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4 Possible Causes for Mutation in the NADH Dehydrogenase Subunit 5 Gene

  • Leigh's Disease

    From Wikidata Jump to navigation Jump to search A mitochondrial metabolism disease characterized by progressive loss of mental and movement abilities. Symptoms usually begin between ages of three months and two years and include loss of appetite, vomiting, irritability and seizure activity. Infantile necrotizing[…][wikidata.org]

  • MELAS Syndrome

    ) transition mutation in the cytochrome c oxidase subunit 3 (COX3) gene and a novel 13849A C (Asn505His) transversion mutation in the NADH dehydrogenase subunit 5 (ND5) gene[ncbi.nlm.nih.gov] ) transition mutation in the cytochrome c oxidase subunit 3 ( COX3 ) gene and a novel 13849A C (Asn505His) transversion mutation in the NADH dehydrogenase subunit 5 ( ND5[nature.com] Neither of these mutations was found in 205 normal controls. Both mutations were identified from the proband and his mother, but not his father.[ncbi.nlm.nih.gov]

  • Leber's Hereditary Optic Neuropathy

    Reports DC Wallace , G Singh , MT Lott , JA Hodge , TG Schurr , AM Lezza , LJ Elsas 2nd , EK Nikoskelainen Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322. See all Hide authors and affiliations Science 09 Dec 1988: Vol. 242, Issue 4884, pp. 1427-1430 DOI: 10.1126/science.3201231 Abstract[…][doi.org]

  • Ophthalmoplegia

    subunit 2 (ND2), tRNA-Trp, non-coding nucleotides (MT-NC3), and NADH dehydrogenase subunit 5 (MT-ND5).[cysonline.org] Results: In the present study, none of the mutations were reported in the coding region of PEO1 gene, while four mutations were observed in mtDNA genes, namely NADH dehydrogenase[cysonline.org] 2], non-coding nucleotide region or MT-NC3 (5585, G/A, reported at MITOMAP) [Figure 3], and in NADH dehydrogenase subunit 5 (MT-ND5) (12705, C/T, synonymous, reported at[cysonline.org]

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