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47 Possible Causes for Myopia of Variable Severity

  • Marfan Syndrome

    A study by Benarroch et al suggested that clinical variability in MFS may result from alternative splicing of FBN1. [6] FBN1 mutations cause several Marfan-like disorders,[emedicine.com] […] such as the MASS (myopia, mitral valve prolapse, borderline and nonprogressive aortic enlargement, nonspecific skin and skeletal findings) phenotype and isolated ectopia[emedicine.com]

  • Nephroblastoma

    Bohring-Opitz syndrome is a rare genetic condition characterized by distinctive facial features, variable microcephaly, hypertrichosis, nevus flammeus, severe myopia, unusual[cancer.gov]

  • Ectopia Lentis

    One cousin also had peripheral pulmonic branch stenosis at birth and was later found to have ectopia lentis and severe myopia.[ncbi.nlm.nih.gov] The inheritance is likely autosomal dominant with variable expression and incomplete penetrance and further defines this syndrome to include congenital heart defects.[ncbi.nlm.nih.gov]

  • Acute Zonal Occult Outer Retinopathy

    Variables affecting initial visual function were moderate anterior vitreous cells, myopia severity, and a-wave amplitudes on electroretinography; factors affecting final visual[ncbi.nlm.nih.gov]

  • Funnel Chest

    A study by Benarroch et al suggested that clinical variability in MFS may result from alternative splicing of FBN1. [6] FBN1 mutations cause several Marfan-like disorders,[emedicine.medscape.com] […] such as the MASS (myopia, mitral valve prolapse, borderline and nonprogressive aortic enlargement, nonspecific skin and skeletal findings) phenotype and isolated ectopia[emedicine.medscape.com]

  • Mowat-Wilson Syndrome

    Clinical heterogeneity in Cohen syndrome Our study has identified several areas of clinical variability in Cohen syndrome.[jmg.bmj.com] In addition, there are a number of less specific but supportive criteria which we believe are very common in Cohen syndrome, namely: (1) early onset, progressive myopia, ([jmg.bmj.com]

  • Proliferative Vitreoretinopathy

    myopia, presenile cataract, night blindness of variable degree associated with progressive chorioretinal atrophy, retinal traction and retinal detachment in the advanced[ncbi.nlm.nih.gov] myopia Presenile cataract Night blindness of variable degree associated with progressive chorioretinal atrophy Retinal traction and detachment at advanced stages of the disease[ncbi.nlm.nih.gov] […] vitreoretinopathy (ERVR), is characterized by "optically empty vitreous" on slit-lamp examination and avascular vitreous strands and veils, mild or occasionally moderate to severe[ncbi.nlm.nih.gov]

  • Congenital Muscular Dystrophy

    The congenital eye abnormalities are variable and include severe myopia, glaucoma, optic nerve hypoplasia and retinal hypoplasia 180.[doi.org] Concerning the degree of cortical malformation, CNS involvement is also variable within the spectrum pachygyria/polymicrogyria/agyria associated to posterior fossa changes[doi.org]

  • Baller-Gerold Syndrome

    This patient also had some minor oral-facial anomalies, severe nonfamilial myopia, bilateral conductive hearing loss, ureteric reflux, and skeletal anomalies other than those[ncbi.nlm.nih.gov] This patient confirms the clinical variability among the patients and the wide pleiotropic effects of the BGS gene.[ncbi.nlm.nih.gov]

  • Phthisis Bulbi

    myopia, presenile cataract, night blindness of variable degree associated with progressive chorioretinal atrophy, retinal traction and retinal detachment at advanced stages[findzebra.com] myopia Presenile cataract Night blindness of variable degree associated with progressive chorioretinal atrophy Retinal traction and detachment at advanced stages of the disease[findzebra.com] […] vitreoretinopathy (ERVR), is characterized by “optically empty vitreous” on slit-lamp examination and avascular vitreous strands and veils, mild or occasionally moderate to severe[findzebra.com]

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