Neurodegeneration Causes & Reasons

Neu starten

Ad Html Headline Ad Text Headline

Ad Label Ad Html Description Ad Text Description

Determine your risk of now. Restart test

Caution! In case of an emergency:

Seek emergency care

Caution! In case of an emergency: Seek emergency care

Hi, I'm Symptoma.

Neurodegeneration Symptom Checker: Possible causes include Vitamin B12 Deficiency. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search.

For full functionality of this site it is necessary to enable JavaScript.

How to enable JavaScript?

Patient File

Sex unknown, Age unknown

Reported Symptoms

Neurodegeneration,

Negated

None

Unsure

None

Possible Causes

Vitamin B12 Deficiency

[…] on cognitive function, this study lends support to the notion that high serum folate concentrations in older people with VB12 deficiency may be associated with increased neurodegeneration [ncbi.nlm.nih.gov]

Oxidative stress is implicated in various human diseases and conditions, such as a neurodegeneration, which is the major symptom of vitamin B 12 deficiency, although the underlying [ncbi.nlm.nih.gov]

Neurodegeneration in methylmalonic aciduria involves inhibition of complex II and the tricarboxylic acid cycle, and synergistically acting excitotoxicity. [doi.org]

Show info

Alzheimer Disease

Furthermore, in DLB, Aβ 1–42 may promote α-synuclein accumulation and neurodegeneration. [dx.doi.org]

A. (2003) Alpha-synuclein overexpression protects against paraquat-induced neurodegeneration. J. Neurosci. 23, 3095–3099. [dx.doi.org]

Show info

Pallidopyramidal Syndrome

AB - Kufor-Rakeb syndrome is an autosomal recessive nigro-striatal-pallidal-pyramidal neurodegeneration. [research.manchester.ac.uk]

Understanding how FBXO7 mutations cause disease will shed further light on the molecular mechanisms of neurodegeneration, with potential implications also for more common [moh-it.pure.elsevier.com]

Conclusions: We conclusively show that recessive FBXO7 mutations cause progressive neurodegeneration with extrapyramidal and pyramidal system involvement, delineating a novel [n.neurology.org]

Show info

Parkinson Disease

In this review, we address the current concept of neuroinflammation and its involvement in PD-associated neurodegeneration. [ncbi.nlm.nih.gov]

However, 5-10% of PD cases are inherited as monogenic diseases, which provides a chance to understand the molecular mechanisms underlying neurodegeneration. [ncbi.nlm.nih.gov]

Open Access Review 1 Department of Biological Sciences, The University of Alabama, Tuscaloosa, AL 35487, USA 2 Departments of Neurology and Neurobiology, Center for Neurodegeneration [doi.org]

Show info

Lafora Disease

These animals did not show the increase in markers of neurodegeneration, the impairments in electrophysiological properties of hippocampal synapses, nor the susceptibility [ncbi.nlm.nih.gov]

Lafora disease is a metabolic disorder resulting in accumulation of water-insoluble glucan in the cytoplasm, and manifests as a debilitating neurodegeneration that ends with [ncbi.nlm.nih.gov]

Our results emphasize the relevance of the laforin-malin complex in the control of glycogen metabolism and highlight altered glycogen accumulation as a key contributor to neurodegeneration [ncbi.nlm.nih.gov]

Show info

X-linked Parkinsonism-Spasticity Syndrome

Test Registry Neurodegeneration With Brain Iron Accumulation 3 Basal Ganglia Disease, Adult-Onset Neuroferritinopathy NBIA3 606159 Genetic Test Registry Neurodegeneration [ukgtn.nhs.uk]

MeSH Descriptor Source: MeSH 2019 deskriptory Main Heading Hallervordenův-Spatzův syndrom English Heading Pantothenate Kinase-Associated Neurodegeneration See (Czech) neurodegenerace [medvik.cz]

Amyotrophic lateral sclerosis, susceptibility to DNAJC6 Parkinson disease 19a, juvenile-onset EIF4G1 Parkinson disease 18 FBXO7 Parkinson disease 15, autosomal recessive FTL Neurodegeneration [asperbio.com]

Show info

Wolfram Syndrome

This work is necessary to position the field for future clinical trials to test interventions for WFS neurodegeneration. [clinicaltrials.gov]

However, the mechanisms underlying neurodegeneration caused by WFS1 deficiency remain elusive. [ncbi.nlm.nih.gov]

In patients with Wolfram syndrome, these mechanisms underlie progressive neurodegeneration and endocrine dysfunction. [care.diabetesjournals.org]

Show info

Progressive Myoclonic Epilepsy Type 3

Neurodegeneration and regression occur with seizure onset. Other features include mental retardation, dysarthria, truncal ataxia, and loss of fine finger movements. [malacards.org]

Symptoms The list of signs and symptoms mentioned in various sources for Epilepsy, progressive myoclonic 3 includes the 6 symptoms listed below: * Myoclonic epilepsy * Neurodegeneration [checkorphan.org]

[…] myoclonic type 3 The list of signs and symptoms mentioned in various sources for Epilepsy, progressive myoclonic 3 includes the 6 symptoms listed below: * Myoclonic epilepsy * Neurodegeneration [checkorphan.org]

Show info

Primary Progressive Multiple Sclerosis

Spinal neurodegeneration is an important determinant of disability progression in patients with primary progressive multiple sclerosis. [ncbi.nlm.nih.gov]

The effect of current immunomodulatory treatments on neurodegeneration is insufficient. [ncbi.nlm.nih.gov]

Studies on the histology and pathogenesis show that neurodegeneration is predominant over inflammation in PPMS, even if cellular and humoral immune-mediated mechanisms are [ncbi.nlm.nih.gov]

Show info

Spinal and Bulbar Muscular Atrophy

Pre-clinical studies using animal models show that the pathogenic AR-mediated neurodegeneration is suppressed by androgen inactivation, the efficacy of which has been tested [ncbi.nlm.nih.gov]

Animal studies have revealed that the pathogenesis of SBMA depends on the level of serum testosterone, and that androgen deprivation mitigates neurodegeneration through inhibition [ncbi.nlm.nih.gov]

Abstract Expanded polyglutamine tracts cause neurodegeneration through a toxic gain-of-function mechanism. [ncbi.nlm.nih.gov]

Show info

Progressive Myoclonic Epilepsy Type 8

Knockdown of Cers1 in mouse neuroblastoma cells triggered endoplasmic reticulum stress, the unfolded protein response, and apoptosis, suggesting a mechanism for neurodegeneration [onlinelibrary.wiley.com]

[…] levels of ceramides and sphingolipids containing very long‐chain fatty acids have been associated with many neurodegenerative disorders, including cerebellar Purkinje cell neurodegeneration [onlinelibrary.wiley.com]

Show info

Hallervorden-Spatz Syndrome

(disorder) Pigmentary pallidal degeneration Neurodegeneration With Brain Iron Accumulation type 1 Pantothenate Kinase-Associated Neurodegeneration NEURODEGENERATION WITH [wikidata.org]

neurodegeneration; PKAN pantothenate kinase-associated neurodegeneration; XL X-linked 1. [ncbi.nlm.nih.gov]

BRAIN IRON ACCUMULATION 1; NBIA1 PKAN Pkan Neuroaxonal Dystrophy, Juvenile-Onset edit English pantothenate kinase-associated neurodegeneration A neurodegeneration with brain [wikidata.org]

Show info

Amyotrophic Lateral Sclerosis

Here we review some of the recent progress in promoting therapeutic strategies for neurodegeneration. [doi.org]

This review aims to investigate how oxidative stress can affect other proposed mechanisms of neurodegeneration in ALS. [ncbi.nlm.nih.gov]

Strategies for clinical approach to neurodegeneration in amyotrophic lateral sclerosis Cecilia Carlesi, Livia Pasquali, Selina Piazza, Annalisa Lo Gerfo, Elena Caldarazzo [doi.org]

Show info

Neuronal Ceroid Lipofuscinosis

Thus, we sought to determine whether this pathway of apoptosis contributes to rapid neurodegeneration in INCL. [doi.org]

Mutant dnj-14 worms also exhibited age-dependent neurodegeneration of sensory neurons, which was preceded by severe progressive chemosensory defects. [ncbi.nlm.nih.gov]

Autosomal-dominant adult-onset neuronal ceroid lipofuscinosis (ANCL) is characterized by accumulation of autofluorescent storage material in neural tissues and neurodegeneration [ncbi.nlm.nih.gov]

Show info

McLeod Neuroacanthocytosis Syndrome

The mechanism by which these mutations cause neurodegeneration is not known. dcterms:identifier kegg:H00832 void:inDataset Bio2RDF identifier H00832 Bio2RDF namespace kegg [bio2rdf.org]

HARP syndrome is allelic with pantothenate kinase-associated neurodegeneration. [ncbi.nlm.nih.gov]

The mechanism by which these mutations cause neurodegeneration is not known. [genome.jp]

Show info

REM Sleep Behavior Disorder

So far, the number of studies assessing predictive markers of neurodegeneration in RBD is limited. [n.neurology.org]

[…] treatment consequences of RBD in the context of neurodegeneration. 2018 S. Karger AG, Basel. [ncbi.nlm.nih.gov]

"Rapid-eye movement sleep behavior disorder is not just a precursor but also a critical warning sign of neurodegeneration that can lead to brain disease," John Peever, associate [universityherald.com]

Show info

Progressive Supranuclear Palsy

CurePSP CurePSP is the leading source of information and support for patients and their families, other caregivers, researchers, and healthcare professionals on prime of life neurodegeneration [psp.org]

Neurodegeneration: the molecular pathology of dementia and movement disorders. Basel : ISN Neuropath Press ; 2003. p. 103 – 14. 5. [doi.org]

Clinical and neuropathological correlations in atypical neurodegenerations are crucial to describe new entities of overlapping syndromes. [ncbi.nlm.nih.gov]

Show info

Huntington Disease

In this review we consider the current status of research in the field and possible mechanisms whereby the HD mutation might result in neurodegeneration. [ncbi.nlm.nih.gov]

Regulation of autophagy by polyphenols: Paving the road for treatment of neurodegeneration. Biotechnology Advances, Vol. 36, Issue. 6, p. 1768. [dx.doi.org]

Show info

Parkinson's Disease Type 3

On the other hand, pathogenic mutations alone may be sufficient to provoke neurodegeneration. [symptoma.com]

[…] hearing loss; Alternating hemiplegia of childhood 2 AD 12 ATP6AP2 300556 syndromic mental retardation, Hedera type XLR 2 ATP7B 606882 Wilson disease AR 25 C19orf12 614297 neurodegeneration [centogene.com]

The current medications of the disease cure the symptoms; none of them stops neurodegeneration. [journalmeddbu.com]

Show info

Neurodegenerative Disorder

In addition, it is the progressive neurodegeneration which determines the amount of accumulating clinical disability. [ncbi.nlm.nih.gov]

[…] and Repair: The interdepartmental program in Cellular Neuroscience, Neurodegeneration and Repair (CNNR) will accelerate the pace of Yale's research on neurodegeneration diseases [medicine.yale.edu]

Neurodegeneration is the overarching term for conditions with progressive loss of function and eventually death of neurons participating in motor, sensory or cognitive functions [ki.se]

Show info

Motor Neuron Disease

Neurodegeneration 1995 ; 4 : 209 –16. Spreux-Varoquaux O, Bensimon G, Lacomblez L, et al. [doi.org]

Renaud -- Neurodegeneration with brain iron accumulation, Wilson disease, manganism / Alisdair McNeill. [worldcat.org]

[…] cellular signature of aggregated TDP-43 common to nearly all MND and a large proportion of frontotemporal dementia (FTD), has placed MND alongside more traditional cerebral neurodegeneration [ncbi.nlm.nih.gov]

Show info

Classic Progressive Supranuclear Palsy Syndrome

The factors that initiate tau-neurodegeneration are unknown. Diagnostic methods Diagnosis is based on the clinical picture and neuropsychological evaluation. [orpha.net]

Show info

Machado-Joseph Disease

namely at early stages of another polyglutamine-related disorder such as Huntington's disease, we now tested their ability to control MJD-associated neurodegeneration. [ncbi.nlm.nih.gov]

Selective neurodegeneration in MJD is evident in several subcortical brain regions including the cerebellum. [ncbi.nlm.nih.gov]

Since these findings were detected both by lifetime images and by postmortem examination, MRI intensity changes could track the progression of neurodegeneration. [ncbi.nlm.nih.gov]

Show info

Menkes Disease

These diseases are characterized by neurological phenotypes ranging from intellectual disability to neurodegeneration. [ncbi.nlm.nih.gov]

Currently, no therapy effectively arrests the relentless neurodegeneration of Menkes' disease. [ncbi.nlm.nih.gov]

Menkes disease is an X-linked genetic disorder of copper transport that results in death from severe progressive neurodegeneration by the age of 3 years. [ncbi.nlm.nih.gov]

Show info

Spinocerebellar Ataxia Type 1

The objective of this study is to evaluate neurochemical changes associated with neurodegeneration in cerebral tissue in SCA1 patients compared to age- and gender-matched [ncbi.nlm.nih.gov]

Keywords Neurodegeneration Polyglutamine Therapeutic approaches References 1. [doi.org]

These data demonstrate that presymptomatic and progressive neurodegeneration in SCA1 can be noninvasively monitored using MRS. [ncbi.nlm.nih.gov]

Show info

Ataxia Telangiectasia

Our results define a crucial role of the cellular localization of HDAC4 in the events leading to ataxia telangiectasia neurodegeneration. [ncbi.nlm.nih.gov]

The symptoms of ataxia-telangiectasia (A-T) include a progressive neurodegeneration caused by ATM protein deficiency. [ncbi.nlm.nih.gov]

Abstract The symptoms of ataxia-telangiectasia (A-T) include a progressive neurodegeneration caused by ATM protein deficiency. [doi.org]

Show info

Gordon-Holmes Syndrome

KEYWORDS: Ataxia; CHIP; Dementia; Early onset ataxia; Early-onset dementia; Gordon Holmes syndrome; Hypogonadism; Magnetic resonance imaging; Neurodegeneration; Neurodegenerative [ncbi.nlm.nih.gov]

STUB1/CHIP mutations cause Gordon Holmes syndrome as part of a widespread multisystemic neurodegeneration: evidence from four novel mutations. [miami.pure.elsevier.com]

STUB1/CHIP mutations cause Gordon Holmes syndrome as part of widespread multisystemic neurodegeneration: Evidence from novel mutations [abstract]. [mdsabstracts.org]

Show info

Neonatal Adrenoleukodystrophy

The childhood form of the disease is quite devastating as the primary damage is of the form of a progressive neurodegeneration with symptoms that expand from mild to severe [ald.org.nz]

This form of ALD usually progresses rapidly, causes neurodegeneration, and results in death in infancy or young childhood. [healthprioritiesinc.com]

Show info

Niemann-Pick Disease

Oral administration of SAHA prevents oxidative stress and neurodegeneration, and improves behavioral performance in ASMko mice. [ncbi.nlm.nih.gov]

Hepatic NPC1 re-expression did not ameliorate the onset and progression of neurodegeneration of the NPC1-null animal. [ncbi.nlm.nih.gov]

Patients with type A NPD exhibit neurodegeneration beginning at three months of age and death by three years of age. [symptoma.com]

Show info

Progressive Myoclonic Epilepsy Type 7

Ataxia-telangiectasia-like disorder Atherosclerosis-deafness-diabetes-epilepsy-nephropathy syndrome Atypical juvenile parkinsonism Atypical pantothenate kinase-associated neurodegeneration [se-atlas.de]

Despite increasing knowledge of the etiology of most progressive myoclonus epilepsy disorders, the pathogenic mechanisms leading to neurodegeneration and epilepsy remain largely [medlink.com]

Neurodegeneration and regression occur with seizure onset. Other features include mental retardation, dysarthria, truncal ataxia, and loss of fine finger movements. [genecards.org]

Show info

⚕ Symptoma®️ is a digital health assistant but no replacement for the opinion and judgement of medical professionals. By using this website you fully understand and accept that it shall not be used as a diagnostic system for decision-making. It absolutely must not be used to obtain, replace or overrule a clinical diagnosis by a healthcare professional. It is always for the medical professional to make the final diagnosis. The medical information provided on this website is of a general nature and can not substitute for the advice of a medical professional (for example, a qualified doctor or physician)! Information from the internet could and should NOT be solely used to offer or render a medical opinion or otherwise engage in the practice of medicine.

[v-cloak]:not(.noscript-hide) { display: block; }