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15 Possible Causes for Mutation in the CALM2 Gene, Sudden Death

  • Long QT Syndrome

    In many cases of sudden death, autopsies do not clarify the main cause. Cardiovascular complications are usually involved in these deaths.[doi.org] RESULTS: A novel de novo CALM2 mutation (D132H) was discovered by candidate gene screening in a male infant with prenatal bradycardia born to healthy parents.[ncbi.nlm.nih.gov] LQT15LQT15 is caused by heterozygous mutations in the CALM2 (Calmodulin 2) gene (114182) on chromosome 2p21.[en.wikipedia.org]

  • Ventricular Arrhythmia

    […] autopsy in sudden death victims 3.3 Risk prediction of sudden cardiac death 3.4 Prevention of sudden cardiac death in special settings 4.[escardio.org] LQT15LQT15 is caused by heterozygous mutations in the CALM2 (Calmodulin 2) gene (114182) on chromosome 2p21.[en.wikipedia.org] In many cases of sudden death, autopsies do not clarify the main cause. Cardiovascular complications are usually involved in these deaths.[doi.org]

  • Catecholaminergic Polymorphic Ventricular Tachycardia Type 2

    Most sudden deaths occurred within 10 years of CPVT diagnosis.[dx.doi.org] […] that have been discovered and only represent a small percentage of CPVT cases are TRDN (encoding triadin) and CALM1 (encoding calmodulin). 5,6 Mutations in the CALM2 gene[doi.org] Genetic variants of CPVT include RyR2, CASQ2, CALM2, TRD, and possibly KCNJ2 and ANK2 gene mutations.[ncbi.nlm.nih.gov]

  • Catecholaminergic Polymorphic Ventricular Tachycardia

    CPVT is characterized by emotion- and exercise-induced polymorphic ventricular arrhythmias that may lead to sudden cardiac death.[ntvg.nl] RYR2, CASQ2, KCNJ2 , ANK2, CALM1, CALM2, TRDN, SCN5A* Other Panels that Include this Diagnosis Notes on Genes: Priority Genes: These genes include 70% of the mutations that[admerahealth.com] […] cardiac death.[link.springer.com]

  • Long QT Syndrome 13

    Prophylactic β-blocker therapy was started in these two patients to prevent sudden death.[link.springer.com] This prompted candidate-gene screening in a cohort of 82 LQTS genotype-negative patients. Two more patients were carriers of either CALM1 or CALM2 mutations.[smw.ch] In approximately 5 percent of sudden cardiac deaths, no demonstrable anatomic abnormality is found. Some cases are caused by sudden arrhythmia death syndrome.[aafp.org]

  • Long QT Syndrome 10

    […] infant death syndrome (SIDS) in newborns but it is also responsible for about 5% of sudden deaths in adults.[omicsonline.org] This prompted candidate-gene screening in a cohort of 82 LQTS genotype-negative patients. Two more patients were carriers of either CALM1 or CALM2 mutations.[smw.ch] Congenital long QT syndrome is one of a group of abnormalities of cardiac repolarization that can cause syncope and sudden death in apparently healthy people.[mdedge.com]

  • Long QT Syndrome 15

    The overall incidence of sudden death and aborted sudden death was 24% in all patients and 17% in compliant patients.[slideplayer.es] Congenital deaf mutism, functional heart disease with prolongation of the QT interval, and sudden death. Am Heart J. 1957;54:59-68. 4. Romano C, Gemme G, Pongiglione R.[revistas.uis.edu.co] Sudden nocturnal death in young males from ventricular flutter. Japanese heart journal. 1985;26:585-591 26.[med.niigata-u.ac.jp]

  • Jervell-Lange-Nielsen Syndrome

    […] described the sudden death of deaf girl.[litfl.com] A malignant form of LQTS associated to recurrent cardiac arrest due to VF in infants is associated to mutations in CALM1 and CALM2 genes encoding calmodulin (Crotti et al.[itaca.edu.es] death.[journals.sagepub.com]

  • Glycogen Storage Disease due to Muscle Phosphorylase Kinase Deficiency

    In all affected individuals, muscle GSD 0 impairs the heart's ability to effectively pump blood and increases the risk of cardiac arrest and sudden death, particularly after[icdlist.com] There are autosomal recessive forms of GSD IX (caused by mutations in PHKB, PHKG1, PHKG2, CALM1, CALM2, and CALM3 ), a X-linked liver form (caused by mutations in PHKA2 ),[bmcmedgenet.biomedcentral.com] This may produce sudden death. ( 71, 72 ).[annalsofneurosciences.org]

  • Glycogen Storage Disease Type 9

    […] cardiac death in midlife, and molecular perturbations that are similar to--but less severe than--those observed for the R531Q mutation.[ncbi.nlm.nih.gov] There are autosomal recessive forms of GSD IX (caused by mutations in PHKB, PHKG1, PHKG2, CALM1, CALM2, and CALM3 ), a X-linked liver form (caused by mutations in PHKA2 ),[bmcmedgenet.biomedcentral.com] In all affected individuals, muscle GSD 0 impairs the heart's ability to effectively pump blood and increases the risk of cardiac arrest and sudden death, particularly after[icdlist.com]

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