Necrosis: Causes & Reasons

Possible Causes for Necrosis

We present a rare case of massive tongue necrosis occurring simultaneously with bilateral osteoradionecrosis (ORN) of the jaw in a patient with a history of treatment, including [ncbi.nlm.nih.gov]

National study on avascular necrosis of the jaws including bisphosphonate-related necrosis. 2012. [nature.com]

Joe Yes, I had Osteo radio necrosis of the jaw 7 yrs ago. It was quite an ordeal. [cancercompass.com]

Necrotizing Fasciitis

Pain often occurs at the time of the injection, but tissue necrosis typically becomes apparent a few days later. [ncbi.nlm.nih.gov]

What is necrosis? Experts explain necrosis as an unnatural cell death. [globalnews.ca]

A case is presented here, as well as a review of the clinical features of 15 other patients previously described, in whom eyelid necrosis due to periorbital necrotizing fasciitis [ncbi.nlm.nih.gov]

Granuloma Annulare

All cases of NL demonstrated pattern 1; nearly all cases of GA (18/19) demonstrated pattern 2; most sarcoidosis (10/12) demonstrated pattern 3; and nongranulomatous necrosis [ncbi.nlm.nih.gov]

This case provides further evidence that tumour necrosis factor-α inhibitors may be a treatment option for patients with recalcitrant, generalized GA. [ncbi.nlm.nih.gov]

Granuloma annulare induced by anti-tumor necrosis factor therapy. Ann Rheum Dis 2008;67:567-70. [ PUBMED ] [ FULLTEXT ] 6. [e-ijd.org]

Necrotizing Ulcerative Gingivitis

OLS > Experimental Factor Ontology EFO > EFO:1001058 http://www.ebi.ac.uk/efo/EFO_1001058 An acute or chronic GINGIVITIS characterized by redness and swelling, NECROSIS extending [ebi.ac.uk]

Three specific clinical characteristics must be present to diagnose NUG, pain (usually of rapid onset) interdental necrosis, and bleeding. [ncbi.nlm.nih.gov]

Most cases (52%) were stage 1, with necrosis of the tip of the interdental papilla only; 19% were stage 2, with the entire papilla affected; 22% had necrosis of marginal [ncbi.nlm.nih.gov]

Radiodermatitis

necrosis or ulceration of full thickness dermis with spontaneous bleeding. [omicsonline.org]

After an asymptomatic period which can last several months, poikiloderma, sclerosis, necrosis, and ulceration of the skin may be observed as typical clinical features of chronic [ncbi.nlm.nih.gov]

Grade 4 – Skin necrosis or ulceration of full thickness dermis (middle layer of skin). [dermnetnz.org]

Pyoderma Gangrenosum

We aimed to summarize currently available data on the use of tumor necrosis factor (TNF) antagonists in the management of PASH syndrome and report on our own experience with [ncbi.nlm.nih.gov]

Pyoderma gangrenosum is a chronic, neutrophilic, progressive skin necrosis of unknown etiology often associated with systemic illness and sometimes skin injury. [msdmanuals.com]

Tumour necrosis factor inhibitors [ncbi.nlm.nih.gov]

Hereditary Protein C Deficiency

Heparin appears to be ineffective in the prevention of both the purpura fulminans syndrome and the coumarin-induced skin necrosis. [ncbi.nlm.nih.gov]

Attention should be paid to the risk of coumarin-induced skin necrosis. [orpha.net]

necrosis in protein C deficiency. [ncbi.nlm.nih.gov]

Rothmann-Makai Syndrome

Rothmann-Makai syndrome a rare syndrome of idiopathic circumscribed panniculitis with fat cell necrosis, lipophagic granuloma, and cyst formation; it usually subsides spontaneously [medicine.academic.ru]

Look at other dictionaries: Rothmann-Makai syndrome — a rare syndrome of idiopathic circumscribed panniculitis with fat cell necrosis, lipophagic granuloma, and cyst formation [medicine.enacademic.com]

Mucormycosis

The maxilla rarely undergoes necrosis due to its rich vascularity. [ncbi.nlm.nih.gov]

Thrombosis of internal maxillary artery or descending palatine artery results in necrosis of maxilla. [jidonline.com]

We present an unusual case of tongue necrosis probably due to the healthcare-associated mucormycosis (HCM) in a diabetic patient. [ncbi.nlm.nih.gov]

Psittacosis

Liver histologic findings at autopsy showed severe central necrosis. [ncbi.nlm.nih.gov]

Diagnosis is suggested by the placental histopathologic findings, which consist of an intense, acute intervillositis, perivillous fibrin deposition with villous necrosis, [ncbi.nlm.nih.gov]

Dissemination is characterized by foci of necrosis in the liver and spleen and diffuse mononuclear cell infiltrates in the heart, kidneys and brain. [histopathology-india.net]

Immune Complex-Mediated Small Vessel Vasculitis

necrosis ( 10 ). [synapse.koreamed.org]

[…] phagocytic activity, and release of proteolytic enzymes (e.g. collagenase and elastase) ↓ Destruction of vessels, formation of platelet thrombi ↓ Ischmia, hemorrhage, and necrosis [de.slideshare.net]

This results in fibrinoid necrosis of the vascular wall. [vin.com]

Scedosporiosis

Figure 2: Dense inflammation and necrosis within the entire dermis and extending to the subcutaneous tissue (H and E, ×400) Figure 3: Cellular infiltrate containing lymphocytes [ijdvl.com]

B, Retinal necrosis over the optic nerve and macula as well as scleral thickening caused by fungal infection. [jamanetwork.com]

[…] infection may present in a wide range of pulmonary manifestations from simple colonisation to mycetoma formation and invasive disease, simulating aspergillosis.1 Antitumour necrosis [thorax.bmj.com]

Noma

This condition refers to the spontaneous necrosis of both the soft and hard tissues in the oral cavity. [symptoma.com]

In this way flap necrosis can be prevented, without the risk of a scar contracture of the neck. [ncbi.nlm.nih.gov]

This case report, with a survey of recent relevant literature, highlights the different stages in the development of tissue necrosis, including onset and progression, with [ncbi.nlm.nih.gov]

Primary Hyperoxaluria

There's deposition in the skin that can also lead to skin necrosis. Deposition at the retina can cause blindness. [raredr.com]

Fatal cutaneous necrosis mimicking calciphylaxis in a patient with type I primary hyperoxaluria. Arch Dermatol. 1995; 131: 821-823 Arbus G.S. Sniderman S. [jaad.org]

Aetiology Acute tubular necrosis, enteric hyperoxaluria, cystic fibrosis, coeliac disease, diabetes, foods (e.g., beef greens, rhubarb, spinach, beets, chard, okra, peanuts [medical-dictionary.thefreedictionary.com]

Primary Hyperoxaluria Type 1

Progression of laminar necrosis of infarcted cortex seen by CTH seen 9 days (B) and 54 days (C) after the ACA infarction. [pubmed.ncbi.nlm.nih.gov]

[…] hypertrophy, systolic and diastolic dysfunction ECG, echocardiography CT: calcifications Thyroid d Hypothyroidism US Thyroid function tests Skin e (Painful) skin nodules, skin [academic.oup.com]

Epidemic Typhus

At autopsy, there are few gross findings except for splenomegaly and occasional areas of necrosis. [histopathology-india.net]

If untreated, the infection can lead to gangrene and necrosis (death of body tissue). [iamat.org]

Photophobia- Skin necrosis- digit gangrene, Untreated case mortality : 40% The diagnosis of epidemic typhus was established by demonstrating increasing antibody titers from [the-travel-doctor.com]

Primary Hyperoxaluria Type 2

Progression of laminar necrosis of infarcted cortex seen by CTH seen 9 days (B) and 54 days (C) after the ACA infarction. [pubmed.ncbi.nlm.nih.gov]

Pituitary Cushing Syndrome

Avascular necrosis of the femoral head (AVN) is not a common cause of musculoskeletal disability. [ncbi.nlm.nih.gov]

Articular MRI showed inflammation and necrosis of both knees and ankles, and left hip and right elbow (compatible with osteomyelitis). [ncbi.nlm.nih.gov]

Acta Endocrinol (Copenh). 129 : 114 – 120. 7, Hardy J. 1982 Hemorrhage, necrosis, and apoplexy in pituitary adenomas. [academic.oup.com]

Acute Kidney Injury

Acute [Disease/Finding], acute tubular necrosis, acute renal tubular necrosis, acute necrosis tubular, Lower nephron nephrosis, Acute Tubular Necrosis, Acute tubular necrosis [fpnotebook.com]

Granular “muddy brown” casts – think of necrosis from the “N” in ATN and necrosis tends to be dark. [foamcast.org]

Acute renal failure with tubular necrosis, TUBULAR NECROSIS ACUTE, lower nephron nephrosis, Renal tubular necrosis acute, Nephrosis lower nephron, Kidney Tubular Necrosis [fpnotebook.com]

Ischemic Ulcer

necrosis in chronic renal insufficiency, (3) nonuremic calciphylaxis in morbid obesity with proximal skin necrosis (eutrophication: body water enriched with nutrients or [journals.lww.com]

[…] of right toe with bone necrosis Chronic ulcer of right toe with fat layer exposure Chronic ulcer of right toe with muscle necrosis Chronic ulcer of right toe, bone necrosis [icd9data.com]

[…] anorganic substances leading to calcification), and (4) calciphylaxis with proximal skin necrosis, were compared with PG on pathophysiological features. 3,4 Martorell HYTILU [journals.lww.com]

Femoral Neck Fracture

I was in Stage III Avascular Necrosis of the femoral head pre-collapse. [davidsfeldmanmd.com]

Four cases of femoral neck fracture following avascular necrosis of the femoral head were studied histologically. [ncbi.nlm.nih.gov]

Nonunion and avascular necrosis led to the necessity for additional surgery in 11 of 30 (36%) hips. [link.springer.com]

Pancreatic Abscess

The presence of pancreatic necrosis is associated with an overall increase in mortality. [emedicine.medscape.com]

The mortality rate approaches 100% if intervention and drainage are not undertaken for the infected necrosis or abscess. [emedicine.medscape.com]

A paradigm shift is occurring in the treatment of pancreatic necrosis and peripancreatic infections. [emedicine.medscape.com]

Lipid Cell Tumor of the Ovary

6-23%, Cushing syndrome in 6-10% Usually benign in prepubertal children Clinically malignant in 25-43%, associated with 2+ mitosis per high-power field (92% malignant); necrosis [pathologyoutlines.com]

Size, mitotic activity, necrosis, atypia and hemorrhage are related to malignant behavior. However, some histologically benign SCT might have a malignant outcome. [revistapatologia.com]

Hemorrhage was focally seen, but tumor necrosis was not identified. [hindawi.com]

Acute Pancreatitis

Pancreas The acute pancreatitis ( acute hemorrhagic pancreatic necrosis ) is characterized by acute inflammation and necrosis of pancreas parenchyma, focal enzyme necrosis [pathologyatlas.ro]

Acute pancreatitis also rarely causes renal cortical necrosis leading to acute kidney injury. [ncbi.nlm.nih.gov]

Of 40 patients with normal contrast enhancement, none required laparotomy to debride pancreatic necrosis. [ncbi.nlm.nih.gov]

Acute Renal Failure with Oliguria

Applicable To Medullary [papillary] necrosis NOS Acute medullary [papillary] necrosis Renal medullary [papillary] necrosis The following code(s) above N17.2 contain annotation [icd10data.com]

English if acute tubular necrosis is the diagnosis, and the cause is remedied, then recovery will probably occur fairly quickly. [mymemory.translated.net]

Non-Oliguric Renal Failure

Applicable To Medullary [papillary] necrosis NOS Acute medullary [papillary] necrosis Renal medullary [papillary] necrosis The following code(s) above N17.2 contain annotation [icd10data.com]

Diagnosis and treatment of acute tubular necrosis [Review]. [clinchem.aaccjnls.org]

The initial approach to predict the prognosis of the clinical syndrome of acute tubular necrosis (ATN) due to ischemia, toxins or both were the RIFLE criteria [ 1 ]. [ndt.oxfordjournals.org]

Acute Interstitial Nephritis

Acute tubular necrosis, a rare but well-known side effect of tenofovir, was suspected, but kidney biopsy confirmed interstitial nephritis. [ncbi.nlm.nih.gov]

Renal histology revealed mainly acute tubular necrosis with mild tubulo-interstitial mononuclear cellular infiltrate. [ncbi.nlm.nih.gov]

UEs were no better at distinguishing AIN from acute tubular necrosis compared with other kidney diseases. [ncbi.nlm.nih.gov]

Pancreatitis

The presence of pancreatic necrosis is associated with an overall increase in mortality. [emedicine.medscape.com]

[…] of pancreatic parenchyma lack of parenchymal enhancement often multifocal infected necrosis difficult to distinguish from aseptic liquefactive necrosis the presence of gas [radiopaedia.org]

The morbidity and mortality associated with acute pancreatitis are substantially higher when necrosis is present, especially when the area of necrosis is also infected. 1 [dx.doi.org]

Prostate Sarcoma

Includes phyllodes tumors (like those of the breast) Essential features Cellular pleomorphism exceeding that of stromal proliferation of undetermined malignant potential Necrosis [pathologyoutlines.com]

[…] tumour composed of fascicle forming, moderately pleomorphic, spindle/oval shaped cells with prominent nucleoli, dense chromatin, 1-3 mitosis in every high power field and necrosis [journalagent.com]

On histological examination, mitoses were easily found: 3/10 fields and there were multiple foci of necrosis. [acanceresearch.com]

Macronodular Cirrhosis

Macronodular or multilobular cirrhosis apparently results from more discrete insults producing one or more episodes of acute necrosis producing local necrosis with collapse [medicine.tamu.edu]

[…] macronodular cirrhosis cirrhosis in which regenerative nodules are more than 3 mm in diameter, seen most often following subacute hepatic necrosis due to toxic or viral hepatitis [medicine.academic.ru]

[…] septa and changes in the parenchymal nodules such as necrosis and cholestasis. [meddean.luc.edu]