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206 Possible Causes for Myocyte Hypertrophy

  • Dilated Cardiomyopathy 1R

    hypertrophy Mitochondrial abnormalities Syndromes Naxos disease 1 Plakoglobin (JUP) ; Chromosome 17q21.2; Recessive Mutations: 2 bp deletion at C-terminus (2157TG) Plakoglobin[] Aldosterone directly stimulates cardiac myocyte hypertrophy. J Card Fail. 2004;10:511-8. Medline 134 .[] , as well as atrophied, myocytes exist, the volume density of myofibrils is reduced, and mitochondrial density is normal, but the mitochondria are more numerous and small.[]

  • Familial Hypertrophic Cardiomyopathy 17

    Inhalt Cellular adaptations in hypertrophy and heart failure 257 256 Interaction between cardiac myocytes and the extracellular matrix 275 Role of transforming growth factor[] hypertrophy Mitochondrial abnormalities Syndromes Naxos disease 1 Plakoglobin (JUP) ; Chromosome 17q21.2; Recessive Mutations: 2 bp deletion at C-terminus (2157TG) Plakoglobin[] […] based on myocyte hypertrophy from those in which LV mass and wall thickness are increased by interstitial infiltration or intracellular accumulation of metabolic substrates[]

  • Familial Isolated Restrictive Cardiomyopathy

    Micro-scopy of RV endomyocardial biopsies from H974 showed interstitial fibrosis with mild myocyte hypertrophy, but no myocyte or myofibrillar disarray.[] In valvular disease, excess hemodynamic demands result in myocyte hypertrophy, subsequent chamber enlargement, and myocardial fibrosis.[] Postmortem microscopy of heart tissue showed myocyte and myofibrillar disarray, myocyte hypertrophy, and fibrosis similar to the findings in HCM patients ( 14 , 15 ).[]

  • Acromesomelic Dysplasia

    hypertrophy Kishimoto, Kishimoto; Rossi, Rossi; Garbers, Garbers Cardiac hypertrophy in transgenic rats expressing a dominantnegative mutant of the natriuretic peptide receptor[] Nawaz; Muhammad, Muhammad; Ahmad, Ahmad A genetic model provides evidence that the receptor for atrial natriuretic peptide (guanylyl cyclase‐A) inhibits cardiac ventricular myocyte[]

  • Friedreich Ataxia

    Histologically, both ventricles had irregular areas of marked myocyte hypertrophy with associated interstitial fibrosis and focal myofibre disarray.[] The total adaptation of the heart depends on the response of the myocytes individually, but hypertrophy can be symmetrical, implicating all the parts of the heart, or asymmetrical[] The heart showed asymmetric left ventricular hypertrophy, with an interventricular septal thickness of 20-25 mm (the remainder of the left ventricular wall measured 15 mm)[]

  • Myotonic Dystrophy

    Myocyte hypertrophy with concurrent fibrosis seems to be the anatomical correlate.[] Heart muscle shows fibrosis of the conducting system, myocyte hypertrophy and fatty infiltration.[]

  • Nemaline Myopathy

    hypertrophy, myocyte death, and/or sarcomeric structural alterations seen in diseases of striated muscle in vivo.[] […] be to identify how primary alterations in force generation, force transmission, and/or regulation of force production lead to the secondary, multifactorial phenotypes of myocyte[]

  • Sinus Bradycardia

    LVH is the most common feature.Here there is simple myocyte hypertrophy, without pathological fibrosis.This differentiates athlete’s, heart from HOCM .[]

  • Acute Myocarditis

    The biopsy specimen of Patient 5 showed nonspecific interstitial fibrosis and myocytic hypertrophy (despite a mild, persistent increase in serum creatine kinase and a positive[]

  • Autosomal Dominant Limb-Girdle Muscular Dystrophy Type 1A

    Blaxall is a renowned translational basic scientist who has significantly contributed the current understanding of myocardial signalling pathways and myocyte hypertrophy.[]

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