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13 Possible Causes for Mutation in the CDK6 Gene, Recurrent Abdominal Pain

  • Malignant Gastric Neoplasm

    Figure 5: Integrated molecular description of gastric cancer. a , Mutations, copy-number changes and translocations for select genes are shown across samples organized by[nature.com] Additionally, frequent amplifications of cell cycle mediators ( CCNE1, CCND1 and CDK6 ) suggest the potential for therapeutic inhibition of cyclin-dependent kinases ( Supplementary[nature.com]

  • Gastric Adenocarcinoma

    In Pt2, the SETBP1 gene (p.S944N) was mutated, as it is in myeloid malignancies ( 20 ), together with amplification of AKAP9 and CDK6 (cyclin-dependent kinase 6).[pnas.org] Figure 5: Integrated molecular description of gastric cancer. a, Mutations, copy-number changes and translocations for select genes are shown across samples organized by molecular[nature.com] Intriguingly, mutations of the gene encoding the voltage-dependent calcium channel protein, CACNA1D p.V529G , was found in both Pt1 and Pt2.[pnas.org]

  • Pancreatic Neoplasm

    Thus when mutations in the CDKN2A gene disrupt the function of p16(INK4), there is improper progression from the G1 to the S phase, allowing continued, uncontrolled cell proliferation[ncbi.nlm.nih.gov] Patients are usually in their seventh to eighth decade of life and present with abdominal pain, or recurrent pancreatitis, thought to be caused by obstruction of the pancreatic[bcm.edu] The commonest clinical complications are gastrointestinal hemorrhage, perforation, chronic debilitating abdominal pain, recurrent pancreatitis, duodenal stenosis and risk[pubs.sciepub.com]

  • Biliary Carcinoma

    pain.[acgcasereports.gi.org] This tendency is the same as that for K-ras mutations and the pancreaticobiliary maljunction may override the effect of p53 gene mutations.[atlasgeneticsoncology.org] In 2013, he had local recurrence with metastasis to the liver.[acgcasereports.gi.org]

  • CDK4-linked Melanoma

    The mass was noticed by her six months ago and was associated with recurrent episodes of intermittent pain in the right upper quadrant.[oatext.com] However, we are not aware of CDK6 mutations associated with melanoma ( 48 ).[cancerres.aacrjournals.org] […] postmenopausal female of Asian ethnicity reported to the general surgery outpatient department of a Tertiary health care centre in Central India with complaints of slowly enlarging abdominal[oatext.com]

  • Rhabdomyosarcoma

    RESULTS: The patient presented with severe abdominal pain and distention 32 days after the operation and recurrent disease was diagnosed.[cancerindex.org] The discovery that p16 gene is mutated or deleted in a striking proportion of human tumors raised the possibility that abnormalities in p16 might predispose to cancer development[ncbi.nlm.nih.gov] […] induces dephosphoryla-tion of pRB by inhibiting binding of cyclin-dependent kinase (CDK)4 and CDK6 to cyclin D, resulting in G1 growth arrest.[ncbi.nlm.nih.gov]

  • Gastric Cancer

    This report describes the case of a 55-year-old female patient who presented with a 10-year history of recurrent and worsening abdominal pain and melena that had been occurring[ncbi.nlm.nih.gov] Figure 5: Integrated molecular description of gastric cancer. a, Mutations, copy-number changes and translocations for select genes are shown across samples organized by molecular[nature.com] Additionally, frequent amplifications of cell cycle mediators ( CCNE1, CCND1 and CDK6 ) suggest the potential for therapeutic inhibition of cyclin-dependent kinases ( Supplementary[nature.com]

  • Gallbladder Carcinoma

    Complications of the disease include recurrence of tumor, resulting in visceral pain from intra-abdominal involvement.[clinicaladvisor.com] This tendency is the same as that for K-ras mutations and the pancreaticobiliary maljunction may override the effect of p53 gene mutations.[atlasgeneticsoncology.org] Recurrent disease should be suspected in patients who are having unexplained weight loss, obstructive jaundice, or increasing intra-abdominal pain.[clinicaladvisor.com]

  • Burkitt Lymphoma

    A man aged 17 years presented with a history of recurrent abdominal pain over the past 3 weeks.[ncbi.nlm.nih.gov] , PTEN, NOTCH1, and ATM ; amplifications of RAF1, MDM4, MDM2, KRAS, IKBKE, and CDK6 ; deletion of CDKN2A ; overexpression of MIR17HG ; activating mutations of TCF3 and/or[atlasgeneticsoncology.org] Additional gene alterations include the following: truncating mutations of ARID1A and amplification of MCL1 ; point mutations of LRP6 ; truncating alterations of LRP1B, PTPRD[atlasgeneticsoncology.org]

  • Noonan Syndrome-Like Disorder with Juvenile Myelomonocytic Leukemia

    […] fever easy bruising bone and joint pain abdominal pain (caused by abnormal blood cells accumulating in organs like the kidneys, liver, and spleen) Diagnosis A doctor who[rchsd.org] In one-third we observed chromosome abnormalities (e.g. trisomy 8, del20q) and gain or loss of genes (e.g. NF1, RB1 and CDK6 ).[bmccancer.biomedcentral.com] The symptoms of all types of leukemia are generally the same and include: fatigue and weakness swollen lymph nodes recurrent infections (such as bronchitis or tonsillitis)[rchsd.org]

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