Neurodegeneration Causes & Reasons

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Neurodegeneration Symptom Checker: Possible causes include Alzheimer Disease. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search.

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Possible Causes

Alzheimer Disease

Furthermore, in DLB, Aβ 1–42 may promote α-synuclein accumulation and neurodegeneration. [dx.doi.org]

A. (2003) Alpha-synuclein overexpression protects against paraquat-induced neurodegeneration. J. Neurosci. 23, 3095–3099. [dx.doi.org]

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Pallidopyramidal Syndrome

Pantothenate kinase-associated neurodegeneration (PKAN) and PLA2G6-associates neurodegeneration (PLAN): Review of two major neurodegeneration with brain iron accumulation [annalsofian.org]

AB - Kufor-Rakeb syndrome is an autosomal recessive nigro-striatal-pallidal-pyramidal neurodegeneration. [research.manchester.ac.uk]

Understanding how FBXO7 mutations cause disease will shed further light on the molecular mechanisms of neurodegeneration, with potential implications also for more common [moh-it.pure.elsevier.com]

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Wolfram Syndrome

This work is necessary to position the field for future clinical trials to test interventions for WFS neurodegeneration. [clinicaltrials.gov]

In patients with Wolfram syndrome, these mechanisms underlie progressive neurodegeneration and endocrine dysfunction. [care.diabetesjournals.org]

Ultimately, a better understanding of the trajectory of neurodegeneration in WFS and the development of effective interventions may be relevant to other more common neurodegenerative [clinicaltrials.gov]

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Parkinson Disease

In this review, we address the current concept of neuroinflammation and its involvement in PD-associated neurodegeneration. [ncbi.nlm.nih.gov]

However, 5-10% of PD cases are inherited as monogenic diseases, which provides a chance to understand the molecular mechanisms underlying neurodegeneration. [ncbi.nlm.nih.gov]

Open Access Review 1 Department of Biological Sciences, The University of Alabama, Tuscaloosa, AL 35487, USA 2 Departments of Neurology and Neurobiology, Center for Neurodegeneration [doi.org]

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Lafora Disease

These animals did not show the increase in markers of neurodegeneration, the impairments in electrophysiological properties of hippocampal synapses, nor the susceptibility [ncbi.nlm.nih.gov]

Lafora disease is a metabolic disorder resulting in accumulation of water-insoluble glucan in the cytoplasm, and manifests as a debilitating neurodegeneration that ends with [ncbi.nlm.nih.gov]

Our results emphasize the relevance of the laforin-malin complex in the control of glycogen metabolism and highlight altered glycogen accumulation as a key contributor to neurodegeneration [ncbi.nlm.nih.gov]

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Spinal and Bulbar Muscular Atrophy

Pre-clinical studies using animal models show that the pathogenic AR-mediated neurodegeneration is suppressed by androgen inactivation, the efficacy of which has been tested [ncbi.nlm.nih.gov]

Animal studies have revealed that the pathogenesis of SBMA depends on the level of serum testosterone, and that androgen deprivation mitigates neurodegeneration through inhibition [ncbi.nlm.nih.gov]

AR induces diverse molecular events, such as transcriptional dysregulation, axonal transport disruption, and mitochondrial dysfunction, which play causative roles in the neurodegeneration [ncbi.nlm.nih.gov]

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Hallervorden-Spatz Syndrome

(disorder) Pigmentary pallidal degeneration Neurodegeneration With Brain Iron Accumulation type 1 Pantothenate Kinase-Associated Neurodegeneration NEURODEGENERATION WITH [wikidata.org]

neurodegeneration; PKAN pantothenate kinase-associated neurodegeneration; XL X-linked 1. [ncbi.nlm.nih.gov]

BRAIN IRON ACCUMULATION 1; NBIA1 PKAN Pkan Neuroaxonal Dystrophy, Juvenile-Onset edit English pantothenate kinase-associated neurodegeneration A neurodegeneration with brain [wikidata.org]

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X-linked Parkinsonism-Spasticity Syndrome

Test Registry Neurodegeneration With Brain Iron Accumulation 3 Basal Ganglia Disease, Adult-Onset Neuroferritinopathy NBIA3 606159 Genetic Test Registry Neurodegeneration [ukgtn.nhs.uk]

MeSH Descriptor Source: MeSH 2019 deskriptory Main Heading Hallervordenův-Spatzův syndrom English Heading Pantothenate Kinase-Associated Neurodegeneration See (Czech) neurodegenerace [medvik.cz]

Amyotrophic lateral sclerosis, susceptibility to DNAJC6 Parkinson disease 19a, juvenile-onset EIF4G1 Parkinson disease 18 FBXO7 Parkinson disease 15, autosomal recessive FTL Neurodegeneration [asperbio.com]

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Neuronal Ceroid Lipofuscinosis

Thus, we sought to determine whether this pathway of apoptosis contributes to rapid neurodegeneration in INCL. [doi.org]

Mutant dnj-14 worms also exhibited age-dependent neurodegeneration of sensory neurons, which was preceded by severe progressive chemosensory defects. [ncbi.nlm.nih.gov]

Autosomal-dominant adult-onset neuronal ceroid lipofuscinosis (ANCL) is characterized by accumulation of autofluorescent storage material in neural tissues and neurodegeneration [ncbi.nlm.nih.gov]

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McLeod Neuroacanthocytosis Syndrome

The mechanism by which these mutations cause neurodegeneration is not known. dcterms:identifier kegg:H00832 void:inDataset Bio2RDF identifier H00832 Bio2RDF namespace kegg [bio2rdf.org]

HARP syndrome is allelic with pantothenate kinase-associated neurodegeneration. [ncbi.nlm.nih.gov]

The mechanism by which these mutations cause neurodegeneration is not known. [genome.jp]

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Progressive Myoclonic Epilepsy Type 3

Neurodegeneration and regression occur with seizure onset. Other features include mental retardation, dysarthria, truncal ataxia, and loss of fine finger movements. [malacards.org]

Symptoms The list of signs and symptoms mentioned in various sources for Epilepsy, progressive myoclonic 3 includes the 6 symptoms listed below: * Myoclonic epilepsy * Neurodegeneration [checkorphan.org]

[…] myoclonic type 3 The list of signs and symptoms mentioned in various sources for Epilepsy, progressive myoclonic 3 includes the 6 symptoms listed below: * Myoclonic epilepsy * Neurodegeneration [checkorphan.org]

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Neurodegenerative Disorder

In addition, it is the progressive neurodegeneration which determines the amount of accumulating clinical disability. [ncbi.nlm.nih.gov]

All of these conditions lead to progressive brain damage and neurodegeneration. [news-medical.net]

[…] and Repair: The interdepartmental program in Cellular Neuroscience, Neurodegeneration and Repair (CNNR) will accelerate the pace of Yale's research on neurodegeneration diseases [medicine.yale.edu]

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REM Sleep Behavior Disorder

So far, the number of studies assessing predictive markers of neurodegeneration in RBD is limited. [n.neurology.org]

[…] treatment consequences of RBD in the context of neurodegeneration. 2018 S. Karger AG, Basel. [ncbi.nlm.nih.gov]

"Rapid-eye movement sleep behavior disorder is not just a precursor but also a critical warning sign of neurodegeneration that can lead to brain disease," John Peever, associate [universityherald.com]

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Primary Progressive Multiple Sclerosis

Spinal neurodegeneration is an important determinant of disability progression in patients with primary progressive multiple sclerosis. [ncbi.nlm.nih.gov]

The effect of current immunomodulatory treatments on neurodegeneration is insufficient. [ncbi.nlm.nih.gov]

Studies on the histology and pathogenesis show that neurodegeneration is predominant over inflammation in PPMS, even if cellular and humoral immune-mediated mechanisms are [ncbi.nlm.nih.gov]

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Huntington Disease

In this review we consider the current status of research in the field and possible mechanisms whereby the HD mutation might result in neurodegeneration. [ncbi.nlm.nih.gov]

Regulation of autophagy by polyphenols: Paving the road for treatment of neurodegeneration. Biotechnology Advances, Vol. 36, Issue. 6, p. 1768. [dx.doi.org]

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Amyotrophic Lateral Sclerosis

Here we review some of the recent progress in promoting therapeutic strategies for neurodegeneration. [doi.org]

This review aims to investigate how oxidative stress can affect other proposed mechanisms of neurodegeneration in ALS. [ncbi.nlm.nih.gov]

Strategies for clinical approach to neurodegeneration in amyotrophic lateral sclerosis Cecilia Carlesi, Livia Pasquali, Selina Piazza, Annalisa Lo Gerfo, Elena Caldarazzo [doi.org]

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Spinocerebellar Ataxia Type 1

The objective of this study is to evaluate neurochemical changes associated with neurodegeneration in cerebral tissue in SCA1 patients compared to age- and gender-matched [ncbi.nlm.nih.gov]

Keywords Neurodegeneration Polyglutamine Therapeutic approaches References 1. [doi.org]

These data demonstrate that presymptomatic and progressive neurodegeneration in SCA1 can be noninvasively monitored using MRS. [ncbi.nlm.nih.gov]

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Progressive Myoclonic Epilepsy Type 8

Knockdown of Cers1 in mouse neuroblastoma cells triggered endoplasmic reticulum stress, the unfolded protein response, and apoptosis, suggesting a mechanism for neurodegeneration [onlinelibrary.wiley.com]

[…] levels of ceramides and sphingolipids containing very long‐chain fatty acids have been associated with many neurodegenerative disorders, including cerebellar Purkinje cell neurodegeneration [onlinelibrary.wiley.com]

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Progressive Supranuclear Palsy

CurePSP CurePSP is the leading source of information and support for patients and their families, other caregivers, researchers, and healthcare professionals on prime of life neurodegeneration [psp.org]

Neurodegeneration: the molecular pathology of dementia and movement disorders. Basel : ISN Neuropath Press ; 2003. p. 103 – 14. 5. [doi.org]

Progressive Supranuclear Palsy: A Review of Co-existing Neurodegeneration To send this article to your Dropbox account, please select one or more formats and confirm that [doi.org]

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Gordon-Holmes Syndrome

KEYWORDS: Ataxia; CHIP; Dementia; Early onset ataxia; Early-onset dementia; Gordon Holmes syndrome; Hypogonadism; Magnetic resonance imaging; Neurodegeneration; Neurodegenerative [ncbi.nlm.nih.gov]

STUB1/CHIP mutations cause Gordon Holmes syndrome as part of a widespread multisystemic neurodegeneration: evidence from four novel mutations. [miami.pure.elsevier.com]

STUB1/CHIP mutations cause Gordon Holmes syndrome as part of widespread multisystemic neurodegeneration: Evidence from novel mutations [abstract]. [mdsabstracts.org]

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Neonatal Adrenoleukodystrophy

The childhood form of the disease is quite devastating as the primary damage is of the form of a progressive neurodegeneration with symptoms that expand from mild to severe [ald.org.nz]

This form of ALD usually progresses rapidly, causes neurodegeneration, and results in death in infancy or young childhood. [healthprioritiesinc.com]

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Ataxia Telangiectasia

Our results define a crucial role of the cellular localization of HDAC4 in the events leading to ataxia telangiectasia neurodegeneration. [ncbi.nlm.nih.gov]

The symptoms of ataxia-telangiectasia (A-T) include a progressive neurodegeneration caused by ATM protein deficiency. [ncbi.nlm.nih.gov]

Abstract The symptoms of ataxia-telangiectasia (A-T) include a progressive neurodegeneration caused by ATM protein deficiency. [doi.org]

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Autosomal Recessive Spastic Paraplegia Type 43

Exome sequencing revealed a homozygous missense variant (c.187G C; p.Ala63Pro) in C19orf12, a gene recently implicated in neurodegeneration with brain [spatax.wordpress.com]

Exome sequencing revealed a homozygous missense variant (c.187G C; p.Ala63Pro) in C19orf12, a gene recently implicated in neurodegeneration with brain iron accumulation (NBIA [experts.umich.edu]

Exome sequencing revealed a homozygous missense variant (c.187G C; p.Ala63Pro) in C19orf12, a gene recently implicated in neurodegeneration with brain ABSTRACT We report here [spatax.wordpress.com]

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Menkes Disease

These diseases are characterized by neurological phenotypes ranging from intellectual disability to neurodegeneration. [ncbi.nlm.nih.gov]

Currently, no therapy effectively arrests the relentless neurodegeneration of Menkes' disease. [ncbi.nlm.nih.gov]

Menkes disease is an X-linked genetic disorder of copper transport that results in death from severe progressive neurodegeneration by the age of 3 years. [ncbi.nlm.nih.gov]

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Classic Progressive Supranuclear Palsy Syndrome

The factors that initiate tau-neurodegeneration are unknown. Diagnostic methods Diagnosis is based on the clinical picture and neuropsychological evaluation. [orpha.net]

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Prion Disease

To investigate the involvement of GPI-PLD in the processes of neurodegeneration in prion diseases, we examined the mRNA and protein expression levels of GPI-PLD in the brains [ncbi.nlm.nih.gov]

However, despite considerable research effort, the molecular mechanisms underlying prion-induced neurodegeneration are poorly understood. [ncbi.nlm.nih.gov]

It is therefore expected that some of these prion-modifier genes may be of wider relevance in neurodegeneration. The Author 2014. Published by Oxford University Press. [ncbi.nlm.nih.gov]

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Dentatorubral-Pallidoluysian Atrophy

It has been discussed in Huntington's disease that expanded polyglutamine can lead to oxidative neurodegeneration. [ncbi.nlm.nih.gov]

Youdim Springer Science & Business Media, 06.12.2012 - 216 Seiten We organized the Seventh International Winter Conference on Neurodegeneration and Neuroinflammation in a [books.google.de]

We attempted to quantify global and region-specific neurodegeneration in DRPLA using analysis of apparent diffusion coefficient (ADC) maps. [ncbi.nlm.nih.gov]

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Niemann-Pick Disease

Oral administration of SAHA prevents oxidative stress and neurodegeneration, and improves behavioral performance in ASMko mice. [ncbi.nlm.nih.gov]

Hepatic NPC1 re-expression did not ameliorate the onset and progression of neurodegeneration of the NPC1-null animal. [ncbi.nlm.nih.gov]

Patients with type A NPD exhibit neurodegeneration beginning at three months of age and death by three years of age. [symptoma.com]

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Machado-Joseph Disease

namely at early stages of another polyglutamine-related disorder such as Huntington's disease, we now tested their ability to control MJD-associated neurodegeneration. [ncbi.nlm.nih.gov]

Selective neurodegeneration in MJD is evident in several subcortical brain regions including the cerebellum. [ncbi.nlm.nih.gov]

Since these findings were detected both by lifetime images and by postmortem examination, MRI intensity changes could track the progression of neurodegeneration. [ncbi.nlm.nih.gov]

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Motor Neuron Disease

Neurodegeneration 1995 ; 4 : 209 –16. Spreux-Varoquaux O, Bensimon G, Lacomblez L, et al. [doi.org]

Renaud -- Neurodegeneration with brain iron accumulation, Wilson disease, manganism / Alisdair McNeill. [worldcat.org]

[…] cellular signature of aggregated TDP-43 common to nearly all MND and a large proportion of frontotemporal dementia (FTD), has placed MND alongside more traditional cerebral neurodegeneration [ncbi.nlm.nih.gov]

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