Mydriasis: Causes & Reasons

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Possible Causes for Mydriasis

Acute Amphetamine Intoxication

Physical examination revealed a significant malaise, mydriasis and peripheral coldness. [omicsonline.org]

During the acute phase, diaphoresis, hypertension, tachycardia, mydriasis, agitation, and even psychosis can be present. [clinicaladvisor.com]

The sixth patient had characteristic serial attacks of seizures, hyperthermia, tachycardia and mydriasis. [omicsonline.org]

Acute Angle Closure Glaucoma

Examination revealed reactive mydriasis, and upper lid retraction on the right side. [ncbi.nlm.nih.gov]

The bilateral mydriasis was diagnosed as an unusual clinical presentation of simultaneous bilateral AAC glaucoma. [ncbi.nlm.nih.gov]

CONCLUSION: Cocaine causes mydriasis and can induce angle closure in predisposed individuals. [ncbi.nlm.nih.gov]

Anticholinergic Toxicity

Tachycardia, hyperthermia, mydriasis and urinary retention are effects caused by inhibition of peripheral receptors, whereas hallucinations, seizure, and even coma might be [symptoma.com]

Mydriasis can also occur from isolated local contact of Jimsonweed with the eye (cornpicker's pupil). [emjournal.net]

Anticholinergic syndrome (overdose) Etiology Clinical features Dry mouth, warm, flushed skin, thirst, tachycardia, arrhythmias, mydriasis, confusion, and agitation Possibly [amboss.com]

Botulism

Fixed dilated pupils (Mydriasis) Over excitation of radial fibers of the iris which increases the pupillary aperture is referred to as a mydriasis or blown pupil. [medicaljoyworks.com]

Over the next days she became increasingly weak, developed bilateral ptosis, the muscle stretch reflexes were lost, and mydriasis with slow pupillary responses was noted. [ncbi.nlm.nih.gov]

An 11-year-old boy presented with bilateral ptosis and mydriasis, dry mouth, difficulty in swallowing, dysphonia, urine retention and constipation. [ncbi.nlm.nih.gov]

Glaucoma

In older cases the pupil will dilate and this is called mydriasis. [doi.org]

Angle closure, with palpable hardness of the eye, mydriasis, and anterior prominence of the lens, was described in greater detail in the 18th and 19th centuries. [ncbi.nlm.nih.gov]

2-selective adrenergic agonists (topical) Apraclonidine 1 drop two to three times a day Decrease aqueous production; may increase uveoscleral aqueous outflow; may cause mydriasis [msdmanuals.com]

Alcohol Withdrawal Delirium

[…] generalised tonic-clonic seizures Stage IV – after 48 hrs global confusional state autonomic hyperactivity tremors hallucinations seizures hyperadrenergic: diaphoresis, flushing, mydriasis [lifeinthefastlane.com]

Mydriasis. Ataxia. Altered mental status. Cardiovascular collapse. Risk factors[6] Previous history of delirium tremens. Previous history of alcohol withdrawal seizures. [patient.info]

Clinical findings associated with DTs may include the following: Tachycardia Hyperthermia Hypertension Tachypnea Diaphoresis Tremor Mydriasis Altered mental status Severe [emedicine.medscape.com]

Organophosphate Poisoning

Tachycardia and mydriasis must not be used to limit or to stop subsequent doses of atropine. [openanesthesia.org]

Miosis is replaced by mydriasis. [derangedphysiology.com]

Second, excessive ACh at nicotinic acetylcholine receptors in preganglionic sympathetic synapses and at motor end plates may cause mydriasis, tachycardia, weakness, hypertension [emedicine.com]

Head Trauma

[…] man was in a motor vehicle accident and received a head injury that resulted in intracranial bleeding at multiple sites, fractures of facial bones, and immediate traumatic mydriasis [nejm.org]

Coma

Mydriasis is also common. This indicator can be used to include patients in one of two groups: V1: Autonomic responses to painful stimuli are present. [doi.org]

Accidental Hypothermia

Patients also may have mydriasis, and it should be noted that mild hypothermia usually does not depress pupillary light reflexes. Respiratory. [ahcmedia.com]

Substance Abuse

Abstract Hospital-wide rumors and anecdotal reports had suggested that there was a potentially serious problem of alcohol and drug abuse among the psychiatric patients of this hospital. The authors describe a systematic, evaluative approach which gave direct and detailed information on the nature and extent of[…] [ncbi.nlm.nih.gov]

Stroke

Beyond F.A.S.T. – Other Symptoms You Should Know Sudden NUMBNESS or weakness of face, arm, or leg, especially on one side of the body Sudden CONFUSION, trouble speaking or understanding speech Sudden TROUBLE SEEING in one or both eyes Sudden TROUBLE WALKING, dizziness, loss of balance or coordination Sudden[…] [strokeassociation.org]

Hernia

Abstract Esophageal hiatal hernia is defined as the prolapse of one or more intra-abdominal organs through the esophageal hiatus. Four types are identified: type Ι or sliding hiatal hernia, type II or paraesophageal hernia (PEH), type III or mixed hernia and type IV. Congenital type II esophageal hiatal hernia is[…] [ncbi.nlm.nih.gov]

Primary Progressive Multiple Sclerosis

We present three patients with a clinical course and cerebrospinal fluid findings consistent with a diagnosis of primary progressive multiple sclerosis (PPMS). Extensive and repeated magnetic resonance imaging (MRI) examinations showed only diffuse abnormality in brain and spinal cord, but no focal lesions. We propose[…] [ncbi.nlm.nih.gov]

Epilepsy

PURPOSE: Exogenous estrogens might lead to seizure worsening in women with epilepsy (WWE) by lowering the seizure threshold and inducing glucuronidation in women taking lamotrigine. Assisted reproduction techniques are increasingly used and often require estrogenic and estrogen raising hormone therapy. We aimed at[…] [ncbi.nlm.nih.gov]

Hypoxia

Introduction to hypoxia Symptoms, types and clinical presentation of hypoxia Etiopathogenesis of hypoxia Hypoxia diagnosis Hypoxia management References Further reading Introduction to hypoxia In medicine, hypoxia is a condition in which the human body tissues are not oxygenated sufficiently to maintain adequate[…] [news-medical.net]

Middle Ear Cholesteatoma

[…] case of mydriasis related to Datura inoxia. [emj.bmj.com]

Mydriasis can affect one pupil at a time or both at once. Mydriasis that affects only one eye is called anisocoria. [medicalnewstoday.com]

Gardener’s mydriasis. Lancet1992;339:752. ↵ Reader AL. Mydriasis from Datura wrightii. Am J ophthalmol1977;84:263–4. ↵ Thompson HS, Newsome DA, Lowenfeld IE. [emj.bmj.com]

Sudden Cardiac Death

Mechanisms of sudden cardiac death (SCD) in subjects with apparently normal hearts are poorly understood. In survivors, clinical investigations may not establish normal cardiac structure with certainty. Large autopsy series may provide a unique opportunity to confirm structural normalcy of the heart before[…] [ncbi.nlm.nih.gov]

Cardiac Arrest

Cardiac arrest Other names Cardiopulmonary arrest, circulatory arrest, sudden cardiac arrest (SCA), sudden cardiac death (SCD)[1] CPR being administered during a simulation of cardiac arrest. Specialty Cardiology, emergency medicine Symptoms Loss of consciousness, abnormal or no breathing[1][2] Usual onset Older[…] [en.wikipedia.org]

Ventricular Fibrillation

Congenital left ventricular diverticulum (CLVD) is a rare congenital anomaly and may be associated with fatal adverse events. A previously healthy 20-year-old man collapsed as a result of sudden ventricular fibrillation (VF). Despite intractable VF, he had return of spontaneous circulation with cardiopulmonary[…] [ncbi.nlm.nih.gov]

Multiple Sclerosis

Multiple sclerosis (MS) is the most common chronic disabling disease of the central nervous system (CNS) in young adults. It is characterized by the presence of multiple demyelinating inflammatory lesions disseminated in the CNS. Pseudotumoral lesions (PL) are rarely observed in patients with MS. These atypical lesions[…] [ncbi.nlm.nih.gov]

Brain Death

Brain death is the complete loss of brain function (including involuntary activity necessary to sustain life). It differs from persistent vegetative state, in which the person is alive and some autonomic functions remain. It is also distinct from an ordinary coma, whether induced medically or caused by injury and/or[…] [en.wikipedia.org]

Hypovolemic Shock

The authors describe a new computed tomography finding associated with significant thoracoabdominal trauma: thyroidal and perithyroidal edema and fluid without evidence for direct thyroid injury. It does not seem to be related to direct or indirect thyroid injury but is rather a secondary finding related to the[…] [ncbi.nlm.nih.gov]

Spleen Disease

[…] case of mydriasis related to Datura inoxia. [emj.bmj.com]

Mydriasis can happen for many different reasons. [healthline.com]

Gardener’s mydriasis. Lancet1992;339:752. ↵ Reader AL. Mydriasis from Datura wrightii. Am J ophthalmol1977;84:263–4. ↵ Thompson HS, Newsome DA, Lowenfeld IE. [emj.bmj.com]

Oculomotor Nerve Paralysis

The affected individual will also have a ptosis, or drooping of the eyelid, and mydriasis (pupil dilation). [en.wikipedia.org]

[…] palpebrae superioris Downward and lateral rotation of eye- due to paralysis of all extra ocular muscle except lateral rectus and superior oblique muscle Dilatation of pupil (Mydriasis [physiologyexam.com]

To the Editor: Baker and Cannon (Nov. 3 issue) 1 describe a patient with left-sided ptosis and mydriasis after cranial trauma. [nejm.org]

Barbiturate Overdose

Tragically, there have been many famous people who died of barbiturate overdose. Celebrities who overdosed on barbiturates include Marilyn Monroe, Judy Garland, and Aimee Semple McPherson. What are barbiturates, and what is barbiturate overdose? Barbiturates are depressant drugs that have strong sedative[…] [ranker.com]

Multisystemic Smooth Muscle Dysfunction Syndrome

Important additional clinical features were extremely wide pupils not reacting to light admission (mydriasis), microcephaly and feeding difficulties with pathologic signs [thieme-connect.com]

Congenital mydriasis is an extremely rare pupil anomaly and is the feature for the early diagnosis of this new syndrome. [ncbi.nlm.nih.gov]

Initially described as a case report in 1999, it was characterized in 2010 as a syndrome of congenital mydriasis, patent ductus arteriosus, and aneurysmal arterial disease—in [en.wikipedia.org]

Insulinoma

Practice Essentials Insulinomas are the most common cause of hypoglycemia resulting from endogenous hyperinsulinism. Approximately 90-95% of insulinomas are benign, and long-term cure with total resolution of preoperative symptoms is expected after complete resection. [1, 2] See the image below. CT scan image with[…] [emedicine.medscape.com]

Anisocoria

Figure 1 Episodic unilateral mydriasis. Either pupil may be dilated during an episode. References 1. Thompson HS, Newsome DA, Loewenfeld IE. [nature.com]

Cornpicker’s pupil: Jimson weed mydriasis. J Iowa Med Soc 1971; 61:475-477. ↑ Rubinfeld RS, Currie JN. Accidental mydriasis from blue nightshade ‘lipstick’. [eyewiki.aao.org]

A unilaterally fixed mydriasis, also known as a 'blown pupil,' is considered an ominous sign concerning for intracranial pathology. [ncbi.nlm.nih.gov]

Tonic Pupil

This situation is different from the heterogeneous group with benign episodic unilateral mydriasis. [unboundmedicine.com]

A 46-year-old woman observed transient unilateral mydriasis during a classic migraine attack. [ncbi.nlm.nih.gov]

However, mydriasis can also be caused by a more general neuropathy or pharmacologic blockade. [4] Common clinical findings associated with Adie’s syndrome beyond mydriasis [eyewiki.com]