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13 Possible Causes for Neck Weakness, Presynaptic Defect at the Neuromuscular Junction

  • Lambert Eaton Myasthenic Syndrome

    Neurological examination revealed ptosis, dysarthria, neck weakness, hyporeflexia of all limbs, and autonomic failure.[ncbi.nlm.nih.gov] A c.923C T variant affecting an adjacent residue (p.Pro308Leu) produced a presynaptic neuromuscular junction defect and a dominant hereditary motor neuropathy in a second[ncbi.nlm.nih.gov] The disease began with neck weakness, followed by asymmetric, bilateral lid ptosis.[docksci.com]

  • Infantile Botulism

    Wound infection was not established, but 2 weeks after gastrostomy the patient developed nausea and vomiting, with ileus, progressive dysphonia, neck and proximal weakness[pediatricneurologybriefs.com] […] suck as usual has a wobbly head because the neck is weak lacks facial expression has weak arms and legs has trouble breathing is not able to swallow Did you know?[canada.ca] […] in arms or legs; general fatigue Difficulty breathing, sometimes severe In infants, usually constipation at first; also lethargy and a "floppy" neck, arms and legs, demonstrating[drugs.com]

  • Ptosis

    She demonstrated shaky giveaway weakness when testing masseter, neck flexor and neck extensor muscles.[imedpub.com] These disorders are distinguished by molecular defects and the localization of the dysfunction at the presynaptic, postsynaptic, and neuromuscular junction.[journals.lww.com] Abnormal head positions like this could cause serious neck problems. Treatment Surgery can treat ptosis by tightening the levator, or eyelid-lifting muscle.[fortworth2020.com]

  • Paraneoplastic Neurologic Syndrome

    The weakness predominantly affects the hips and shoulders, and can also affect the neck, causing difficulty in holding the head up, and muscles of the throat and esophagus[rarediseases.org] […] in defective neuromuscular transmission.[dl.ndl.go.jp] If the level of injury includes your neck, you can have severe disability affecting all four limbs. Lambert-Eaton myasthenic syndrome.[mayoclinic.org]

  • Idiopathic Camptocormia

    […] and Foot Deformities 510 Case 81 A Woman with Droopy Eyelids and Ophthalmoplegia 515 Case 82 A Man with Weakness and Swelling in the Neck 522 Case 83 A Woman with Muscle[books.google.de] Botulinum toxin : Botulinum toxin acts by producing chemodenervation and local paralysis in the injected muscle due to presynaptic neuromuscular junction defect.[ijmr.org.in] He had no diplopia, dysarthria, dysphagia, limb weakness, or fatiguability. Examination showed severe neck extensor weakness, Medical Research Council (MRC) grade 2.[jnnp.bmj.com]

  • Infantile-Onset Autosomal Recessive Nonprogressive Cerebellar Ataxia

    weakness occurs due to cranial nerve involvement.[explainmedicine.com] […] dominant [slow channel syndrome]) neuromuscular junction; not associated with antibodies to AChR; symptoms: usually begin in the neonatal period, ocular, bulbar, respiratory[neupsykey.com] Type III syndrome is characterized by neck pain which radiates to the medial scapula, chest wall, shoulder area, or head.[4].[explainmedicine.com]

  • Congenital Myasthenic Syndrome

    , bulbar symptoms, neck muscle weakness, and proximal limb weakness that sometimes entails the loss of ambulation.[ncbi.nlm.nih.gov] Congenital myasthenic syndromes are classified as presynaptic, synaptic, or postsynaptic, depending on the primary defect's location within the neuromuscular junction.[ncbi.nlm.nih.gov] In our cohort, the RAPSN mutations lead to a relatively homogeneous phenotype, characterized by fluctuating ptosis, occasional bulbar symptoms, neck muscle weakness, and mild[ncbi.nlm.nih.gov]

  • Slow-Channel Congenital Myasthenic Syndrome

    Patients typically present with fatigability and static weakness of neck, hand and finger extensors.[ncbi.nlm.nih.gov] […] by the site of the transmission defect: presynaptic, synaptic, and postsynaptic.[link.springer.com] […] and Foot Deformities 510 Case 81 A Woman with Droopy Eyelids and Ophthalmoplegia 515 Case 82 A Man with Weakness and Swelling in the Neck 522 Case 83 A Woman with Muscle[books.google.com]

  • Juvenile Myasthenia Gravis

    MG causes weakness in muscles that control the eyes, face, neck, and limbs.[mda.org] Classification of congenital myasthenic syndrome Usually classified according to the defective site of the neuromuscular junction, it is often divided into presynaptic, synaptic[intechopen.com] Drooping eyelids, slurred speech, difficulty eating, and weakness in the arms, hands, fingers, legs and neck.[hopkinsmedicine.org]

  • Congenital Myasthenic Syndrome Type 1B

    For instance, neck pain may occur because of weakness in the neck muscles.[mda.org.au] […] within the neuromuscular junction Presynaptic Synaptic Postsynaptic P.J.[authorstream.com] All affected patients have limb-girdle weakness with lesser facial and neck muscle weakness but a few have severe bulbar weakness and few have significant limitation of the[rarediseases.org]

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