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18 Possible Causes for Muscle Hypotonia, Syndactyly, Wide Space Between the First and Second Toe

  • Dubowitz Syndrome

    An autosomal recessive disorder characterized by intrauterine growth retardation, postnatal retardation, microcephaly, sparse hair, toe syndactyly, and characteristic facial[ncbi.nlm.nih.gov] Low or weak muscle tone 0001252 Neuroblastoma Cancer of early nerve cells 0003006 Otitis media Middle ear infection 0000388 Pes planus Flat feet Flat foot [ more ] 0001763[rarediseases.info.nih.gov] Minor anomalies as clinodactylyl of the firth digits, cutaneous syndactyly of toes, foot deformity, sacral dimple and cryptorchidism may be seen.[ncbi.nlm.nih.gov]

  • Craniofrontonasal Dysplasia

    Hand polydactyly Hemihypotrophy of lower limb Preaxial foot polydactyly Sandal gap Toe syndactyly Abnormality of prenatal development or birth Thickened nuchal skin fold[familydiagnosis.com] Some individuals affected by CFND may also have diminished muscle tone (hypotonia), developmental delays, hearing impairment (sensorineural deafness), a sunken chest (pectus[rarediseases.org] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov]

  • Russell-Silver Syndrome

    Syndactyly (fusion) of toes. Sprengel's neck deformity - unilateral shortening and webbing to trunk. X-ray abnormalities include: Delayed bone age.[patient.info] Generalized low muscle tone in neonate 0008935 Hyperhidrosis Excessive sweating Increased sweating Profuse sweating Sweating Sweating profusely Sweating, increased [ more[rarediseases.info.nih.gov] […] craniofacial disproportion (triangular faces), asymmetric limb, curling up of the fifth digit (small finder or pinky) called clinodactyly, campodactyly (fixed flexion of digits), syndactyly[symptoma.com]

  • Weaver Syndrome

    Cryptorchidism Undescended testes Undescended testis [ more ] 0000028 Downslanted palpebral fissures Downward slanting of the opening between the eyelids 0000494 Finger syndactyly[rarediseases.info.nih.gov] Other common symptoms include hypertonia (increased muscle tone, tight muscles) as well as hypotonia (decreased muscle tone, "floppy" muscles) and a hoarse low-pitched cry[encyclopedia.com] Other features include cerebellar nystagmus, strabismus, pes planus, kyphoscoliosis, unequal lower limb length, syndactyly, large hands and feet, abnormal dermatoglyphics,[scielo.br]

  • Ring Chromosome 10

    The patient was referred to our Unit because of persistent thrombocytopenia and syndactyly, pes planus and a bilateral Babinski sign.[omicsonline.org] Low or weak muscle tone 0001252 Pectus excavatum Funnel chest 0000767 Renal hypoplasia/aplasia Absent/small kidney Absent/underdeveloped kidney [ more ] 0008678 Sandal gap[rarediseases.info.nih.gov] […] include permanent flexion (camptodactyly) and/or overlapping of certain fingers; an unusually large distance between the great toes (hallux) and the second toes; webbing (syndactyly[rarediseases.org]

  • Atelosteogenesis Type 2

    Syndactyly, Malik-Percin type Syndactyly of toes, telecanthus, ano- and renal malformations (STAR) syndrome Syndactyly type Lueken Oculodentodigital dysplasia Syndactyly[emedicine.medscape.com] He had difficulty in walking, mild proximal muscular hypotonia in the lower extremities and hyperactive deep tendon reflexes.[nature.com] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov]

  • Macrocephaly-Developmental Delay Syndrome

    Keywords: Cutis marmorata telangiectatica congenita, macrocephaly, syndactyly How to cite this article: Mulye S, Majethia A, Kumar R.[ijpd.in] However, young AS patients may also exhibit feeding difficulties and muscle hypotonia.[clinchem.aaccjnls.org] space between first and second toes (sandal toes) clinodactyly of the fifth finger All of these are found in individuals without DS.[medicalhomeportal.org]

  • Genee-Wiedemann Syndrome

    Postaxial limb deficiency, syndactyly and abnormal ulna/radius are noted. Intelligence is usually normal.[jomfp.in] Grubben de Cock Borghgraef syndrome 0 *Developmental Disabilities *Eczema/congenital *Muscle Hypotonia/congenital *Tooth Abnormalities *Limb Deformities, Congenital.[reference.md] He had a wide space between the first and second toe of his feet and subungual fibroma on the second and third toe of the right foot and on the third toe of the left foot.[jmg.bmj.com]

  • Familial Congenital Nasolacrimal Duct Obstruction

    For example, in Apert syndrome, syndactyly of the hands and feet frequently occurs.[entokey.com] Cramp Muscle Hypertonia Muscle Hypotonia Muscle Neoplasms Muscle Rigidity Muscle Spasticity Muscle Weakness Muscular Atrophy Muscular Atrophy, Spinal Muscular Diseases Muscular[medgene.med.harvard.edu] space between first and second toes (sandal toes) clinodactyly of the fifth finger All of these are found in individuals without DS.[medicalhomeportal.org]

  • Cutis Laxa

    Cutis laxa has also been described in children with Lenz-Majewski hyperostotic dwarfism in association with syndactyly, brachydactyly, mental retardation, hypertelorism and[caribbean.scielo.org] Individuals with EFEMP2 -related cutis laxa usually present with muscle hypotonia. Other common findings are arachnodactyly, joint laxity, and pectus deformities.[ncbi.nlm.nih.gov] Other reported osteoarticular features are: a wide space between the first and second toes; talipes equinovarus; metatarsus adductus; genu recurvatum or genu valgum; flat[scielo.br]

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