Neurofibrillary Tangle Causes & Reasons

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Neurofibrillary Tangle Symptom Checker: Possible causes include Alzheimer Disease. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search.

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Possible Causes

Alzheimer Disease

To determine the relation of neuritic plaques (NPs) and neurofibrillary tangles (NFTs) to the development and evolution of Alzheimer disease (AD). [ncbi.nlm.nih.gov]

The observation of Lewy bodies in familial AD cases suggests that like neurofibrillary tangles, the formation of Lewy bodies can be induced by the pathological state caused [ncbi.nlm.nih.gov]

Scientists found two important causes of cell death in AD, deposition of amyloid plaques and formation of neurofibrillary tangles. [flexikon.doccheck.com]

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Progressive Supranuclear Palsy

Its pathology reveals that Alzheimer's neurofibrillary tangles (NFTs) are situated especially in the nuclei of basal ganglia and brainstem. [ncbi.nlm.nih.gov]

PSP is defined neuropathologically by the accumulation of neurofibrillary tangles in the subthalamic nucleus, pallidum, red nucleus, substantia nigra, striatum, pontine tegmentum [ncbi.nlm.nih.gov]

Alzheimer's disease pathology was advanced with PSP-like neurofibrillary tangles distribution, and Lewy bodies were abundant in limbic lobe, while scarce in lower brainstem [ncbi.nlm.nih.gov]

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Boxer's Dementia

Dale GE, Leigh PN, Luthert P, Anderton BH, Roberts GW (1991) Neurofibrillary tangles in dementia pugilistica are ubiquitinated. [link.springer.com]

Neurofibrillary tangles have been found in the brains of dementia pugilistica patients, but not in the same distribution as is usually found in people with Alzheimer's. [diki.pl]

Differential distribution of neurofibrillary tangles in the cerebral cortex of dementia pugilistica and Alzheimer's disease cases. [doi.org]

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Early-Onset Autosomal Dominant Alzheimer Disease

These mutations result in an incompletely understood cascade of events resulting in neuronal death, synapse loss, and the formation of neurofibrillary tangles and senile plaques [orpha.net]

tangles. [disabled-world.com]

A post-mortem diagnosis can be achieved through an examination that reveals intraneuronal neurofibrillary tangles and beta-amyloid neuritic plaques. [disabled-world.com]

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Classic Progressive Supranuclear Palsy Syndrome

tangles and neuropil threads to a lesser extent.[33, 39] Much like Alzheimer disease, PSP is characterized by neurofibrillary tangles causing nerve cell loss, gliosis, and [eyewiki.aao.org]

Pathological examination disclosed histopathological features of PSP, including argyrophilic and tau-positive tufted astrocytes, neurofibrillary tangles, coiled bodies, and [okayama.pure.elsevier.com]

The neurofibrillary tangles deposited in PSP can be distinguished from those seen in Alzheimer's disease in a number of ways. [pmj.bmj.com]

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Hallervorden-Spatz Syndrome

Numerous neurofibrillary tangles (NFTs) were found within the hippocampal cortex, neocortex and brain stem. [ncbi.nlm.nih.gov]

Neurofibrillary tangles were abundant in the hippocampus, cerebral neocortex, basal ganglia, and brain stem. Neuritic plaques and amyloid deposits were absent. [ncbi.nlm.nih.gov]

tangles due to hyperphosphorilated tau aggregation. [ncbi.nlm.nih.gov]

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Dialysis Dementia

Senile plaques and or neurofibrillary tangles were found in 5 of the 7 cases, 3 with and 2 without DES. [ncbi.nlm.nih.gov]

This neurofibrillary neuronal degeneration resembles that found in experimental aluminum toxicity, but differs in several respects from the neurofibrillary tangles characteristic [ncbi.nlm.nih.gov]

Silver staining of senile plaques and neurofibrillary tangles in paraffin sections — a simple and effective method. [link.springer.com]

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Cerebral Cortical Atrophy

الصفحة 506 - GW, 1991, The topographical and neuroanatomical distribution of neurofibrillary tangles and neuritic plaques in the cerebral cortex of patients with Alzheimer's [books.google.com]

Significantly higher neurofibrillary tangle and senile plaque densities were found in the more atrophic side in most of the areas studied. [link.springer.com]

In many people with posterior cortical atrophy, the affected part of the brain shows amyloid plaques and neurofibrillary tangles, similar to the changes that occur in Alzheimer [alz.org]

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ADan Amyloidosis

These findings support the notion that parenchymal amyloid fibril formation is not a prerequisite for the development of neurofibrillary tangles. [indiana.pure.elsevier.com]

tangles. [ri.conicet.gov.ar]

FDD is a novel form of CNS amyloidosis with extensive neurofibrillary degeneration occurring with parenchymal, predominantly pre-amyloid rather than amyloid, deposition. [indiana.pure.elsevier.com]

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ABri Amyloidosis

Two non-Aβ cerebral amyloidoses, familial British and Danish dementias, share many aspects of Alzheimer disease, including the presence of neurofibrillary tangles, parenchymal [pure.au.dk]

Cerebral amyloid angiopathy, non-neuritic and perivascular plaques and neurofibrillary tangles are the predominant pathological lesions. [genecards.org]

tangles. [ncbi.nlm.nih.gov]

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Dementia with Lewy Bodies

tangle burden. [ncbi.nlm.nih.gov]

Neurofibrillary tangles (NFT) were almost restricted to the entorhinal cortex, while senile plaques were absent. [ncbi.nlm.nih.gov]

The association between ante mortem [(11)C]-Pittsburgh Compound B (PiB) retention and β-amyloid (Aβ) load, Lewy body (LB) and neurofibrillary tangle (NFT) densities were investigated [ncbi.nlm.nih.gov]

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Brain Stem Hemorrhage

tangles (NFTs), which are histopathological changes associated with Alzheimer's disease (AD). [ncbi.nlm.nih.gov]

We report findings from an autopsy of a male in his 40s who died of a brain stem hemorrhage associated with cerebral amyloid angiopathy (CAA), senile plaques (SPs) and neurofibrillary [ncbi.nlm.nih.gov]

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Striatonigral Degeneration

Neuropathological examination revealed striato-nigral degeneration (SND) and neurofibrillary tangles (NFT) characterizing progressive supranuclear palsy. [ncbi.nlm.nih.gov]

tangles K. [dokumen.tips]

tangles in the cerebral cortex. [ncbi.nlm.nih.gov]

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Presenile Dementia with Bone Cysts

From Epidemiology 160 cases, mainly in Finland & Japan onset third decade Pathology basal ganglia calcification gliosis white matter demyelination senile plaques neurofibrillary [anvita.info]

Medical and Biotech [MESH] Definitions Neuropil Threads Abnormal structures located chiefly in distal dendrites and, along with NEUROFIBRILLARY TANGLES and SENILE PLAQUES, [bioportfolio.com]

tangles Bradykinesia Jaundice Hypoalbuminemia Encephalopathy Hallucinations Limitation of joint mobility Prolonged prothrombin time Chorea Prolonged partial thromboplastin [mendelian.co]

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Neurodegenerative Disorder

Delineation of the patterns of cell loss and the identification of disease-specific cellular markers have aided in nosologic classification: senile plaques, neurofibrillary [nejm.org]

[…] brain fibers called neurofibrillary tangles. [courses.lumenlearning.com]

In this video he explains the plaques and tangles behind Alzheimer’s Disease. Neurofibrillary tangles in the brain may foreshadow trouble. [brainfacts.org]

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Posterior Cortical Atrophy

Posterior cortical atrophy is a dementia syndrome with symptoms of cortical visual dysfunction, associated with amyloid plaques and neurofibrillary tangles predominantly affecting [ncbi.nlm.nih.gov]

Determining the relative contribution of amyloid plaques and neurofibrillary tangles to brain dysfunction in Alzheimer disease is critical for therapeutic approaches, but [ncbi.nlm.nih.gov]

Both cases displayed very high densities of neurofibrillary tangles and senile plaques in the primary visual cortex, secondary visual cortex, visual association areas of the [ncbi.nlm.nih.gov]

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Nivelon-Nivelon-Mabille Syndrome

tangles Neurofibroma Neurofibromatosis Neurofibromatosis type 2 Neurofibromatosis type 3 Neurofibromatosis type 6 Neurofibromatosis, familial intestinal Neurofibromatosis [ssf.f15ijp.com]

[…] syndrome Neuroectodermal tumors primitive Neuroendocrine cancer Neuroendocrine carcinoma of the cervix Neuroendocrine tumor Neuroepithelioma Neurofaciodigitorenal syndrome Neurofibrillary [ssf.f15ijp.com]

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Degenerative Brain Disorder

In this video he explains the plaques and tangles behind Alzheimer’s Disease. Neurofibrillary tangles in the brain may foreshadow trouble. [brainfacts.org]

Preliminary research suggests that repeated head trauma cause the toxic protein tau to build up in the brain, leading to neurofibrillary tangles and the death of neurons, [apa.org]

tangles in this disease and other tauopathies. [neuroscience.cam.ac.uk]

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Parenchymatous Cortical Cerebellar Degeneration

Extensive neuronal loss and abundant neuritic plaques and neurofibrillary tangles involving the entire neocortex were observed (Braak neurofibrillary and amyloid stages VI-C [alzforum.org]

Vascular variant of prion protein cerebral amyloidosis with tau-positive neurofibrillary tangles: the phenotype of the stop codon 145 mutation in PRNP. [cambridge.org]

tangles). [alzforum.org]

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Neurodegeneration with Brain Iron Accumulation

The hallmark pathological lesions of NBIA 1 are axonal spheroids, but Lewy body (LB)-like intraneuronal inclusions, glial inclusions, and rare neurofibrillary tangles also [ncbi.nlm.nih.gov]

Autopsy examination of genetically-confirmed cases demonstrates Lewy bodies, neurofibrillary tangles, and other hallmarks of apparently distinct neurodegenerative disorders [ncbi.nlm.nih.gov]

Neurofibrillary tangles were abundant in the hippocampus, cerebral neocortex, basal ganglia, and brain stem. Neuritic plaques and amyloid deposits were absent. [ncbi.nlm.nih.gov]

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Postencephalitic Parkinson Disease

tangles? [malacards.org]

Postencephalitic parkinsonism shares histopathological features with other tauopathies as a multisystem degeneration with tau-positive neurofibrillary tangles that have biochemical [onlinelibrary.wiley.com]

The brain regions affected contain neurofibrillary tangles, similar to those seen in Alzheimer's disease. [en.wikipedia.org]

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Frontotemporal Dementia

tangles. [ncbi.nlm.nih.gov]

The PET tracer [ 18 F]AV1451 binds with high affinity to paired helical filaments tau that comprises neurofibrillary tangles in Alzheimer disease (AD), while postmortem studies [ncbi.nlm.nih.gov]

tangle stage of IV or greater and β-amyloid stage B or C, 15 even in the presence of other pathological features. [dx.doi.org]

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Binswanger Disease

Cerebral vascular amyloid deposits, senile plaques and neurofibrillary tangles have been found in subcortical arteriosclerotic encephalopathy (Binswanger disease). [ncbi.nlm.nih.gov]

Abnormally phosphorylated tau that accumulates intraneuronally forming neurofibrillary tangles (NFTs). [librepathology.org]

AD is characterized by two abnormalities in the brain: amyloid plaques and neurofibrillary tangles. [alzheimersweekly.com]

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Motor Neuron Disease

In addition, neurofibrillary tangles (NFTs) and neuritic plaques were present in the frontal cortex, temporal cortex and hippocampus, and to a lesser degree, in the amygdala [ncbi.nlm.nih.gov]

Numerous senile plaques and topographically limited neurofibrillary tangles were also observed. [ncbi.nlm.nih.gov]

In addition, the affected regions exhibited neuronal cytoplasmic inclusions resembling neurofibrillary tangles. [ncbi.nlm.nih.gov]

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Primary Progressive Aphasia

Many neurofibrillary tangles with neuropil threads were found in the cerebral cortex. [ncbi.nlm.nih.gov]

Neuropathological examination revealed the typical pathology of PSP: loss of neurons, gliosis, occurrence of neurofibrillary tangles, oligodendroglial coiled bodies, and tuft-shaped [ncbi.nlm.nih.gov]

[…] the leftward asymmetry of the atrophy, and where neurofibrillary tangles show a greater density in memory than language areas despite the predominantly aphasic phenotype. [ncbi.nlm.nih.gov]

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Familial Alzheimer-Like Prion Disease

OBJECTIVE: To describe the Alzheimer disease (AD)-like clinical and pathological features, including marked neurofibrillary tangle (NFT) pathology, of a familial prion disease [ncbi.nlm.nih.gov]

Neurofibrillary tangles are damaged proteins (tau proteins) that collect into "tangles," which cause improper functioning of nerve cells, leading them to disintegrate. [onhealth.com]

A recent retrospective analysis found that people with neurofibrillary tangles primarily outside the hippocampus tend to progress faster and die earlier than AD patients with [alzforum.org]

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Niemann-Pick Disease Type C

Post-mortem neuropathological examination of five cases of Niemann-Pick disease type C revealed neurofibrillary tangles in many parts of the brain. [ncbi.nlm.nih.gov]

During the routine neuropathological study of NPC patients, we found neurofibrillary tangles (NFT) in a series of cases with a slowly progressive chronic course. [ncbi.nlm.nih.gov]

Neuropathological studies have demonstrated brainstem atrophy associated with neuronal inclusions and loss, and neurofibrillary tangles, although it is not known whether this [ncbi.nlm.nih.gov]

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Brain Concussion

Many neurofibrillary tangles in the nerve cells of the frontal and temporal cortex. .. particularly marked in the anteromedial temporal gray matter including the amygdaloid [theatlantic.com]

CHRONIC REPEATED CONCUSSION In 2005 and 2006, Omalu et al.20,21 described the widespread deposition of beta-amyloid and neurofibrillary tangles, pathology often appreciated [apsf.org]

Focal axonal injury and spots of micro-bleeding lead to the deposition of abnormal tau proteins in the brain tissue – called the tau-positive neurofibrillary tangles (NFTs [drpawluk.com]

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Subacute Sclerosing Panencephalitis

Sami Ulus Children's Hospital, Ankara, Turkey. drdeniz_yuksel@yahoo.com.tr Abstract Neurofibrillary tangles (NFTs) have been shown in 20% of subacute sclerosing panencephalitis [ncbi.nlm.nih.gov]

Brain histopathology in certain SSPE patients shows, neurofibrillary tangles composed of abnormally phosphorylated, microtubule-associated protein tau (PHF-tau). [ncbi.nlm.nih.gov]

Brain biopsies or postmortem histopathological examination show evidence of astrogliosis, neuronal loss, degeneration of dendrites, demyelination, neurofibrillary tangles, [ncbi.nlm.nih.gov]

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Post-Encephalitic Syndrome

The brain regions affected contain neurofibrillary tangles, similar to those seen in Alzheimer's disease. [en.wikipedia.org]

tangles in residual neurons in many subcortical nuclei. [alzheimer-europe.org]

Neuropathology: multisystem neuronal degeneration and cell loss, with gliosisin many brainstem nuclei, in particular substantia nigra, locus ceruleus, and others with globous neurofibrillary [alzheimer-europe.org]

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