Myoglobinuria: Causes & Reasons

Possible Causes for Myoglobinuria

He had no history of exercise-induced cramps, myalgias, or myoglobinuria. [ncbi.nlm.nih.gov]

Mahler: Chronic progressive myopathy with myoglobinuria: demonstration of a glycogenolytic defect in the muscle. [whonamedit.com]

This causes the release of proteins like creatine kinase and myoglobin in the urine causing it to turn dark red or brown called myoglobinuria. [symptoma.com]

Glycogen Storage Disease Type 7

Occasionally, myoglobinuria. The symptoms are similar to those seen in McArdle's disease (Type V glycogenosis). [whonamedit.com]

All probands showed exercise intolerance, hyperCKemia, cramps and myoglobinuria. One patient had a mild hypertrophic cardiomyopathy. [ncbi.nlm.nih.gov]

So far, more than one hundred patients have been described with prominent clinical symptoms characterized by muscle cramps, exercise intolerance, rhabdomyolysis and myoglobinuria [ncbi.nlm.nih.gov]

Glycogen Storage Disease Type 10

Muscle phosphoglycerate mutase deficiency results in a myopathic condition characterised by repeated cramps, possible myoglobinuria and muscle pain. [ncbi.nlm.nih.gov]

Patients: Two unrelated men (21 and 26 years old) with PGAMD who since their teens had experienced muscle cramps, muscle pain, and episodes of myoglobinuria provoked by brief [utsouthwestern.influuent.utsystem.edu]

Serum creatine kinase (CK) levels are increased between episodes of myoglobinuria. Less than 50 cases have been described so far. [orpha.net]

Hereditary Myopathy with Lactic Acidosis due to ISCU Deficiency

Low succinate dehydrogenase (SDH) activity in a patient with a hereditary myopathy with paroxysmal myoglobinuria. [ncbi.nlm.nih.gov]

[…] with Deficiency of Succinate Dehydrogenase and Aconitase Myopathy with Deficiency of Iron-Sulfur Cluster Assembly Enzyme Myopathy with Exercise Intolerance, Swedish Type Myoglobinuria [purl.bioontology.org]

Abstract Recently, we described a patient with severe exercise intolerance and episodic myoglobinuria, associated with marked impairment of succinate oxidation and deficient [jci.org]

Haff Syndrome

Paralytic myoglobinuria occurring in work horses, which develop the disease on resuming work FULL TEXT [annals.org]

Anything that will cause myoglobinuria will cause myoglobinemia. [palpath.com]

[…] people have suffered from eating fish from Lake Kotokel. 12 are in the hospital, 3 have been discharged, and one person has died as a result of foodborne toxic paroxysmal myoglobinuria [zoonosesonline.org]

Malignant Hyperthermia

There is myoglobinuria. Specific early changes are a rise of the end expiratory CO2 together with the metabolic acidosis. [patient.info]

Urine is tested for myoglobinuria. [msdmanuals.com]

Monitor renal function, check myoglobinuria, coagulation screen, temperature, electrolytes and CK. Forced diuresis to help protect the kidneys. [patient.info]

Mitochondrial Trifunctional Protein Deficiency

Abstract A 23-year-old man with recurrent myoglobinuria had low muscle-free carnitine levels and deficient fasting ketogenesis. [neurology.org]

Reye-like symptoms, and early death (n=4); a hepatic form with recurrent hypoketotic hypoglycemia (n=2); and a milder later-onset neuromyopathic phenotype with episodic myoglobinuria [ncbi.nlm.nih.gov]

All patients have exercise intolerance and develop myoglobinuria and muscle pain with strenuous exercise. [medicalhomeportal.org]

Pompe Disease

Then take post venous samples looking at CK Ammonia, and lactate in 5, 10 20 minute increments and take urine sample for myoglobinuria. [youtube.com]

[…] metabolism affecting muscle alone or together with other tissues, and they cause two main clinical syndromes: episodic, recurrent exercise intolerance with cramps, myalgia, and myoglobinuria [ncbi.nlm.nih.gov]

This leads to myoglobinuria and then released in urine and leads to Renal Failure. Therefore the use of statin is contra-indicated in these types of patients. [youtube.com]

Electrocution by Lightning

All patients should be evaluated for myoglobinuria a common complication of electrical injury. [lightninginjury.lab.uic.edu]

Renal system Acute tubular necrosis, leading to acute kidney injury, is common, usually secondary to myoglobinuria, direct damage to renal vessels and inadequate rehydration [patient.info]

Myoglobinuria, renal failure, and compartment syndrome are more likely in commercial electrical injury. [emsworld.com]

Acute Amphetamine Intoxication

Acidification of the urine increases amphetamine excretion, but is believed to increase risk of acute renal failure if myoglobinuria is present. [erowid.org]

Cardiovascular: Palpitations Hypertensive crisis Tachycardia or (reflex) bradycardia Dysrhythmias (usually tachydysrhythmias) Cardiovascular collapse Other: Rhabdomyolysis Myoglobinuria [emergency.unboundmedicine.com]

With appropriate supportive and symptomatic therapy, prognosis is good. quail poisoning Acute myoglobinuria caused by eating game birds of the species Coturnix coturnix. [medical-dictionary.thefreedictionary.com]

Strychnine Poisoning

Moreover, hyperthermia, rhabdomyolysis, renal failure due to myoglobinuria, and severe metabolic acidosis can develop in the setting of prolonged spasms, but the most important [symptoma.com]

Phencyclidine Intoxication

Other useful laboratory studies include electrolytes, glucose, BUN, creatinine, creatine kinase (CK), and urinalysis dipstick for occult blood (positive with myoglobinuria [accessmedicine.mhmedical.com]

Together with the behavioral effects of high-dose PCP, these effects probably account for muscle trauma, which, in a number of patients, has resulted in rhabdomyolysis, myoglobinuria [aibolita.com]

Acidification is contraindicated in the presence of myoglobinuria, if renal or hepatic function is abnormal, or in overdose situations, when plasma acidification may compromise [basicmedicalkey.com]

Glycogen Storage Disease Type 11

5 years GSD V / GSD 5 (McArdle disease) Muscle glycogen phosphorylase (PYGM) 1 in 100,000 500,000[9][8] No No No Exercise-induced cramps, Rhabdomyolysis Renal failure by myoglobinuria [scientiait.com]

PHKG2 / PHKA1) Yes Yes Yes None Delayed motor development, Developmental delay GSD X / GSD 10 Phosphoglycerate mutase (PGAM2) Exercise-induced muscle cramps and weakness Myoglobinuria [scientiait.com]

Carbon Monoxide Poisoning

[…] for albumin and glucose in chronic intoxification; bHCG for pregnancy) Laboratory FBC (mild leukocytosis) BSL (hyperglycaemia) UEC (hypokalaemia, acute renal failure from myoglobinuria [lifeinthefastlane.com]

[…] level is 10 mmol/L or higher, the patient may have concomitant cyanide poisoning. [3] Blood urea nitrogen (BUN) and creatinine levels - Acute kidney failure may result from myoglobinuria [emedicine.medscape.com]

Lithium Toxicity

This occurs because most dipstick tests cannot distinguish myoglobinuria from hematuria or hemoglobinuria. [foamcast.org]

Rhabdomyolysis

There are also direct tests for myoglobinuria, such as immunoassays, but as the time course suggests myoglobinuria is present very early, their usefulness may be limited. [patient.info]

Rhabdomyolysis is characterized by muscle necrosis and release of intracellular constituents, causing muscle pain, weakness, and myoglobinuria. [ncbi.nlm.nih.gov]

Meyer-Betz disease - muscle pain, weakness and myoglobinuria following strenuous exercise. [patient.info]

Acute Exertional Rhabdomyolysis

[…] that rhabdomyolysis in hypothyroidism may be due to a reversible defect in glycogenolysis and that hypothyroidism should be excluded in patients with rhabdomyolysis and/or myoglobinuria [ncbi.nlm.nih.gov]

Rhabdomyolysis, myoglobinuria and exercise. Sports Med 1988; 6:93-106. (11.)Better OS, Stein JH. [drplace.com]

Occurs as equine paralytic myoglobinuria in horses after unaccustomed exercise while on a heavy carbohydrate diet, in sheep and cattle after violent physical exercise, in [medical-dictionary.thefreedictionary.com]

Paroxysmal Rhabdomyolysis

But none of them developed myoglobinuria. [jpgmonline.com]

Primary Myoglobinuria: Differentiate Myoglobinuria from Hemoglobinuria. Indian J Clin Biochem. 2017 Jul. 32 (3):367-369. [Medline]. [emedicine.medscape.com]

Clinically, febrile episodes lasting (7-10 days) preceded myoglobinuria attacks. [cags.org.ae]

Traumatic Rhabdomyolysis

Abstract Twenty-one patients developed acute renal failure in association with nontraumatic rhabdomyolysis and myoglobinuria. [annals.org]

Laboratory tests revealed marked elevation of creatinine kinase(CK) levels and myoglobinuria. [neurologyindia.com]

pages={117-126} } Pekka J Saukko, Eberhard Lignitz, +1 author Wolfgang Keil Published 2004 in Zeitschrift für Rechtsmedizin DOI: 10.1007/BF00200505 Rhabdomyolysis with myoglobinuria [semanticscholar.org]

Secondary Myopathy

Myoglobinuria. d. Progressive muscle weakness in some metabolic myopathies. 8. • Past medical history: a. [slideshare.net]

Myoglobinuria. Progressive muscle weakness in some metabolic myopathies. [patient.info]

In children and adults, exercise intolerance and myoglobinuria are the most common presenting features. [the-rheumatologist.org]

Tricyclic Antidepressant Overdose

Background Pharmacokinetics Clinical Dx Management Disposition Background Largely superseded by newer antidepressants Classic TCAs (e.g. Imipramine, Amitriptyline) have greatest toxicity Rapidly absorbed from GIT Peak plasma concentration in 2 to 8 hours Delayed gastric emptying in overdose (anti-muscarinic effect)[…] [emed.ie]

Barbiturate Overdose

Tragically, there have been many famous people who died of barbiturate overdose. Celebrities who overdosed on barbiturates include Marilyn Monroe, Judy Garland, and Aimee Semple McPherson. What are barbiturates, and what is barbiturate overdose? Barbiturates are depressant drugs that have strong sedative[…] [ranker.com]

Bacterial Myositis

Blood cultures Myoglobinuria Related articles: Myopathy, [learningneurology.com]

Muscle necrosis was evident from the raised creatine kinase levels and myoglobinuria. [atmph.org]

Myoglobinuria (the presence of a muscle protein in the urine) is indicative of muscle tissue breakdown. [nmihi.com]

Amanita Phalloides Poisoning

Amanita phalloides mushrooms are extremely toxic. A variety of treatments have been proposed based as often on anecdotal experience as on firm evidence. General consensus exists regarding some treatments, such as the use of silibinin, penicillin, and activated charcoal. The most polarized debate concerns the value[…] [ncbi.nlm.nih.gov]

Glycogen Storage Disease Type 13

[…] they divide the glycogenoses into 2 clinical groups: (i) those that cause exercise intolerance, cramps, and recurrent episodes of muscle breakdown (rhabdomyolysis) with myoglobinuria [medlink.com]

[…] ability to perform strenuous exercise, short intense (sprint or weight lifting) or sustained strenuous (uphill walk or stair climbing); Painful muscle cramping -50% have myoglobinuria [quizlet.com]

Muscle carnitine palmityltransferase deficiency and myoglobinuria. [195.83.227.65]

Phosphoglycerate Kinase 1 Deficiency

There is recurrent myoglobinuria, especially after exercise. Serum CK levels are high or normal. Anaerobic exercise produces no rise in lactate. [patient.info]

Complications Myoglobinuria (The presence of myoglobin in the urine) from prolonged exercise can produce renal damage. [mda.org.au]

After these episodes they noticed that the urine was dark brown, indicating rhabdomyolysis and myoglobinuria. The neurological examinations were without remarks. [biomedsearch.com]

Muscle Phosphorylase Kinase Deficiency

David WS (2000) Myoglobinuria. Neurol Clin 18(1):215–43 Google Scholar 24. [link.springer.com]

[…] and out as cola-colored urine — myoglobinuria. [mda.org]

Glycogen Storage Disease Type 9

Ten adult patients complained of exercise intolerance; five of them had cramps and three had recurrent myoglobinuria. Resting serum CK was increased in five. [ncbi.nlm.nih.gov]

Complications Myoglobinuria (The presence of myoglobin in the urine) from prolonged exercise can produce renal damage. [mda.org.au]

GSD due to muscle PhK deficiency presents in adolescence or adulthood with exercise intolerance, myalgia, and sometimes myoglobinuria but symptoms are generally mild. [orpha.net]

Polyglucosan Body Myopathy Type 2

Myoglobinuria has been reported rarely ( 67 ). [annalsofneurosciences.org]

the patient had the expected high levels of serum CK, but extremely low level of LDH.  All have exercise intolerance, cramps, with or without myoglobinuria. 48. [slideshare.net]

Myopathic Carnitine Deficiency

One of the patients developed recurrent myoglobinuria and had one episode of renal failure. [scielo.br]

Symptoms Clinically, carnitine deficiency manifests during childhood or early adult life as progressive proximal muscle weakness, exertional myalgias, or, rarely, myoglobinuria [checkorphan.org]

When severe, myoglobinuria may result in acute renal failure. [emedicine.medscape.com]