Create issue ticket

4 Possible Causes for Mutation in the IL21 Gene

  • Common Variable Immunodeficiency 11

    DgiDB (Drug Gene Interaction Database) IL21 DoCM (Curated mutations) IL21 (select the gene name) CIViC (Clinical Interpretations of Variants in Cancer) IL21 (select a term[atlasgeneticsoncology.org] Note The disease is caused by mutations affecting the gene represented in this entry. Sequence similarity : Belongs to the IL-15/IL-21 family. {ECO:0000305}.[sinobiological.com] ) intoGen IL21 Cancer3D IL21 (select the gene name) Impact of mutations [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] Diseases OMIM 605384[atlasgeneticsoncology.org]

  • X-Linked Severe Combined Immunodeficiency

    The majority of patients have X-linked SCID caused by mutations in the IL2RG gene encoding the common γ chain (γc).[doi.org] The γc chain is shared by the IL2, IL4, IL7, IL9, IL15 and IL21 cytokine receptors [ 31 ].[doi.org]

  • Common Variable Immunodeficiency

    We were unable to identify obvious disease causing mutations in the protein coding regions of the analyzed genes in the studied cohort.[ncbi.nlm.nih.gov] Eleven additional SNPs in the genes encoding BCMA, APRIL, IL10, IL10Rα, IL21 and IL21R were observed at similar frequencies as in healthy donors.[doi.org] Eleven additional SNPs in the genes encoding BCMA, APRIL, IL10, IL10Ralpha, IL21 and IL21R were observed at similar frequencies as in healthy donors.[ncbi.nlm.nih.gov]

  • Severe Combined Immunodeficiency

    The majority of patients have X-linked SCID caused by mutations in the IL2RG gene encoding the common γ chain (γc).[doi.org] The γc chain is shared by the IL2, IL4, IL7, IL9, IL15 and IL21 cytokine receptors [ 31 ].[doi.org]

Further symptoms