Myoglobinuria: Causes & Reasons

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Possible Causes for Myoglobinuria

McArdle Disease

He had no history of exercise-induced cramps, myalgias, or myoglobinuria. [ncbi.nlm.nih.gov]

This causes the release of proteins like creatine kinase and myoglobin in the urine causing it to turn dark red or brown called myoglobinuria. [symptoma.com]

Urine studies are indicated because myoglobinuria may occur after exercise. [patient.info]

Glycogen Storage Disease Type 7

Urine studies are needed to find if myoglobinuria is present. In case of Tarui’s, disease myoglobinuria is seen after exercise. [symptoma.com]

Monitor renal function tests if myoglobinuria is present. Urinalysis: There may be myoglobinuria after exercise. [patient.info]

All probands showed exercise intolerance, hyperCKemia, cramps and myoglobinuria. One patient had a mild hypertrophic cardiomyopathy. [ncbi.nlm.nih.gov]

Glycogen Storage Disease Type 10

Serum creatine kinase (CK) levels are increased between episodes of myoglobinuria. Less than 50 cases have been described so far. [orpha.net]

Some people with this condition also have recurrent episodes of myoglobinuria. [malacards.org]

If untreated, myoglobinuria can lead to kidney failure. [ghr.nlm.nih.gov]

Hereditary Myopathy with Lactic Acidosis due to ISCU Deficiency

Low succinate dehydrogenase (SDH) activity in a patient with a hereditary myopathy with paroxysmal myoglobinuria. [ncbi.nlm.nih.gov]

Mutations in this gene have been found in patients with myopathy with severe exercise intolerance and myoglobinuria. [mybiosource.com]

[…] with Deficiency of Succinate Dehydrogenase and Aconitase Myopathy with Deficiency of Iron-Sulfur Cluster Assembly Enzyme Myopathy with Exercise Intolerance, Swedish Type Myoglobinuria [purl.bioontology.org]

Haff Syndrome

Paralytic myoglobinuria occurring in work horses, which develop the disease on resuming work FULL TEXT [annals.org]

Anything that will cause myoglobinuria will cause myoglobinemia. [palpath.com]

[…] people have suffered from eating fish from Lake Kotokel. 12 are in the hospital, 3 have been discharged, and one person has died as a result of foodborne toxic paroxysmal myoglobinuria [zoonosesonline.org]

Malignant Hyperthermia

Urine is tested for myoglobinuria. [msdmanuals.com]

Clinical manifestations include: CO 2 increase, tachycardia, haemodynamic instability, metabolic and respiratory acidosis, profuse sweating, hyperpyrexia, CPK increase, myoglobinuria [ncbi.nlm.nih.gov]

This condition (myoglobinuria) can lead to acute kidney injury or even kidney failure. Death may occur. [msdmanuals.com]

Mitochondrial Trifunctional Protein Deficiency

Abstract A 23-year-old man with recurrent myoglobinuria had low muscle-free carnitine levels and deficient fasting ketogenesis. [neurology.org]

Reye-like symptoms, and early death (n=4); a hepatic form with recurrent hypoketotic hypoglycemia (n=2); and a milder later-onset neuromyopathic phenotype with episodic myoglobinuria [ncbi.nlm.nih.gov]

All patients have exercise intolerance and develop myoglobinuria and muscle pain with strenuous exercise. [medicalhomeportal.org]

Pompe Disease

Then take post venous samples looking at CK Ammonia, and lactate in 5, 10 20 minute increments and take urine sample for myoglobinuria. [youtube.com]

[…] metabolism affecting muscle alone or together with other tissues, and they cause two main clinical syndromes: episodic, recurrent exercise intolerance with cramps, myalgia, and myoglobinuria [ncbi.nlm.nih.gov]

This leads to myoglobinuria and then released in urine and leads to Renal Failure. Therefore the use of statin is contra-indicated in these types of patients. [youtube.com]

Electrocution by Lightning

All patients should be evaluated for myoglobinuria a common complication of electrical injury. [lightninginjury.lab.uic.edu]

Renal system Acute tubular necrosis, leading to acute kidney injury, is common, usually secondary to myoglobinuria, direct damage to renal vessels and inadequate rehydration [patient.info]

Myoglobinuria, renal failure, and compartment syndrome are more likely in commercial electrical injury. [emsworld.com]

Acute Amphetamine Intoxication

Acidification of the urine increases amphetamine excretion, but is believed to increase risk of acute renal failure if myoglobinuria is present. [erowid.org]

Cardiovascular: Palpitations Hypertensive crisis Tachycardia or (reflex) bradycardia Dysrhythmias (usually tachydysrhythmias) Cardiovascular collapse Other: Rhabdomyolysis Myoglobinuria [emergency.unboundmedicine.com]

With appropriate supportive and symptomatic therapy, prognosis is good. quail poisoning Acute myoglobinuria caused by eating game birds of the species Coturnix coturnix. [medical-dictionary.thefreedictionary.com]

Strychnine Poisoning

Moreover, hyperthermia, rhabdomyolysis, renal failure due to myoglobinuria, and severe metabolic acidosis can develop in the setting of prolonged spasms, but the most important [symptoma.com]

Phencyclidine Intoxication

Together with the behavioral effects of high-dose PCP, these effects probably account for muscle trauma, which, in a number of patients, has resulted in rhabdomyolysis, myoglobinuria [aibolita.com]

Acidification is contraindicated in the presence of myoglobinuria, if renal or hepatic function is abnormal, or in overdose situations, when plasma acidification may compromise [basicmedicalkey.com]

Carbon Monoxide Poisoning

[…] for albumin and glucose in chronic intoxification; bHCG for pregnancy) Laboratory FBC (mild leukocytosis) BSL (hyperglycaemia) UEC (hypokalaemia, acute renal failure from myoglobinuria [lifeinthefastlane.com]

[…] level is 10 mmol/L or higher, the patient may have concomitant cyanide poisoning. [3] Blood urea nitrogen (BUN) and creatinine levels - Acute kidney failure may result from myoglobinuria [emedicine.medscape.com]

Lithium Toxicity

This occurs because most dipstick tests cannot distinguish myoglobinuria from hematuria or hemoglobinuria. [foamcast.org]

Rhabdomyolysis

There are also direct tests for myoglobinuria, such as immunoassays, but as the time course suggests myoglobinuria is present very early, their usefulness may be limited. [patient.info]

Rhabdomyolysis is characterized by muscle necrosis and release of intracellular constituents, causing muscle pain, weakness, and myoglobinuria. [ncbi.nlm.nih.gov]

Meyer-Betz disease - muscle pain, weakness and myoglobinuria following strenuous exercise. [patient.info]

Paroxysmal Rhabdomyolysis

But none of them developed myoglobinuria. [jpgmonline.com]

Primary Myoglobinuria: Differentiate Myoglobinuria from Hemoglobinuria. Indian J Clin Biochem. 2017 Jul. 32 (3):367-369. [Medline]. [emedicine.medscape.com]

Paralysis Sex Factors Pub Type(s) Journal Article Language fre PubMed ID 5621103 TY - JOUR T1 - [Idiopathic paroxysmal rhabdomyolysis or essential myoglobinuria (Meyer-Betz [unboundmedicine.com]

Acute Exertional Rhabdomyolysis

[…] that rhabdomyolysis in hypothyroidism may be due to a reversible defect in glycogenolysis and that hypothyroidism should be excluded in patients with rhabdomyolysis and/or myoglobinuria [ncbi.nlm.nih.gov]

Rhabdomyolysis, myoglobinuria and exercise. Sports Med 1988; 6:93-106. (11.)Better OS, Stein JH. [drplace.com]

Keywords: Acute kidney injury, creatine kinase, myoglobinuria, strenuous exercise, white collar rhabdomyolysis How to cite this article: Bhakthavatsalam R K, Venu G, Raju [indianjnephrol.org]

Traumatic Rhabdomyolysis

Abstract Twenty-one patients developed acute renal failure in association with nontraumatic rhabdomyolysis and myoglobinuria. [annals.org]

Laboratory tests revealed marked elevation of creatinine kinase(CK) levels and myoglobinuria. [neurologyindia.com]

[…] of myoglobinuria does not exclude rhabdomyolysis. [ceaccp.oxfordjournals.org]

Tricyclic Antidepressant Overdose

Abstract In order to evaluate the enzymes CPK and LDH as potential biochemical markers of tricyclic antidepressant (TCA) cardiotoxicity, we prospectively followed 29 patients with TCA overdose. Serum CPK and LDH were obtained on all patients at admission. Population characteristics included a mean age of 33 y, a[…] [ncbi.nlm.nih.gov]

Secondary Myopathy

Myoglobinuria. d. Progressive muscle weakness in some metabolic myopathies. 8. • Past medical history: a. [slideshare.net]

Myoglobinuria. Progressive muscle weakness in some metabolic myopathies. [patient.info]

In children and adults, exercise intolerance and myoglobinuria are the most common presenting features. [the-rheumatologist.org]

Barbiturate Overdose

Tragically, there have been many famous people who died of barbiturate overdose. Celebrities who overdosed on barbiturates include Marilyn Monroe, Judy Garland, and Aimee Semple McPherson. What are barbiturates, and what is barbiturate overdose? Barbiturates are depressant drugs that have strong sedative[…] [ranker.com]

Amanita Phalloides Poisoning

Amanita phalloides mushrooms are extremely toxic. A variety of treatments have been proposed based as often on anecdotal experience as on firm evidence. General consensus exists regarding some treatments, such as the use of silibinin, penicillin, and activated charcoal. The most polarized debate concerns the value[…] [ncbi.nlm.nih.gov]

Glycogen Storage Disease Type 13

[…] they divide the glycogenoses into 2 clinical groups: (i) those that cause exercise intolerance, cramps, and recurrent episodes of muscle breakdown (rhabdomyolysis) with myoglobinuria [medlink.com]

[…] ability to perform strenuous exercise, short intense (sprint or weight lifting) or sustained strenuous (uphill walk or stair climbing); Painful muscle cramping -50% have myoglobinuria [quizlet.com]

Muscle carnitine palmityltransferase deficiency and myoglobinuria. [195.83.227.65]

Phosphoglycerate Kinase 1 Deficiency

There is recurrent myoglobinuria, especially after exercise. Serum CK levels are high or normal. Anaerobic exercise produces no rise in lactate. [patient.info]

After these episodes they noticed that the urine was dark brown, indicating rhabdomyolysis and myoglobinuria. The neurological examinations were without remarks. [biomedsearch.com]

Complications Myoglobinuria (The presence of myoglobin in the urine) from prolonged exercise can produce renal damage. [mda.org.au]

Muscle Phosphorylase Kinase Deficiency

David WS (2000) Myoglobinuria. Neurol Clin 18(1):215–43 Google Scholar 24. [link.springer.com]

[…] and out as cola-colored urine — myoglobinuria. [mda.org]

Glycogen Storage Disease Type 9

Complications Myoglobinuria (The presence of myoglobin in the urine) from prolonged exercise can produce renal damage. [mda.org.au]

Ten adult patients complained of exercise intolerance; five of them had cramps and three had recurrent myoglobinuria. Resting serum CK was increased in five. [ncbi.nlm.nih.gov]

Myopathic Carnitine Deficiency

Symptoms Clinically, carnitine deficiency manifests during childhood or early adult life as progressive proximal muscle weakness, exertional myalgias, or, rarely, myoglobinuria [checkorphan.org]

When severe, myoglobinuria may result in acute renal failure. [emedicine.medscape.com]

It is characterized by recurrent myalgia coupled with myoglobinuria, weakness, and elevated serum CK levels. [medicalbag.com]

Conium Maculatum Poisoning

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Polyglucosan Body Myopathy Type 2

Myoglobinuria has been reported rarely ( 67 ). [annalsofneurosciences.org]

the patient had the expected high levels of serum CK, but extremely low level of LDH.  All have exercise intolerance, cramps, with or without myoglobinuria. 48. [slideshare.net]

Cocaine Abuse

A 43-year-old woman with a history of cocaine abuse presented with decreased mental responsiveness and cyanosis of the extremities several hours after repeated use of "crack" cocaine. She developed bilateral hand compartment syndrome requiring emergency fasciotomy and gangrene of both hands and legs despite[…] [ncbi.nlm.nih.gov]