Adverse effects include headache, nausea, vomiting, diarrhea, myalgia, arthralgia, chills, fever, arrhythmia, hypotension, chest pain (especially in patients with coronary
[intechopen.com]
[…] phenomenon [ ra-nōz´ ] intermittent bilateral attacks of ischemia of the fingers or toes and sometimes the ears or nose, marked by severe pallor, and often accompanied by paresthesia
[medical-dictionary.thefreedictionary.com]
Most patients with mild disease only notice skin discoloration upon cold exposure.
[medicinenet.com]