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32 Possible Causes for Muscle Biopsy showing Variation In Fiber Size, Unable to Stand

  • Muscular Dystrophy

    The majority of individuals are unable to sit or stand without support, and some affected children may never learn to walk.[web.archive.org] Muscle biopsies of the proband showed large variations in muscle fiber size, necrotic and regenerating fibers and an increase in endomysial collagen tissue.[ncbi.nlm.nih.gov] variation in muscle fiber size not segregated by motor unit.[merckmanuals.com]

  • Duchenne Muscular Dystrophy

    This can result in trouble standing-up. Most are unable to walk by the age of twelve. Affected muscles may look larger due to increased fat content.[dbpedia.org] Children with Duchenne may be slower to sit, stand or walk. Most are unable to run and jump properly due to weakness in the core muscles of the body.[duchenne.com] This can result in trouble standing up. Most are unable to walk by the age of 12. Affected muscles may look larger due to increased fat content.[en.wikipedia.org]

  • Limb-Girdle Muscular Dystrophy

    They are usually unable to stand without using their own body to steady themselves and, as such, present with Gower’s sign (where patients use their own hands to push off[lecturio.com] Muscle biopsy can show diffuse variation in fiber size, necrosis, regeneration and fibrosis.[dnatesting.uchicago.edu] Muscle biopsy shows evidence of a dystrophy with random variation in fiber size and evidence of degeneration and regeneration. Type one fibers may predominate.[ncbi.nlm.nih.gov]

  • Becker Muscular Dystrophy

    A child with Duchenne MD may: have difficulty walking, running or jumping have difficulty standing up learn to speak later than usual be unable to climb the stairs without[nhs.uk] The muscle biopsy was myopathic with increased fiber size variation and many internal nuclei, but no dystrophy. No comorbidity was found.[ncbi.nlm.nih.gov] Muscle biopsy revealed mild myopathic features including variation in fiber size and a few necrotic and regenerating muscle fibers.[doi.org]

  • Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2B

    They are usually unable to stand without using their own body to steady themselves and, as such, present with Gower’s sign (where patients use their own hands to push off[lecturio.com] EMG showed myopathic changes and skeletal muscle biopsies showed severe myopathic changes with variation of fiber size, fiber splitting, increased connective tissue, and some[checkorphan.org]

  • Polymyositis

    The muscle biopsy showed loss of fascicular architecture, variation in fiber size with atrophic fibers, and degenerating and regenerating fibers with adipose tissue infiltration[annalsofian.org]

  • Dermatomyositis

    Muscle biopsy from a patient with polymyositis showing endomysial inflammatory cells (arrows) and variations of fiber size without a specific pattern (C, H&E 40 ).[doi.org] The main muscle biopsy features are fiber size variability, cellular invasion of non-necrotic muscle fibers expressing MHC-1 antigens, and scattered necrotic and regenerating[doi.org] fibers (Figures 8 and 9 ).[doi.org]

  • Arthrogryposis due to Muscular Dystrophy

    Children with SMA type II may eventually be able to sit, but they are unable to learn to stand or to walk.[healthofchildren.com] Muscle biopsy shows variation in fiber size, a central nucleus, and replacement of muscle tissue by fibrosis and proliferation of adipose tissue.[pediatricneuro.com] These children are unable to learn to sit or to stand. The disease is usually fatal prior to the age of two.[healthofchildren.com]

  • Antenatal Onset Minicore Myopathy with Arthrogryposis

    Loss of ambulation age 9 - 13 DMD Grades: Floor to stand test 1 - Unable to stand from supine, even with use of a chair 2 - Assisted Gowers - requires furniture for assist[quizlet.com] Muscle biopsies in all four patients showed similar changes.[bioline.org.br] : Swimming, Biking Standing and walking programs ROM - home program Resistive exercise?[quizlet.com]

  • Congenital Muscular Dystrophy

    He was unable to stand, speak, and was incontinent.[neurologyindia.com] Muscle biopsies of the proband showed large variations in muscle fiber size, necrotic and regenerating fibers and an increase in endomysial collagen tissue.[ncbi.nlm.nih.gov] Most patients are unable to walk or manage to walk for only a short period of time, usually before puberty. Children can stand and walk with the aid of leg splints.[orpha.net]

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