Muscle Twitch & Severe Peripheral Motor Neuropathy: Causes & Reasons

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Patient File

Sex unknown, Age unknown

Reported Symptoms

Muscle Twitch, Severe Peripheral Motor Neuropathy,

Negated

None

Unsure

None

Possible Causes

Peripheral Neuropathy

We treated a 52-year-old man who had severe disabling classic peripheral neuropathy since 1998 with Scrambler Therapy (Calmare), an FDA-cleared peripheral non-invasive neuromodulation [ncbi.nlm.nih.gov]

On clinical examination, muscle twitches of fingers of both hands, as well as the abductor halluces and the dorsal interossei muscles of the right foot were observed. [ncbi.nlm.nih.gov]

If severely affected, the patient may develop chronic muscle wasting. How is Peripheral Neuropathies Treated? [healthengine.com.au]

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Chronic Kidney Insufficiency

The restless legs syndrome is a manifestation of sensory peripheral neuropathy. Motor neuropathy is a late phenomenon in uremia. [meddean.luc.edu]

[…] mass muscle twitching and cramps easy bruising and bleeding blood in your stools hiccups excessive thirst decreased interest in sex impotence insomnia sleep apnea You may [healthline.com]

peripheral sensory and motor neuropathies, muscle cramps, hyperreflexia, restless legs syndrome, and seizures (usually the result of hypertensive or metabolic encephalopathy [merckmanuals.com]

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Motor Neuron Disease

In recent years, several reports show association of HIV infection with Amyotrophic Lateral Sclerosis - Syndrome, Motor Neuron Diseases and peripheral neuropathies. [ncbi.nlm.nih.gov]

A 69-year-old man with long-standing depression and failing memory presented with muscle twitches of 8 months' duration. [ncbi.nlm.nih.gov]

[…] wasting and weakness, absent reflexes, loss of weight and muscle twitching. [mndnsw.asn.au]

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Paraneoplastic Syndrome

More than half of the patients with the rare osteosclerotic form of myeloma develop a severe predominantly motor paraneoplastic peripheral neuropathy. [theoncologist.onlinelibrary.wiley.com]

Accordingly, this syndrome is associated with muscle weakness, muscle wasting, and muscle twitching. [brighamandwomens.org]

[…] to muscle twitching and cardiac arrhythmias. [msdmanuals.com]

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Multifocal Motor Neuropathy

[…] types of peripheral neuropathy (sensory, motor, autonomic, and mixed) occurring with diabetes mellitus; the most common is a chronic, symmetrical sensory polyneuropathy affecting [dobeti.me.ht]

Usually, the arms and hands are affected first and symptoms include muscle weakness, cramps and uncontrollable twitching. [medic8.com]

An autopsy showed severe widespread demyelination without lymphoma cell infiltration in the peripheral nerves. [ncbi.nlm.nih.gov]

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Neuropathy

If severely affected, the patient may develop chronic muscle wasting. How is Peripheral Neuropathies Treated? [healthengine.com.au]

They may also suffer from cramps, muscle twitching, muscle and bone loss, and changes in the skin, hair and nails. [livescience.com]

[…] to lack of activity muscle twitching and cramps. [diabetes.org.uk]

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Brachial Plexus Neuropathy

CIDP It is an acquired, immune-mediated peripheral neuropathy, presents with relapsing and remitting motor and sensory loss in multiple limbs [ 30 ]. [omicsonline.org]

Most frequently, it is idiopathic but can be associated with several conditions like HIV, diabetes, inflammatory bowel disease, Sjogren’s syndrome, lymphoma, IgM, IgG or IgA [omicsonline.org]

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Spastic Paraparesis-Deafness Syndrome

neuropathy and evidence of lower motor involvement. [now.aapmr.org]

Apraxia (Medical Encyclopedia) Hand or foot spasms (Medical Encyclopedia) Muscle atrophy (Medical Encyclopedia) Muscle function loss (Medical Encyclopedia) Muscle twitching [icdlist.com]

Early predictions of outcomes Caution is warranted in estimating the degree of eventual disability as a result of variation in severity and disease progression. [now.aapmr.org]

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Peripheral Motor Neuropathy

peripheral neuropathy primarily affecting motor neurons. [ncbi.nlm.nih.gov]

Motor neuropathy symptoms may include: Muscle weakness Cramps Muscle twitching Loss of muscle and bone Changes in skin, hair, or nails Sensory neuropathy symptoms may include [columbianeurology.org]

[…] weakness or loss of muscle control trouble with balance and coordination muscle twitching, cramping, or spasms difficulty walking or moving limbs Symptoms of autonomic neuropathy [healthline.com]

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Cross Syndrome

neuropathy Motor delay Intestinal pseudo-obstruction Alacrima Ileus Cerebral dysmyelination Decreased lacrimation Peripheral hypomyelination Neonatal asphyxia Spotty hyperpigmentation [mendelian.co]

Stimulators Emphysema Encephalitis Endurance Epilepsy Epstein-Barr Virus Exercise Machines Exercise Techniques Fartlek Fascia Fast Twitch Fat Fatigue Fats and Oils Feldenkrais [ptonthenet.com]

Coma Intellectual disability, severe Meconium ileus Myelin outfoldings Hypoplasia of the cochlea Erythema Entropion Hyperkeratosis Hypertriglyceridemia Sensory axonal neuropathy [mendelian.co]

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Peripheral Sensory Neuropathy

Peripheral neuropathy may also be caused by several heavy metals. [questdiagnostics.com]

Common symptoms of motor neuropathy include: Muscle weakness. Difficulty walking or moving your arms or legs. Muscle twitching. Cramps. Spasms. Loss of muscle control. [my.clevelandclinic.org]

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Polyneuropathy

Peripheral sensori-motor neuropathy  Distal, bilateral,symmetrical, stocking-glove distribution.  Symptoms range from numbness (“deadness”) to severe pain. [slideshare.net]

Some of the common symptoms of Polyneuropathy are: Numbness of the extremities Hypersensitivity Tingling or burning sensation Muscle pain and weakness Involuntary muscle twitching [epainassist.com]

An exam may show: Decreased feeling (may affect touch, pain, vibration, or position sensation) Diminished reflexes (most commonly the ankle) Muscle atrophy Muscle twitches [nlm.nih.gov]

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Machado-Joseph Disease

[…] features, such as Parkinsonism, dystonia, peripheral neuropathy, and lower motor neuron disease. [ncbi.nlm.nih.gov]

As symptoms arise, medications are typically prescribed for sleep problems, muscle twitching, urinary dysfunction and cramping. [babymed.com]

twitching Numbness, tingling, cramps, and pain in the hands, feet, arms, and legs (neuropathy) Loss of muscle tissue (atrophy) Many individuals with MJD also have vision [rarediseases.about.com]

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Renal Function Impairment

peripheral sensory and motor neuropathies, muscle cramps, hyperreflexia, restless legs syndrome, and seizures (usually the result of hypertensive or metabolic encephalopathy [merckmanuals.com]

twitching Seizures or coma (in severe cases) Stomach and back pain Fever Rash Nosebleed Causes of Acute Kidney Failure There are three main reasons your kidneys fail all [webmd.com]

With more severe renal disease (eg, estimated glomerular filtration rate [eGFR] 15 mL/min/1.73 m 2 ), neuromuscular symptoms may be present, including coarse muscular twitches [merckmanuals.com]

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Distal Spinal Muscular Atrophy Type 4

Several subtypes of inherited peripheral neuropathies were delineated and classified as hereditary motor and sensory neuropathies (HMSN), hereditary motor neuropathies (HMN [molgen.ua.ac.be]

[…] may include: Tremor of the hands Muscle cramps when performing physical activities Muscle twitches and weakness of limb muscles As the condition progresses: Weakness of the [thehumanthebody.com]

Diseases of the peripheral nerves (peripheral neuropathies, or polyneuropathies ) can produce symptoms similar to the motor neuron diseases. [britannica.com]

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Oculomotor Apraxia

[…] primary motor peripheral axonal motor neuropathy. [ncbi.nlm.nih.gov]

Oculomotor apraxia is characterized as involuntary jerking movements, muscle twitches, and disturbances in nerve function along with eye movement abnormalities. [patientslikeme.com]

In addition to ataxia and oculomotor apraxia, affected individuals can have involuntary jerking movements (chorea) or muscle twitches (myoclonus); these movement problems [ghr.nlm.nih.gov]

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Neuromuscular Junction Disorder

Diseases of the peripheral nerves (peripheral neuropathies, or polyneuropathies ) can produce symptoms similar to the motor neuron diseases. [britannica.com]

The most common side effects from these agents are gastrointestinal disturbances (nausea, diarrhea) and muscle twitching. [medtextfree.wordpress.com]

The neuronal hyperexcitability results in skeletal muscle overactivity, which manifests as muscle twitching or myokymia (which is often confused with fasciculation), cramps [jnnp.bmj.com]

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Chronic Kidney Disease

peripheral sensory and motor neuropathies, muscle cramps, hyperreflexia, restless legs syndrome, and seizures (usually the result of hypertensive or metabolic encephalopathy [merckmanuals.com]

twitches and cramps, water retention, undernutrition, peripheral neuropathies, and seizures. [msdmanuals.com]

Symptoms can include urinating at night, fatigue, nausea, itching, muscle twitching and cramps, loss of sensation, confusion, difficulty breathing, and yellow-brown skin. [merckmanuals.com]

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Monomelic Amyotrophy

Signs and symptoms initially progressed, but spontaneously arrested after several years. Upper motor neuron, sensory, and sphincteric symptoms and signs remained absent. [ahcmedia.com]

Unlike other lower motor neuron diseases, MMA is not believed to be hereditary and fasciculations (involuntary muscle twitches) are rare. [wikidoc.org]

For people who have this disease, 'fasciculations,' or involuntary muscle twitches, are rare. Hirayama's disease is much less common in North America. [disabled-world.com]

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Ischemic Peripheral Neuropathy

Diagnosis of Painful Peripheral Neuropathy Diagnosis of painful peripheral neuropathy may require several steps. [neuromodulation.com]

Muscle weakness Cramps Muscle twitching Loss of muscle and bone Changes in skin, hair, or nails Numbness Loss of sensation or feeling in body parts Loss of balance or other [hopkinsmedicine.org]

Other symptoms and signs may include: Muscle cramping and shrinking Fasciculations (when a muscle twitches without your control) Reflex abnormalities Autonomic Autonomic [verywellhealth.com]

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Kidney Disease

Under 6.05B2, the peripheral neuropathy must be a severe impairment. (See §§ 404.1520(c), 404.1521, 416.920(c), and 416.921 of this chapter.) [ssa.gov]

Symptoms can include urinating at night, fatigue, nausea, itching, muscle twitching and cramps, loss of sensation, confusion, difficulty breathing, and yellow-brown skin. [merckmanuals.com]

Damage to muscles and nerves can cause muscle twitches, muscle weakness, cramps, and pain. [merckmanuals.com]

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Diabetic Autonomic Neuropathy

Diabetic autonomic neuropathy is a subgroup of diabetic neuropathy, a group of nerve diseases affecting the peripheral nerves outside the brain and spinal cord. [columbianeurology.org]

[…] to lack of activity muscle twitching and cramps. [diabetes.org.uk]

Muscle cramping or twitching, trouble swallowing or breathing, paralysis of affected body parts and reduced muscle control may also occur. [livestrong.com]

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Infantile-Onset Ascending Hereditary Spastic Paralysis

Here we screened a large HSP cohort that was not selected for clinical signs of peripheral neuropathy and found involvement of peripheral motor nerves in 44% of patients. [ojrd.biomedcentral.com]

A single motor neuron may innervate many muscle fibres and a fibre can undergo many action potentials in the time taken for a single muscle twitch. [wikivisually.com]

Apraxia (Medical Encyclopedia) Hand or foot spasms (Medical Encyclopedia) Muscle atrophy (Medical Encyclopedia) Muscle function loss (Medical Encyclopedia) Muscle twitching [icdlist.com]

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Diabetic Polyneuropathy

Signs and symptoms [ edit ] Illustration depicting areas affected by diabetic neuropathy Diabetic neuropathy affects all peripheral nerves including sensory neurons, motor [en.wikipedia.org]

[…] to lack of activity muscle twitching and cramps. [diabetes.org.uk]

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Carcinomatous Myopathic Syndrome

Diagnostic Approach The differential diagnosis of peripheral neuropathy is significantly narrowed by a focused clinical assessment that addresses several key issues ( Figure [aafp.org]

[…] atrophy Muscle biopsy Muscle function loss Muscle twitching Myopathic changes Myotonia congenita Rhabdomyolysis Volkmann ischemic contracture Weakness [ Read More ] [icdlist.com]

Muscle atrophy (Medical Encyclopedia) Muscle function loss (Medical Encyclopedia) Muscle twitching (Medical Encyclopedia) Rhabdomyolysis (Medical Encyclopedia) Weakness [icdlist.com]

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Distal Hereditary Motor Neuropathy Type 1

Charcot-Marie-Tooth disease is closely related to several less common peripheral neuropathies: distal hereditary motor neuropathy (dHMN), hereditary sensory neuropathy (HSN [tidsskriftet.no]

twitching first noted in late teens or early adulthood There are other diseases that are similar to spinal muscular atrophy, but have different genetic causes. [togetherinsma.com]

It results in severe demyelination with delayed motor skills and is much more severe than type 1. [patient.info]

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Autonomic Neuropathy

[…] and autonomic neuropathy. [ncbi.nlm.nih.gov]

Muscle cramping or twitching, trouble swallowing or breathing, paralysis of affected body parts and reduced muscle control may also occur. [livestrong.com]

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Distal Spinal Muscular Atrophy Type 5

The Charcot foot has been documented to occur as a consequence of various peripheral neuropathies; however, diabetic neuropathy has become the most common etiology. [care.diabetesjournals.org]

There are a couple of reports of fasciculations, or involuntary muscle twitches, in the legs. There are several reports of erectile dysfunction. [cmtausa.org]

Chronic forms CIDP Acquired demyelinating neuropathy reaching maximal severity in at least 8 weeks.: MMN Peripheral neuropathy with slowly progressive or remitting asymmetric [neupsykey.com]

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Primary Orthostatic Tremor

This form of tremor often occurs in peripheral neuropathies, for example in demyelinating neuropathy. [lecturio.com]

Bathien N, Rondot P, Toma S (1980) Inhibition and synchronisation of tremor induced by muscle twitch. J Neurol Neurosurg Psychiatry 43:713–718 PubMed Google Scholar 2. [link.springer.com]

The twitching can't be controlled by the person experiencing it. In its simplest form, myoclonus consists of a muscle twitch followed by relaxation. [my-ms.org]

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Alcoholic Neuropathy

Rarely if the neuropathy is severe patients may also develop peripheral weakness (motor symptoms). [braindiseases.info]

I also notice more muscle twitches than normal like in my legs. [rooshvforum.com]

Muscle wasting (loss of muscle tissue due to lack of activity). Muscle twitching and cramps. [patient.info]

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