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1,003 Possible Causes for Mutation in the Hereditary Hemochromatosis Gene, Nocturnal Paroxysmal Dyspnea, P Mitrale

  • Congestive Heart Failure

    Lancellotti P, Gerard PL, Pierard LA. Long-term outcome of patients with heart failure and dynamic functional mitral regurgitation.[emedicine.com] Features due to left heart failure: Dyspnea, orthopnea and paroxysmal nocturnal dyspnea: These symptoms develop due to congestion of the lungs.[symptoma.com] The actuarial survival rates of persons who are homozygous for the mutation of the hemochromatosis gene C282Y have been reported to be 95%, 93%, and 66%, at 5, 10, and 20[doi.org]

  • Cardiomyopathy

    […] markedly longer chordae tendineae (DCM-lowMR: 24 [20-26] mm; controls: 14 [13-16] mm; P 0.01) and larger anterior leaflets (DCM-lowMR: 30 [27-31] mm; controls: 22 [20-24] mm; P[ncbi.nlm.nih.gov] Symptoms: Patients with cardiomyopathy will typically present with dyspnea, orthopnea, paroxysmal nocturnal dyspnea, bilateral edema, and fatigue.[symptoma.com] These symptoms of heart failure most commonly include dyspnea , orthopnea , paroxysmal nocturnal dyspnea , and fluid retention. How Is Postpartum Cardiomyopathy Treated?[verywellhealth.com]

    Missing: Mutation in the Hereditary Hemochromatosis Gene
  • Aortic Valve Stenosis

    P., Rouf, R., Habashi, J. & Dietz, H. C. Mitral valve disease in Marfan syndrome and related disorders. J. Cardiovasc. Transl. Res. 4, 741–747 (2011). 134. Chang, S.[doi.org] Other symptoms associated with AS are related to cardiac failure, such as paroxysmal nocturnal dyspnea, orthopnea, and dyspnea on exertion.[symptoma.com] The patient also presented dyspnea on minimal exertion, orthopnea, paroxysmal nocturnal dyspnea and edema of lower limbs. The patient denied fever.[web.archive.org]

    Missing: Mutation in the Hereditary Hemochromatosis Gene
  • Mitral Valve Insufficiency

    .  Electrocardiography: P mitrale is broad, notched P waves in several or many leads with a prominent late negative component to the P wave in lead V1, and may be seen in[slideshare.net] Patients may be asymptomatic or may have manifestations like fatigue caused by reduced cardiac output, tachypnea or dyspnea, orthopnea, paroxysmal nocturnal dyspnea and hemoptysis[symptoma.com] nocturnal dyspnea), as well as symptoms of cardiogenic shock (i.e., shortness of breath at rest).[en.wikipedia.org]

    Missing: Mutation in the Hereditary Hemochromatosis Gene
  • Dilated Cardiomyopathy

    […] markedly longer chordae tendineae (DCM-lowMR: 24 [20-26] mm; controls: 14 [13-16] mm; P 0.01) and larger anterior leaflets (DCM-lowMR: 30 [27-31] mm; controls: 22 [20-24] mm; P[ncbi.nlm.nih.gov] The following are the symptoms with which a patient may present: fatigue, orthopnea, dyspnea on exertion, paroxysmal nocturnal dyspnea, increasing edema, weight gain, or an[symptoma.com] At presentation she had dyspnea at rest, orthopnea and paroxysmal nocturnal dyspnea.[doi.org]

    Missing: Mutation in the Hereditary Hemochromatosis Gene
  • Aortic Valve Insufficiency

    […] significant linear relationship between mitral tenting area and severity of mitral regurgitation (P 0.001).[oadoi.org] As the disease progresses, orthopnea and paroxysmal nocturnal dyspnea start to occur. Angina is predominantly nocturnal in these patients.[symptoma.com] Angina with exertion, orthopnea, and paroxysmal nocturnal dyspnea are also principal complaints.[medical-dictionary.thefreedictionary.com]

    Missing: Mutation in the Hereditary Hemochromatosis Gene
  • Mitral Valve Stenosis

    […] of mitral valvular disease.[web.archive.org] As the stenosis worsens, symptoms of orthopnea, paroxysmal nocturnal dyspnea or dyspnea on exertion develops.[symptoma.com] As stenosis intensifies Dyspnea may be encountered at rest and may evolve to include orthopnea and paroxysmal nocturnal dyspnea.[pathwaymedicine.org]

    Missing: Mutation in the Hereditary Hemochromatosis Gene
  • Heart Failure

    The RV S/D ratio was significantly higher in the event group than in the event-free group (1.8 0.8 versus 1.2 0.5, P 0.008).[ncbi.nlm.nih.gov] Major criteria: · Paroxysmal nocturnal dyspnea · Neck vein distention · Rales · Radiographic cardiomegaly (increasing heart size on chest radiography) · Acute pulmonary edema[web.archive.org] The actuarial survival rates of persons who are homozygous for the mutation of the hemochromatosis gene C282Y have been reported to be 95%, 93%, and 66%, at 5, 10, and 20[doi.org]

  • Rheumatic Heart Disease

    (30.4% vs. 19%, p 0.001).[ncbi.nlm.nih.gov] […] atrial fibrillation (Paf)発作性心房細動 paroxysmal nocturnal dyspnea発作性夜間呼吸困難 paroxysmal supraventricular tachycardia(PSVT)発作性上室性頻拍 paroxysmal ventricular tachycardia (PVT)発作性心室頻拍[tokyo-med.ac.jp] Children with CHF may also experience shortness of breath on lying flat (orthopnea) or episodes of shortness of breath that wake them from sleep (paroxysmal nocturnal dyspnea[ssa.gov]

    Missing: Mutation in the Hereditary Hemochromatosis Gene
  • Left Cardiac Ventricle Disorder

    A pansystolic murmur of mitral regurgitation at the apex may occur in either HFrEF or HFpEF.[merckmanuals.com] Attacks of breathlessness severe enough to wake the patient frequently occur during sleep ( paroxysmal nocturnal dyspnea ).[medical-dictionary.thefreedictionary.com] When the legs are elevated at night, the fluid redistributes centrally, causing pulmonary edema that results in orthopnea (dyspnea while lying flat) or paroxysmal nocturnal[healio.com]

    Missing: Mutation in the Hereditary Hemochromatosis Gene