Create issue ticket

451 Possible Causes for Myelosuppression, Pancytopenia

  • Aplastic Anemia

    Azathioprine-induced aplastic anemia and fatal myelosuppression is a rare occurrence in patients with systemic lupus erythematosus (SLE).[ncbi.nlm.nih.gov] Severe pancytopenia was diagnosed a median of 10 wk after the initiation of therapy.[ncbi.nlm.nih.gov] Lack of in vitro colony (CFUC) formation and myelosuppressive activity in patients with severe aplastic anemia after autologous hematologic reconstitution.[springermedizin.at]

  • Colchicine

    Chronic administration of colchicine is associated with bone marrow suppression, myelosuppression, leukopenia, thrombocytopenia or aplastic anemia.[aocd.org] The patient's clinical manifestations included abdominal cramps, vomiting, pancytopenia, hypocholesterolemia, and rhabdomyolysis.[ncbi.nlm.nih.gov] […] be used to treat pain from other causes; drug is not analgesic Must be kept out of reach of children; fatal overdoses have been reported Blood dyscrasias (eg, leukopenia, myelosuppression[reference.medscape.com]

  • Alkylating Agent

    Dose escalation was terminated at 708 mg/m(2) for prolonged myelosuppression in 1 of 7 patients, and 600 mg/m(2) was selected as the recommended Phase II dose, with no significant[ncbi.nlm.nih.gov] Acute leukemia developed 44 months after initial diagnosis and was preceded by a 10 month period of pancytopenia following cessation of thiotepa.[ncbi.nlm.nih.gov] Dose-limiting toxicities (gastrointestinal and myelosuppression) were seen with 500 and 600 mg/m(2) of cloretazine combined with the 4-day ara-C schedule but not seen with[ncbi.nlm.nih.gov]

  • Primary Myelofibrosis

    Mild myelosuppression can be seen with pegylated interferon; however, bone marrow aplasia in patients with myelofibrosis has not been reported.[ncbi.nlm.nih.gov] Primary myelofibrosis is a unique entity among BCR-ABL-negative myeloproliferative diseases, manifesting as bone marrow fibrosis and pancytopenia.[ncbi.nlm.nih.gov] Combining JAK-inhibitors with agents that target parallel prosurvival pathways or agents that enhance hematopoiesis may enhance efficacy and/or mitigate on-target myelosuppression[ncbi.nlm.nih.gov]

  • Ganciclovir

    Two SLE patients and one patient post chemotherapy for a non Hodgkin's lymphoma presented with myelosuppression and persistent cytomegalovirus retinitis despite systemic ganciclovir[ncbi.nlm.nih.gov] Seizures, pancytopenia, diabetes, diarrhoea, and (probably) drug-induced liver damage and cholangitis were observed in the course of treatment.[ncbi.nlm.nih.gov] Drug interactions Concomitant administration of zidovudine and other myelosuppressive drugs has been associated with severe haematological abnormalities.[apps.who.int]

  • Temozolomide

    Recent reports have demonstrated that TMZ-induced myelosuppression correlates with survival in patients with GBM.[ncbi.nlm.nih.gov] However, pancytopenia is rarely reported.[ncbi.nlm.nih.gov] Hematologic Common (1% to 10%): Thrombocytopenia , hemorrhage, leukopenia, neutropenia , lymphopenia, febrile neutropenia , anemia Post-marketing surveillance: Prolonged pancytopenia[drugs.com]

  • Myeloproliferative Disease

    Other patients can undergo myelosuppressive therapy with hydroxyurea. Radioactive phosphorous can be used as an alternative therapy in older patients.[emedicine.medscape.com] Four years later, at the age of 16, her brother was diagnosed as having acute myelofibrosis, and some months afterwards he died from fulminant pneumonia coincidently with pancytopenia[ncbi.nlm.nih.gov] ( D61.82 ) pancytopenia (due to) (with) congenital (pure) red cell aplasia ( D61.01 ) pancytopenia (due to) (with) hairy cell leukemia ( C91.4- ) pancytopenia (due to) (with[icd10data.com]

  • Chronic Myeloid Leukemia

    The chemotherapyinduced myelosuppression required several dose alterations.[vetline.de] We present a case of 29-year-old white male farmer, with chronic myeloid leukemia treated with imatinib who developed significant pancytopenia, leading to discontinuation[ncbi.nlm.nih.gov] As a result of bone marrow infiltration, one or all series are suppressed, generating pancytopenia (anemia, neutropenia and thrombocytopenia).[pathologyatlas.ro]

  • Radiation Exposure

    Latent phase - Myelosuppression is the hallmark of latent phase, developing between 1 and 5 weeks after initial exposure, again depending on the severity of exposure.[symptoma.com] […] doses cause initial anorexia, lethargy and vomiting then normality for several weeks followed by vomiting, nasal discharge, dysentery, recumbency, septicemia and a profound pancytopenia[medical-dictionary.thefreedictionary.com] In March 2015, filgrastim (Neupogen) was approved by the FDA to increase survival in patients acutely exposed to myelosuppressive doses of radiation (suspected or confirmed[emedicine.medscape.com]

  • Chlorambucil

    […] by 0.1 mg/kg/dose until response observed) monthly or 0.03-0.1 mg/kg/day continuously Reduce initial dose if administered within 4 weeks after a full course of radiation/myelosuppressive[reference.medscape.com] Overdose and treatment Evidence of overdose includes reversible pancytopenia in adults, and vomiting, ataxia, abdominal pain, muscle twitching, and major motor seizures.[glowm.com] Symptoms And Treatment Of Overdose: Symptoms and Treatment: Reversible pancytopenia was the main finding of inadvertent overdose of chlorambucil.[rxmed.com]

Further symptoms

Similar symptoms