Create issue ticket

107 Possible Causes for Nasal Voice, Tongue Weakness, Vacuolization

  • Oculo-Pharyngo-Distal Myopathy

    Muscular dystrophy changes with rimmed vacuoles were the main histopathological changes.[ncbi.nlm.nih.gov] […] muscles Bulbar Dysphagia: Oropharyngeal Dysarthria: Hoarse & Nasal voice Tongue weakness Limbs Legs Arms Distal: Anterior tibial; Finger extensors Onset: 5 years after disease[neuromuscular.wustl.edu] Eleven of his relatives, over a period of three generations, had ptosis, dysphagia, nasal voice and difficulty in walking.[scinapse.io]

  • Oculopharyngeal Muscular Dystrophy

    In contrast, patients with distal myopathy with rimmed vacuoles revealed many rimmed vacuoles, on average in 20% of the fibers, and their oculopharyngeal muscles were spared[ncbi.nlm.nih.gov] Symptoms may include: difficulty swallowing (dysphagia) tongue weakness and atrophy weakness in the proximal muscles drooping eyelids (ptosis) difficulty gazing upwards and[muscle.ca] Eleven of his relatives, over a period of three generations, had ptosis, dysphagia, nasal voice and difficulty in walking.[ncbi.nlm.nih.gov]

  • Progressive Bulbar Palsy

    IVIg) Myopathies, including inclusion body myositis, which is characterized by wasting and weakness of deep finger flexors and the quadriceps femoris with typical rimmed vacuoles[emedicine.medscape.com] Clinical manifestations include dysarthria, dysphagia, facial weakness, tongue weakness, and fasciculations of the tongue and facial muscles.[icd9data.com] The muscles innervated by cranial nerves and corticobulbar tracts are predominantly affected, causing progressive difficulty with chewing, swallowing, and talking; nasal voice[merckmanuals.com]

  • Distal Myopathy Type 3

    Tubulofilamentous inclusion, myeloid bodies, and autophagic vacuoles in the area corresponding to rimmed vacuoles ( d ; bar 1 μm).[karger.com] (ie, tongue and pharyngeal weakness) is manifested by symptoms of dysarthria and dysphagia.[sites.google.com] Pharyngeal and laryngeal weakness may result in monotonous nasal voice. IQ is low-normal with hostile, reticent, suspicious, uncooperative personality.[neuroweb.us]

  • Limb-Girdle Muscular Dystrophy

    […] pathology Vacuoles/ultrastructure Substances Chromatin LMNA protein, human Lamin Type A MyoD Protein MyoD1 myogenic differentiation protein PAX7 Transcription Factor PAX7[ncbi.nlm.nih.gov] Involvement of the heart, respiratory muscles or tongue. (Facial weakness is not usual.)[patient.info] […] ophthalmoplegia (100%) Conjugate Non-restrictive Impairment greatest in upgaze No ptosis or aberrant eye movements Weakness Symmetric Severity: 4/5 Face: Mild; Eyes Mouth Voice[neuromuscular.wustl.edu]

  • Zebra Body Myopathy

    0003236 5 limb-girdle muscular dystrophy 59 32 hallmark (90%) Very frequent (99-80%) HP:0006785 6 waddling gait 59 32 hallmark (90%) Very frequent (99-80%) HP:0002515 7 rimmed vacuoles[malacards.org] Abdominal muscle weakness, cardiomyopathy, respiratory muscle involvement and various brain abnormalities have also been reported.[mendelian.co] Consequently, patients with this genetic mutation often cannot lift their heads and speak with a nasal voice.[en.wikipedia.org]

  • Secondary Myopathy

    Sensorimotor neuropathy Hypothyroid (amiodarone) Elevated serum CK EMG: fibs, PSWs, myotonia (choroquine), myopathic MUAPs NCS: axonal sensorimotor neuropathy Autophagic vacuoles[neurology.mhmedical.com] (ie, tongue and pharyngeal weakness) is manifested by symptoms of dysarthria and dysphagia.[sites.google.com] Some infants may have an abnormal waddling walk (gait), swallowing difficulties (dysphagia), speech difficulties (dysarthria), and a nasal tone to the voice.[rarediseases.org]

  • Polyglucosan Body Myopathy Type 2

    ; DMRV; Nonaka myopathy; Rimmed vacuole myopathy; Quadriceps Sparing Myopathy; GNE myopathy "OMIM Entry # 605820 - Nonaka Myopathy" .[en.wikipedia.org] (ie, tongue and pharyngeal weakness) is manifested by symptoms of dysarthria and dysphagia.[sites.google.com] Pharyngeal and laryngeal weakness may result in monotonous nasal voice. IQ is low-normal with hostile, reticent, suspicious, uncooperative personality.[neuroweb.us]

  • Glomus Jugulare Tumor

    […] histologic) description Classic organoid (zellballen) or nesting pattern of paragangliomas with central round / oval chief cells containing abundant eosinophilic granular or vacuolated[pathologyoutlines.com] Difficulty swallowing Hoarseness Shoulder drooping Tongue weakness In rare cases, these tumors may produce the hormone norepinephrine, which may cause: Headaches Anxiety[upmc.com] […] box), nasal, and orbit (eye).[dariuskohanmd.com]

  • Acquired Amyloid Myopathy

    Vacuoles rimmed with basophilic granules. Inclusion body myositis IBM. Vacuole filled with granules. Modified Gomori trichrome stain. Inclusion body myositis IBM.[neuropathology-web.org] Symptoms can include: Swelling of ankles and legs Weakness Weight loss Shortness of breath Numbness or tingling in the hands or feet Diarrhea Severe fatigue Enlarged tongue[sinoemedicalassociation.org] In the localized form of amyloidosis, air passages and ducts may be obstructed by amyloid deposits in the nasal sinuses, voice box (larynx) and throat (trachea) and bronchial[rarediseases.org]

Similar symptoms