Myocardial Fibrosis: Causes & Reasons

Possible Causes for Myocardial Fibrosis

Biopsy can detect endocardial fibrosis and thickening, myocardial infiltration by iron or amyloid, chronic myocardial fibrosis, or in the case of Fabry disease, inclusions [merckmanuals.com]

In more advanced instances, radiotherapy may induce myocardial fibrosis, which will lead to restrictive cardiomyopathy. [academic.oup.com]

It is classified as Nonobliterative (myocardial infiltration by an abnormal substance) Obliterative (fibrosis of the endocardium and subendocardium) Either type may be diffuse [merckmanuals.com]

Myocarditis due to Radiation

In general, potential heart-related adverse events from immunotherapy are myocardial fibrosis, myocarditis, and acute heart failure, which have been reported among patients [medpagetoday.com]

Alterations in the myocardial extracellular matrix by matrix metalloproteinases and tissue inhibitors of metalloproteinases are critical during myocardial fibrosis and cardiac [ecrjournal.com]

Applicable To Chronic (interstitial) myocarditis Myocardial fibrosis Myocarditis NOS Type 1 Excludes Type 1 Excludes Help A type 1 excludes note is a pure excludes. [icd10data.com]

Ischemic Cardiomyopathy

The percentage of myocardial fibrosis (%F) was determined after Elastica Masson-Goldner staining as follows: (fibrosis area/[fibrosis area+myocardial area])×100. [ncbi.nlm.nih.gov]

We sought to assess the association of focal and diffuse myocardial fibrosis with left ventricular reversed remodeling (LVRR). [ncbi.nlm.nih.gov]

The combination of cell loss and myocardial fibrosis, myocyte lengthening, and mural slippage of cells resulted in 4.6-fold expansion of left ventricular cavitary volume and [doi.org]

Fabry Disease

[…] ventricular (LV) hypertrophy, while myocardial fibrosis was always detected in association to LV hypertrophy in men. [ncbi.nlm.nih.gov]

CONCLUSION: Sympathetic neuronal damage is frequent in AFD patients, and it may precede myocardial damage, such as fibrosis. [ncbi.nlm.nih.gov]

[…] to the late development of myocardial fibrosis. [escardio.org]

Endomyocardial Fibrosis

A 50-year-old female patient with endo- myocardial fibrosis presented with unusual calcifications of the right ventricular endocardium that embedded the tricuspid valve papillary [ncbi.nlm.nih.gov]

Finally, on cardiac MRI subendocardial late gadolinium hyperenhancement was observed in the left ventricular apex ( Figure 1 D, arrow), reflecting myocardial fibrosis. [revportcardiol.org]

Endomyocardial fibrosis: electron-beam CT features. Radiology. Mar 1996;198(3):755-60. ↑ Nieveen J, Huber J. Familial myocardial fibrosis. Acta Med Scand. [wikidoc.org]

Cardiomyopathy

Myocardial fibrosis correlated with systolic function, and patients with poor outcomes had more extensive myocardial fibrosis. [jamanetwork.com]

KEYWORDS: diabetic cardiomyopathy; heart failure; inflammation; metabolic dysregulation; myocardial fibrosis [ncbi.nlm.nih.gov]

[…] have proved to be valuable features of CMR. [1, 3] LGE accurately identifies areas of myocardial fibrosis that can have prognostic significance. [emedicine.com]

Fungal Myocarditis

[…] degeneration 心筋変性 myocardial disease 心筋疾患 myocardial dysfunction syndrome 心筋不全症候群 myocardial failure 心筋不全 myocardial fibrosis 心筋線維症/心筋線維化 myocardial infarction 心筋梗塞 MI myocardial [jpeds.or.jp]

Associated with myocardial infarction. 21.  Acute pericarditis - most often of viral origin.  Acute pericarditis - heal by resolution or by pericardial fibrosis ranging [slideshare.net]

[…] enhancement in myocarditis is an indication of irreversible myocardial necrosis and fibrosis. distribution of enhancement is variable, but classically involves the subepicardial [radiopaedia.org]

Acute Chagas Disease with Myocarditis

[…] considered as myocardial fibrosis. [jcmr-online.biomedcentral.com]

Chronic Chagas' Disease: The dominant factor in the chronic stages of Chagas' disease is almost always some degree of myocardial fibrosis. [histopathology-india.net]

[…] by the presence of areas of myocardial fibrosis in patients with Chagas' heart disease. [revespcardiol.org]

Drug-Induced Cardiomyopathy

Restrictive cardiomyopathy without endomyocardial fibrosis Reversible myocardial perfusion defect Secondary restrictive cardiomyopathy Specific heart muscle disorder Tachycardia-induced [icd9data.com]

The dominant lesion found in our cases was myocardial fibrosis. [romj.org]

The combination of myocyte injury and necrosis associated with myocardial fibrosis results in impaired mechanical function. [clevelandclinicmeded.com]

Acute Myocarditis

Myocardial edema was evaluated using T2-STIR images. Myocardial fibrosis was assessed in conventional late gadolinium enhancement (LGE) images. [ncbi.nlm.nih.gov]

fibrosis. [ncbi.nlm.nih.gov]

Abstract Current cardiac magnetic resonance (CMR) quantitative signs for the diagnosis of myocarditis include myocardial edema, fibrosis and myocardial hyperemia (Hyp). [ncbi.nlm.nih.gov]

Systemic Scleroderma

[…] of the esophagus, dyspnea due to pulmonary fibrosis, myocardial fibrosis, and renal vascular changes resembling those of malignant hypertension; Raynaud phenomenon, atrophy [medical-dictionary.thefreedictionary.com]

Undetected early cardiac manifestations can progress silently to myocardial fibrosis. [rheumatology.oxfordjournals.org]

fibrosis. [emedicine.com]

Bacterial Myocarditis

fibrosis Myocarditis NOS Type 1 Excludes acute or subacute myocarditis ( I40.- ) virus, viral I40.0 bacterial I40.0 (acute) infective I40.0 pneumococcal I40.0 septic I40.0 [icd10data.com]

Pathogenesis Characterized by: Myocardial inflammation,necrosis and fibrosis. Cardiomegaly and diminished systolic function occur due to myocardial damage. [slideshare.net]

Fibrosis is seen in the later phase of certain myocardial lesions. [histopathology-india.net]

Endocardial Fibroelastosis

Observations that favor a viral etiology include a clinical presentation similar to that of chronic myocarditis, findings of myocarditis or myocardial fibrosis in affected [chdbabies.com]

These alterations consisted of chronic myocardial inflammation, extensive interstitial fibrosis, severe degenerative changes in myocardial cells, and a marked proliferation [ncbi.nlm.nih.gov]

The combination of myocyte injury and necrosis associated with myocardial fibrosis results in impaired mechanical function. [clevelandclinicmeded.com]

Viral Myocarditis

fibrosis Myocarditis NOS Type 1 Excludes acute or subacute myocarditis ( I40.- ) virus, viral I40.0 ICD-10-CM Diagnosis Code I40.0 Infective myocarditis 2016 2017 2018 2019 [icd10data.com]

Myocardial edema as a feature of inflammation and myocardial necrosis or fibrosis can be frequently observed in patients with acute myocarditis by cardiovascular magnetic [ncbi.nlm.nih.gov]

[…] progressive) (senile) I51.4 ICD-10-CM Diagnosis Code I51.4 Myocarditis, unspecified 2016 2017 2018 2019 Billable/Specific Code Applicable To Chronic (interstitial) myocarditis Myocardial [icd10data.com]

Diphtheritic Myocarditis

fibrosis Myocarditis NOS Type 1 Excludes acute or subacute myocarditis ( I40.- ) in (due to) diphtheria A36.81 diphtheritic A36.81 ICD-10-CM Codes Adjacent To A36.81 A32.9 [icd10data.com]

Pathogenesis Characterized by: Myocardial inflammation,necrosis and fibrosis. Cardiomegaly and diminished systolic function occur due to myocardial damage. [slideshare.net]

Diffuse Cutaneous Systemic Scleroderma

fibrosis. [emedicine.com]

Diffuse myocardial fibrosis or cardiac conduction abnormalities occur. [merckmanuals.com]

Myocardial fibrosis. Left ventricular (LV) systolic dysfunction, LV diastolic dysfunction. [patient.co.uk]

Hemochromatosis-Related Cardiomyopathy

The combination of myocyte injury and necrosis associated with myocardial fibrosis results in impaired mechanical function. [clevelandclinicmeded.com]

Myocardial fibrosis associated with HCM is an important arrhythmogenic substrate. [textbookofcardiology.org]

The myocardial wall in RCM is too rigid to allow for relaxation due to fibrosis or infiltration by other tissues. [med-ed.virginia.edu]

Alcoholic Cardiomyopathy

Quantitative evaluation of myocardial hypertrophy and interstitial fibrosis performed on EMB tissue samples using the morphometric approach was not predictive of recovery. [ncbi.nlm.nih.gov]

The combination of myocyte injury and necrosis associated with myocardial fibrosis results in impaired mechanical function. [clevelandclinicmeded.com]

The efficacy of abstinence has been shown in persons with early disease (eg, prior to the onset of severe myocardial fibrosis) and in individuals with more advanced disease [emedicine.com]

Rheumatic Heart Disease

This case demonstrated that contrast-enhanced magnetic resonance imaging could exactly detect and define the extent of myocardial fibrosis in a patient with rheumatic valvular [ncbi.nlm.nih.gov]

fibrosis after rheumatic fever and if yes, how much extent it involves. [ncbi.nlm.nih.gov]

[…] disease can be easily detected with conventional echocardiography by evaluating morphologic change of the valve, it still remains problematic to determine whether there is myocardial [ncbi.nlm.nih.gov]

Hemochromatosis

Heart: enlarged with hemosiderin within myocardial fibers Joints: acute synovitis, calcium pyrophosphate deposition (pseudogout) Pancreas: intensely pigmented, diffuse interstitial [pathologyoutlines.com]

In addition to the iron deposition in the heart, the loss of myocyte and severe interstitial fibrosis were present. [ncbi.nlm.nih.gov]

fibrosis Skin: hemosiderin in dermal macrophages and fibroblasts, also increased melanin production; causes slate gray skin Testes: small, atrophic testis, due to hypothalamic [pathologyoutlines.com]

Late-Onset Fabry Disease

Relation of burden of myocardial fibrosis to malignant ventricular arrhythmias and outcomes in Fabry disease. [scielo.br]

In severe hypertrophy, lysosomal inclusions occupy ~60% of the myocardial cells, and there is extensive myocardial fibrosis and severe narrowing of arteriole lumens. [mdpi.com]

Notably, myocardial fibrosis was found in 7/8 patients, of whom 2 were under 40 years. Stroke occurred in 4 patients. [link.springer.com]

Scleroderma with Renal Involvement

[…] vessels. 18 Cardiac fibrosis can now be assessed using cardiac magnetic resonance imaging, but no long-term studies have assessed the incidence and outcomes of patients with [aafp.org]

[…] pulmonary disease can also lead to cardiac dysfunction. 17 Single-photon emission CT of asymptomatic patients can detect abnormal microcirculation and vasoreactivity of myocardial [aafp.org]

Hypertensive Heart Disease

Unlike the increasing evidence of myocardial fibrosis in aortic stenosis, the prognosis associated with myocardial fibrosis in patients with hypertension is currently not [clinicaltrials.gov]

Myocardial fibrosis, a common end point in hypertensive heart disease, has been linked to the development of left ventricular hypertrophy and diastolic dysfunction. [ncbi.nlm.nih.gov]

Abstract Myocardial fibrosis is commonly observed in left ventricular (LV) hypertrophied heart during Arterial Hypertension. [ncbi.nlm.nih.gov]

Hypertrophic Cardiomyopathy

Hypothesis:Ramipril will reduce LV mass, improve diastolic function, and reduce myocardial fibrosis in cats with HCM without congestive heart failure (CHF). [doi.org]

Concentric hypertrophy showed the greatest myocardial fibrosis mass (p < 0.001) and the greatest R wave size in D1 (p = 0.0280). [ncbi.nlm.nih.gov]

Myocardial Fibrosis

In this review, we describe the pathophysiology of myocardial fibrosis, examine the imaging techniques used to evaluate fibrosis, and discuss the relationship between myocardial [ncbi.nlm.nih.gov]

Myocardial fibrosis detected by magnetic resonance imaging has also been reported in athletes. [ncbi.nlm.nih.gov]

Pathogenesis of myocardial fibrosis Myocardial fibrosis develops in response to a cardiac insult, which may include ischaemia, pressure or volume overload, viral infection [heart.bmj.com]

Left Ventricular Hypertrophy

Diffuse myocardial fibrosis can occur in LVH and interfere with ECG voltage measures. [ncbi.nlm.nih.gov]

On post-mortem examination, left ventricle hypertrophy and idiopathic interstitial myocardial fibrosis was found. [ncbi.nlm.nih.gov]

“Post-mortem evidence of idiopathic left ventricular hypertrophy and idiopathic interstitial myocardial fibrosis: is exercise the cause?” [c-r-y.org.uk]

Radiation Pericarditis

Radiation induced myocardial fibrosis can result in a broad spectrum of myocardial dysfunction spanning progressive stages of diastolic dysfunction to overt systolic heart [acc.org]

fibrosis and frequently simulates chronic constrictive pericarditis on clinical and hemody-namic features. [webview.isho.jp]

Late cardiovascular effects can manifest clinically years or even decades after treatment resulting in a variety of cardiovascular complications including myocardial fibrosis [acc.org]

Loeffler Endocarditis

Myocardial biopsy revealed fibrosis and thrombus formation indicative of Loeffler endocarditis, and a peripheral smear showed pre-B-cell acute lymphoid leukemia. [ncbi.nlm.nih.gov]

Brockington IF, Olsen EGJ (1973) Löffler’s endocarditis and Davies’ endo-myocardial fibrosis. Am Heart J 85: 308 CrossRef Google Scholar 9. [link.springer.com]

fibrosis and thrombus formation causing a restrictive cardiomyopathy. 4), 5) Our patient was started on imatinib and steroids and his symptoms improved over 2 weeks. [synapse.koreamed.org]

Diffuse Intraventricular Block

Such conduction delays may be due to myocardial fibrosis, amyloidosis, cardiomyopathy or hypertrophy. [ecgwaves.com]

[…] artery distribution (suggesting that the fibrosis was not related to a previous myocardial infarction) or to the presence of pulmonary, renal, or hypertensive disease. [journals.plos.org]

The combination of myocyte injury and necrosis associated with myocardial fibrosis results in impaired mechanical function. [clevelandclinicmeded.com]

Infiltrative Cardiomyopathy

The most common causes of restrictive cardiomyopathy are amyloidosis and scarring of the heart from an unknown cause (idiopathic myocardial fibrosis). [lutheranhealthcare.org]

Cardiomyopathy - restrictive; Infiltrative cardiomyopathy; Idiopathic myocardial fibrosis Falk RH and Hershberger RE. [medlineplus.gov]

fibrosis Role in prognosis Differential diagnosis Nuclear imaging Endomyocardial biopsy Laboratory tests Genetic testing and family screening Counselling in probands Methods [escardio.org]