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740 Possible Causes for Myelosuppression

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  • Drug-induced Bone Marrow Suppression

    Description Myelosuppression is a decrease in the production of blood cells.[] Symptoms of Myelosuppression Myelosuppression does not hurt in and of itself.[] What do you need to know about myelosuppression?[]

  • Aplastic Anemia

    Azathioprine-induced aplastic anemia and fatal myelosuppression is a rare occurrence in patients with systemic lupus erythematosus (SLE).[] Lack of in vitro colony (CFUC) formation and myelosuppressive activity in patients with severe aplastic anemia after autologous hematologic reconstitution.[]

  • Leukoerythroblastic Anemia

    Although thalidomide and lenalidomide can alleviate anemia in myelofibrosis, their use is limited by their respective potential to cause peripheral neuropathy and myelosuppression[] Suppression of the bone marrow can co-exist with factors shortening red cell survival in many situations (for example, a cancer patient on a myelosuppressive chemotherapeutic[]

  • Chronic Lymphocytic Leukemia

    Although purine analogue based combinations produce complete responses (CRs) in many patients, the use of these combinations has been limited by toxicity including myelosuppression[] The 3 most frequent side effects were infusion-related toxicity, myelosuppression, and infections. Table 2.[] Previous phase 2 single-agent studies and combination-treatment studies of rituximab with alkylator-based chemotherapy in lymphoma have not demonstrated myelosuppression as[]

  • Myeloproliferative Disease

    Other patients can undergo myelosuppressive therapy with hydroxyurea. Radioactive phosphorous can be used as an alternative therapy in older patients.[] Patients with painful, massively enlarged spleens refractory to myelosuppressive therapy are occasionally treated with radiation therapy, but they may ultimately require splenectomy[]

  • Mustard Gas Poisoning

    […] growth factor.  Limited clinical evidence suggests a significant role for mustard gas-induced myelosuppression in the overall morbidity of mustard gas victims.  Initial[] Abstract The authors describe the development of a clinical protocol to treat mustard gas-induced myelosuppression with granulocyte colony stimulating factor (GCSF), a hematopoietic[]

  • Philadelphia Chromosome Positive Chronic Myeloid Leukemia

    Myelosuppression was reported in patients with normal baseline laboratory values as well as in patients with pre-existing laboratory abnormalities.[] Of these, 15 of 31 patients with intolerance to imatinib related to myelosuppression experienced grade 3/4 myelosuppression on bosutinib; 13% discontinued because of myelosuppression[] Ponatinib also carries warnings/precautions for congestive heart failure, hypertension, pancreatitis, hemorrhage, fluid retention, cardiac arrhythmias, myelosuppression, tumor[]

  • Primary Myelofibrosis

    Mild myelosuppression can be seen with pegylated interferon; however, bone marrow aplasia in patients with myelofibrosis has not been reported.[] SUMMARY: Combining JAK-inhibitors with agents that target parallel prosurvival pathways or agents that enhance hematopoiesis may enhance efficacy and/or mitigate on-target myelosuppression[] Myelosuppressive therapy [ 1 ] Hydroxycarbamide is the first-line choice for the control of the hyperproliferation manifestations of MF.[]

  • Chronic Myeloid Leukemia

    Myelosuppressive drugs (eg, hydroxyurea ), stem cell transplantation, and interferon alfa are also sometimes used.[] Although a variety of medications have been used in chronic myeloid leukemia, including myelosuppressive agents and interferon alpha, the tyrosine kinase inhibitor imatinib[] Drugs that inhibit bone marrow activity (myelosuppressive drugs) may slow the progression of the disease.[]

  • Secondary Myelofibrosis

    Grade 3 or higher myelosuppression occurred in 22 patients (88%), of whom 18 (82%) had a return to grade 2 or lower myelosuppression or to baseline values; plots of drug reintroduction[] My hope is that pacritinib might become an option for them because even though ruxolitinib is well tolerated, one of the downsides is often myelosuppression, and many patients[] Hydroxyurea — an oral and usually well-tolerated, non-alkylating, myelosuppressive drug — is widely used in practice.[]

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