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27 Possible Causes for Muscle Biopsy showing Variation In Fiber Size, Vertebral Fractures

  • Duchenne Muscular Dystrophy

    We describe the case of a 20-year-old boy with DMD suffering from back pain due to multiple vertebral fractures who was treated with teriparatide.[ncbi.nlm.nih.gov] […] compression fractures.[ncbi.nlm.nih.gov] This must be balanced against side-effects, including osteoporosis and vertebral fractures. Prednisolone is the usual treatment.[patient.info]

  • Muscular Dystrophy

    Vertebral Fractures in Duchenne Muscular Dystrophy Patients Managed With Deflazacort. J Pediatr Orthop. 2018 Jul. 38 (6):320-324. [Medline].[emedicine.com] Muscle biopsies of the proband showed large variations in muscle fiber size, necrotic and regenerating fibers and an increase in endomysial collagen tissue.[ncbi.nlm.nih.gov] variation in muscle fiber size not segregated by motor unit.[merckmanuals.com]

  • Becker Muscular Dystrophy

    fractures: High frequency; Up to 100% by 9 years Short stature 27 ?[neuromuscular.wustl.edu] The muscle biopsy was myopathic with increased fiber size variation and many internal nuclei, but no dystrophy. No comorbidity was found.[ncbi.nlm.nih.gov] fractures. [17] Other bone mass—enhancing drugs may be worthy of further investigation, but research is lacking in this area.[emedicine.medscape.com]

  • Rigid Spine Syndrome

    Colon cancer Acute kidney injury Neoplasm of the pancreas Amyloidosis Elevated serum creatinine Spinal cord compression Vertebral compression fractures Increased lactate[mendelian.co] Muscle biopsy performed in the older brother showed increase in fibrosis, variation in fiber size, type I fibre predominance, and the presence of central and eccentric cores[cags.org.ae] In some individuals with CMD, muscle biopsy may only show fiber size variation with absence of or only mild manifestations of fibrosis, necrosis, or regeneration [ Wang et[ncbi.nlm.nih.gov]

  • Epilepsy

    The vertebral compression fractures appear to result from bone demineralization caused by anticonvulsants prescribed to control seizures.[mayo.edu] Muscle biopsy showed mild variation in fiber size.[ncbi.nlm.nih.gov] ., found that the young men with epilepsy who have normal bone density measurements are at risk of developing seizure-related vertebral fractures, and that tests that generally[mayo.edu]

  • Arthrogryposis Multiplex Congenita

    No history of fractures. The laboratory findings showed normal TSH/T4, a negative Guthrie test and normal karyotype.[casesjournal.biomedcentral.com] The muscle biopsies showed fibrosis, variation in fiber size, and extensive fat replacement compatible with muscular dystrophy.[ncbi.nlm.nih.gov] Figure 4 Sagittal 3DCT scan of the spine shows islands of increased sclerosis in areas of relative radiolucencies within the vertebral bodies.[casesjournal.biomedcentral.com]

  • Congenital Muscular Dystrophy

    Vertebral Fractures in Duchenne Muscular Dystrophy Patients Managed With Deflazacort. J Pediatr Orthop . 2018 Jul. 38 (6):320-324. [Medline] .[emedicine.medscape.com] Muscle biopsies of the proband showed large variations in muscle fiber size, necrotic and regenerating fibers and an increase in endomysial collagen tissue.[ncbi.nlm.nih.gov] Muscle biopsy in all our patients showed a dystrophic picture with extensive pericellular fibrosis, fiber size variation, and rounding.[annalsofian.org]

  • Facioscapulohumeral Muscular Dystrophy

    COMPLICATIONS: inappropriate positioning; there should be a 10 - 20 degree angle between vertebral border of scapula and the spine. rib and scapula fractures brachial plexus[gait.aidi.udel.edu] Muscle biopsy showed increased variation in fiber size and multifocal degenerating fibers with lymphocytic infiltration.[ncbi.nlm.nih.gov] When we examined her at 59 years of age, she displayed asymmetric and predominant weakness of facial and proximal muscles.[ncbi.nlm.nih.gov]

  • Oculopharyngeal Muscular Dystrophy

    Vertebral Fractures in Duchenne Muscular Dystrophy Patients Managed With Deflazacort. J Pediatr Orthop . 2018 Jul. 38 (6):320-324. [Medline] .[emedicine.medscape.com] Muscle biopsy in the four affected patients showed variation in fiber size, and the presence of small angulated fibers and occasional rimmed vacuoles.[ncbi.nlm.nih.gov] Electron microscopic examination revealed an accumulation of filamentous inclusions in muscle fiber nuclei.[ncbi.nlm.nih.gov]

  • Emery-Dreifuss Muscular Dystrophy Type 1

    Vertebral Fractures in Duchenne Muscular Dystrophy Patients Managed With Deflazacort. J Pediatr Orthop . 2018 Jul. 38 (6):320-324. [Medline] .[emedicine.medscape.com] Serum creatine kinase was increased and muscle biopsy showed moderate fiber size variation, internalized nuclei, and absence of emerin staining.[genome.jp] Muscle Histopathology shows nonspecific myopathic or dystrophic changes: variation in fiber size, increase in internal nuclei, increase in endomysial connective tissue, necrotic[physio-pedia.com]

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