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6,366 Possible Causes for Mutation in the CDK6 Gene, Personality Change, Sister Mary Joseph's Nodule

  • Malignant Neoplasm of Pancreas

    Mary Joseph nodule or nodules) Possible presence of palpable metastatic mass in the rectal pouch (Blumer shelf) Possible presence of palpable metastatic cervical nodes: Nodes[emedicine.medscape.com] Psychosocial Assess for the presence of irritability, depression, and personality changes.[medical-dictionary.thefreedictionary.com] I changed my diet and exercise consistently which minimizes a reoccurance.[netrf.org]

    Missing: Mutation in the CDK6 Gene
  • Malignant Gastric Neoplasm

    Other possible signs of metastatic disease include left supraclavicular adenopathy (Virchow's node), periumbilical node (Sister Mary Joseph nodule), and an anterior axillary[symptoma.com] Most cancers are caused by gene changes that happen during a person’s lifetime, but a person’s cancer risk can be higher if they have one of these rare inherited mutations[debbiesdream.org] Figure 5: Integrated molecular description of gastric cancer. a , Mutations, copy-number changes and translocations for select genes are shown across samples organized by[nature.com]

  • Gastric Adenocarcinoma

    ., left supraclavicular), Sister Mary Joseph’s nodule (periumbilical), or Blumer’s shelf (metastatic tumor felt on rectal examination, with growth in the rectouterine/rectovesical[aafp.org] Because there is no one risk factor directly associated with gastric cancer, there is no strict lifestyle change that can greatly decrease a person's risk of developing gastric[oncolink.org] In Pt2, the SETBP1 gene (p.S944N) was mutated, as it is in myeloid malignancies ( 20 ), together with amplification of AKAP9 and CDK6 (cyclin-dependent kinase 6).[pnas.org]

  • Adenocarcinoma of the Colon

    A Sister Marie Joseph nodule may develop at the umbilicus from tumour infiltration. Liver metastases are quite asymptomatic in the early stages.[surgwiki.com] changes, odd sensations in the legs or arms, or changes in thinking.[medicalnewstoday.com] Having inherited changes in certain genes that increase the risk of familial adenomatous polyposis (FAP) or Lynch syndrome (hereditary nonpolyposis colorectal cancer).[cancer.gov]

    Missing: Mutation in the CDK6 Gene
  • Pancreatic Adenocarcinoma

    If cutaneous metastases do indeed occur, it is often near the umbilicus, known as the Sister Mary Joseph's nodule.[ncbi.nlm.nih.gov] changes, odd sensations in the legs or arms, or changes in thinking.[medicalnewstoday.com] Subcutaneous metastases (referred to as a Sister Mary Joseph nodule or nodules) in the paraumbilical area signify advanced disease.[emedicine.medscape.com]

    Missing: Mutation in the CDK6 Gene
  • Adenocarcinoma of the Ovary

    Mary Joseph nodule* Table 6 History and Examination Findings Associated with Ovarian Cancer Family history Bilateral breast cancer Early-onset breast cancer (younger than[aafp.org] The genes in cells carry the hereditary information that is received from a person’s parents.[my.clevelandclinic.org] Mary Joseph nodule . [21] Rarely, teratomas can cause growing teratoma syndrome or peritoneal gliomatosis . [21] Some experience menometrorrhagia and abnormal vaginal bleeding[en.wikipedia.org]

    Missing: Mutation in the CDK6 Gene
  • Gastric Cancer

    Abstract Sister Mary Joseph nodule is a metastatic lesion of the umbilicus, which is an uncommon phenomenon that carries an ominous prognosis.[ncbi.nlm.nih.gov] Because there is no one risk factor directly associated with gastric cancer, there is no strict lifestyle change that can greatly decrease a person's risk of developing gastric[oncolink.org] Figure 5: Integrated molecular description of gastric cancer. a, Mutations, copy-number changes and translocations for select genes are shown across samples organized by molecular[nature.com]

  • Glioblastoma Multiforme

    General symptoms for metastatic brain tumors include: Headaches Weakness on one side of the body Problems with balance Seizures Behavior, memory and personality changes Glioblastoma[uwhealth.org] The inherited predisposition factors in pediatric HGG are as follows: germline mutations in tumor suppressor genes TP53 and neurofibromin 1 (NF1); oncogenic NTRK fusions [[doi.org] Personality changes How is glioblastoma multiforme diagnosed?[igeaneuro.com]

    Missing: Sister Mary Joseph's Nodule
  • Vitamin B12 Deficiency

    ., paresthesia, peripheral neuropathy, spinal cord degeneration), Psychiatric symptoms (irritability, personality change, depression), Cardiovascular problems (e.g., myocardial[kidsnewtocanada.ca] changes.[www2.gov.bc.ca] changes Hematologic signs and symptoms: Anemia Macrocytosis (enlarged red-blood cells) Generalized weakness Fatigue Shortness of breath Pallor Signs & symptoms in infants[b12awareness.org]

    Missing: Mutation in the CDK6 Gene Sister Mary Joseph's Nodule
  • Cutaneous Metastasis in Breast Cancer

    The Sister Mary Joseph nodule is a well known cutaneous metastasis.[radiopaedia.org] […] or personality changes Metastasis to the liver may cause: Jaundice Itchy skin or rash Abnormally high enzymes in the liver Abdominal pain, appetite loss, nausea, and vomiting[nationalbreastcancer.org] […] appearing at the umbilicus is called a Sister Mary Joseph nodule and is a sign of extensive colorectal cancer October is breast cancer awareness month.[comderm.com]

    Missing: Mutation in the CDK6 Gene