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23 Possible Causes for Muscle Twitch, Onset of Symptoms in First or Second Decade of Life, Psychomotor Retardation

  • Hallervorden-Spatz Syndrome

    There is an early onset classic form with symptoms of extrapyramidal disease beginning in the first decade of life and rapid progression to loss of ambulation in about 15[disorders.eyes.arizona.edu] They may experience involuntary muscle contractions (dystonia) of the head and neck, resulting in repetitive movements and contortions.[ghr.nlm.nih.gov] Others with atypical disease may not have symptoms until the second or third decades.[disorders.eyes.arizona.edu]

  • Paraplegia

    Clinical Correlations: Spastic paraplegia 7 may have its onset in the second decade of life but sometimes much later.[disorders.eyes.arizona.edu] , but also to cause muscle hypertrophy and muscle fibre shift from fast twitch type 2X to 2A. 3 In addition to these effects, oxidative enzyme activity has also been shown[bjsm.bmj.com] retardation with or without seizures AR 13 13 HSPD1 * Spastic paraplegia, Leukodystrophy, hypomyelinating AD/AR 5 5 IBA57 Multiple mitochondrial dysfunctions syndrome 3,[blueprintgenetics.com]

  • Spastic Paraparesis-Deafness Syndrome

    Clinical Correlations: Spastic paraplegia 7 may have its onset in the second decade of life but sometimes much later.[disorders.eyes.arizona.edu] Apraxia (Medical Encyclopedia) Hand or foot spasms (Medical Encyclopedia) Muscle atrophy (Medical Encyclopedia) Muscle function loss (Medical Encyclopedia) Muscle twitching[icdlist.com] retardation with or without seizures AR 13 13 HSPD1 * Spastic paraplegia, Leukodystrophy, hypomyelinating AD/AR 5 5 IBA57 Multiple mitochondrial dysfunctions syndrome 3,[blueprintgenetics.com]

  • Huntington's Disease

    However, in some families a juvenile form of HD has been seen with an onset of symptoms in the first or second decades of life.[encyclopedia.com] For bystanders these muscle twitches are often invisible or can be explained as nervousness.[ncbi.nlm.nih.gov] Physical symptoms Rapid, involuntary movements of the fingers, limbs, and facial muscles (chorea); this varies in severity from mild twitching to more severe thrashing as[labtestsonline.org]

  • Tay-Sachs Disease

    Late-onset Tay-Sachs disease (chronic form) is a rare variant phenotype with appearance of first symptoms during the second or third decade of life. 4 A juvenile form is also[doi.org] Initial symptoms, which usually develop between 3 and 6 months, can include mild muscle weakness, twitching or jerking of muscles (myoclonic jerks), and an exaggerated startle[rarediseases.org] The patients was a 3-year-old boy with psychomotor retardation and attacked by seizures since 8 months of age. On funduscopy, the maculla presented a cherry-red spot.[ncbi.nlm.nih.gov]

  • Autosomal Dominant Spastic Paraplegia Type 42

    onset, usually within the first or second decades of life.[jamanetwork.com] Stimulus intensity was adjusted to produce a small muscle twitch. Overall bandpass was chosen 1 to 1500 Hz, analysis time was 100 ms.[ojrd.biomedcentral.com] CCHLND is an autosomal recessive disorder characterized by congenital cataracts, severe psychomotor retardation, and hearing loss associated with decreased serum ceruloplasmin[slc.bioparadigms.org]

  • Young Adult-Onset Distal Hereditary Motor Neuropathy

    Age of onset is in the second and third decades of life and rarely in the first. Recovery is usually complete and begins weeks to months after the onset of symptoms.[emedicine.medscape.com] There are a couple of reports of fasciculations, or involuntary muscle twitches, in the legs. There are several reports of erectile dysfunction.[cmtausa.org] retardation Oculoauriculofrontonasal syndrome Arts syndrome Erythropoietic protoporphyria Fuhrmann syndrome Mastocytosis cutaneous with short stature conductive hearing loss[checkrare.com]

  • Myoadenylate Deaminase Deficiency

    Childhood onset weakness, contractures, and early cardiac involvement. Symptoms usually develop in the first or second decade of life.[sites.google.com] Lamb, Effect of low cytoplasmic [ATP] on excitation–contraction coupling in fast‐twitch muscle fibres of the rat, The Journal of Physiology, 560, 2, (451-468), (2004).[doi.org] We report a 20-year-old man with gigantism syndrome, hypertrophic cardiomyopathy, muscle weakness, exercise intolerance, and severe psychomotor retardation since childhood[ncbi.nlm.nih.gov]

  • Limb-Girdle Muscular Dystrophy Type 1E

    The onset of symptoms usually occurs in the first or second decade of life. Affected individuals usually present with impairment of upper extremity elevation.[icd10data.com] No history of distal muscle weakness, twitching of the muscles, pain in the limbs, breathlessness, cranial nerve involvement or sensory symptoms and no bladder, bowel disturbances[jcdr.net] retardation-progressive brain atrophy-basal ganglia disease syndrome Infantile systemic hyalinosis Infantile-onset X-linked spinal muscular atrophy Intellectual disability[se-atlas.de]

  • Spastic Paraplegia

    Clinical Correlations: Spastic paraplegia 7 may have its onset in the second decade of life but sometimes much later.[disorders.eyes.arizona.edu] Apraxia (Medical Encyclopedia) Hand or foot spasms (Medical Encyclopedia) Muscle atrophy (Medical Encyclopedia) Muscle function loss (Medical Encyclopedia) Muscle twitching[icdlist.com] Retardation and Characteristic Facies 2 AR 616801 Mast Syndrome AR 248900 Mental Retardation, X-Linked, Syndromic, Claes-Jensen Type XL 300534 Neuropathy, Hereditary Sensory[preventiongenetics.com]

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