Myopathy: Causes & Reasons

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Possible Causes for myopathy

Muscle Strain

[…] accessory muscle Muscle atrophy, i.e. too much fat Muscle edema, i.e. too much water while retaining normal architecture due to muscle injury, myositis and imflammatory myopathy [radiologyassistant.nl]

Polymyalgia Rheumatica

METHODS: We studied 60 patients who had undergone 18 F-FDG PET/CT scans for workup of suspected PMR, arthritis, enthesitis, or myopathy. [ncbi.nlm.nih.gov]

Gupta A, Thompson PD (2011) The relationship of vitamin D deficiency to statin myopathy. Atherosclerosis 215: 23–29. View Article Google Scholar 26. [journals.plos.org]

Phillips P, Haas R, Bannykh S, Hathaway S, Gray N, et al. (2002) Statin-associated myopathy with normal creatine kinase levels. Ann Intern Med 137: 581–585. [journals.plos.org]

Muscular Dystrophy

Nemaline myopathy Nemaline myopathy. Clusters of rod bodies. Gomori trichrome. Nemaline myopathy Nemaline myopathy. EM. [neuropathology-web.org]

In this study we describe a boy with HMGCR-positive necrotizing myopathy and highlight the clinical features of the patient. [ncbi.nlm.nih.gov]

Myopathy, central core Myopathy, congenital Myopathy, myotubular Myotubular myopathy Walker Walbug muscular dystrophy, congenital Walker walburg congenital muscular dystrophy [icd9data.com]

Duchenne Muscular Dystrophy

It is associated with a wide variety of myopathic disorders that affect paraspinal muscles, including inflammatory and inherited myopathies. [ncbi.nlm.nih.gov]

Exemple avec la myopathie de Duchenne dont Simon est atteint depuis l'âge de 2 ans. [youtube.com]

MRI, EMG and NCV were compatible with proximal muscle myopathy. [ncbi.nlm.nih.gov]

Rhabdomyolysis

[…] for patients with mitochondrial myopathies. 5 Conclusion Mitochondrial myopathies should be considered in patients presenting with recurrent muscle pain and elevation of [jaoa.org]

Zocor Myopathy A number of patients have reported the onset of Zocor myopathy. [drugdangers.com]

How common is statin induced myopathy? [doi.org]

Acute Exertional Rhabdomyolysis

These include metabolic myopathies, disorders of calcium homoeostasis and other structural myopathies, and the sickle cell trait ( table 1 ). [bmjopensem.bmj.com]

The rare cases of acute renal failure in marathon runners may be a situation of the ‘perfect storm’ where there are several factors (heat stress, dehydration, latent myopathy [link.springer.com]

Minicore (multicore) myopathy Minicore (multicore) myopathy Minicore myopathy, also called, multicore myopathy and multiminicore myopathy, falls under the umbrella of congenital [docplayer.net]

Paroxysmal Rhabdomyolysis

Type 2 muscle atrophy - Alcoholic myopathy, Thomas Klopstock, M.D.,1994, last updated 2011 PATHOGENESIS Acute Alcoholic Myopathy Acute alcoholic myopathy develops suddenly [flipper.diff.org]

[…] addresses the complete range of specific neuromuscular diseases: neuronopathies, peripheral neuropathies, neuromuscular junction disorders, muscle ion channel disorders, myopathies [books.google.com]

Recessive mutations in ANO5 (OMIM#608662) cause a wide spectrum of myopathies including LGMD2L, distal myopathy and isolated hyperCKemia. [ojrd.biomedcentral.com]

Rhabdomyosarcoma

Tardive tibial muscular dystrophy (TMD) [MIM:600334]: Autosomal dominant, late-onset distal myopathy. [genecards.org]

In addition, TTN mutations have been implicated in congenital myopathies involving cardiac and skeletal muscle, hereditary myopathy with early respiratory failure, tibial [nejm.org]

PMID 30810839 Centronuclear myopathy with cardiomyopathy due to recessive titinopathy. Martinez-Thompson JM, et al. Muscle Nerve, 2019 Apr. [ncbi.nlm.nih.gov]

Becker Muscular Dystrophy

In a boy with myopathy and an increase of muscle fibres with central nuclei we detected a heterozygous 387G-- T nucleotide transversion in the MYF6 gene (MIM*159991). [ncbi.nlm.nih.gov]

We describe two families which were initially classified as metabolic myopathies, until the diagnosis of atypical BMD was established after dystrophin analysis at the protein [ncbi.nlm.nih.gov]

X-linked recessive inherited disorder characterized by slowly progressive muscle weakness of the legs and pelvis Benign pseudohypertrophic muscular dystrophy benign congenital myopathy [wikidata.org]

Secondary Myopathy

We present a family with a distal myopathy secondary to a mutation in myotilin. [eprints.soton.ac.uk]

The myopathy is inhibited by prior sciatic nerve section and is accentuated by cholinesterase inhibition. [neurology.org]

Metabolic myopathies may be often accompanied by secondary hypovitaminosis D. Muscle biopsies can help in differentiating HDM from other myopathies. [chanrejournals.com]

Intestinal Pseudo-Obstruction

Pure phenotypic neonatal IP presentation in a myofibrillar myopathy is extremely rare and not reported in the literature. [ncbi.nlm.nih.gov]

Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) is most commonly associated with a mitochondrial DNA A to G point mutation at nucleotide [ncbi.nlm.nih.gov]

The condition is caused by a diverse range of intestinal myopathies and neuropathies. [ncbi.nlm.nih.gov]

MELAS Syndrome

Abstract Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome is a rare neurodegenerative disease caused by the decreased ability [ncbi.nlm.nih.gov]

MELAS syndrome (mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes) is one of the classic mitochondrial encephalomyopathies with variable clinical [ncbi.nlm.nih.gov]

Key words: Mitochondrial myopathy, encephalopathy, lactic acidosis, stroke, MELAS syndrome [scopemed.org]

Traumatic Rhabdomyolysis

[…] or muscle compression (eg, crush syndrome or prolonged immobilization) -Nontraumatic exertional (eg, marked exertion in untrained individuals, hyperthermia, or metabolic myopathies [forums.acdis.org]

It can be induced by numerous factors, including a crush injury to a limb, overuse of skeletal muscle, heat, alcoholism, viral infections, metabolic disorders, myopathies, [nejm.org]

) muscular dystrophies and myopathies ( G71 - G72 ) myopathy in amyloidosis ( E85.- ) myopathy in polyarteritis nodosa ( M30.0 ) myopathy in rheumatoid arthritis ( M05.32 [icd10data.com]

Systemic Scleroderma

MRI findings were compatible with myopathy or myositis in 14 (78 %) patients, tenosynovitis in 11 (61 %) patients and enthesitis in 10 (56 %) patients. [ncbi.nlm.nih.gov]

Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia syndrome (disorder) Crest syndrome Lipodermatosclerosis Lung disease with systemic sclerosis Myopathy [icd9data.com]

M34.2 Systemic sclerosis induced by drug and chemical M34.8 Other forms of systemic sclerosis M34.81 Systemic sclerosis with lung involvement M34.82 Systemic sclerosis with myopathy [icd10data.com]

Polymyositis

Furthermore, glucocorticosteroid (GC) toxicity leads to a significant disability known as steroid myopathy, particularly in elderly patients. [ncbi.nlm.nih.gov]

myopathies. [ncbi.nlm.nih.gov]

We herein attempted to determine the features and etiologies of these myopathies. [ncbi.nlm.nih.gov]

Limb-Girdle Muscular Dystrophy

For this reason our finding extends the histological spectrum of myopathies due to ANO5 mutations as well as the possible differential diagnoses for necrotizing myopathy. [ncbi.nlm.nih.gov]

In this report, a French family with an autosomal-dominant late-onset distal myopathy of the tibial muscular dystrophy phenotype segregating in several members of the family [ncbi.nlm.nih.gov]

Abstract Myopathies are a clinically and etiologically heterogeneous group of disorders that can range from limb girdle muscular dystrophy (LGMD) to syndromic forms with associated [ncbi.nlm.nih.gov]

Oculopharyngeal Muscular Dystrophy

[…] some ultrastructural characteristics with distal myopathy with rimmed vacuoles and hereditary inclusion body myopathy. [ncbi.nlm.nih.gov]

The question whether oculopharyngodistal myopathy (MIM 164310) is a distinct disease entity or a variant of oculopharyngeal muscular dystrophy (MIM 164300) persists. [ncbi.nlm.nih.gov]

The findings indicate that oculopharyngeal muscular dystrophy and distal myopathy are related in their etiology and distal myopathy and inclusion body myositis are regarded [ncbi.nlm.nih.gov]

Erb Muscular Dystrophy

4, 5 Tropomyosin Hypertrophic cardiomyopathy 3 Nemaline myopathy 1 Titin Hypertrophic cardiomyopathy 9 Other Fibrillin Marfan syndrome Weill–Marchesani syndrome Filamin FG [en.wikipedia.org]

ocular Mitochondrial ocular myopathy Muscular dystrophy Muscular dystrophy, distal Muscular dystrophy, Duchenne Muscular dystrophy, Emery Dreifuss Muscular dystrophy, Erbs [icd9data.com]

Observations on myopathy. Proc R Soc Med. 1922. 16:1. [emedicine.medscape.com]

Facioscapulohumeral Muscular Dystrophy

OBJECTIVES: To report cases of chronic autoimmune necrotizing myopathy with anti-signal recognition particle antibodies (anti-SRP myopathy) initially misdiagnosed as muscular [ncbi.nlm.nih.gov]

Most genetically confirmed FSHD patients exhibit unspecific morphological signs of a degenerative myopathy. [ncbi.nlm.nih.gov]

[…] oculopharyngeal myopathy, polymyositis, rigid spine syndrome, congenital myopathies, and some limb girdle muscular dystrophies, as well as in various neurogenic diseases. [ncbi.nlm.nih.gov]

Tropical Myositis

Other parasitic myopathies such as trichinosis and cysticercosis are acquired through consumption of poorly cooked meats. [mja.com.au]

[…] the description of novel mutations in patients with neuromuscular diseases and the application of new technologies to explore the pathogenesis and treatment of congenital myopathies [books.google.com]

Human immunodeficiency virus ( HIV ) has been found to be a strong risk factor for pyomyositis, due to immune compromise, primary HIV myopathy, antiretroviral therapy, and [dermnetnz.org]

Stiff-Person Syndrome

( G72.1 ) cramp and spasm ( R25.2 ) drug-induced myopathy ( G72.0 ) myalgia ( M79.1- ) stiff-man syndrome ( G25.82 ) Type 2 Excludes nontraumatic hematoma of muscle ( M79.81 [icd10data.com]

The same patient also developed a seizure disorder at age 14 years and subsequently neuropathy and myopathy at age 48 years, when diagnosed as having diabetes mellitus and [jamanetwork.com]

[…] back-references to G25.82 : Type 1 Excludes: M62 ICD-10-CM Diagnosis Code M62 Other disorders of muscle 2016 2017 2018 2019 Non-Billable/Non-Specific Code Type 1 Excludes alcoholic myopathy [icd10data.com]

Multiple Myeloma

Early radiologic identification of polyarticular amyloid arthropathy and myopathy should prompt confirmatory biopsy to confirm the diagnosis. [ncbi.nlm.nih.gov]

Neurologic findings may include a sensory level change (ie, loss of sensation below a dermatome corresponding to a spinal cord compression), neuropathy, myopathy, a Tinel [emedicine.medscape.com]

[…] or pain without tenderness Neurologic assessment: Sensory level change (ie, loss of sensation below a dermatome corresponding to a spinal cord compression), neuropathy, myopathy [emedicine.com]

Dermatomyositis

Classification of the Autoimmune Myopathies. View Table Favorite Table Download (.pdf) Table 27–1. Classification of the Autoimmune Myopathies. [accessmedicine.mhmedical.com]

Immunoglobulin Treatment in Polymyositis and Dermatomyositis, Idiopathic Inflammatory Myopathies - Recent Developments, Jan Tore Gran, IntechOpen, DOI: 10.5772/22904. [intechopen.com]

Lesson on Idiopathic Inflammatory Myopathies (Polymyositis vs Dermatomyositis). [youtube.com]

Chronic Progressive External Ophthalmoplegia

Here, we report a patient with chronic progressive external ophthalmoplegia complicated with inflammatory myopathy and after treated with prednisone as myositis, he had a [ncbi.nlm.nih.gov]

In conclusion, mitochondrial myopathy was definitely diagnosed. [ncbi.nlm.nih.gov]

Patients present clinically with multiple manifestations, including myopathies and multiple system disorders. [ncbi.nlm.nih.gov]

Glycogen Storage Disease Type 2

He was diagnosed with GSD III at the age of 7 months due to motor retardation, myopathy, and hepatomegaly. [ojrd.biomedcentral.com]

At late-onset, the spectrum of vacuolar myopathy is more divergent, ranging from almost normal to severe. [ncbi.nlm.nih.gov]

Patients at the other end of the spectrum present in the third to seventh decade, usually with a slowly progressive proximal myopathy. [ommbid.mhmedical.com]

Glycogen Storage Disease Type 5

Haller, Metabolic and Mitochondrial Myopathies, Neurologic Clinics, 32, 3, (777), (2014). [doi.org]

Turnbull, Investigation of metabolic myopathies, Myopathies, 10.1016/S0072-9752(07)86009-X, (193-204), (2007). G. Nogales-Gadea, J. Arenas and A. L. [doi.org]

He was diagnosed with GSD III at the age of 7 months due to motor retardation, myopathy, and hepatomegaly. [ojrd.biomedcentral.com]

Glycogen Storage Disease Type 7

In addition to causing hemolysis and exertional myopathy, heart disease may be a prominent clinical component of PFK deficiency in this breed and has not been previously recognized [doi.org]

Turnbull, Investigation of metabolic myopathies, Myopathies, 10.1016/S0072-9752(07)86009-X, (193-204), (2007). Zuhair N. [doi.org]

McArdle: Myopathy due to a defect in muscle glycogen breakdown. Clinical Science, London, 1951, 10: 13-33. S. Tarui, G. Okuno, Y. [whonamedit.com]

Schwartz-Jampel Syndrome

Structural and functional mutations of the perlecan gene cause Schwartz-Jampel syndrome, with myotonic myopathy and chondrodysplasia. [jhu.pure.elsevier.com]

[…] autosomal recessive disease characterized by neuromyotonia and chondrodysplasia that has material basis in hypomorphic mutations in the HSPG2 gene on chromosome 1p36 myotonic myopathy [wikidata.org]

The main clinical features of this syndrome include generalized myotonic myopathy, skeletal dysplasia, blepharophimosis, microstomia, contracture of joints and short stature [ncbi.nlm.nih.gov]

Sternocleidomastoid Hematoma

Separate arterial supplies predispose to ischemia in the sternal head, resulting in focal myopathy and fibrosis. Get access to the full text of this article [onlinelibrary.wiley.com]

[…] utero or difficult birth can lead to development of the compartment syndrome and congenital muscular torticollis sequela.Acquired SCM torticollis, can be post traumatic, myopathy [physio-pedia.com]

Paramyotonia Congenita

[…] a myopathy. [web.archive.org]

myopathy. [mayoclinic.org]

Paramyotonia congenita (OMIM 168300) is a non-dystrophic myopathy caused by mutations in the SCN4A gene that sometimes can be confused with myotonia congenita. [ncbi.nlm.nih.gov]