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6,083 Possible Causes for Muscle Hypotonia, Osteoporosis, UDP-GlcNAc Decreased

  • Celiac Disease

    Secondary osteoporosis occurs in many diseases. Celiac disease-induced osteoporosis is the consequence of secondary hyperparathyroidism.[ncbi.nlm.nih.gov] The child has failure to thrive , apathy, anorexia, pallor, generalized hypotonia, abdominal distention, and muscle wasting.[merckmanuals.com] It also improves glycemic control in patients with type 1 diabetes mellitus and enhances the absorption of medications for associated hypothyroidism and osteoporosis.[ncbi.nlm.nih.gov]

    Missing: UDP-GlcNAc Decreased
  • Duchenne Muscular Dystrophy

    To date, only bisphosphonates have been used to treat osteoporosis in DMD.[ncbi.nlm.nih.gov] , absent deep tendon reflexes and fasciculations 3 Mildly elevated creatine kinase levels, severe limb contractures present at an early age 4 Acute onset of weakness, hypotonia[orthobullets.com] In 45 patients, the z-score was less than -2.0 in spinal BMD defined as osteoporosis.[ncbi.nlm.nih.gov]

    Missing: UDP-GlcNAc Decreased
  • Hypophosphatasia

    KEYWORDS: ALKALINE PHOSPHATASE; ASFOTASE ALFA; HYPOPHOSPHATASIA; OSTEOMALACIA; OSTEOPOROSIS [Indexed for MEDLINE] Free full text[ncbi.nlm.nih.gov] Motor delays and waddling gait have been attributed to muscle hypotonia. In severe cases, impaired hearing can develop over time.[biodonsys.com] Young children and infants affected with severe forms of HPP, but also adults often present with myopathy characterized by hypotonia or muscle weakness.[ncbi.nlm.nih.gov]

    Missing: UDP-GlcNAc Decreased
  • Hyponatremia

    NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, and Therapy: Osteoporosis prevention, diagnosis, and therapy.[ncbi.nlm.nih.gov] Motor delays and waddling gait have been attributed to muscle hypotonia. In severe cases, impaired hearing can develop over time.[biodonsys.com] Some infants have diminished muscle tone (hypotonia), so that a baby appears “floppy”, attributable to elevated levels of calcium in the blood (hypercalcemia).[rarediseases.org]

    Missing: UDP-GlcNAc Decreased
  • Osteoporosis-Pseudoglioma Syndrome

    OBJECTIVES: To determine whether intravenous bisphosphonate treatment is helpful for children with osteoporosis pseudoglioma syndrome who have severe osteoporosis.[ncbi.nlm.nih.gov] hypotonia, obesity, mental retardation (in some cases), ligament laxity, severe osteoporosis, multiple fractures, short stature, kyphoscoliosis, hyperextensible joints, and[iofbonehealth.org] Terminological discussion followed and it was suggested that these individuals had osteoporosis-pseudoglioma syndrome.[ncbi.nlm.nih.gov]

    Missing: UDP-GlcNAc Decreased
  • Homocystinuria

    Most homocystinuria patients diagnosed in adulthood have severe osteoporosis, and homocystinuria is frequently mentioned as a cause of osteoporosis.[ncbi.nlm.nih.gov] hypotonia at birth; progressive scoliosis, present at birth or within the first year of life; and scleral fragility and increased risk of rupture of the globe.[medicalhomeportal.org] Osteoporosis - in two thirds of patients by age 15. Fatty infiltration of liver . Pancreatitis .[patient.info]

    Missing: UDP-GlcNAc Decreased
  • Rathbun Syndrome

    This is not the same as osteoporosis, another bone disorder that also can lead to bone fractures.[softbonescanada.ca] Some infants have diminished muscle tone (hypotonia), so that a baby appears “floppy”, attributable to elevated levels of calcium in the blood (hypercalcemia).[rarediseases.org] Factors influencing fracture risk, T score, and management of osteoporosis in patients with rheumatoid arthritis in the Consortium of Rheumatology Researchers of North America[profiles.umassmed.edu]

    Missing: UDP-GlcNAc Decreased
  • Singleton Merten Syndrome

    There are no life-threatening causes of osteoporosis . However, complications resulting from untreated osteoporosis are common.[wikidoc.org] Other findings may include neurologic problems, generalized short stature, muscle weakness; poor muscle tone ( hypotonia ); progressive wasting of the muscles ( muscle atrophy[rarediseases.info.nih.gov] Other findings may include neurologic problems, generalized short stature, muscle weakness; poor muscle tone (hypotonia); progressive wasting of the muscles (muscle atrophy[malacards.org]

    Missing: UDP-GlcNAc Decreased
  • Immunodeficiency Type 23

    Impaired function of PGM3 is demonstrated by decreased enzyme activity, reduced UDP-GlcNAc and reduced N-linked glycosylation and O-linked glycosylation [4] PGM3 is composed[en.wikipedia.org] Decreased muscle tone Low muscle tone [ more ] 0001290 Global developmental delay 0001263 High palate Elevated palate Increased palatal height [ more ] 0000218 Hyporeflexia[rarediseases.info.nih.gov] Common neurological symptoms include diminished muscle tone (hypotonia), seizures, deficits in attaining developmental milestones (developmental disability), varying degrees[rarediseases.org]

    Missing: Osteoporosis
  • Alpha-Mannosidosis

    He is also at risk for osteoporosis, which we will need to monitor.[lukechaplin.wordpress.com] (hypotonia), and reduced sensation or other nervous system abnormalities in the extremities (peripheral neuropathy).[ismrd.org] Symptoms of the moderate form of alpha-mannosidosis include: coarse facial features hypotonia skeletal abnormalities mental retardation progressive muscle weakness hearing[egl-eurofins.com]

    Missing: UDP-GlcNAc Decreased

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