Neonatal Jaundice: Causes & Reasons

Warning: Do not use in emergencies, if pregnant, if under 18, or as a substitute for a doctor’s advice or diagnosis. Learn more

Possible Causes for Neonatal Jaundice

Neonatal Jaundice

BACKGROUND: Neonatal morbidity due to neonatal jaundice is an alarming situation, which needs to be detected and managed at the earliest possible. [ncbi.nlm.nih.gov]

[…] understood, development of a genetic test panel for risk of severe and/or prolonged neonatal jaundice may become feasible. [7] Once excreted into bile and transferred to [emedicine.com]

Many different etiologies come into play together, and at times, it is difficult to isolate the cause of neonatal jaundice. [ncbi.nlm.nih.gov]

Hereditary Spherocytosis

In this article the authors present a case of pathological neonatal jaundice resistant to phototherapy in a baby with a family history of Gilbert's syndrome and hereditary [ncbi.nlm.nih.gov]

We evaluated a neonate with severe jaundice but a negative family history. [ncbi.nlm.nih.gov]

ICD-10-CM Diagnosis Code P59.9 Neonatal jaundice, unspecified 2016 2017 2018 2019 Billable/Specific Code Code on Newborn Record Applicable To Neonatal physiological jaundice [icd10data.com]

Giant Cell Hepatitis

P59.29 P58.41 Neonatal jaundice due to drugs or toxins transmitted from mother P58.42 Neonatal jaundice due to drugs or toxins given to newborn P58.5 Neonatal jaundice due [icd10data.com]

Neonatal jaundice first becomes visible in the face and forehead. Blanching reveals the underlying colour. [patient.info]

jaundice from other and unspecified causes P59.0 Neonatal jaundice associated with preterm delivery P59.1 Inspissated bile syndrome P59.2 Neonatal jaundice from other and [icd10data.com]

Polycythemia Neonatorum

[…] damage P59.3 Neonatal jaundice from breast milk inhibitor P59.8 Neonatal jaundice from other specified causes P59.9 Neonatal jaundice, unspecified P60 Disseminated intravascular [icd10data.com]

Gallery images and information: Diagnosis Polycythemia Neonatorum pic source Neonatal Jaundice 1 638 x 479 jpeg 79kB pic source Neonatal Jaundice 1 638 x 479 jpeg 54kB pic [mnogolok.info]

P39.4 Neonatal skin infection Inclusion: Neonatal pyoderma| excludes: pemphigus neonatorum (L00)| staphylococcal scalded skin syndrome (L00)| P58.3 Neonatal jaundice due [codelay.com]

Fetal Erythroblastosis

The newborn can present with a number of features including: clinical evidence of a fetal anemia neonatal jaundice neonatal hepatosplenomegaly generalized body edema The condition [radiopaedia.org]

After birth, however, the immature neonatal liver is not capable of handling a high bilirubin load and this can result in severe neonatal jaundice. [patient.info]

Other causes of neonatal jaundice Intrauterine congenital infections (syphilis, cytomegalovirus, parvovirus). Erythrocyte membrane defects. [patient.info]

Kernicterus

Clinical experience with Sephadex gel filtration for evaluation of the bilirubin binding affinity of serum in neonatal jaundice is reported. [ncbi.nlm.nih.gov]

[…] return to top Physiological Jaundice Most of the cases of neonatal jaundice is physiological in nature and is not worrisome. [sharinginhealth.ca]

Indirect hyperbilirubinemia in the neonate. In: Maisels MJ, Watchko JF, editors. Neonatal Jaundice. [dovepress.com]

Biliary Atresia

Choledochal cyst and biliary atresia are rare but important causes of neonatal jaundice. Both present with jaundice and acholic stool in neonatal period. [ncbi.nlm.nih.gov]

METHODS: Twenty children with neonatal jaundice and no drainage as shown on the HIDA scan underwent a diagnostic laparoscopy through an umbilical 5 mm port. [ncbi.nlm.nih.gov]

Issues that should raise your concern: Prolonged neonatal jaundice Physiologic jaundice in healthy, full-term newborns typically resolves by the 5th or 6th day. [pedemmorsels.com]

Congenital Hemolytic Anemia

He required phototherapy for neonatal jaundice. [casesjournal.biomedcentral.com]

Clinical description Clinically, PK-deficient patients suffer from a highly variable degree of chronic hemolysis, ranging from severe neonatal jaundice and fatal anemia at [orpha.net]

The clinical picture of PK deficiency is variable, from hydrops fetalis to neonatal jaundice and anemia. 3 In our patient jaundice and anemia was present. [medcraveonline.com]

Neonatal Sepsis

The distribution of 70 respondents obtained as much 15 neonates have history neonatal sepsis of which 12 neonatal jaundice and 3 not became neonatal jaundice. [eprints.ums.ac.id]

Jaundice in the newborn breastfed babies. Pathological neonatal jaundice can be caused by a number of factors, including: blood group incompatibility;... [evidence.nhs.uk]

Late diagnosis of neonatal jaundice both increases the severity and complication. [ijp.mums.ac.ir]

Niemann-Pick Disease Type C

[…] type C (NP-C) is a lysosomal lipid storage disease (see this term) characterized by variable clinical signs, depending on the age of onset, such as prolonged unexplained neonatal [orpha.net]

We report the case of a Russian newborn with early-infantile onset Niemann-Pick disease type C who displayed prolonged neonatal jaundice and hepatosplenomegaly. [ncbi.nlm.nih.gov]

jaundice or cholestasis, isolated unexplained splenomegaly, and progressive, often severe neurological symptoms such as cognitive decline, cerebellar ataxia, vertical supranuclear [orpha.net]

Congenital Hypothyroidism

CASE DESCRIPTION: A female infant presenting with prolonged neonatal jaundice was found to have isolated CCH, with TSH of 2.2 mU/L (Reference range, 0.4-3.5) and free T4 of [ncbi.nlm.nih.gov]

ICD-10-CM Diagnosis Code P59.9 Neonatal jaundice, unspecified 2016 2017 2018 2019 Billable/Specific Code Code on Newborn Record Applicable To Neonatal physiological jaundice [icd10data.com]

(yellow) R17 ICD-10-CM Diagnosis Code R17 Unspecified jaundice 2016 2017 2018 2019 Billable/Specific Code Type 1 Excludes neonatal jaundice ( P55, P57 - P59 ) newborn P59.9 [icd10data.com]

Biliary Tree Disease

[…] obstructive Neonatal cholestasis North American Indian intrahepatic cholestasis Obstructive hyperbilirubinemia Obstructive jaundice Papillary mass of biliary tract Postpartum [icd9data.com]

(inflammatio of wall of bile ducts with entry of neutrophils into lumen). - sepsis dominates clinical picture. 1/3 of neonatal cholestasis. complete or partial obstruction [quizlet.com]

[…] extrahepatic and intrahepatic o Multiple cystic dilatations only of intrahepatic bile ducts (corresponds to Caroli disease, see Digestive Pathology lecture #6) - May cause: o Neonatal [medschool.lsuhsc.edu]

Congenital Liver Cirrhosis

Explain why fractionation of serum bilirubin is necessary in infants who remain jaundiced after 2 weeks of age. [pedsinreview.aappublications.org]

Keywords: Autopsy; Cholestatic Jaundice; Neonate. [indianpediatrics.net]

Characterize the syndrome of “neonatal hepatitis” and explain how it differs from viral hepatitis. [pedsinreview.aappublications.org]

TORCH Syndrome

IUGR), jaundice, hepatosplenomegaly, elevated transaminase concentrations, and thrombocytopenia. [pedsinreview.aappublications.org]

They include hepatosplenomegaly (enlargement of the liver and spleen), fever, lethargy, difficulty feeding, anemia, petechiae, purpurae, jaundice, and chorioretinitis. [en.wikipedia.org]

[…] system [CNS] manifestations, early jaundice, and low platelets), hence the usefulness of the TORCH concept. [accesspediatrics.mhmedical.com]

Alpha-1 Antitrypsin Deficiency

Severe (ZZ) AATD can also lead to neonatal jaundice and hepatitis in infancy and childhood that typically resolves before returning in a subset of individuals in the fourth [aacc.org]

Neonates with A1AT deficiency may present with neonatal jaundice and hepatitis; older children may develop hepatitis, cirrhosis and liver failure due to A1AT deficiency. [patient.info]

"An osteopathic approach to reduction of readmissions for neonatal jaundice". [en.wikipedia.org]

Gaucher Disease Type 2

NP-C can present in the neonatal period with fetal hydrops and cholestatic jaundice. [ncbi.nlm.nih.gov]

Zellweger Syndrome

neonatal jaundice Prolonged yellowing of skin in newborn 0006579 Protruding tongue Prominent tongue Tongue sticking out of mouth [ more ] 0010808 Pulmonary hypoplasia Small [rarediseases.info.nih.gov]

Neonatal seizures are frequent. Liver dysfunction may be evident as neonatal jaundice and elevation in liver function tests. [path.upmc.edu]

[…] stroma 0007759 Optic disc pallor 0000543 Patent ductus arteriosus 0001643 Pigmentary retinopathy 0000580 Posteriorly rotated ears Ears rotated toward back of head 0000358 Prolonged [rarediseases.info.nih.gov]

Hereditary North American Indian Childhood Cirrhosis

Manifesting first as transient neonatal jaundice, the disease evolves into periportal fibrosis and cirrhosis during a period ranging from childhood to adolescence. [orpha.net]

jaundice advances over time to biliary cirrhosis with severe liver fibrosis.[1] Eventually, liver failure occurs, and requires liver transplantation.[1] References[edit] [en.wikipedia.org]

[…] codes for cirhin.[2] NAIC is a ribosomopathy.[3][4] An R565W mutation of CIRH1A[2][5] leads to partial impairment of cirhin interaction with NOL11.[5] Initial transient neonatal [en.wikipedia.org]

Acute Hepatic Porphyria

No-charge genetic testing for acute hepatic porphyria Alnylam has partnered with Invitae to offer genetic testing at no charge for individuals who may carry a gene mutation known to be associated with acute hepatic porphyria (AHP). On average, it takes up to 15 years from symptom onset for a patient to receive[…] [invitae.com]

Mucopolysaccharidosis

Mucopolysaccharidoses (MPS) are lysosomal storage disorders caused by the deficiency of enzymes needed for the stepwise breakdown of glycosaminoglycans (also known as mucopolysaccharides). During the last decades the enzyme deficiencies underlying each disease – as well as the molecular defects causing them –[…] [news-medical.net]

Gaucher Disease

Summary Epidemiology The prevalence is approximately 1/100,000. The annual incidence of GD in the general population is about 1/60,000, but it can reach up to 1/1,000 in Ashkenazi Jewish populations. Clinical description The clinical manifestations of this disease are highly variable. GD type 1 (90% of cases) is the chronic[…] [orpha.net]

Myxedema

Myxedema coma occurs as a result of long-standing, undiagnosed, or undertreated hypothyroidism and is usually precipitated by a systemic illness. Myxedema coma can result from any of the causes of hypothyroidism, most commonly chronic autoimmune thyroiditis. It can also occur in patients who had thyroidectomy or[…] [emedicine.com]

Crigler-Najjar Syndrome Type 1

Physiological neonatal jaundice may peak at 85–170 µmol/l and decline to normal adult concentrations within two weeks. Prematurity results in higher levels. [en.wikipedia.org]

jaundice, unspecified 2016 2017 2018 2019 Billable/Specific Code Code on Newborn Record Applicable To Neonatal physiological jaundice (intense)(prolonged) NOS due to or associated [icd10data.com]

Differential diagnosis [ edit ] Neonatal jaundice may develop in the presence of sepsis, hypoxia, hypoglycemia, hypothyroidism, hypertrophic pyloric stenosis, galactosemia [en.wikipedia.org]

Exchange Transfusion

[…] should not be discounted. [32] The purpose of treating neonatal jaundice is to avoid neurotoxicity. [emedicine.medscape.com]

Neonatal hemolytic diseases. Journal of Organization of Blood Transfusion 2000; 19: 1-3. 14. Lucus GN. Neonatal Jaundice due to ABO-in compatibility in Sirilanka. [jpma.org.pk]

Guidelines for management of neonatal jaundice currently in use in all pediatric departments in Norway. [emedicine.medscape.com]

Gilbert Syndrome

The role of GS in neonatal jaundice is unknown. [ncbi.nlm.nih.gov]

Sukru Aynacioglu, Reinhold Kerb, Murat Yurdakok and Atila Bozkurt, Neonatal Jaundice and Bilirubin UDP‐Glucuronosyl Transferase 1A1 Gene Polymorphism in Turkish Patients, [doi.org]

Although peak jaundice levels did not differ among groups, newborn infants with the molecular marker for GS have an accelerated increase in neonatal jaundice during the first [ncbi.nlm.nih.gov]

Mucopolysaccharidosis Type 7

At Pappas Capital, we are dedicated to furthering life science discoveries and bringing groundbreaking solutions to market. 05.09.2019 Montreal and Charlotte, NC, May 8, 2019 — Milestone Pharmaceuticals ... Read More Pappas Capital is laser focused on the life science sector. For nearly 25 years we have been investing[…] [pappasventures.com]

Glucose-6-Phosphate Dehydrogenase Deficiency

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the commonest enzyme disorder of human beings and a globally important cause of neonatal jaundice, which can lead to [ncbi.nlm.nih.gov]

G6PD deficiency is found to one important cause of neonatal jaundice developing on day 2 onwards. [ncbi.nlm.nih.gov]

BACKGROUND: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an X-linked disorder which causes neonatal jaundice in most cases, and under certain conditions, can cause [ncbi.nlm.nih.gov]

Favism

Prolonged neonatal jaundice is serious and should be followed up promptly. [en.wikipedia.org]

There was no family history of favism or neonatal jaundice. The baby received transfusions and the parents were advised about the food and drugs to be avoided. [imagebank.hematology.org]

Neonatal jaundice Other names Neonatal hyperbilirubinemia, neonatal icterus, jaundice in newborns Jaundice in a newborn Specialty Pediatrics Symptoms Yellowish discoloration [en.wikipedia.org]

Rotor Syndrome

Serum levels of zinc and bilirubin were compared for 114 neonates without jaundice jaundice(control group) and 149 neonates with jaundice (case group) using atomic absorption [ijp.mums.ac.ir]

A biliblanket is a portable phototherapy device for the treatment of neonatal jaundice ( hyperbilirubinemia ). [diki.pl]

Inheritance: autosomal recessive Clinical features Excessive, persistent neonatal jaundice Neurological symptoms caused by kernicterus Diagnosis ↑↑ Indirect bilirubin (20– [amboss.com]

Pyruvate Kinase Deficiency

RESULTS: 7 of the 218 cases of neonatal jaundice were PK deficient with 30-40% reduction in PK activity. [ncbi.nlm.nih.gov]

These data demonstrate that G6PD deficiency is an important cause for neonatal jaundice in Egyptians. Neonatal screening for its deficiency is recommended. [ncbi.nlm.nih.gov]

We discovered four neonates with PK deficiency born in a small community of polygamists. All four had early, severe, hemolytic jaundice. [ncbi.nlm.nih.gov]