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109 Possible Causes for Muscular Atrophy, Onset at Age 5-10 Years, Restless Legs Syndrome

  • Primary Progressive Multiple Sclerosis

    In late-stage Roche, they have treatments that are being tested for Alzheimer’s disease, Autism, and for Spinal Muscular Atrophy.[mdmag.com] […] and especially early age at onset, are associated with a better course. [13] [114] The average life expectancy is 30 years from the start of the disease, which is 5 to 10[en.wikipedia.org] Roche has more than a dozen investigational medicines in clinical development for diseases that include multiple sclerosis, Alzheimer’s disease, spinal muscular atrophy, Parkinson[finance.yahoo.com]

  • Diabetic Neuropathy

    View/Print Table TABLE 2 Symptoms of Diabetic Neuropathy Sensorimotor neuropathy Muscular symptoms: muscle weakness (not fatigue), atrophy, balance problems, ataxic gait Sensory[aafp.org] […] of DM Symptomatic evidence 5 years: 4% to 10% 25 years: 13% to 15% Mean time after DM onset: 8 years Increased Frequency: Women; Increased Age Objective evidence (Clinical[neuromuscular.wustl.edu] […] symptoms: muscle weakness (not fatigue), atrophy, balance problems, ataxic gait Sensory symptoms: pain, paresthesia, numbness, paralysis, cramping, nighttime falls, antalgic[aafp.org]

  • Multiple Sclerosis

    syndrome (RLS).[ncbi.nlm.nih.gov] Table 1 Patient demographics Female 319 (64%) Male 178 (36%) Age 5 (1%) 21–30 86 (17%) 31–40 151 (30%) 41–50 143 (29%) 60 112 (23%) Onset 143 (29%) 5–10 years ago 177 (36%[dx.doi.org] […] and especially early age at onset, are associated with a better course.[13][115] The average life expectancy is 30 years from the start of the disease, which is 5 to 10 years[en.wikipedia.org]

  • Charcot-Marie-Tooth Disease Type 2S

    atrophy with respiratory distress (sequence analysis of IGHMBP2 gene) Charcot-Marie-Tooth disease (disease exome based NGS panel for 43 genes) Spinal muscular atrophy (NGS[cgcgenetics.com] Abstract Article abstract In a series of 44 consecutive patients with Charcot-Marie-Tooth disease (CMT), we found restless legs syndrome (RLS) in 10 of 27 CMT type 2 (CMT2[neurology.org] Age at onset of symptoms was before 10 years in 21 patients (84%). Eight patients (32%) experienced their first symptoms before age 5 years.[jamanetwork.com]

  • Multifocal Motor Neuropathy

    2 Patient 1 2 3 4 5 6 7 8 9 10 11 Clinical features Sex M M F M M M M M M M M Age at onset (years) 47 30 31 42 30 43 20 48 40 38 58 Site of onset UL LL UL UL UL LL LL UL UL[brain.oxfordjournals.org] Abstract Multifocal motor neuropathy (MMN) and progressive muscular atrophy (PMA) are associated with IgM monoclonal gammopathy or the presence IgM anti-GM1-antibodies.[ncbi.nlm.nih.gov] Restless legs syndrome (RLS) has been frequently reported in association with peripheral neuropathy, and it is especially frequent in some forms of polyneuropathy with preferential[ncbi.nlm.nih.gov]

  • Diabetes Mellitus Type 2

    atrophy, ataxia, retinitis pigmentosa, and diabetes mellitus Newly diagnosed diabetes Non-insulin dependent diabetes mellitus in nonobese Photomyoclonus, diabetes mellitus[icd9data.com] Epidemiology Type 1 : 5% of all patients with diabetes Childhood onset ; : typically 20 years but can occur at any age; peaks at age 4–6 years and 10–14 years Highest prevalence[amboss.com] Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy. Nature 352, 77–79 (1991). 39. Cazzola, R. & Giovanni, A.[dx.doi.org]

  • Charcot-Marie-Tooth Disease

    2015 ICD-9-CM Diagnosis Code 356.1 Peroneal muscular atrophy 2015 Billable Thru Sept 30/2015 Non-Billable On/After Oct 1/2015 ICD-9-CM 356.1 is a billable medical code that[icd9data.com] Ondo W, Jankovic J (1996) Restless legs syndrome: clinicoetiologic correlates. Neurology 47:1435–1441 PubMed Google Scholar 30.[doi.org] Onset is usually by the age of 10 years with: Muscle weakness and wasting starting from the intrinsic muscles of the feet, and gradually affecting the lower leg and lower[patient.info]

  • Adult-Onset Cervical Dystonia Type DYT23

    Spinal muscular atrophy type 2 SMN1 Spinal muscular atrophy type 3, modifier of SMN2 Spinal muscular atrophy type 3 SMN1 Spinal muscular atrophy type 4 SMN1 Spinal muscular[centogene.com] Having published over300 papers and co-edited 4 books on PD and restless legs syndrome, Prof.[books.google.com] In early-onset PTDs, dystonia usually generalizes within 510 years while, in late-onset forms, dystonia tends to remain focal or segmental ( Ozelius and Bressman, 2011 ).[frontiersin.org]

  • Amyotrophic Lateral Sclerosis

    The patients were a 54-year-old man with progressive muscular atrophy who underwent removal of internal fixators in the arm and leg, and a 66-year-old woman with amyotrophic[ncbi.nlm.nih.gov] Restless Legs Syndrome Study Group.[doi.org] The male to female ratio is 2:1. [ 3 ] About 5-10% of cases are inherited. [ 5 ] The mean age of onset is 43-52 years in familial and 58-63 years in sporadic cases of ALS.[patient.info]

  • Young Adult-Onset Distal Hereditary Motor Neuropathy

    Treatment for spinal muscular atrophy Unfortunately, there is currently no specific treatment for SMA.[betterhealth.vic.gov.au] Symptomatic therapy of neuropathic pain, joint/bone pain, paresthesias, cramps, fatigue, and restless leg syndrome is done as for other neuropathies. 35.1.1.8 Prognosis Genetic[neupsykey.com] The male to female ratio is 2:1. [ 3 ] About 5-10% of cases are inherited. [ 5 ] The mean age of onset is 43-52 years in familial and 58-63 years in sporadic cases of ALS.[patient.info]

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