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5,228 Possible Causes for Mutation in the Heat Shock Transcription Factor 4, Slow Progression

  • Early-Onset Nuclear Cataract

    Genetics This type of congenital cataract may be caused by mutations in the heat-shock transcription factor-4 gene ( HSF4 ) located at 16q21-q22.1.[disorders.eyes.arizona.edu] Cortical cataracts also tend to have a slow, steady progression but cause more trouble with glare and haziness.[health.clevelandclinic.org] In addition, a balanced diet containing a reasonable amount of antioxidant vitamins may help slow the progression of cataracts, while supporting overall health.[ophthalmicconsultants.com]

  • Lamellar Cataract

    The p.Arg116His mutation in the heat shock transcription factor-4 (HSF4) has been associated with age-related cataracts, but it is also seen in 2% of the normal population[ncbi.nlm.nih.gov] "Antioxidant vitamin supplementation for preventing and slowing the progression of age-related cataract".[en.wikipedia.org] Genetics This type of congenital cataract may be caused by mutations in the heat-shock transcription factor-4 gene ( HSF4 ) located at 16q21-q22.1.[disorders.eyes.arizona.edu]

  • Mal de Meleda

    Slow progression without remission.[ijdvl.com] Mutations in the heat-shock transcription factor 4 gene (HSF4; MIM: 602438) may result in both autosomal dominant and autosomal recessive congenital cataracts.[hal-riip.archives-ouvertes.fr] Lesions were progressive with slow involvement of dorsal aspect of palms and soles.[jemds.com]

  • Autosomal Recessive Congenital Cataract 5

    Mutations in the heat-shock transcription factor 4 gene (HSF4; MIM: 602438) may result in both autosomal dominant and autosomal recessive congenital cataracts.[hal-riip.archives-ouvertes.fr] Presentation - aged 10-30 years: slow, progressive, bilateral visual loss (night vision better than day), photophobia, poor colour vision nystagmus.[patient.info] All exons and adjacent splice sites of the heat shock transcription factor 4 gene ( HSF4 ) were sequenced.[bmcmedgenet.biomedcentral.com]

  • Macular Degeneration

    It is a slow progressive disease that affects the central area of the retina called the macula.[healingtheeye.com] However, taking supplements of omega-3 fatty acids does not slow the progression of the disorder.[merckmanuals.com] Dietary supplements may help slow progression of the disorder. Eye injections and laser treatments may be necessary for some people.[merckmanuals.com]

    Missing: Mutation in the Heat Shock Transcription Factor 4
  • Retinitis Pigmentosa

    Findings of controlled trials indicate that nutritional interventions, including vitamin A palmitate and omega-3-rich fish, slow progression of disease in many patients.[ncbi.nlm.nih.gov] Some extreme cases may have a rapid evolution over two decades or a slow progression that never leads to blindness.[ncbi.nlm.nih.gov] However, patients generally demonstrate a slow, progressive loss of peripheral vision over many years, until only central (tunnel) vision remains.[uclahealth.org]

    Missing: Mutation in the Heat Shock Transcription Factor 4
  • Coronary Cataract

    transcription factor-4 (HSF4), aquaporin-0 (AQP0, MIP), and beaded filament structural protein-2 (BFSP2) [2], [3].[journals.plos.org] Nuclear cataract • Due to excessive amount of nuclear sclerosis and yellowing which causes central opacity • Slow progression • Interferes more with distant vision than near[slideshare.net] In many of these cases the progress was extremely slow extending over decades and in spite of spoke formation vision may be only slightly affected if at all.[embryology.med.unsw.edu.au]

  • Diabetic Nephropathy

    Reducing dietary salt intake may help slow progression of diabetic kidney disease.[emedicine.medscape.com] Reducing the amount of protein in your diet also may be helpful to slow progressing kidney disease.[drugs.com] Dietary salt reduction may help slow progression of kidney disease in both type 1 and type 2 diabetes.[emedicine.medscape.com]

    Missing: Mutation in the Heat Shock Transcription Factor 4
  • Primary Lateral Sclerosis

    Primary lateral sclerosis denotes a clinical state with the insidious onset and slow progression of neurological dysfunction limited to the corticospinal tract.[ncbi.nlm.nih.gov] CONCLUSIONS: Clinically pure PLS can be defined by isolated UMN signs 4 years after symptom onset, and is a syndrome of slow progression with high levels of function.[ncbi.nlm.nih.gov] Although absolute guarantees cannot be given, some measure of reassurance may be derived from the overall slow progression in these patients.[emedicine.com]

    Missing: Mutation in the Heat Shock Transcription Factor 4
  • Primary Progressive Multiple Sclerosis

    progressive multiple sclerosis has been hailed as “big news” by doctors and charities.[telegraph.co.uk] While many long-term therapies are approved for use in RRMS, they’re not effective in slowing progression in people with PPMS.[healthline.com] Although the results of the INFORMS study suggest that fingolimod may not slow down the progression, some PPMS patients might still benefit from a disease-modifying treatment[ncbi.nlm.nih.gov]

    Missing: Mutation in the Heat Shock Transcription Factor 4

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