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548 Possible Causes for Neurofibrillary Tangle

  • Alzheimer Disease

    To determine the relation of neuritic plaques (NPs) and neurofibrillary tangles (NFTs) to the development and evolution of Alzheimer disease (AD).[ncbi.nlm.nih.gov] The observation of Lewy bodies in familial AD cases suggests that like neurofibrillary tangles, the formation of Lewy bodies can be induced by the pathological state caused[ncbi.nlm.nih.gov] Neurofibrillary tangles and beta-amyloid plaques have been observed in the amygdala in Alzheimer disease.[ncbi.nlm.nih.gov]

  • Progressive Supranuclear Palsy

    Its pathology reveals that Alzheimer's neurofibrillary tangles (NFTs) are situated especially in the nuclei of basal ganglia and brainstem.[ncbi.nlm.nih.gov] PSP is defined neuropathologically by the accumulation of neurofibrillary tangles in the subthalamic nucleus, pallidum, red nucleus, substantia nigra, striatum, pontine tegmentum[ncbi.nlm.nih.gov] Alzheimer's disease pathology was advanced with PSP-like neurofibrillary tangles distribution, and Lewy bodies were abundant in limbic lobe, while scarce in lower brainstem[ncbi.nlm.nih.gov]

  • Classic Progressive Supranuclear Palsy Syndrome

    tangles and neuropil threads to a lesser extent.[33, 39] Much like Alzheimer disease, PSP is characterized by neurofibrillary tangles causing nerve cell loss, gliosis, and[eyewiki.aao.org] Pathological examination disclosed histopathological features of PSP, including argyrophilic and tau-positive tufted astrocytes, neurofibrillary tangles, coiled bodies, and[okayama.pure.elsevier.com] The neurofibrillary tangles deposited in PSP can be distinguished from those seen in Alzheimer's disease in a number of ways.[pmj.bmj.com]

  • Early-Onset Autosomal Dominant Alzheimer Disease

    These mutations result in an incompletely understood cascade of events resulting in neuronal death, synapse loss, and the formation of neurofibrillary tangles and senile plaques[orpha.net] tangles.[disabled-world.com] A post-mortem diagnosis can be achieved through an examination that reveals intraneuronal neurofibrillary tangles and beta-amyloid neuritic plaques.[disabled-world.com]

  • Boxer's Dementia

    Dale GE, Leigh PN, Luthert P, Anderton BH, Roberts GW (1991) Neurofibrillary tangles in dementia pugilistica are ubiquitinated.[link.springer.com] Neurofibrillary tangles have been found in the brains of dementia pugilistica patients, but not in the same distribution as is usually found in people with Alzheimer's.[diki.pl] Differential distribution of neurofibrillary tangles in the cerebral cortex of dementia pugilistica and Alzheimer's disease cases.[doi.org]

  • Posterior Cortical Atrophy

    Determining the relative contribution of amyloid plaques and neurofibrillary tangles to brain dysfunction in Alzheimer disease is critical for therapeutic approaches, but[ncbi.nlm.nih.gov] Posterior cortical atrophy is a dementia syndrome with symptoms of cortical visual dysfunction, associated with amyloid plaques and neurofibrillary tangles predominantly affecting[ncbi.nlm.nih.gov] Both cases displayed very high densities of neurofibrillary tangles and senile plaques in the primary visual cortex, secondary visual cortex, visual association areas of the[ncbi.nlm.nih.gov]

  • Hallervorden-Spatz Syndrome

    Numerous neurofibrillary tangles (NFTs) were found within the hippocampal cortex, neocortex and brain stem.[ncbi.nlm.nih.gov] tangles due to hyperphosphorilated tau aggregation.[ncbi.nlm.nih.gov] In addition, there was diffuse sponginess in the atrophic cortex as well as widespread Alzheimer's neurofibrillary tangles (NFTs) and Lewy bodies (LBs) in the cortical and[ncbi.nlm.nih.gov]

  • ADan Amyloidosis

    These findings support the notion that parenchymal amyloid fibril formation is not a prerequisite for the development of neurofibrillary tangles.[indiana.pure.elsevier.com] tangles.[ri.conicet.gov.ar] FDD is a novel form of CNS amyloidosis with extensive neurofibrillary degeneration occurring with parenchymal, predominantly pre-amyloid rather than amyloid, deposition.[indiana.pure.elsevier.com]

  • Cerebral Cortical Atrophy

    الصفحة 506 - GW, 1991, The topographical and neuroanatomical distribution of neurofibrillary tangles and neuritic plaques in the cerebral cortex of patients with Alzheimer's[books.google.com] Significantly higher neurofibrillary tangle and senile plaque densities were found in the more atrophic side in most of the areas studied.[link.springer.com] In many people with posterior cortical atrophy, the affected part of the brain shows amyloid plaques and neurofibrillary tangles, similar to the changes that occur in Alzheimer[alz.org]

  • Dementia with Lewy Bodies

    tangle burden.[ncbi.nlm.nih.gov] Neurofibrillary tangles (NFT) were almost restricted to the entorhinal cortex, while senile plaques were absent.[ncbi.nlm.nih.gov] The association between ante mortem [(11)C]-Pittsburgh Compound B (PiB) retention and β-amyloid (Aβ) load, Lewy body (LB) and neurofibrillary tangle (NFT) densities were investigated[ncbi.nlm.nih.gov]

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