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24 Possible Causes for Mutation in the CDK6 Gene, Weight Loss

  • Malignant Gastric Neoplasm

    Abstract An 81-year-old man was admitted with upper abdominal pain and weight loss.[ncbi.nlm.nih.gov] Figure 5: Integrated molecular description of gastric cancer. a , Mutations, copy-number changes and translocations for select genes are shown across samples organized by[nature.com] A 49-year-old man presented with 5 months' history of abdominal pain, anorexia, and rapid weight loss.[ncbi.nlm.nih.gov]

  • Oropharyngeal Carcinoma

    See a doctor if any of the following symptoms are present: A sore throat that persists Pain or difficulty with swallowing Unexplained weight loss Voice changes Ear pain A[my.clevelandclinic.org] Notably, germline mutations in TP53 and RB1 genes are associated with high risks for lung cancer (and other specific cancers, in particular retinoblastomas in RB1 mutated[doi.org] The possible signs of oropharyngeal cancer are: A sore throat that persists for over 2 weeks Throat pain or difficulty swallowing Unexplained rapid weight loss Voice changes[en.wikipedia.org]

  • Gastric Adenocarcinoma

    A 56-year-old woman presented with epigastric pain and weight loss. Endoscopy showed an irregular depressed hyperemic lesion covered with a whitish plaque on the cardia.[ncbi.nlm.nih.gov] In Pt2, the SETBP1 gene (p.S944N) was mutated, as it is in myeloid malignancies ( 20 ), together with amplification of AKAP9 and CDK6 (cyclin-dependent kinase 6).[pnas.org] loss.[symptoma.com]

  • Gallbladder Carcinoma

    The clinical presentation, comprised of nonspecific signs such as abdominal pain in the right upper quadrant, weight loss, jaundice, and fever, is often insidious.[symptoma.com] This tendency is the same as that for K-ras mutations and the pancreaticobiliary maljunction may override the effect of p53 gene mutations.[atlasgeneticsoncology.org] A 45-year-old woman came to us with complaints of flatulent dyspepsia associated with weight loss and anorexia.[ncbi.nlm.nih.gov]

  • Acute Myelomonocytic Leukemia

    This case report describes a 53-year-old male who presented with gingival enlargement and bleeding, fatigue, and recent weight loss as initial manifestations of acute myelomonocytic[ncbi.nlm.nih.gov] In one-third we observed chromosome abnormalities (e.g. trisomy 8, del20q) and gain or loss of genes (e.g. NF1, RB1 and CDK6 ).[bmccancer.biomedcentral.com] Symptoms of AML include: Fever Shortness of breath Easy bruising or bleeding Bleeding under the skin Weakness or feeling tired Weight loss or loss of appetite Tests that examine[icdlist.com]

  • Adenocarcinoma of Gallbladder and Extrahepatic Biliary Tract

    Cholangiocarcinoma symptoms include yellow coloring of the skin and eyes ( jaundice ), itching, abdominal pain, bloating, and weight loss.[medicinenet.com] This tendency is the same as that for K-ras mutations and the pancreaticobiliary maljunction may override the effect of p53 gene mutations.[atlasgeneticsoncology.org] loss.[secure.ssa.gov]

  • Biliary Carcinoma

    loss and loss of appetite Who to See and Types of Treatments Available Patients suffering from symptoms of cholangiocarcinoma of the biliary tract must consult a physician[docdoc.com.sg] This tendency is the same as that for K-ras mutations and the pancreaticobiliary maljunction may override the effect of p53 gene mutations.[atlasgeneticsoncology.org] Jaundice together with unintentional weight loss and anorexia are particularly concerning, because they often times indicate that the disease has advanced to its later stages[news-medical.net]

  • Gastric Cancer

    The patient presented with chronic continuous abdominal pain and weight loss over a 6-month period.[ncbi.nlm.nih.gov] Figure 5: Integrated molecular description of gastric cancer. a, Mutations, copy-number changes and translocations for select genes are shown across samples organized by molecular[nature.com] We report the case of 45-year-old man with 3-month history of abdominal pain and weight loss.[ncbi.nlm.nih.gov]

  • Pancreatic Neoplasm

    The presenting symptoms were abdominal pain, fever, or weight loss.[ncbi.nlm.nih.gov] Thus when mutations in the CDKN2A gene disrupt the function of p16(INK4), there is improper progression from the G1 to the S phase, allowing continued, uncontrolled cell proliferation[ncbi.nlm.nih.gov] loss, and deterioration in functional status.[ncbi.nlm.nih.gov]

  • Burkitt Lymphoma

    Described herein is the case of a nine-year-old boy with abdominal pain, jaundice, emesis, weight loss, diarrhea, who developed hyperlipidemia and cholestasis.[ncbi.nlm.nih.gov] , PTEN, NOTCH1, and ATM ; amplifications of RAF1, MDM4, MDM2, KRAS, IKBKE, and CDK6 ; deletion of CDKN2A ; overexpression of MIR17HG ; activating mutations of TCF3 and/or[atlasgeneticsoncology.org] He came at our attention for fever and weight loss suspected for parasitic cyst discharge and also for lymphoproliferative disorder.[ncbi.nlm.nih.gov]

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