disorder characterized by muscle weakness and as well as weakness or paralysis of the external eye muscles.[checkorphan.org] Multicore myopathy, classified with the benign congenital myopathies, is manifest clinically as proximal muscle weakness, hypotonia, and delayed motor development.[ncbi.nlm.nih.gov]

  • Arthrogryposis due to Muscular Dystrophy

    Muscle biopsy shows variation in fiber size, a central nucleus, and replacement of muscle tissue by fibrosis and proliferation of adipose tissue.[pediatricneuro.com] Glossary Amyotrophy -Muscle wasting or weakness Atrophy -when motor neurons in the cord are damaged the muscles become weak and shrink in size Fasciculations -muscle twitching[childneurologyfoundation.org] Muscular dystophies are characterized by progressive skeletal muscle weakness, defects in muscle proteins, and the death of muscle cells and tissue.[ipass.org.uk]

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