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99 Possible Causes for Muscle Biopsy showing Variation In Fiber Size, No Muscle Weakness

  • Muscular Dystrophy

    Muscle biopsies of the proband showed large variations in muscle fiber size, necrotic and regenerating fibers and an increase in endomysial collagen tissue.[] It causes progressive weakness in muscles of the face, arms, legs, and around the shoulders and chest.[] variation in muscle fiber size not segregated by motor unit.[]

  • Duchenne Muscular Dystrophy

    Occasionally, however, females who carry a DMD gene mutation may have muscle weakness and cramping.[] Generally, proximal muscle weakness is noticed earlier followed by distal muscle weakness.[] Muscular dystrophies are a group of genetic conditions characterized by progressive muscle weakness and wasting (atrophy).[]

  • Becker Muscular Dystrophy

    The muscle biopsy was myopathic with increased fiber size variation and many internal nuclei, but no dystrophy. No comorbidity was found.[] Later symptoms Muscle weakness: Affects the proximal muscles of the limbs mainly.[] Muscle biopsy revealed mild myopathic features including variation in fiber size and a few necrotic and regenerating muscle fibers.[]

  • Limb-Girdle Muscular Dystrophy

    Muscle biopsy can show diffuse variation in fiber size, necrosis, regeneration and fibrosis.[] However, most patients in the current family showed distal as well as proximal limb weakness rather than weakness of toe and finger flexor muscles that were typical features[] Muscle biopsy shows evidence of a dystrophy with random variation in fiber size and evidence of degeneration and regeneration. Type one fibers may predominate.[]

  • Limb-Girdle Muscular Dystrophy Type 2B

    EMG showed myopathic changes and skeletal muscle biopsies showed severe myopathic changes with variation of fiber size, fiber splitting, increased connective tissue, and some[] Moreover, polymyositis (PM) is manifested as symmetrical proximal muscle weakness of the four limbs, accompanied by an increased level of serum CK.[] Muscle weakness affecting the heart muscles or muscles necessary for breathing is uncommon in people with LGMD2B.[]

  • Congenital Merosin-Positive Muscular Dystrophy

    (Top) Muscle biopsy showing variation in muscle fiber size with atrophic and hypertrophic fibers.[] weakness and contractures, associated with dystrophic changes on skeletal muscle biopsy.[] Three alpha-actinin-3-deficient patients had pure CMD and presented in the newborn period with muscle weakness, hypotonia and arthrogryposis.[]

  • Rigid Spine Syndrome

    Muscle biopsy performed in the older brother showed increase in fibrosis, variation in fiber size, type I fibre predominance, and the presence of central and eccentric cores[] Diseases related with Edema and Generalized muscle weakness In the following list you will find some of the most common rare diseases related to Edema and Generalized muscle[] In some individuals with CMD, muscle biopsy may only show fiber size variation with absence of or only mild manifestations of fibrosis, necrosis, or regeneration [ Wang et[]

  • Limb-Girdle Muscular Dystrophy Type 2G

    weakness and atrophy.[] Foot drop 0009027 Increased connective tissue 0009025 Increased variability in muscle fiber diameter 0003557 Muscular dystrophy 0003560 Proximal muscle weakness in lower[] A rare autosomal recessive degenerative myopathy (OMIM:601954) characterised by proximal and distal muscle weakness and atrophy in the limbs, dystrophic changes on muscle[]

  • Multicore Myopathy with External Ophthalmoplegia

    muscle weakness ; High palate ; Hydrops fetalis ; Increased connective tissue ; Increased variability in muscle fiber diameter ; Joint laxity ; Motor delay ; Muscular dystrophy[] Overview A rare disorder characterized by muscle weakness and as well as weakness or paralysis of the external eye muscles.[] Multicore myopathy, classified with the benign congenital myopathies, is manifest clinically as proximal muscle weakness, hypotonia, and delayed motor development.[]

  • Arthrogryposis due to Muscular Dystrophy

    Muscle biopsy shows variation in fiber size, a central nucleus, and replacement of muscle tissue by fibrosis and proliferation of adipose tissue.[] Glossary Amyotrophy -Muscle wasting or weakness Atrophy -when motor neurons in the cord are damaged the muscles become weak and shrink in size Fasciculations -muscle twitching[] Muscular dystophies are characterized by progressive skeletal muscle weakness, defects in muscle proteins, and the death of muscle cells and tissue.[]

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