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19 Possible Causes for Mutation in the CDK6 Gene, Nausea

  • Adenocarcinoma of Gallbladder and Extrahepatic Biliary Tract

    This tendency is the same as that for K-ras mutations and the pancreaticobiliary maljunction may override the effect of p53 gene mutations.[atlasgeneticsoncology.org] Other symptoms may include: • Abdominal pain; Fever, nausea and vomiting; • Bloating; • Anorexia; and • Bloating.[secure.ssa.gov] Most patients are asymptomatic until the disease is advanced but presenting symptoms include abdominal pain (usually in the upper right quadrant), nausea, vomiting, jaundice[orpha.net]

  • Malignant Gastric Neoplasm

    Figure 5: Integrated molecular description of gastric cancer. a , Mutations, copy-number changes and translocations for select genes are shown across samples organized by[nature.com] Gastric cancer symptoms can be nausea, vomiting and epigastric discomfort which is similar to early pregnancy symptoms.[ncbi.nlm.nih.gov] Herceptin was added to the regimen, but the symptoms were not relieved, the patient suffered from dizziness and nausea.[ncbi.nlm.nih.gov]

  • Gastric Cancer

    Figure 5: Integrated molecular description of gastric cancer. a, Mutations, copy-number changes and translocations for select genes are shown across samples organized by molecular[nature.com] Its presenting symptoms include headache, nausea and seizures.[ncbi.nlm.nih.gov] The main symptoms were nausea and stomach discomfort and they were seen as pregnancy signs.[ncbi.nlm.nih.gov]

  • Gastric Adenocarcinoma

    In Pt2, the SETBP1 gene (p.S944N) was mutated, as it is in myeloid malignancies ( 20 ), together with amplification of AKAP9 and CDK6 (cyclin-dependent kinase 6).[pnas.org] This 65-year-old patient was admitted with nausea, vomiting and abdominal pain, in addition to loss of weight (13 Kg in 3 months).[ncbi.nlm.nih.gov] In the MWA group, side effects were reported in eight patients who developed abdominal pain, transient fever, or nausea.[ncbi.nlm.nih.gov]

  • Glioblastoma Multiforme

    The inherited predisposition factors in pediatric HGG are as follows: germline mutations in tumor suppressor genes TP53 and neurofibromin 1 (NF1); oncogenic NTRK fusions [[doi.org] Main presenting symptoms included headache (85%), nausea or vomiting (65%), and seizures (35%). Papilledema (45%) was the most common physical finding.[ncbi.nlm.nih.gov] A 72-year-old man, who had been in complete remission from multiple myeloma for 1 year after treatment that included lenalidomide, presented with confusion, headache, nausea[ncbi.nlm.nih.gov]

  • Medulloblastoma

    Poor prognosis: Group 3, MYC amplification, photoreceptor/GABAergic gene expression Intermediate prognosis: Group 4, gene expression of neuronal/glutamatergic, CDK6 amplification[en.wikipedia.org] Medulloblastoma occurs in the 4th ventricle and usually presents with symptoms of increased intracranial pressure (headaches, nausea, vomiting) and signs of obstructive hydrocephalus[ncbi.nlm.nih.gov] We present an unusual medulloblastoma in a 3.9-year-old boy who had a 2-week history of nausea and vertigo.[ncbi.nlm.nih.gov]

  • Biliary Carcinoma

    This tendency is the same as that for K-ras mutations and the pancreaticobiliary maljunction may override the effect of p53 gene mutations.[atlasgeneticsoncology.org] The most frequent adverse reactions were gastrointestinal manifestations such as anorexia, nausea, vomiting, and diarrhea; also noted was alopecia.[ncbi.nlm.nih.gov] Grade 3-4 hyperbilirubinemia (31%) and nausea/vomiting (31%) were observed and likely related to the underlying disease.[ncbi.nlm.nih.gov]

  • Pancreatic Neoplasm

    Thus when mutations in the CDKN2A gene disrupt the function of p16(INK4), there is improper progression from the G1 to the S phase, allowing continued, uncontrolled cell proliferation[ncbi.nlm.nih.gov] The most common (at least 30 percent) grade 1-4 adverse reactions were diarrhea, nausea, asthenia, vomiting, and fatigue.[web.archive.org] Like pancreatic adenocarcinoma, islet cell tumors may cause abdominal pain, weight loss, nausea, and vomiting.[webmd.com]

  • Rhabdomyosarcoma

    The discovery that p16 gene is mutated or deleted in a striking proportion of human tumors raised the possibility that abnormalities in p16 might predispose to cancer development[ncbi.nlm.nih.gov] Common side effects resulting from chemotherapy and radiation therapy included neutropenia, mucositis, nausea and vomiting, and radiodermatitis, long-term side effects included[ncbi.nlm.nih.gov] An 8-year-old girl presenting with headache and nausea was referred to the authors' institution.[ncbi.nlm.nih.gov]

  • Gallbladder Carcinoma

    This tendency is the same as that for K-ras mutations and the pancreaticobiliary maljunction may override the effect of p53 gene mutations.[atlasgeneticsoncology.org] […] a malignant neoplasm of the bile reservoir, characterized by anorexia, nausea, vomiting, weight loss, progressively worsening right upper quadrant pain, and eventually jaundice[medical-dictionary.thefreedictionary.com] Right upper quadrant abdominal pain, fever, jaundice, nausea, vomiting, pruritus, anorexia, and weight loss are the most important complaints in the literature when it comes[symptoma.com]

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