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9 Possible Causes for Muscle Succinate Dehydrogenase Decreased

  • Hereditary Myopathy with Lactic Acidosis due to ISCU Deficiency

    Abstract Recently, we described a patient with severe exercise intolerance and episodic myoglobinuria, associated with marked impairment of succinate oxidation and deficient activity of succinate dehydrogenase and aconitase in muscle mitochondria (1). We now report additional enzymatic and immunological[…][jci.org]

  • Myopathy

    dehydrogenase in regenerating muscle [ Kollberg et al 2011 ].[ncbi.nlm.nih.gov] This observation suggests that increased levels of misspliced ISCU and decreased levels of ISCU protein that accompany muscle maturation and physical activity-related oxidative[ncbi.nlm.nih.gov] […] homozygous for the common Swedish pathogenic variant had higher muscle levels of normally spliced ISCU RNA and ISCU protein and normal levels of histochemically assessed succinate[ncbi.nlm.nih.gov]

  • Multiple Symmetric Lipomatosis

    Levels of respiratory-chain enzyme show a significant decrease of cytochrome-c oxidase, succinic dehydrogenase, and citrate synthase activity [52].[clicktocurecancer.info] There is evidence for a mitochondrial dysfunction in muscle fibres.[clicktocurecancer.info]

  • Familial Progressive Polyneuropathy

    Histopathological studies of biopsied muscle specimens from patient 1 revealed numerous ragged red fibers as well as fibers with increased succinate dehydrogenase activity[jstage.jst.go.jp] […] and decreased cytochrome c oxidase activity.[jstage.jst.go.jp] Multiple mtDNA deletions were detected, both by Southern blot and long-range PCR assays of total DNA from the biopsied muscle specimens.[jstage.jst.go.jp]

  • Launois Syndrome

    Levels of respiratory-chain enzyme show a significant decrease of cytochrome-c oxidase, succinic dehydrogenase, and citrate synthase activity [52].[clicktocurecancer.info] There is evidence for a mitochondrial dysfunction in muscle fibres.[clicktocurecancer.info]

  • Mitochondrial Myopathy

    These ragged-red fibers contain mild accumulations of glycogen and neutral lipids, and may show an increased reactivity for succinate dehydrogenase and a decreased reactivity[en.wikipedia.org] A muscle biopsy was performed for biochemical evaluation, which revealed several abnormalities including decreased levels of citric acid synthase (49% of normal), cytochrome[jmedicalcasereports.biomedcentral.com] On biopsy, the muscle tissue of patients with these diseases usually demonstrate "ragged red" muscle fibers.[en.wikipedia.org]

  • Myoadenylate Deaminase Deficiency

    Approximately 10% of the muscle fibers showed a marked decreased reactivity of CCO in the respective stain ( fig. 2C ).[anesthesiology.pubs.asahq.org] By oxidative enzyme histochemistry (reduced nicotinamide adenine dinucleotide-tetrazolium reductase (NADH-TR), succinate dehydrogenase (SDH), cytochrome-c-oxidase [CCO]),[anesthesiology.pubs.asahq.org]

  • Mitochondrial Myopathy and Sideroblastic Anemia

    […] or fibroblasts; (2) evidence of mutations or deletions in mt-DNA; (3) characteristic changes, such as ragged red muscle fibres on trichrome Gomori stain, or decreased succinate[adc.bmj.com] dehydrogenase or cytochrome C oxidase staining in muscle biopsy; (4) evidence of abundant abnormal ultrastructure of mitochondria; (5) excretion of abnormal organic acids[adc.bmj.com] […] mitochondrial disorder was based on accepted clinical presentations and at least one of the following: (1) deficiency of respiratory chain enzymes or pyruvate utilisation enzymes in muscle[adc.bmj.com]

  • Adenosine Monophosphate Deaminase Deficiency

    Approximately 10% of the muscle fibers showed a marked decreased reactivity of CCO in the respective stain ( fig. 2C ).[anesthesiology.pubs.asahq.org] By oxidative enzyme histochemistry (reduced nicotinamide adenine dinucleotide-tetrazolium reductase (NADH-TR), succinate dehydrogenase (SDH), cytochrome-c-oxidase [CCO]),[anesthesiology.pubs.asahq.org]

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