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14 Possible Causes for Mutation in the CDK6 Gene, Pediatric Disorder, Personality Change

  • Rhabdomyosarcoma

    Shrieve, Demographics, stage distribution, and relative roles of surgery and radiotherapy on survival of persons with primary prostate sarcomas, Cancer Medicine, 7, 12, (6030[doi.org] Dana-Farber/Boston Children's Children with rhabdomyosarcoma are treated through the Bone and Soft Tissue Tumor Program at Dana-Farber/Boston Children's Cancer and Blood Disorders[dana-farber.org] The discovery that p16 gene is mutated or deleted in a striking proportion of human tumors raised the possibility that abnormalities in p16 might predispose to cancer development[ncbi.nlm.nih.gov]

  • Glioblastoma Multiforme

    General symptoms for metastatic brain tumors include: Headaches Weakness on one side of the body Problems with balance Seizures Behavior, memory and personality changes Glioblastoma[uwhealth.org] […] in children Health Articles See all » Treatments for Pediatric Spinal Deformities Infrared Therapy: Health Benefits and Risks Everything You Need to Know About Giving Up[news-medical.net] The inherited predisposition factors in pediatric HGG are as follows: germline mutations in tumor suppressor genes TP53 and neurofibromin 1 (NF1); oncogenic NTRK fusions [[doi.org]

  • Medulloblastoma

    […] in sensation on one side of the body Seizures Unusual sleepiness or change in energy level Change in personality or behavior Unexplained weight loss or weight gain More advanced[columbianeurosurgery.org] Tobey J MacDonald, MD Professor, Department of Pediatrics, Emory University School of Medicine; Director, Pediatric Brain Tumor Program, Aflac Chair for Neuro-Oncology, Aflac[emedicine.com] Poor prognosis: Group 3, MYC amplification, photoreceptor/GABAergic gene expression Intermediate prognosis: Group 4, gene expression of neuronal/glutamatergic, CDK6 amplification[en.wikipedia.org]

  • Acute Myelomonocytic Leukemia

    CML is an acquired leukemia, resulting from a change in a person's DNA. This change results in an uncontrolled growth of white cells.[nationalcmlsociety.org] […] in the care of patients with or at risk for genetic disorders.[books.google.com] In one-third we observed chromosome abnormalities (e.g. trisomy 8, del20q) and gain or loss of genes (e.g. NF1, RB1 and CDK6 ).[bmccancer.biomedcentral.com]

  • Biliary Carcinoma

    If you are concerned about any changes you experience, please talk with your doctor.[cancer.net] Adds five new chapters including "Screening and Surveillance of the GI Tract, "Congenital and Developmental Disorders of the GI Tract, "Pediatric Enteropathies of the GI Tract[books.google.com] This tendency is the same as that for K-ras mutations and the pancreaticobiliary maljunction may override the effect of p53 gene mutations.[atlasgeneticsoncology.org]

  • Gastric Adenocarcinoma

    Because there is no one risk factor directly associated with gastric cancer, there is no strict lifestyle change that can greatly decrease a person's risk of developing gastric[oncolink.org] […] in children Health Articles See all » Treatments for Pediatric Spinal Deformities Infrared Therapy: Health Benefits and Risks Everything You Need to Know About Giving Up[news-medical.net] In Pt2, the SETBP1 gene (p.S944N) was mutated, as it is in myeloid malignancies ( 20 ), together with amplification of AKAP9 and CDK6 (cyclin-dependent kinase 6).[pnas.org]

  • Gastric Cancer

    Because there is no one risk factor directly associated with gastric cancer, there is no strict lifestyle change that can greatly decrease a person's risk of developing gastric[oncolink.org] […] in children Health Articles See all » Treatments for Pediatric Spinal Deformities Infrared Therapy: Health Benefits and Risks Everything You Need to Know About Giving Up[news-medical.net] Figure 5: Integrated molecular description of gastric cancer. a, Mutations, copy-number changes and translocations for select genes are shown across samples organized by molecular[nature.com]

  • Noonan Syndrome-Like Disorder with Juvenile Myelomonocytic Leukemia

    A person’s genes are made of DNA. Both copies of the person’s genes are checked for possible changes.[stjude.org] Frieden, two of the most important names in the fields of dermatology and pediatrics.[books.google.com] In one-third we observed chromosome abnormalities (e.g. trisomy 8, del20q) and gain or loss of genes (e.g. NF1, RB1 and CDK6 ).[bmccancer.biomedcentral.com]

  • Autosomal Dominant Microcephaly

    WNT5A Selected Pathogenic Variants DNA Nucleotide Change (Alias 1 ) Predicted Protein Change (Alias 1 ) Reference Sequences c.206G A p.Cys69Tyr NM_003392 .4 NP_003383 .2 c[ncbi.nlm.nih.gov] Hum Genet 57:93–95 Google Scholar Edwards JH (1982) Chromosomal abnormalities in mendelian disorders.[springerlink.com] […] in the ZNF335 gene ({610827}) on 20q13; MCPH11 ({615414}), caused by mutation in the PHC1 gene ({602978}) on 12p13; MCPH12 ({616080}), caused by mutation in the CDK6 gene[diseaseinfosearch.org]

  • Melanoma-Astrocytoma Syndrome

    Changes in vision * Seizures * Vomiting * Personality changes * Dementia * Memory problems * Thinking problems * Concentration problems * Walking problems * Coordination problems[checkorphan.org] Neurology 60:1139–1145 CrossRef PubMed Google Scholar Jentarra G, Snyder SL, Narayanan V (2006) Genetic aspects of neurocutaneous disorders.[link.springer.com] . 4 MTAP encodes methylthioadenosine phosphorylase—an enzyme that appears to also exhibit features of a tumour suppressor gene.[jmg.bmj.com]