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494 Possible Causes for Muscle Weakness, Round Face, Splenomegaly

  • Mucopolysaccharidosis

    Compression of the cervical spinal cord, caused by glycosaminoglycan infiltration of the dura, may lead to spastic paresis if not corrected by neurosurgical intervention.[orpha.net] […] trunk (dwarfism), dysplasia (abnormal bone size and/or shape) and other skeletal irregularities, thickened skin, enlarged organs such as liver (hepatomegaly) or spleen (splenomegaly[en.wikipedia.org] Nursing Diagnosis - Self care deficit related to inability to carryout ADLS / tremors - Impaired physical mobility related to weakness of bones and muscles - Risk for injury[slideshare.net]

  • Rheumatoid Arthritis

    Fatigue, muscle weakness, and weight loss are common symptoms.[britannica.com] It is extremely rare for RA to present as FS or develop after initially presenting as neutropaenia and splenomegaly.[ncbi.nlm.nih.gov] These side effects are serious and can include easy bruising, thinning of the bones (osteoporosis), cataracts, weight gain, a round face, susceptibility to infections, diabetes[orthop.washington.edu]

  • Mucopolysaccharidosis 2

    […] attenuated (so-called adult) form usually have a normal intelligence, but often have many complaints such as progressive loss of vision due to retinal dysfunction, spastic paresis[ingentaconnect.com] Individuals with this disorder may experience the following signs: abnormal retina, heart murmur and leaky heart valves, enlarged liver (hepatomegaly) enlarged spleen (splenomegaly[secure.ssa.gov] […] resulting in large rounded cheeks and thick lips – generally manifests between ages 18 months and four years in the early progressive form and about two years later for those[ncbi.nlm.nih.gov]

  • Nelson Syndrome

    Symptoms include a round face, thin arms and legs, severe fatigue and muscle weakness, high blood pressure and high blood sugar, purple or pink stretch marks on the skin,[icd10data.com] Liver disease is suggested if hepatomegaly, small liver, splenomegaly, or peripheral signs of liver disease are present.[emedicine.medscape.com] Other causes of skin pigmentation - e.g. jaundice (also affects the sclerae) and haemochromatosis (more of a bronze colour, may be associated with hepatomegaly and possibly splenomegaly[checkorphan.org]

  • Iatrogenic Cushing's Disease

    Potty belly due to muscle weakness, fat redistribution and water retention. Muscle weakness leads to instability in standing and walking.[secondchanceaihadogs.com] […] disorders Spasticity Specialized nutrition support Spinal cord tracts and reflexes Spinal muscular atrophy Spinal stenosis Spinocerebellar ataxia Spleen Splenic rupture Splenomegaly[amboss.com] Essential finding at presentation were an obese infant, full round face, length 62cm ( 5 th percentile), BMI 36.7kg/m 2 ( 95 th percentile); BP 100/60mmHg.[panafrican-med-journal.com]

  • ACTH-Independent Cushing Syndrome

    Symptoms include a round face, thin arms and legs, severe fatigue and muscle weakness, high blood pressure and high blood sugar, purple or pink stretch marks on the skin,[icd10data.com] […] disorders Spasticity Specialized nutrition support Spinal cord tracts and reflexes Spinal muscular atrophy Spinal stenosis Spinocerebellar ataxia Spleen Splenic rupture Splenomegaly[amboss.com] Typically, patients have the following clinical features 6 : rounded face, sometimes described as 'moon-shaped' progressive centripetal obesity and weight gain prominent supraclavicular[radiopaedia.org]

  • ACTH-Dependent Cushing Syndrome

    weakness, difficulty concentrating, insomnia, and depressed mood.[journals.aace.com] […] disorders Spasticity Specialized nutrition support Spinal cord tracts and reflexes Spinal muscular atrophy Spinal stenosis Spinocerebellar ataxia Spleen Splenic rupture Splenomegaly[amboss.com] Case: A 26-year-old male patient presented with moon face, purplish striae, supraclavicular fat pads and proximal muscle weakness.[endocrine-abstracts.org]

  • Liver Cirrhosis

    These conditions often lead to sarcopenia, which is the loss of skeletal muscle volume and increased muscle weakness.[wjgnet.com] We performed LS in 83 patients with massive splenomegaly ( 30 cm) secondary to portal hypertension and liver cirrhosis.[ncbi.nlm.nih.gov] face ("chipmunk cheeks") Enlarged abdomen Inability to sleep Mood swings Hand tremors (shaking) Acne Steroid dependency Note: Patients must never stop or reduce the prednisone[emedicinehealth.com]

  • Glycogen Storage Disease due to Liver Phosphorylase Kinase Deficiency

    Infant-onset Type 2 GSD symptoms include: Muscle weakness and floppiness Delayed motor skills Weak breathing Progressive heart muscle enlargement and reduced pumping may lead[cancercarewny.com] 0 (Glycogen synthase deficiency) Type IV or Anderson’s disease (Hepatomegaly may be absent and death is early, i.e. in 2 years due to early cirrhosis) Hepatomegaly with splenomegaly[epomedicine.com] Full-cheeked round face and osteopenia have been reported on exceptional occasions in cases with an X-linked inheritance.[orpha.net]

  • Lupus Erythematosus

    weakness while simultaneously increases their muscle endurance.[physio-pedia.com] […] keratoconjunctivitis sicca as well as more uncommon manifestations Haematologic manifestations, including cytopenias, thrombophilia, thromboembolic disease, lymphadenopathy and splenomegaly[els.net] Depending on the dosage, people who require steroids may develop Cushing's syndrome, symptoms of which may include obesity, puffy round face, diabetes mellitus, increased[en.wikipedia.org]

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