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21 Possible Causes for Mutation in the CDK6 Gene, Personality Change

  • Glioblastoma Multiforme

    General symptoms for metastatic brain tumors include: Headaches Weakness on one side of the body Problems with balance Seizures Behavior, memory and personality changes Glioblastoma[uwhealth.org] The inherited predisposition factors in pediatric HGG are as follows: germline mutations in tumor suppressor genes TP53 and neurofibromin 1 (NF1); oncogenic NTRK fusions [[doi.org] Personality changes How is glioblastoma multiforme diagnosed?[igeaneuro.com]

  • Pancreatic Neoplasm

    Psychosocial Assess for the presence of irritability, depression, and personality changes.[medical-dictionary.thefreedictionary.com] Thus when mutations in the CDKN2A gene disrupt the function of p16(INK4), there is improper progression from the G1 to the S phase, allowing continued, uncontrolled cell proliferation[ncbi.nlm.nih.gov] Untreated hypoglycemia can cause headaches, visual disturbances, personality changes, seizures and, in severe cases, coma and death.[rarediseases.org]

  • Biliary Carcinoma

    If you are concerned about any changes you experience, please talk with your doctor.[cancer.net] This tendency is the same as that for K-ras mutations and the pancreaticobiliary maljunction may override the effect of p53 gene mutations.[atlasgeneticsoncology.org] Early bile duct cancer usually does not cause pain, but a person may experience pain if the cancer is large or has spread.[cancer.net]

  • Rhabdomyosarcoma

    Shrieve, Demographics, stage distribution, and relative roles of surgery and radiotherapy on survival of persons with primary prostate sarcomas, Cancer Medicine, 7, 12, (6030[doi.org] The discovery that p16 gene is mutated or deleted in a striking proportion of human tumors raised the possibility that abnormalities in p16 might predispose to cancer development[ncbi.nlm.nih.gov] Shu-Wei Chou, Hsiu-Hao Chang, Meng-Yao Lu, Yung-Li Yang, Dong-Tsamn Lin, Kai-Hsin Lin and Shiann-Tarng Jou, Clinical outcomes of pediatric patients with newly diagnosed rhabdomyosarcoma[doi.org]

  • Malignant Gastric Neoplasm

    Some risk factors, like smoking, can be changed. Others, like a person’s age or family history, can’t be changed.[cancer.org] Figure 5: Integrated molecular description of gastric cancer. a , Mutations, copy-number changes and translocations for select genes are shown across samples organized by[nature.com] Most cancers are caused by gene changes that happen during a person’s lifetime, but a person’s cancer risk can be higher if they have one of these rare inherited mutations[debbiesdream.org]

  • Gastric Adenocarcinoma

    Because there is no one risk factor directly associated with gastric cancer, there is no strict lifestyle change that can greatly decrease a person's risk of developing gastric[oncolink.org] In Pt2, the SETBP1 gene (p.S944N) was mutated, as it is in myeloid malignancies ( 20 ), together with amplification of AKAP9 and CDK6 (cyclin-dependent kinase 6).[pnas.org] Guidelines for the diagnosis of HDGC syndrome have been proposed, but may change over time as more is learned about this condition.[cancer.net]

  • Gastric Cancer

    Because there is no one risk factor directly associated with gastric cancer, there is no strict lifestyle change that can greatly decrease a person's risk of developing gastric[oncolink.org] Figure 5: Integrated molecular description of gastric cancer. a, Mutations, copy-number changes and translocations for select genes are shown across samples organized by molecular[nature.com] Guidelines for the diagnosis of HDGC syndrome have been proposed, but may change over time as more is learned about this condition.[cancer.net]

  • Medulloblastoma

    […] in sensation on one side of the body Seizures Unusual sleepiness or change in energy level Change in personality or behavior Unexplained weight loss or weight gain More advanced[columbianeurosurgery.org] Poor prognosis: Group 3, MYC amplification, photoreceptor/GABAergic gene expression Intermediate prognosis: Group 4, gene expression of neuronal/glutamatergic, CDK6 amplification[en.wikipedia.org] Early stages of medulloblastoma show signs of nonspecific headache, slight imbalance, change in the personality and fatigue.[symptoma.com]

  • Familial Melanoma of the Eyelid

    Many cancers begin when one or more genes in a cell are mutated (changed), creating an abnormal protein.[dermnetnz.org] Thus CDKN2A acts as a tumour suppressor gene by inhibiting cellular proliferation.[ncbi.nlm.nih.gov] Normally gene testing is only carried out on a family member who has themselves had cancer, as a mutated gene is more likely to be found in such a person.[genomel.org]

  • Noonan Syndrome-Like Disorder with Juvenile Myelomonocytic Leukemia

    A person’s genes are made of DNA. Both copies of the person’s genes are checked for possible changes.[stjude.org] In one-third we observed chromosome abnormalities (e.g. trisomy 8, del20q) and gain or loss of genes (e.g. NF1, RB1 and CDK6 ).[bmccancer.biomedcentral.com] For that one gene, the person’s cells carry one working copy and one copy that is changed. This change causes the gene to not work properly. It is called a mutation.[stjude.org]

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