Necrosis: Causes & Reasons

Possible Causes for Necrosis

We present a rare case of massive tongue necrosis occurring simultaneously with bilateral osteoradionecrosis (ORN) of the jaw in a patient with a history of treatment, including [ncbi.nlm.nih.gov]

National study on avascular necrosis of the jaws including bisphosphonate-related necrosis. 2012. [nature.com]

Joe Yes, I had Osteo radio necrosis of the jaw 7 yrs ago. It was quite an ordeal. [cancercompass.com]

Necrotizing Fasciitis

Pain often occurs at the time of the injection, but tissue necrosis typically becomes apparent a few days later. [ncbi.nlm.nih.gov]

A case is presented here, as well as a review of the clinical features of 15 other patients previously described, in whom eyelid necrosis due to periorbital necrotizing fasciitis [ncbi.nlm.nih.gov]

What is necrosis? Experts explain necrosis as an unnatural cell death. [globalnews.ca]

Radiodermatitis

necrosis or ulceration of full thickness dermis with spontaneous bleeding. [omicsonline.org]

Effects can range from erythematous rash to desquamation and necrosis. This response can cause significant pain and limitation of usual lifestyle activities. [ons.org]

After an asymptomatic period which can last several months, poikiloderma, sclerosis, necrosis, and ulceration of the skin may be observed as typical clinical features of chronic [ncbi.nlm.nih.gov]

Granuloma Annulare

All cases of NL demonstrated pattern 1; nearly all cases of GA (18/19) demonstrated pattern 2; most sarcoidosis (10/12) demonstrated pattern 3; and nongranulomatous necrosis [ncbi.nlm.nih.gov]

Tumor necrosis factor (TNF)-alpha inhibitor therapy has been reported to be effective in treating granuloma annulare but has also been reported as a potential inciting factor [msdmanuals.com]

Excisional biopsy revealed ill-defined granulomas with central necrosis, chronic inflammation and sclerotic collagen; several features consistent with granuloma annulare. [ncbi.nlm.nih.gov]

Necrotizing Ulcerative Gingivitis

Three specific clinical characteristics must be present to diagnose NUG, pain (usually of rapid onset) interdental necrosis, and bleeding. [ncbi.nlm.nih.gov]

Most cases (52%) were stage 1, with necrosis of the tip of the interdental papilla only; 19% were stage 2, with the entire papilla affected; 22% had necrosis of marginal [ncbi.nlm.nih.gov]

Abstract Acute necrotizing ulcerative gingivitis-periodontitis (ANUG/NUP) is a relatively uncommon periodontal disease characterized by gingival necrosis and ulceration, pain [ncbi.nlm.nih.gov]

Pyoderma Gangrenosum

We aimed to summarize currently available data on the use of tumor necrosis factor (TNF) antagonists in the management of PASH syndrome and report on our own experience with [ncbi.nlm.nih.gov]

Tumour necrosis factor inhibitors [ncbi.nlm.nih.gov]

Topic Resources Pyoderma gangrenosum is a chronic, neutrophilic, progressive skin necrosis of unknown etiology often associated with systemic illness and sometimes skin injury [msdmanuals.com]

Hereditary Protein C Deficiency

Heparin appears to be ineffective in the prevention of both the purpura fulminans syndrome and the coumarin-induced skin necrosis. [ncbi.nlm.nih.gov]

Attention should be paid to the risk of coumarin-induced skin necrosis. [orpha.net]

Mucormycosis

The maxilla rarely undergoes necrosis due to its rich vascularity. [ncbi.nlm.nih.gov]

Thrombosis of internal maxillary artery or descending palatine artery results in necrosis of maxilla. [jidonline.com]

We present an unusual case of tongue necrosis probably due to the healthcare-associated mucormycosis (HCM) in a diabetic patient. [ncbi.nlm.nih.gov]

Rothmann-Makai Syndrome

Rothmann-Makai syndrome a rare syndrome of idiopathic circumscribed panniculitis with fat cell necrosis, lipophagic granuloma, and cyst formation; it usually subsides spontaneously [medicine.en-academic.com]

Similar articles [Primary multinodular panniculitis or fat necrosis in children]. Larbre F, Larbre B, De Parscau L. Larbre F, et al. Pediatrie. 1989;44(3):193-6. [pubmed.ncbi.nlm.nih.gov]

These include erythema nodosum, subcutaneous fat necrosis of the newborn, sclerema neonatorum, poststeroid panniculitis, and cold panniculitis. [unboundmedicine.com]

Psittacosis

Liver histologic findings at autopsy showed severe central necrosis. [ncbi.nlm.nih.gov]

Dissemination is characterized by foci of necrosis in the liver and spleen and diffuse mononuclear cell infiltrates in the heart, kidneys and brain. [histopathology-india.net]

Diagnosis is suggested by the placental histopathologic findings, which consist of an intense, acute intervillositis, perivillous fibrin deposition with villous necrosis, [ncbi.nlm.nih.gov]

Immune Complex-Mediated Small Vessel Vasculitis

necrosis ( 10 ). [synapse.koreamed.org]

[…] phagocytic activity, and release of proteolytic enzymes (e.g. collagenase and elastase) ↓ Destruction of vessels, formation of platelet thrombi ↓ Ischmia, hemorrhage, and necrosis [de.slideshare.net]

Local Immune Complex Disease (Arthus Reaction) The Arthus reaction is a localized area of tissue necrosis resulting from acute immune complex vasculitis, usually elicited [humpath.com]

Scedosporiosis

Figure 2: Dense inflammation and necrosis within the entire dermis and extending to the subcutaneous tissue (H and E, ×400) Figure 3: Cellular infiltrate containing lymphocytes [ijdvl.com]

Figure 2: Histopathological examination cross sectional study of lobectomy specimen-H&E staining showing septate fungal hyphae with acute angle branching and area of necrosis [ijpmonline.org]

B, Retinal necrosis over the optic nerve and macula as well as scleral thickening caused by fungal infection. [jamanetwork.com]

Noma

In this way flap necrosis can be prevented, without the risk of a scar contracture of the neck. [ncbi.nlm.nih.gov]

This condition refers to the spontaneous necrosis of both the soft and hard tissues in the oral cavity. [symptoma.com]

This case report, with a survey of recent relevant literature, highlights the different stages in the development of tissue necrosis, including onset and progression, with [ncbi.nlm.nih.gov]

Primary Hyperoxaluria Type 1

Aetiology Acute tubular necrosis, enteric hyperoxaluria, cystic fibrosis, coeliac disease, diabetes, foods (e.g., beef greens, rhubarb, spinach, beets, chard, okra, peanuts [medical-dictionary.thefreedictionary.com]

Progression of laminar necrosis of infarcted cortex seen by CTH seen 9 days (B) and 54 days (C) after the ACA infarction. [pubmed.ncbi.nlm.nih.gov]

[…] hypertrophy, systolic and diastolic dysfunction ECG, echocardiography CT: calcifications Thyroid d Hypothyroidism US Thyroid function tests Skin e (Painful) skin nodules, skin [academic.oup.com]

Epidemic Typhus

At autopsy, there are few gross findings except for splenomegaly and occasional areas of necrosis. [histopathology-india.net]

If untreated, the infection can lead to gangrene and necrosis (death of body tissue). [iamat.org]

Photophobia- Skin necrosis- digit gangrene, Untreated case mortality : 40% The diagnosis of epidemic typhus was established by demonstrating increasing antibody titers from [the-travel-doctor.com]

Primary Hyperoxaluria

Fatal cutaneous necrosis mimicking calciphylaxis in a patient with type I primary hyperoxaluria.Arch Dermatol. 1995; 131: 821-823 Arbus G.S. Sniderman S. [jaad.org]

There's deposition in the skin that can also lead to skin necrosis. Deposition at the retina can cause blindness. [raredr.com]

Primary Hyperoxaluria Type 2

Progression of laminar necrosis of infarcted cortex seen by CTH seen 9 days (B) and 54 days (C) after the ACA infarction. [pubmed.ncbi.nlm.nih.gov]

Pituitary Cushing Syndrome

Avascular necrosis of the femoral head (AVN) is not a common cause of musculoskeletal disability. [ncbi.nlm.nih.gov]

Articular MRI showed inflammation and necrosis of both knees and ankles, and left hip and right elbow (compatible with osteomyelitis). [ncbi.nlm.nih.gov]

Acta Endocrinol (Copenh). 129 : 114 – 120. 7, Hardy J. 1982 Hemorrhage, necrosis, and apoplexy in pituitary adenomas. [academic.oup.com]

Acute Kidney Injury

Acute [Disease/Finding], acute tubular necrosis, acute renal tubular necrosis, acute necrosis tubular, Lower nephron nephrosis, Acute Tubular Necrosis, Acute tubular necrosis [fpnotebook.com]

Granular “muddy brown” casts – think of necrosis from the “N” in ATN and necrosis tends to be dark. [foamcast.org]

Acute renal failure with tubular necrosis, TUBULAR NECROSIS ACUTE, lower nephron nephrosis, Renal tubular necrosis acute, Nephrosis lower nephron, Kidney Tubular Necrosis [fpnotebook.com]

Ischemic Ulcer

necrosis in chronic renal insufficiency, (3) nonuremic calciphylaxis in morbid obesity with proximal skin necrosis (eutrophication: body water enriched with nutrients or [journals.lww.com]

[…] of right toe with bone necrosis Chronic ulcer of right toe with fat layer exposure Chronic ulcer of right toe with muscle necrosis Chronic ulcer of right toe, bone necrosis [icd9data.com]

[…] anorganic substances leading to calcification), and (4) calciphylaxis with proximal skin necrosis, were compared with PG on pathophysiological features. 3,4 Martorell HYTILU [journals.lww.com]

Femoral Neck Fracture

Four cases of femoral neck fracture following avascular necrosis of the femoral head were studied histologically. [ncbi.nlm.nih.gov]

I was in Stage III Avascular Necrosis of the femoral head pre-collapse. [davidsfeldmanmd.com]

Nonunion and avascular necrosis led to the necessity for additional surgery in 11 of 30 (36%) hips. [link.springer.com]

Pancreatic Abscess

The presence of pancreatic necrosis is associated with an overall increase in mortality. [emedicine.medscape.com]

The mortality rate approaches 100% if intervention and drainage are not undertaken for the infected necrosis or abscess. [emedicine.medscape.com]

When this occurs prior to the formation of the fibrous wall, it is termed infected necrosis. [odlarmed.com]

Lipid Cell Tumor of the Ovary

Size, mitotic activity, necrosis, atypia and hemorrhage are related to malignant behavior. However, some histologically benign SCT might have a malignant outcome. [revistapatologia.com]

6-23%, Cushing syndrome in 6-10% Usually benign in prepubertal children Clinically malignant in 25-43%, associated with 2+ mitosis per high-power field (92% malignant); necrosis [pathologyoutlines.com]

Hemorrhage was focally seen, but tumor necrosis was not identified. [hindawi.com]

Acute Pancreatitis

Pancreas The acute pancreatitis ( acute hemorrhagic pancreatic necrosis ) is characterized by acute inflammation and necrosis of pancreas parenchyma, focal enzyme necrosis [pathologyatlas.ro]

No relationship was found between the aetiology and the presence of pancreatic necrosis, EXPN, location of pancreatic necrosis or presence of collections. [ncbi.nlm.nih.gov]

Acute pancreatitis also rarely causes renal cortical necrosis leading to acute kidney injury. [ncbi.nlm.nih.gov]

Acute Renal Failure with Oliguria

Applicable To Medullary [papillary] necrosis NOS Acute medullary [papillary] necrosis Renal medullary [papillary] necrosis The following code(s) above N17.2 contain annotation [icd10data.com]

Granular “muddy brown” casts – think of necrosis from the “N” in ATN and necrosis tends to be dark. [foamcast.org]

Non-Oliguric Renal Failure

Applicable To Medullary [papillary] necrosis NOS Acute medullary [papillary] necrosis Renal medullary [papillary] necrosis The following code(s) above N17.2 contain annotation [icd10data.com]

Diagnosis and treatment of acute tubular necrosis [Review]. [clinchem.aaccjnls.org]

The initial approach to predict the prognosis of the clinical syndrome of acute tubular necrosis (ATN) due to ischemia, toxins or both were the RIFLE criteria [ 1 ]. [ndt.oxfordjournals.org]

Pancreatitis

The presence of pancreatic necrosis is associated with an overall increase in mortality. [emedicine.medscape.com]

The morbidity and mortality associated with acute pancreatitis are substantially higher when necrosis is present, especially when the area of necrosis is also infected. 1 [content.nejm.org]

The mortality rate approaches 100% if intervention and drainage are not undertaken for infected necrosis or abscess. [emedicine.medscape.com]

Benign Neoplasm of the Breast

Fat necrosis may be mistaken as cancer on a mammogram ; however symptoms of fat necrosis usually subside within a month. Biopsy can confirm fat necrosis. [imaginis.com]

The damaged area of breast tissue can lead to a lump formation known as fat necrosis. Necrosis refers to cell death. [wolfcreeksurgeons.com]

What is fat necrosis? Fat necrosis is a condition in which painless, round, firm lumps caused by damaged and disintegrating fatty tissues form in the breast tissue. [hopkinsmedicine.org]

Intestinal Infarction

A patient with a rare combination of bilateral lingual necrosis and intestinal infarction, caused by giant cell arteritis, is described and the literature reviewed. [ncbi.nlm.nih.gov]

Death occurred 3 days later as a result of leg muscle necrosis and intestinal ileus with infarction. [ncbi.nlm.nih.gov]

Register Ischaemic Hepatic Necrosis and Intestinal Infarction in a Haemodialysis Patient - 24 Hours access EUR €36.00 GBP £28.00 USD $45.00 Rental This article is also available [doi.org]

Pleomorphic Xanthoastrocytoma

No necrosis, mitotic activity, phagocytic macrophages or apoptotic fragments were seen. [ncbi.nlm.nih.gov]

Increased mitotic activity, high MIB-1 and proliferating cell nuclear antigen labelling indices and necrosis are poor prognostic factors, whereas abundant lymphocytic infiltration [ncbi.nlm.nih.gov]

necrosis. [acsjournals.onlinelibrary.wiley.com]