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2,153 Possible Causes for Neurodegeneration

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  • Hallervorden-Spatz Syndrome

    (disorder) Pigmentary pallidal degeneration Neurodegeneration With Brain Iron Accumulation type 1 Pantothenate Kinase-Associated Neurodegeneration NEURODEGENERATION WITH[wikidata.org] neurodegeneration; PKAN pantothenate kinase-associated neurodegeneration; XL X-linked 1.[ncbi.nlm.nih.gov] BRAIN IRON ACCUMULATION 1; NBIA1 PKAN Pkan Neuroaxonal Dystrophy, Juvenile-Onset edit English pantothenate kinase-associated neurodegeneration A neurodegeneration with brain[wikidata.org]

  • Wolfram Syndrome

    This work is necessary to position the field for future clinical trials to test interventions for WFS neurodegeneration.[clinicaltrials.gov] In patients with Wolfram syndrome, these mechanisms underlie progressive neurodegeneration and endocrine dysfunction.[care.diabetesjournals.org] Ultimately, a better understanding of the trajectory of neurodegeneration in WFS and the development of effective interventions may be relevant to other more common neurodegenerative[clinicaltrials.gov]

  • Alzheimer Disease

    Serum NfL may thus be a feasible biomarker of early AD-related neurodegeneration. Copyright 2017 The Author(s).[ncbi.nlm.nih.gov] Furthermore, in DLB, Aβ 1–42 may promote α-synuclein accumulation and neurodegeneration.[doi.org] A. (2003) Alpha-synuclein overexpression protects against paraquat-induced neurodegeneration. J. Neurosci. 23, 3095–3099.[doi.org]

  • Spinocerebellar Ataxia Type 1

    The objective of this study is to evaluate neurochemical changes associated with neurodegeneration in cerebral tissue in SCA1 patients compared to age- and gender-matched[ncbi.nlm.nih.gov] Keywords Neurodegeneration Polyglutamine Therapeutic approaches References 1.[doi.org] These data demonstrate that presymptomatic and progressive neurodegeneration in SCA1 can be noninvasively monitored using MRS.[ncbi.nlm.nih.gov]

  • Neurodegenerative Disorder

    In addition, it is the progressive neurodegeneration which determines the amount of accumulating clinical disability.[ncbi.nlm.nih.gov] […] and Repair: The interdepartmental program in Cellular Neuroscience, Neurodegeneration and Repair (CNNR) will accelerate the pace of Yale's research on neurodegeneration diseases[medicine.yale.edu] All of these conditions lead to progressive brain damage and neurodegeneration.[news-medical.net]

  • Parkinson's Disease

    In this review, we address the current concept of neuroinflammation and its involvement in PD-associated neurodegeneration.[ncbi.nlm.nih.gov] However, 5-10% of PD cases are inherited as monogenic diseases, which provides a chance to understand the molecular mechanisms underlying neurodegeneration.[ncbi.nlm.nih.gov] Open Access Review 1 Department of Biological Sciences, The University of Alabama, Tuscaloosa, AL 35487, USA 2 Departments of Neurology and Neurobiology, Center for Neurodegeneration[doi.org]

  • Lafora Disease

    These animals did not show the increase in markers of neurodegeneration, the impairments in electrophysiological properties of hippocampal synapses, nor the susceptibility[ncbi.nlm.nih.gov] Lafora disease is a metabolic disorder resulting in accumulation of water-insoluble glucan in the cytoplasm, and manifests as a debilitating neurodegeneration that ends with[ncbi.nlm.nih.gov] Our results emphasize the relevance of the laforin-malin complex in the control of glycogen metabolism and highlight altered glycogen accumulation as a key contributor to neurodegeneration[ncbi.nlm.nih.gov]

  • REM Sleep Behavior Disorder

    So far, the number of studies assessing predictive markers of neurodegeneration in RBD is limited.[n.neurology.org] […] treatment consequences of RBD in the context of neurodegeneration. 2018 S. Karger AG, Basel.[ncbi.nlm.nih.gov] "Rapid-eye movement sleep behavior disorder is not just a precursor but also a critical warning sign of neurodegeneration that can lead to brain disease," John Peever, associate[universityherald.com]

  • Neurodegeneration with Brain Iron Accumulation

    In addition to pantothenate kinase-associated neurodegeneration (PKAN) and phospholipase A2-associated neurodegeneration (PLAN), fatty acid hydroxylase-associated neurodegeneration[ncbi.nlm.nih.gov] […] acid hydroxylase-associated neurodegeneration, respectively).[ncbi.nlm.nih.gov] "Neurodegeneration with Brain Iron Accumulation Information Page". National Institute of Neurological Disorders and Stroke.[en.wikipedia.org]

  • Beta-Propeller Protein-Associated Neurodegeneration

    Neurodegeneration with brain iron accumulation (NBIA) is a heterogeneous group of inherited neurologic disorders with iron accumulation in the basal ganglia, which share magnetic[ncbi.nlm.nih.gov] Beta-propeller protein-associated neurodegeneration is a newly described X-linked dominant condition due to heterozygous mutations in WDR45.[ncbi.nlm.nih.gov] Static encephalopathy of childhood with neurodegeneration in adulthood is a phenotypically distinctive, X-linked dominant subtype of neurodegeneration with brain iron accumulation[ncbi.nlm.nih.gov]

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