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140 Possible Causes for Muscle Hypotonia, Sandal Gap

  • Dubowitz Syndrome

    gap Gap between 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between[rarediseases.info.nih.gov] Low or weak muscle tone 0001252 Neuroblastoma Cancer of early nerve cells 0003006 Otitis media Middle ear infection 0000388 Pes planus Flat feet Flat foot [ more ] 0001763[rarediseases.info.nih.gov] […] frequency of infection infections, recurrent Predisposition to infections Susceptibility to infection [ more ] 0002719 Respiratory insufficiency Respiratory impairment 0002093 Sandal[rarediseases.info.nih.gov]

  • Craniofrontonasal Dysplasia

    gap Scoliosis Sensorineural hearing impairment Sprengel anomaly Thickened nuchal skin fold Woolly hair Aplasia / Hypoplasia of the corpus callosum Aplasia / Hypoplasia of[familydiagnosis.com] Some individuals affected by CFND may also have diminished muscle tone (hypotonia), developmental delays, hearing impairment (sensorineural deafness), a sunken chest (pectus[rarediseases.org] Low or weak muscle tone 0001252 Oral cleft Cleft of the mouth 0000202 Plagiocephaly Flat head syndrome Flattening of skull Rhomboid shaped skull [ more ] 0001357 Sandal gap[rarediseases.info.nih.gov]

  • Early Infantile Epileptic Encephalopathy Type 2

    gap Widely spaced teeth Finger clinodactyly Feeding difficulties in infancy Tented upper lip vermilion Short chin Focal seizures with impairment of consciousness or awareness[mendelian.co] Learning problems (intellectual disabilities), developmental delay, and low muscle tone (hypotonia) are also usually seen in children who have this condition.[diseaseinfosearch.org] Other signs and symptoms may include intellectual disability, reduced muscle tone ( hypotonia ), hypsarrhythmia (an irregular pattern seen on EEG ), dyskinesia (involuntary[rarediseases.info.nih.gov]

  • Down Syndrome

    The space between the first and second toes may also be widened (sandal-gap toes).[merckmanuals.com] From Wikidata Jump to navigation Jump to search chromosomal disease characterized by flat-looking facial features and weak muscle tone (hypotonia) in infancy and is caused[wikidata.org] […] specific clinical signs at birth Neonatal signs of Down syndrome [ 20, 30 ] Most reliable and discriminative signs Small ears Wide space in between the 1st and 2nd toe (“Sandal[ncbi.nlm.nih.gov]

  • Multiple Congenital Anomalies - Hypotonia - Seizures Type 3

    gap Microdontia Renal hypoplasia/aplasia Bilateral single transverse palmar creases Aganglionic megacolon Hypotrichosis Depressed nasal ridge Type II diabetes mellitus Thick[mendelian.co] Peripheral hypotonia that may affect any place between the spinal cord and muscle.[news-medical.net] […] and muscle weakness.[pedsinreview.aappublications.org]

  • Nemaline Myopathy Type 4

    He shows sandal gaps on both flat feet with clinodactyly of the fourth and fifth toes (and more) 612513 PMID: 22579565 severe developmental delay, congenital microcephaly,[panelapp.genomicsengland.co.uk] The main clinical manifestations include weakness (usually most severe in the face, the neck flexors and the proximal limb muscles), hypotonia and depressed or absent deep[orpha.net] People with cap myopathy have muscle weakness (myopathy) and poor muscle tone (hypotonia) throughout the body, but they are most severely affected in the muscles of the face[malacards.org]

  • Mowat-Wilson Syndrome

    An exaggerated sandal gap is a common finding (fig 8C, D). Figure 8 The typical appearance of the hands and feet in Cohen syndrome.[jmg.bmj.com] Low or weak muscle tone 0001252 Open mouth Gaped jawed appearance Gaped mouthed appearance Slack jawed appearance [ more ] 0000194 Posteriorly rotated ears Ears rotated toward[rarediseases.info.nih.gov] 0002213 High palate Elevated palate Increased palatal height [ more ] 0000218 Hypertelorism Wide-set eyes Widely spaced eyes [ more ] 0000316 Hypospadias 0000047 Muscular hypotonia[rarediseases.info.nih.gov]

  • Wiedemann-Steiner Syndrome

    gap Hyperplasia of the maxilla Respiratory failure High, narrow palate Constipation Premature birth Severe muscular hypotonia Abnormality of the thorax Hypokinesia Facial[mendelian.co] […] tone ( hypotonia ).[en.wikipedia.org] Hypertonia Small nail Anxiety Babinski sign Ophthalmoplegia Narrow mouth Deeply set eye Abnormal cardiac septum morphology Flat face Unsteady gait Hypopigmentation of the skin Sandal[mendelian.co]

  • Weaver Syndrome

    gap Gap between 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between[rarediseases.info.nih.gov] Other common symptoms include hypertonia (increased muscle tone, tight muscles) as well as hypotonia (decreased muscle tone, "floppy" muscles) and a hoarse low-pitched cry[encyclopedia.com] Other symptoms include diminished muscle tone (hypotonia), muscle weakness, hernias in the abdomen (umbilical hernias), and/or mental retardation.[rarediseases.org]

  • Lenz-Majewski Syndrome

    gap Sensorimotor neuropathy Hypergonadotropic hypogonadism Trophic changes related to pain Short thumb Limb ataxia Hypertrichosis Spondyloepiphyseal dysplasia Rimmed vacuoles[mendelian.co] Hypotonia Bones And Joints Hyperostosis Diaphyseal Undermodeling Of Long Bones Thickening Of Midshaft Cortices Hypoostosis Of Metaphyses And Epiphyses Related: L[neo-genetics.com] Decreased muscle tone Low muscle tone [ more ] 0001290 Humeroradial synostosis Fusion of upper and lower arm bones 0003041 Hyperextensibility of the finger joints Finger[rarediseases.info.nih.gov]

Further symptoms

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