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99 Possible Causes for Muscular Atrophy, Rapid Progression to Disability

  • Polyneuropathy

    Neuronal Peroneal Muscular Atrophy (HMSN II) Autosomal dominant inheritance is also the case with HMSN II.[lecturio.com] For example, patients with GBS present with a definite date of onset followed by rapid progression of impairment and disability.[neurology.org] Ciliary neurotrophic factor-induced sprouting preserves motor function in a mouse model of mild spinal muscular atrophy. Hum. Mol.[doi.org]

  • Primary Progressive Multiple Sclerosis

    Although progression is more rapid, age-related disability milestones are identical to relapsing-onset disease.[ncbi.nlm.nih.gov] In late-stage Roche, they have treatments that are being tested for Alzheimer’s disease, Autism, and for Spinal Muscular Atrophy.[mdmag.com] Roche has more than a dozen investigational medicines in clinical development for diseases that include multiple sclerosis, Alzheimer’s disease, spinal muscular atrophy, Parkinson[finance.yahoo.com]

  • Muscular Dystrophy

    Distal muscular dystrophies are a group of inherited primary muscle disorders showing progressive weakness and atrophy preferentially in the hands, forearm, lower legs, or[ncbi.nlm.nih.gov] It progresses slowly, with short periods of rapid muscle deterioration and weakness. Severity ranges from very mild to completely disabling.[webmd.com] Disease progression is typically very slow, with intermittent spurts of rapid muscle deterioration.[web.archive.org]

  • Primary Lateral Sclerosis

    This locus had not been implicated in ALS or in hereditary spastic parapareses, spinal muscular atrophy, or spinal and bulbar muscular atrophy. [7] A genetically mediated[emedicine.com] Patients with more severe physical disability and a more rapid rate of disease progression had increased sensorimotor connectivity values.[ncbi.nlm.nih.gov] atrophy (PMA) and spinal muscular atrophies (SMAs) Upper and lower motor neurons - ALS ALS is the most common of the MNDs.[emedicine.com]

  • Amyotrophic Lateral Sclerosis

    The patients were a 54-year-old man with progressive muscular atrophy who underwent removal of internal fixators in the arm and leg, and a 66-year-old woman with amyotrophic[ncbi.nlm.nih.gov] One woman with ALS received intracranial injection of adult olfactory ensheathing glia (OEG) transplantation and her disease progressed at a more rapid rate after the procedure[doi.org] BACKGROUND: Informal caregivers of patients with Amyotrophic Lateral Sclerosis (ALS) or Progressive Muscular Atrophy (PMA) face stressful demands due to severe impairments[ncbi.nlm.nih.gov]

  • Chronic Inflammatory Demyelinating Polyneuropathy

    Peroneal muscular atrophy (PMA) and related disorders. I. Clinical manifestations as related to biopsy findings, nerve conduction and electromyography.[doi.org] Compared with patients with MADSAM, patients with typical CIDP showed more rapid progression and severe disability, and demyelination predominant in the distal nerve segments[ncbi.nlm.nih.gov] Peroneal muscular atrophy (PMA) and related disorders: I.[em-consulte.com]

  • Erb Muscular Dystrophy

    It progresses slowly, with short periods of rapid muscle deterioration and weakness. Severity ranges from very mild to completely disabling.[webmd.com] At that time, the differentiation between the spinal muscular atrophies and weakness associated with central nervous system disorders and primary muscle disease had not been[emedicine.medscape.com] atrophy • proximal weakness • onset of weakness is earlier in childhood • absent deep tendon reflexes and fasciculations • CPK levels are normal • pseudohypertrophy is absent[orthobullets.com]

  • Limb-Girdle Muscular Dystrophy

    It progresses slowly, with short periods of rapid muscle deterioration and weakness. Severity ranges from very mild to completely disabling.[webmd.com] atrophy.[ncbi.nlm.nih.gov] […] by Duchenne.1,2 Other descriptions followed: familial atrophy of the pelvic girdle muscles (Leyden in 1876), scapulohumeral muscular atrophy (Erb in 1884), and myopathy with[dash.harvard.edu]

  • Transverse Myelitis

    Doug was the global lead for a series of programs in Alzheimer’s disease, Amyotrophic Lateral Sclerosis (ALS) and Spinal Muscular Atrophy (SMA).[myelitis.org] […] one third remain severely disabled Poor prognostic indicators rapid progression of symptoms back pain spinal shock absent central conduction on somatosensory evoked potential[lifeinthefastlane.com] Progression ; Transverse myelitis (TM) The progression is rapid • time to maximal disability is more than 4 hr and fewer than 21 days. A.[slideshare.net]

  • Guillain-Barré Syndrome

    RESULTS: All six patients had different degrees of muscular atrophy at nadir and in two, respiratory muscles were involved.[ncbi.nlm.nih.gov] A number of factors, including preceding diarrhoea, older age, rapid progression, disability at nadir and specific neurophysiological parameters have been associated with[doi.org] The peroneal muscular atrophy syndrome 8. The ataxic neuropathies 9. Sensory neuropathies 10. Neuropathies in metabolic and degenerative disorders 11.[scinapse.io]

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