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19 Possible Causes for Neck and Proximal Limb Muscle Myopathy

  • Myositis

    Muscle weakness and sometimes pain, often but not always symmetrical and proximal, are limited to the trunk, neck, and limbs.[annals.org] Myositis, or, as it is perhaps more usefully called, idiopathic inflammatory myopathy, is a disease of muscle inflammation.[annals.org]

  • Steroid Myopathy

    It is mostly seen in proximal muscles of the neck upper and lower limbs. Example: Corticosteroids.[omicsonline.org] […] lower limbs and to the neck flexors.[forums.studentdoctor.net] Steroid Myopathy It is a fatal disease that cause muscle weakness. Glucocorticoid-induced myopathy is the most common type of drug-induced myopathy.[omicsonline.org]

  • Hereditary Proximal Myopathy with Early Respiratory Failure

    Typically, patients present with lower limb muscle weakness, which slowly spreads to involve truncal, neck-flexor, facial, bulbar, and respiratory muscles.[medlink.com] Distribution of the weakness may be distal or both proximal and distal.[medlink.com] Skeletal myopathy may be combined with or preceded by cardiomyopathy, conduction blocks, and arrhythmias resulting in premature sudden death.[medlink.com]

  • Nemaline Myopathy

    The main clinical manifestations include weakness (usually most severe in the face, the neck flexors, and the proximal limb muscles), hypotonia, and depressed or absent deep[uniprot.org] Primary involvement of facial, neck and proximal limb musculature is characteristic for NM. All affected muscles are hypotonic and weak.[symptoma.com] Muscle weakness is usually most severe in the face, neck flexors, and the proximal limb muscles.[labcorp.com]

  • Central Core Disease

    Facial, neck, and proximal limb weakness with generalized hypotonia are the characteristic clinical features; but phenotypic severity is widely variable.[neuropathologyblog.blogspot.com] Reported to be one of the most frequent forms of congenital myopathy, this disease usually becomes apparent in infancy or childhood.[neuropathologyblog.blogspot.com] […] congenital myopathy defined by the presence on muscle biopsy microscopy of numerous muscle fibers that lack oxidative activity, thus making "cores" on NADH-stained slides within muscle[neuropathologyblog.blogspot.com]

  • Neurological Disorder

    Myopathy  Weakness of trunk and proximal limb muscles  May be weakness of neck flexion and/or extension and muscles of facial expression  Gait waddling 12.[slideshare.net] […] and limb muscle weakness (fatiguable)  Can involve respiratory muscles 10.[slideshare.net]  Rare (annual incidence 0.4 in 100000)  Clinical features  Fatiguable ptosis  Diplopia with limitation of eye movements  Facial weakness  Dysphagia  Dysarthria  Neck[slideshare.net]

  • Autosomal Recessive Centronuclear Myopathy

    Muscle weakness is usually most severe in the face, the neck flexU ors, and the proximal limb muscles. In some patients there is an additional distal involvement.[zdoc.site] […] have shown monoclonal gammopathy20 28 29 and others have had muscle pain,22 30 paraesthesias,20 or inflammation.20 31 Clinical features The cardinal features of nemaline myopathy[zdoc.site]

  • Nemaline Myopathy Type 4

    […] respiratory, and proximal limb muscles, with a later distal involvement ( 1 – 4 ).[pnas.org] The typical form of congenital nemaline myopathy is characterized by infantile onset of a slowly progressive or nonprogressive weakness of the facial, bulbar, neck flexor,[pnas.org]

  • Alpha-B Crystallinopathy

    Alpha-B crystallinopathy is a an autosomal dominant form of desmin-related myopathy (DRM) that results in weakness of the proximal and distal limb muscle (including neck,[dsimb.inserm.fr] Typically, patients present with lower limb muscle weakness, which slowly spreads to involve truncal, neck-flexor, facial, bulbar, and respiratory muscles.[medlink.com] Patients with progressive myopathy characterized by myofibrillar degeneration that commences at the Z-disk, have been described.[dsimb.inserm.fr]

  • Myofibrillar Myopathy Type 4

    Typically, patients present with lower limb muscle weakness, which slowly spreads to involve truncal, neck-flexor, facial, bulbar, and respiratory muscles.[medlink.com] Distribution of the weakness may be distal or both proximal and distal.[medlink.com] Skeletal myopathy may be combined with or preceded by cardiomyopathy, conduction blocks, and arrhythmias resulting in premature sudden death.[medlink.com]

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