Neonatal Hyperbilirubinemia: Causes & Reasons

Possible Causes for Neonatal Hyperbilirubinemia

Fetal and neonatal edition, 2018 May 25 [PubMed] Bilirubin Albumin Binding and Unbound Unconjugated Hyperbilirubinemia in Premature Infants., Amin SB,Wang H,, The Journal [knowledge.statpearls.com]

Epidemiology of neonatal jaundice in the Jerusalem population. [doi.org]

[…] of pediatrics, 2018 Jan [PubMed] The Importance of Hemolysis and Its Clinical Detection in Neonates with Hyperbilirubinemia., Wong RJ,Bhutani VK,Stevenson DK,, Current pediatric [knowledge.statpearls.com]

Crigler-Najjar Syndrome Type 1

Neomedlight, The Fabric of Light for Phototherapy Section : Neonatal Jaundice Jaundice, also known as icterus, is a yellow pigmentation of the skin which is caused by high [neomedlight.com]

A neonatal hyperbilirubinemia resolved spontaneously. [ncbi.nlm.nih.gov]

We have shown, for the first time, the full recovery of the lethal effects of neonatal hyperbilirubinemia. [ncbi.nlm.nih.gov]

Gilbert Syndrome

Sukru Aynacioglu, Reinhold Kerb, Murat Yurdakok and Atila Bozkurt, Neonatal Jaundice and Bilirubin UDP‐Glucuronosyl Transferase 1A1 Gene Polymorphism in Turkish Patients, [doi.org]

Genetic interactions in the pathogenesis of neonatal hyperbilirubinemia: Gilbert's Syndrome and glucose-6-phosphate dehydrogenase deficiency. [gpnotebook.co.uk]

Jaundice Detection System, Journal of Medical Systems, 40, 7, (2016). [doi.org]

Giant Cell Hepatitis

Idiopathic neonatal hepatitis (INH) remains a diagnosis of exclusion in the neonate with conjugated hyperbilirubinemia. [ncbi.nlm.nih.gov]

Neonatal jaundice first becomes visible in the face and forehead. Blanching reveals the underlying colour. [patient.info]

A previous sibling with neonatal jaundice requiring phototherapy. Visible jaundice in the first 24 hours. Infants of mothers who have diabetes. Male infants. [patient.info]

Hereditary Spherocytosis

neonatal hyperbilirubinemia. [ncbi.nlm.nih.gov]

The absence of a positive family history does not preclude hereditary spherocytosis as a differential for pathologic neonatal hyperbilirubinemia. [ncbi.nlm.nih.gov]

“Hereditary Spherocytosis in Neonates with Hyperbilirubinemia”. PEDIATRICS Vol. 125 No. 1 January 1, 2010 pp. 120 -125 Shah, Vega. [pedclerk.bsd.uchicago.edu]

Polycythemia Neonatorum

Hyperbilirubinemia in the term newborn. Am Fam Physician. 2002;65(4):599–606. PubMed Google Scholar Woodgate P, Jardine LA. Neonatal jaundice. BMJ Clin Evid. 2011;2011. [bmcpediatr.biomedcentral.com]

jaundice. [pathophys.org]

[…] source Hyperbilirubinemia Car... 252 x 182 png 63kB pic source Kern Medical Third Yea... 762 x 529 jpeg 133kB pic source Neonatal Jaundice 1 638 x 479 jpeg 75kB pic source [mnogolok.info]

Rotor Syndrome

A biliblanket is a portable phototherapy device for the treatment of neonatal jaundice ( hyperbilirubinemia ). [diki.pl]

Keywords: Laundice, Zinc, Neonate, Hyperbilirubinemia. [ijp.mums.ac.ir]

Assessment of UGT polymorphisms and neonatal jaundice. Semin Perinatol 2011; 35 :127–33. 47. Crigler JF Jr, Najjar VA. [nature.com]

Neonatal Jaundice

Some of the most common causes of neonatal jaundice include Physiologic hyperbilirubinemia Breastfeeding jaundice Breast milk jaundice Pathologic hyperbilirubinemia due to [msdmanuals.com]

Hyperbilirubinemia: Neonatal jaundice and kernicterus. [bmcpediatr.biomedcentral.com]

Key Points Neonatal jaundice is caused by increased bilirubin production, decreased bilirubin clearance, or increased enterohepatic circulation. [merckmanuals.com]

Pyruvate Kinase Deficiency

We report an infant with neonatal hyperbilirubinemia due to pyruvate kinase deficiency. [ncbi.nlm.nih.gov]

This emphasizes the need for screening neonatal hyperbilirubinemia cases in India for PK deficiency. [ncbi.nlm.nih.gov]

The study detected 10 neonates with G6PD deficiency, which means that the prevalence of G6PD deficiency among Egyptian neonates with hyperbilirubinemia is 14.4% (21.2% of [ncbi.nlm.nih.gov]

Anemia due to Glutathione Metabolism Disorder

Role of hemolysis in neonatal jaundice associated with glucose-6-phosphate dehydrogenase deficiency. J Pediatr. 1995;127:804–6. 20. [aafp.org]

Neonatal hyperbilirubinemia with kernicterus is rarely seen, with neonatal jaundice typically occurring on days 4-7. The mechanism is not completely understood. [clinicaladvisor.com]

Neonatal Hyperbilirubinemia Acute hemolysis with hyperbilirubinemia ie jaundice may lead to kernicterus. Favism It is seen most commonly in children aged 1 to 5 years. [medcaretips.com]

Kernicterus

In 2008, national guidelines for neonatal hyperbilirubinemia were issued in Sweden. [jamanetwork.com]

Sgro M, Campbell D, Barozzino T, Shah V: Acute neurological findings in a national cohort of neonates with severe neonatal hyperbilirubinemia. [karger.com]

MATERIALS AND METHODS: There were 11 patients enrolled in the neonatal bilirubin encephalopathy (NBE) group, 8 patients in the neonatal hyperbilirubinemia (NH) group, and [ncbi.nlm.nih.gov]

Dubin-Johnson Syndrome

We suggest ursodeoxycholic acid in treatment for Dubin-Johnson Syndrome with severe direct hyperbilirubinemia presenting in the neonatal age. [ncbi.nlm.nih.gov]

Dubin-Johnson syndrome (DJS) is an autosomal recessive inherited disorder characterized by conjugated hyperbilirubinemia. Neonatal-onset DJS is rare. [ncbi.nlm.nih.gov]

We suggest ursodeoxycholic acid in treatment for Dubin- Johnson Syndrome with severe direct hyperbilirubinemia presenting in the neonatal age. [degruyter.com]

Cephalhematoma

抄録 So many factors as for etiology of neonatal hyperbilirubinemia have been reported by many workers. [jstage.jst.go.jp]

A small proportion of cases can be accompanied by anemia, hyperbilirubinemia or a skull fracture, or be complicated by calcification or rarely by infection. [pesquisa.bvsalud.org]

Signs and symptoms of Neonatal Jaundice – 1. Itchy skin 2. Pale stools 3. Poor sucking / feeding 4. [indiastudychannel.com]

Congenital Hemolytic Anemia

He required phototherapy for neonatal jaundice. [casesjournal.biomedcentral.com]

In the neonatal period, severe hemolysis and hyperbilirubinemia can leave permanent neurological sequelae. [bioline.org.br]

Neonatal jaundice is common in the first 2 days of life in patients with HS and the hyperbilirubinemia can be severe enough to require exchange transfusion. [clinicaladvisor.com]

Maternal Diabetes Syndrome

High bilirubin level (hyperbilirubinemia). Immature lungs. Neonatal polycythemia (more red blood cells than normal). [medlineplus.gov]

and neonatal hypoglycemia. [pharmacytimes.com]

[…] and maternal blood glucose levels on the OGTT, 10 but the risk of severe hyperbilirubinemia, such as seen in hemolysis, is low. 23 Neonatal respiratory distress There is [dovepress.com]

Thalassemia Minor

Abstract Infants on this island are known to have higher incidences of neonatal hyperbilirubinemia and alpha-thalassemia minor than Caucasians. [ncbi.nlm.nih.gov]

Haemolytic disease and other neonatal jaundice 196·6 (0·04%) 373·9 (0·05%) 105·6 (0·76%) 201·6 (1·00%) .. .. 373·9 (0·05%) .. [ncbi.nlm.nih.gov]

jaundice, mesothelioma, unintentional suffocation, pulmonary aspiration and foreign body in trachea or lung, and foreign body in other part of body. [ncbi.nlm.nih.gov]

Neonatal Sepsis

Late diagnosis of neonatal jaundice both increases the severity and complication. [ijp.mums.ac.ir]

The distribution of 70 respondents obtained as much 15 neonates have history neonatal sepsis of which 12 neonatal jaundice and 3 not became neonatal jaundice. [eprints.ums.ac.id]

(Jaundice) | 4 Care Plans Labor Stages, Induced, Augmented, Dysfunctional, Precipitous Labor | 45 Care Plans Neonatal Sepsis | 8 Care Plans Perinatal Loss (Miscarriage, Stillbirth [nurseslabs.com]

Biliary Atresia

Issues that should raise your concern: Prolonged neonatal jaundice Physiologic jaundice in healthy, full-term newborns typically resolves by the 5th or 6th day. [pedemmorsels.com]

Endoscopic retrograde cholangiopancreatography (ERCP) may be used to investigate direct hyperbilirubinemia among neonates. [symptoma.com]

Conjugated Hyperbilirubinemia There are other causes (ex, neonatal hepatitis), but Biliary Atresia needs to be high on your list of concerns!! [pedemmorsels.com]

Neonatal Intracranial Hemorrhage

This added burden of bilirubin may cause sufficient neonatal hyperbilirubinemia to require phototherapy and, rarely, exchange transfusion. No other treatment is needed. [merckmanuals.com]

Fetal/neonatal injuries include scalp lacerations and bruising, SGH, cephalohematoma, intracranial hemorrhage, neonatal jaundice, subconjunctival and retinal hemorrhage, shoulder [ispub.com]

Galactosemia

To the best of our knowledge, there is no case of galactosemia reported in literature which presented with recurrent neonatal sepsis without hepatomegaly, hyperbilirubinemia [ncbi.nlm.nih.gov]

Consider Galactosemia in the ill-appearing neonate, especially less than 2 weeks of age. [pedemmorsels.com]

Tags: bulging fontanelle Galactosemia Genetic Disorder Hyperbilirubinemia infant formula Soy urine reducing substances Sean M. [pedemmorsels.com]

Cholestasis

For instance, hepatic siderosis has been documented in cases of neonatal acute liver failure. 14 Our patient’s history of coagulopathy, transaminitis, and direct hyperbilirubinemia [pediatrics.aappublications.org]

The primary outcome measured in this study was a composite outcome of one or more fetal or neonatal complications. [journals.plos.org]

The risk of developing neonatal jaundice is the same as for other babies. It is thought that there is no major damage caused to the liver of either mother or baby. [britishlivertrust.org.uk]

Cystic Fibrosis

jaundice, average FEV1 (CF-specific percentile score ( 29 )), average BMI Z-score, age at diagnosis of CF, lung transplantation, number of pulmonary exacerbations in the [ncbi.nlm.nih.gov]

[…] cholelithiasis, cholecystectomy, gastroesophageal reflux, Nissen fundoplication, gastrostomy tube placement, rectal prolapse, appendiceal disease, failure to thrive, steatorrhea, neonatal [ncbi.nlm.nih.gov]

Red Blood Cell Disorder

Clinical description Clinically, PK-deficient patients suffer from a highly variable degree of chronic hemolysis, ranging from severe neonatal jaundice and fatal anemia at [orpha.net]

Prolonged Neonatal jaundice 8. Hepatosplenomegaly 9. Hepatosplenomegaly 10. Delayed mile stones +organomegaly 11. PigmentedGall stones in young Persons 12. [slideshare.net]

Congenital Hypothyroidism

Neonatal hyperbilirubinemia for more than three weeks is common. This is due to immaturity of hepatic glucuronyl transferase [ 8, 14 ]. [ojrd.biomedcentral.com]

CASE DESCRIPTION: A female infant presenting with prolonged neonatal jaundice was found to have isolated CCH, with TSH of 2.2 mU/L (Reference range, 0.4-3.5) and free T4 of [ncbi.nlm.nih.gov]

Microangiopathic Hemolytic Anemia

In the neonatal period, severe hemolysis and hyperbilirubinemia can leave permanent neurological sequelae. [bioline.org.br]

Sickle Cell Anemia

jaundice, mesothelioma, unintentional suffocation, pulmonary aspiration and foreign body in trachea or lung, and foreign body in other part of body. [ncbi.nlm.nih.gov]

jaundice 64·8 (39·5 to 96·3) 19·6 (13·0 to 29·7) −70·0 (−79·78 to −50·43) 0·9 (0·5 to 1·3) 0·3 (0·2 to 0·4) −70·6 (−80·17 to −51·17) Other neonatal disorders 577·6 (457·5 [ncbi.nlm.nih.gov]

[…] newly estimated causes with the same overall assignment of rank causes as GBD 2010: typhoid and paratyphoid separately, haemolytic disease in fetus and newborn and other neonatal [ncbi.nlm.nih.gov]

Hemoglobin Bart's Disease

The typical patient had neonatal jaundice and hemolytic anemia, but did not start requiring transfusions until the second or third decade of life. [clinicaladvisor.com]

Hemorrhagic Disease of the Newborn

The newborn can present with a number of features including: clinical evidence of a fetal anemia neonatal jaundice neonatal hepatosplenomegaly generalized body edema The condition [radiopaedia.org]

TORCH Syndrome

On the contrary, findings resembling congenital infectious diseases including neonatal icterus, hyperbilirubinemia, thrombocytopenia, and hepatomegaly, affect less than half [ncbi.nlm.nih.gov]

Other clinical findings reported are hepatomegaly, neonatal hyperbilirubinemia, cerebellar abnormalities, spasticity, seizures, EEG abnormalities and thrombocytopenia. [indianpediatrics.net]

[…] cholestasis is generally defined as conjugated hyperbilirubinemia that occurs in the newborn period or shortly thereafter. [peertechz.com]

Biliary Tree Disease

[…] cholestasis North American Indian intrahepatic cholestasis Obstructive hyperbilirubinemia Obstructive jaundice Papillary mass of biliary tract Postpartum cholestasis Postpartum [icd9data.com]

[…] hepatorenal syndrome Fibrosis of bile duct Hemobilia Hepatic duct dysplasia Hypertrophy of bile duct Hypertrophy of biliary tract Intrahepatic cholestasis Jaundice obstructive Neonatal [icd9data.com]