Neonatal Tetany: Causes & Reasons

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Possible Causes for Neonatal Tetany

Neonatal Hypocalcemia

tetany occur in excessive incidence. [ncbi.nlm.nih.gov]

Abstract Findings in a case of neonatal tetany in a child whose mother had elevated blood parathyroid hormone levels because of a parathyroid adenoma are given. [annals.org]

CASES of neonatal tetany not due to rickets were reported in the early 1900's. [nejm.org]

Tetanus

[…] hypocalcaemia) 제외：신생아 부갑상선 기능저하증(neonatal hypoparathyroidism)(P71.4) P71.2 신생아 저마그네슘혈증(Neonatal hypomagnesaemia) P71.3 칼슘 또는 마그네슘 결핍이 없는 신생아 파상풍(Neonatal tetany without calcium [dic.impact.pe.kr]

Abstract Neonatal tetanus is a severe, often fatal disease caused by the toxin Clostridium tetani. [ncbi.nlm.nih.gov]

Agent [ Bearbeiten ] Clostridium tetani tetanospasmin tetanospasmin Symptoms [ Bearbeiten ] Spasms Spasms Neonatal tetanus Lock-jaw Prevalence and Treatment [ Bearbeiten ] [commons.wikimedia.org]

Hypocalcemia

Neonates may have hypotonia, tachycardia, tachypnea, apnea, poor feeding, jitteriness, tetany, and/or seizures. [msdmanuals.com]

Between 5 and 10 days of life, "late" neonatal hypocalcemia may result in tetany and seizures. [web.archive.org]

Signs include hypotonia, tachycardia, tachypnea, apnea, poor feeding, jitteriness, tetany, and seizures. [msdmanuals.com]

Hyperphosphatemia

Hyperphosphatemia is a common condition in patients with decreased kidney function, and without treatment, it can lead to a variety of clinical consequences. However, the presence of hyperphosphatemia in patients with normal kidney function may be true or spurious. We present a case of pseudohyperphosphatemia in[…] [ncbi.nlm.nih.gov]

Acid-Base Imbalance

Disturbances in acid-base balance, such as acidosis and alkalosis, have potential to alter the pharmacologic and toxicologic outcomes of statin therapy. Statins are commonly prescribed for elderly patients who have multiple comorbidities such as diabetes mellitus, cardiovascular, and renal diseases. These patients are[…] [ncbi.nlm.nih.gov]

Sepsis of Newborn due to Other and Unspecified Streptococci

[…] disorders of calcium and magnesium metabolism P710 Cow's milk hypocalcaemia in newborn P711 Other neonatal hypocalcaemia P712 Neonatal hypomagnesaemia P713 Neonatal tetany [dentisty.org]

[…] hypocalcaemia P71.2 Neonatal hypomagnesaemia P71.3 Neonatal tetany without calcium or magnesium deficiency P71.4 Transitory neonatal hypoparathyroidism P71.8 Other transitory [whatdotheyknow.com]

Neonatal hypomagnesaemia P71.3 Neonatal tetany without calcium or magnesium deficiency Neonatal tetany NOS P71.4 Transitory neonatal hypoparathyroidism P71.8 Other transitory [embryology.med.unsw.edu.au]

Immunodeficiency due to MASP-2 Deficiency

[…] hypocalcemia, which may present as tetany or seizures, due to hypoplasia of the parathyroid glands, and susceptibility to infection due to a deficit of T cells; micrognathia [panelapp.genomicsengland.co.uk]

(DGS/VCFS) region (proximal region, LCR22-A to -D) Loss was changed to 22q11.2 recurrent (DGS/VCFS) region (proximal, A-D) (includes TBX1) Loss Added phenotypes 188400; neonatal [panelapp.genomicsengland.co.uk]

[…] hypocalcemia, which may present as tetany or seizures, due to hypoplasia of the parathyroid glands, and susceptibility to infection due to a deficit of T cells; Velocardiofacial [panelapp.genomicsengland.co.uk]

Hyperekplexia Type 4

neonatal tetany, and phenothiazine toxicity.40 41 Hyperekplexia may also be misdiagnosed as cerebral palsy.7 The differential diagnoses in adulthood includes neurological [pmj.bmj.com]

Differential diagnosis The differential diagnoses of hyperekplexia in the neonatal period include the congenital stiff-man syndrome, startle epilepsy, myoclonic seizures, [pmj.bmj.com]

Lymphopenic Agammaglobulinemia - Short-Limbed Dwarfism Syndrome

tetany  viral, fungal and bacterial infection 15. [slideshare.net]

Infants often have neonatal tetany with hypocalcemia due to the aplastic parathyroid glands. [plasticsurgerykey.com]

It presents the neonate with hypocalcemic tetany due to severe hypoparathyrodism. [web2.uwindsor.ca]

Tryptophanemia

The common causes are primary neonatal tetany, asphyxia, birth trauma, maternal diabetes, exchange transfusion, IPPV, repaired tracheoesophageal fistula, hypoparathyroidism [atulchoube.wordpress.com]

HYPOCALCIMIA : This causes neonatal seizures particularly after 3 rd day of life. The seizures are of multifocal variety without loss of consciousness. [atulchoube.wordpress.com]

Primary Hypomagnesemia with Secondary Hypocalcemia

Here we present a 14-year-old Turkish girl whose first symptoms manifested as neonatal tetany at 17 days old. [degruyter.com]

The onset of tetany and/or convulsion was between the 9th day and 4th month, which is later than that of other neonatal hypocalcemic illnesses. [ncbi.nlm.nih.gov]

Developmental and Epileptic Encephalopathy Type 8

neonatal tetany, and phenothiazine toxicity.40 41 Hyperekplexia may also be misdiagnosed as cerebral palsy.7 The differential diagnoses in adulthood includes neurological [pmj.bmj.com]

neonatal tetany, and phenothiazine toxicity. 40 41 Hyperekplexia may also be misdiagnosed as cerebral palsy. 7 The differential diagnoses in adulthood includes neurological [pmj.bmj.com]

Differential diagnosis Hyperekplexia in the neonatal period may be misdiagnosed as congenital stiff-man syndrome, startle epilepsy, myoclonic seizures, neonatal tetany, cerebral [medlink.com]

Calcium Gluconate

tetany. [gov.uk]

Calcium Gluconate is used in the treatment of disorders with negative calcium balance, including Vitamin D deficiency, hypoparathyroidism, neonatal tetany and alkalosis. [nclexpreceptor.com]

tetany and tetany due to parathyroid deficiency, vitamin D deficiency and alkalosis. [rxmed.com]

Rare Hyperparathyroidism

Barton (1970): Hyperparathyroidism and atute post partum pancreatitis with neonatal tetany in the child. Am. J. Med. Sci. 260, 160–164. [link.springer.com]

All mothers with neonates showing tetany or seizures should have serum calcium concentrations checked to exclude primary hyperparathyroidism. [bmj.com]

Acute neonatal hypocalcaemia results in tetany and convulsions, usually at 5 to 14 days of age. 6 If the infant is breast fed, tetany can be delayed by one month or more. [bmj.com]

Autoimmune Hypoparathyroidism

2016 2017 2018 2019 Billable/Specific Code Applicable To Carpopedal spasm Type 1 Excludes hysterical tetany ( F44.5 ) neonatal tetany ( P71.3 ) parathyroid tetany ( E20.9 [icd10data.com]

( F44.5 ) neonatal tetany ( P71.3 ) parathyroid tetany ( E20.9 ) post-thyroidectomy tetany ( E89.2 ) parathyroid E20.9 (gland) ICD-10-CM Codes Adjacent To E20.9 E16.1 Other [icd10data.com]

E20.9 Tetany (due to) R29.0 ICD-10-CM Diagnosis Code R29.0 Tetany 2016 2017 2018 2019 Billable/Specific Code Applicable To Carpopedal spasm Type 1 Excludes hysterical tetany [icd10data.com]

Secondary Hypoparathyroidism

2016 2017 2018 2019 Billable/Specific Code Applicable To Carpopedal spasm Type 1 Excludes hysterical tetany ( F44.5 ) neonatal tetany ( P71.3 ) parathyroid tetany ( E20.9 [icd10data.com]

( F44.5 ) neonatal tetany ( P71.3 ) parathyroid tetany ( E20.9 ) post-thyroidectomy tetany ( E89.2 ) parathyroid E20.9 (gland) ICD-10-CM Codes Adjacent To E20.9 E16.1 Other [icd10data.com]

E20.9 Tetany (due to) R29.0 ICD-10-CM Diagnosis Code R29.0 Tetany 2016 2017 2018 2019 Billable/Specific Code Applicable To Carpopedal spasm Type 1 Excludes hysterical tetany [icd10data.com]

Neonatal Severe Hyperparathyroidism

The two other cases were diagnosed with neonatal tetany and had surgical treatment after delivery. [iss.ndl.go.jp]

Neonatal hypocalcemia with tetany is usually a transient phenomenon related to suppression of fetal parathyroid glands resulting from maternal-fetal hypercalcemia, it may [womenshealthsection.com]

If hypercalcemia is detected, during pregnancy or neonatal tetany occurs, it is mandatory to rule out primary hyperparathyroidism. [iss.ndl.go.jp]

Psychogenic Hyperventilation

( F44.5 ) neonatal tetany ( P71.3 ) parathyroid tetany ( E20.9 ) post-thyroidectomy tetany ( E89.2 ) hyperpnea R06.4 hyperventilation R06.4 - see also Hyperventilation ICD [icd10data.com]

tetany (F44.5) neonatal tetany (P71.3) parathyroid tetany (E20.9) post-thyroidectomy tetany (E89.2) hyperpnea R06.4 hyperventilation R06.4 - see also Hyperventilation ICD [icd10data.com]

R06.4 Tetany (due to) R29.0 ICD-10-CM Diagnosis Code R29.0 Tetany 2016 2017 2018 2019 Billable/Specific Code Applicable To Carpopedal spasm Type 1 Excludes hysterical tetany [icd10data.com]

Neonatal Scleroderma

[…] hypocalcemia Excludes 1: neonatal hypoparathyroidism (P71.4) P71.2 Neonatal hypomagnesemia P71.3 Neonatal tetany without calcium or magnesium deficiency Includes: Neonatal [app.drchrono.com]

[…] disorders of calcium and magnesium metabolism P71.0 Cow's milk hypocalcaemia in newborn P71.1 Other neonatal hypocalcaemia Excl.: neonatal hypoparathyroidism (P71.4) P71.2 [embryology.med.unsw.edu.au]

Acute Hyperventilation

( F44.5 ) neonatal tetany ( P71.3 ) parathyroid tetany ( E20.9 ) post-thyroidectomy tetany ( E89.2 ) hyperpnea R06.4 hyperventilation R06.4 - see also Hyperventilation ICD [icd10data.com]

R06.4 Tetany (due to) R29.0 ICD-10-CM Diagnosis Code R29.0 Tetany 2016 2017 2018 2019 Billable/Specific Code Applicable To Carpopedal spasm Type 1 Excludes hysterical tetany [icd10data.com]

(nocturnal) (paroxysmal) R06.00 ICD-10-CM Diagnosis Code R06.00 Dyspnea, unspecified 2016 2017 2018 2019 Billable/Specific Code hyperventilation R06.4 Hyperventilation (tetany [icd10data.com]

Tetanus Neonatorum

Synonyms: neonatal tetanus. (05 Mar 2000) [mondofacto.com]

tetani infections in newborn infants: a tetanus neonatorum review. ( 23949463 ) Gomes A.P....Siqueira-Batista R. 2011 27 Validation of elimination of neonatal tetanus in [malacards.org]

tetani infections in newborn infants: a tetanus neonatorum review. ( 23949463 ) Gomes A.P....Siqueira-Batista R. 2011 27 Completeness of reporting and case ascertainment [malacards.org]

Perinatal Atelectasis

[…] and hypomagnesemia of newborn Cow's milk hypocalcemia Hypocalcemic tetany, neonatal Neonatal hypoparathyroidism Phosphate-loading hypocalcemia 775.5 Other transitory neonatal [theodora.com]

Metabolic Alkalosis

neonatal tetany ( P71.3 ) parathyroid tetany ( E20.9 ) post-thyroidectomy tetany ( E89.2 ) alkalosis E87.3 ICD-10-CM Codes Adjacent To E87.3 E85.9 Amyloidosis, unspecified [icd10data.com]

(due to) R29.0 ICD-10-CM Diagnosis Code R29.0 Tetany 2016 2017 2018 2019 Billable/Specific Code Applicable To Carpopedal spasm Type 1 Excludes hysterical tetany ( F44.5 ) [icd10data.com]

[…] elsewhere classified 2016 2017 2018 2019 Billable/Specific Code Applicable To Electrolyte imbalance NOS Hyperchloremia Hypochloremia alkalosis E87.3 (metabolic) (respiratory) Tetany [icd10data.com]

Vitamin D Deficiency

Maternal deficiency can cause tetany in neonates. Osteomalacia predisposes to fractures. In the elderly, hip fractures may result from only minimal trauma. [merckmanuals.com]

tetany Characteristic bone changes seen on x-ray X-rays of the radius and ulna plus serum levels of calcium, phosphate, alkaline phosphatase, PTH, and 25(OH)D are needed [merckmanuals.com]

Tetany may cause paresthesias of the lips, tongue, and fingers; carpopedal and facial spasm; and, if very severe, seizures. [merckmanuals.com]

Primary Immune Deficiency Disorder

tetany(absence of parathyroid) • Therapy: Thymic transplants 17. • Cleft palate • Antimongoloid eyes • Short philtrum with fish-mouth appearance, • Micrognathia • Low set [slideshare.net]

Other presentations are neonatal hypocalcemic tetany stemming from hypoparathyroidism and congenital cardiovascular anomalies, especially of the great vessels and septa. [ajronline.org]

[…] called thymic hypoplasia • Congenital disorder • Abnormalities in structure derived from 3rd and 4th pharyngeal pouches • Predominantly T cell defect • Charactersitics: Neonatal [slideshare.net]

Hyperventilation

( F44.5 ) neonatal tetany ( P71.3 ) parathyroid tetany ( E20.9 ) post-thyroidectomy tetany ( E89.2 ) hyperpnea R06.4 hyperventilation R06.4 - see also Hyperventilation ICD [icd10data.com]

R06.4 Tetany (due to) R29.0 ICD-10-CM Diagnosis Code R29.0 Tetany 2016 2017 2018 2019 Billable/Specific Code Applicable To Carpopedal spasm Type 1 Excludes hysterical tetany [icd10data.com]

(nocturnal) (paroxysmal) R06.00 ICD-10-CM Diagnosis Code R06.00 Dyspnea, unspecified 2016 2017 2018 2019 Billable/Specific Code hyperventilation R06.4 Hyperventilation (tetany [icd10data.com]

Hereditary Hyperekplexia

neonatal tetany, and phenothiazine toxicity. 40 41 Hyperekplexia may also be misdiagnosed as cerebral palsy. 7 The differential diagnoses in adulthood includes neurological [pmj.bmj.com]

Differential diagnosis The differential diagnoses of hyperekplexia in the neonatal period include the congenital stiff-man syndrome, startle epilepsy, myoclonic seizures, [pmj.bmj.com]

Enamel Hypoplasia

tetany. [15] Furthermore, disturbances in the development of the enamel of permanent teeth can result from trauma to the primary teeth because of the close proximity of the [doi.org]

tetany.[ 15 ] Furthermore, disturbances in the development of the enamel of permanent teeth can result from trauma to the primary teeth because of the close proximity of [ncbi.nlm.nih.gov]

[…] local trauma can lead to DDE. [14] Enamel hypoplasia can also be seen in other pediatric conditions in which hypocalcemia is a major sign as in rickets, prematurity and neonatal [doi.org]

Vitamin D-Dependent Rickets

Hypocalcemia may present with irritability, tetany, seizures, apnea (in the neonate), laryngospasm or paresthesias (in the older child). [clinicaladvisor.com]

Hypercalcemia during pregnancy may also lead to suppression of parathyroid hormone release in the neonate, resulting in hypocalcemia, tetany and seizures. [rxmed.com]

Children: Severe vitamin D deficiency may cause hypocalcaemic seizures or tetany, particularly in the neonatal period and during periods of rapid growth in adolescence. [patient.info]

Clostridium Tetani

This neonate is displaying a bodily rigidity produced by Clostridium tetani exotoxin, called neonatal tetanus. [ppdictionary.com]

Publications "The genome sequence of Clostridium tetani, the causative agent of tetanus disease." [uniprot.org]

[…] controlled through immunization with tetanus toxoid; nevertheless, according to the World Health Organization, an estimated 400,000 cases still occur each year, mainly of neonatal [ncbi.nlm.nih.gov]