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16 Possible Causes for Muscle Biopsy showing Variation In Fiber Size, Sloping Shoulders

  • Muscular Dystrophy

    Muscle biopsies of the proband showed large variations in muscle fiber size, necrotic and regenerating fibers and an increase in endomysial collagen tissue.[ncbi.nlm.nih.gov] […] muscle weakness causes deformities such as pronounced shoulder blades (scapular winging) and sloping shoulders.[web.archive.org] variation in muscle fiber size not segregated by motor unit.[merckmanuals.com]

  • Facioscapulohumeral Muscular Dystrophy

    Muscle biopsy showed increased variation in fiber size and multifocal degenerating fibers with lymphocytic infiltration.[ncbi.nlm.nih.gov] […] level Shoulder muscle weakness causes deformities such as pronounced shoulder blades (scapular winging) and sloping shoulders.[nlm.nih.gov] […] muscle weakness causes deformities such as pronounced shoulder blades (scapular winging) and sloping shoulders.[ufhealth.org]

  • Arthrogryposis due to Muscular Dystrophy

    Muscle biopsy shows variation in fiber size, a central nucleus, and replacement of muscle tissue by fibrosis and proliferation of adipose tissue.[pediatricneuro.com] In the classic manifestations of AMC, shoulders are sloped, adducted, and internally rotated, the elbows are extended, and the wrists and digits are flexed.[msdmanuals.com]

  • Arthrogryposis Multiplex Congenita

    The muscle biopsies showed fibrosis, variation in fiber size, and extensive fat replacement compatible with muscular dystrophy.[ncbi.nlm.nih.gov] In the classic manifestations of AMC, shoulders are sloped, adducted, and internally rotated, the elbows are extended, and the wrists and digits are flexed.[merckmanuals.com] All presented with arthrogryposis multiplex congenita, severe muscle wasting, lung hypoplasia, and hydrops.[ncbi.nlm.nih.gov]

  • Arthrogryposis Syndrome

    Muscle biopsy shows variation in fiber size, a central nucleus, and replacement of muscle tissue by fibrosis and proliferation of adipose tissue.[pediatricneuro.com] In the classic manifestations of AMC, shoulders are sloped, adducted, and internally rotated, the elbows are extended, and the wrists and digits are flexed.[merckmanuals.com]

  • Distal Myopathy

    Muscle histopathology showed non-specific myopathic findings including increased variation in fiber size and increased internalized nuclei.[ncbi.nlm.nih.gov] In FSHD, due to pectoral atrophy and scapular laxity, the anterior axillary folds point inward, toward the neck, and the shoulders often slope downward.[sites.google.com] Muscle Biopsy Muscle biopsy was obtained from the left biceps brachii. It showed marked fiber size variation ranging from 10 to 120 μm.[karger.com]

  • Distal Myopathy Type 3

    Figure 2 Immunohistochemistry, immunoblotting and molecular genetic analysis. ( A ) Micrograph of the muscle biopsy of the right gastrocnemius muscle showing markedly increased[jmedicalcasereports.biomedcentral.com] In FSHD, due to pectoral atrophy and scapular laxity, the anterior axillary folds point inward, toward the neck, and the shoulders often slope downward.[sites.google.com] Muscle biopsy shows evidence of a dystrophy with random variation in fiber size and evidence of degeneration and regeneration. Type one fibers may predominate.[ncbi.nlm.nih.gov]

  • Nemaline Myopathy 1

    A muscle biopsy specimen (only paraffin sections) indicated a primary myopathy with fiber size variation.[jamanetwork.com] shoulders Abnormality of the clavicle Atrioventricular block Abnormality of the humerus Abnormal aortic morphology Anomalous pulmonary venous return Aortic root aneurysm[mendelian.co] An electromyogram showed a myopathic pattern.[jamanetwork.com]

  • Antenatal Onset Minicore Myopathy with Arthrogryposis

    Muscle biopsies in all four patients showed similar changes.[bioline.org.br] In FSHD, due to pectoral atrophy and scapular laxity, the anterior axillary folds point inward, toward the neck, and the shoulders often slope downward.[sites.google.com] There was mild variation in fiber size without central localization of nuclei. Degenerative or regenerative fibers were not seen.[bioline.org.br]

  • Autosomal Dominant Myoglobinuria

    In most cases of LGMD, routine histochemical studies show typical dystrophic features, including various degrees of muscle-fiber degeneration and regeneration, variation in[emedicine.medscape.com] In FSHD, due to pectoral atrophy and scapular laxity, the anterior axillary folds point inward, toward the neck, and the shoulders often slope downward.[sites.google.com] Details of routine muscle histochemistry include the following: In LGMD1A the muscle biopsy may show rimmed vacuoles.[emedicine.medscape.com]

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