Neurofibrillary Tangle: Causes & Reasons

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Possible Causes for Neurofibrillary Tangle

Alzheimer Disease

Based on the distribution of neurofibrillary tangles (NFTs) and senile plaques, it has been proposed that a global cortico-cortical disconnection leads to the loss of integrated [doi.org]

To determine the relation of neuritic plaques (NPs) and neurofibrillary tangles (NFTs) to the development and evolution of Alzheimer disease (AD). [ncbi.nlm.nih.gov]

The observation of Lewy bodies in familial AD cases suggests that like neurofibrillary tangles, the formation of Lewy bodies can be induced by the pathological state caused [ncbi.nlm.nih.gov]

Progressive Supranuclear Palsy

Its pathology reveals that Alzheimer's neurofibrillary tangles (NFTs) are situated especially in the nuclei of basal ganglia and brainstem. [ncbi.nlm.nih.gov]

PSP is defined neuropathologically by the accumulation of neurofibrillary tangles in the subthalamic nucleus, pallidum, red nucleus, substantia nigra, striatum, pontine tegmentum [ncbi.nlm.nih.gov]

Alzheimer's disease pathology was advanced with PSP-like neurofibrillary tangles distribution, and Lewy bodies were abundant in limbic lobe, while scarce in lower brainstem [ncbi.nlm.nih.gov]

Boxer's Dementia

Dale GE, Leigh PN, Luthert P, Anderton BH, Roberts GW (1991) Neurofibrillary tangles in dementia pugilistica are ubiquitinated. [link.springer.com]

原著アルツハイマー病脳，老年者脳におけるneuropil threadsおよび神経原線維変化の免疫細胞化学―共焦点レーザー走査蛍光顕微鏡による観察 Confocal microscopic immunocytochemistry of neuropil threads and neurofibrillary tangles in aged [webview.isho.jp]

Differential distribution of neurofibrillary tangles in the cerebral cortex of dementia pugilistica and Alzheimer's disease cases. [doi.org]

Hallervorden-Spatz Syndrome

Numerous neurofibrillary tangles (NFTs) were found within the hippocampal cortex, neocortex and brain stem. [ncbi.nlm.nih.gov]

Neurofibrillary tangles were abundant in the hippocampus, cerebral neocortex, basal ganglia, and brain stem. Neuritic plaques and amyloid deposits were absent. [ncbi.nlm.nih.gov]

tangles due to hyperphosphorilated tau aggregation. [ncbi.nlm.nih.gov]

Early-Onset Alzheimer Disease

tangles. [disabled-world.com]

These mutations result in an incompletely understood cascade of events resulting in neuronal death, synapse loss, and the formation of neurofibrillary tangles and senile plaques [orpha.net]

A post-mortem diagnosis can be achieved through an examination that reveals intraneuronal neurofibrillary tangles and beta-amyloid neuritic plaques. [disabled-world.com]

Classic Progressive Supranuclear Palsy Syndrome

tangles and neuropil threads to a lesser extent.[33, 39] Much like Alzheimer disease, PSP is characterized by neurofibrillary tangles causing nerve cell loss, gliosis, and [eyewiki.aao.org]

Pathological examination disclosed histopathological features of PSP, including argyrophilic and tau-positive tufted astrocytes, neurofibrillary tangles, coiled bodies, and [okayama.pure.elsevier.com]

The neurofibrillary tangles deposited in PSP can be distinguished from those seen in Alzheimer's disease in a number of ways. [pmj.bmj.com]

Cerebral Cortical Atrophy

Significantly higher neurofibrillary tangle and senile plaque densities were found in the more atrophic side in most of the areas studied. [link.springer.com]

الصفحة 506 - GW, 1991, The topographical and neuroanatomical distribution of neurofibrillary tangles and neuritic plaques in the cerebral cortex of patients with Alzheimer's [books.google.com]

In many people with posterior cortical atrophy, the affected part of the brain shows amyloid plaques and neurofibrillary tangles, similar to the changes that occur in Alzheimer [alz.org]

ABri Amyloidosis

Cerebral amyloid angiopathy, non-neuritic and perivascular plaques and neurofibrillary tangles are the predominant pathological lesions. [genecards.org]

Two non-Aβ cerebral amyloidoses, familial British and Danish dementias, share many aspects of Alzheimer disease, including the presence of neurofibrillary tangles, parenchymal [pure.au.dk]

tangles. [ncbi.nlm.nih.gov]

ADan Amyloidosis

These findings support the notion that parenchymal amyloid fibril formation is not a prerequisite for the development of neurofibrillary tangles. [indiana.pure.elsevier.com]

Cerebral amyloid angiopathy, non-neuritic and perivascular plaques and neurofibrillary tangles are the predominant pathological lesions. [genecards.org]

KW - ADan KW - Amyloid KW - BRI2 gene KW - Danish dementia KW - Neurofibrillary degeneration KW - Pre-amyloid UR - http://www.scopus.com/inward/record.url? [indiana.pure.elsevier.com]

Dementia with Lewy Bodies

tangle burden. [ncbi.nlm.nih.gov]

Neurofibrillary tangles (NFT) were almost restricted to the entorhinal cortex, while senile plaques were absent. [ncbi.nlm.nih.gov]

These correlations remained significant after controlling for several factors, including concurrent Alzheimer's pathology (neuritic plaques and neurofibrillary tangles) and [ncbi.nlm.nih.gov]

Presenile Dementia with Bone Cysts

From Epidemiology ~160 cases, mainly in Finland & Japan onset third decade Pathology basal ganglia calcification gliosis white matter demyelination senile plaques neurofibrillary [anvita.info]

Medical and Biotech [MESH] Definitions Neuropil Threads Abnormal structures located chiefly in distal dendrites and, along with NEUROFIBRILLARY TANGLES and SENILE PLAQUES, [bioportfolio.com]

tangles Bradykinesia Jaundice Hypoalbuminemia Encephalopathy Hallucinations Limitation of joint mobility Prolonged prothrombin time Chorea Prolonged partial thromboplastin [mendelian.co]

Striatonigral Degeneration

Neuropathological examination revealed striato-nigral degeneration (SND) and neurofibrillary tangles (NFT) characterizing progressive supranuclear palsy. [ncbi.nlm.nih.gov]

tangles K. [dokumen.tips]

tangles in the cerebral cortex. [ncbi.nlm.nih.gov]

Neurodegenerative Disorder

Delineation of the patterns of cell loss and the identification of disease-specific cellular markers have aided in nosologic classification: senile plaques, neurofibrillary [nejm.org]

[…] brain fibers called neurofibrillary tangles. [courses.lumenlearning.com]

In this video he explains the plaques and tangles behind Alzheimer’s Disease. Neurofibrillary tangles in the brain may foreshadow trouble. [brainfacts.org]

Parenchymatous Cortical Cerebellar Degeneration

Extensive neuronal loss and abundant neuritic plaques and neurofibrillary tangles involving the entire neocortex were observed (Braak neurofibrillary and amyloid stages VI-C [alzforum.org]

Vascular variant of prion protein cerebral amyloidosis with tau-positive neurofibrillary tangles: the phenotype of the stop codon 145 mutation in PRNP. [cambridge.org]

tangles). [alzforum.org]

Degenerative Brain Disorder

In this video he explains the plaques and tangles behind Alzheimer’s Disease. Neurofibrillary tangles in the brain may foreshadow trouble. [brainfacts.org]

Preliminary research suggests that repeated head trauma cause the toxic protein tau to build up in the brain, leading to neurofibrillary tangles and the death of neurons, [apa.org]

tangles in this disease and other tauopathies. [neuroscience.cam.ac.uk]

Nivelon-Nivelon-Mabille Syndrome

tangles Neurofibroma Neurofibromatosis Neurofibromatosis type 2 Neurofibromatosis type 3 Neurofibromatosis type 6 Neurofibromatosis, familial intestinal Neurofibromatosis [bionity.com]

tangles Neurofibroma Neurofibromatosis type 2 Neurofibromatosis type 3 Neurofibromatosis type 6 Neurofibromatosis, familial intestinal Neurofibromatosis, Type IV, of Riccardi [fact-index.com]

[…] syndrome Neuroectodermal tumors primitive Neuroendocrine cancer Neuroendocrine carcinoma of the cervix Neuroendocrine tumor Neuroepithelioma Neurofaciodigitorenal syndrome Neurofibrillary [bionity.com]

Posterior Cortical Atrophy

Posterior cortical atrophy is a dementia syndrome with symptoms of cortical visual dysfunction, associated with amyloid plaques and neurofibrillary tangles predominantly affecting [ncbi.nlm.nih.gov]

Histology revealed severe diffuse tauopathy with neuronal loss, neurofibrillary tangles, neuropil threads, and tau deposits in astroglia and oligodendroglia in parietal, temporal [ncbi.nlm.nih.gov]

Determining the relative contribution of amyloid plaques and neurofibrillary tangles to brain dysfunction in Alzheimer disease is critical for therapeutic approaches, but [ncbi.nlm.nih.gov]

Neurodegeneration with Brain Iron Accumulation

The hallmark pathological lesions of NBIA 1 are axonal spheroids, but Lewy body (LB)-like intraneuronal inclusions, glial inclusions, and rare neurofibrillary tangles also [ncbi.nlm.nih.gov]

Autopsy examination of genetically-confirmed cases demonstrates Lewy bodies, neurofibrillary tangles, and other hallmarks of apparently distinct neurodegenerative disorders [ncbi.nlm.nih.gov]

Neurofibrillary tangles were abundant in the hippocampus, cerebral neocortex, basal ganglia, and brain stem. Neuritic plaques and amyloid deposits were absent. [ncbi.nlm.nih.gov]

Postencephalitic Parkinson Disease

tangles? [malacards.org]

Postencephalitic parkinsonism shares histopathological features with other tauopathies as a multisystem degeneration with tau-positive neurofibrillary tangles that have biochemical [onlinelibrary.wiley.com]

The brain regions affected contain neurofibrillary tangles, similar to those seen in Alzheimer's disease. [en.wikipedia.org]

Brain Stem Hemorrhage

tangles (NFTs), which are histopathological changes associated with Alzheimer's disease (AD). [ncbi.nlm.nih.gov]

We report findings from an autopsy of a male in his 40s who died of a brain stem hemorrhage associated with cerebral amyloid angiopathy (CAA), senile plaques (SPs) and neurofibrillary [ncbi.nlm.nih.gov]

Dialysis Dementia

Senile plaques and or neurofibrillary tangles were found in 5 of the 7 cases, 3 with and 2 without DES. [ncbi.nlm.nih.gov]

This neurofibrillary neuronal degeneration resembles that found in experimental aluminum toxicity, but differs in several respects from the neurofibrillary tangles characteristic [ncbi.nlm.nih.gov]

Silver staining of senile plaques and neurofibrillary tangles in paraffin sections — a simple and effective method. [link.springer.com]

Post-Encephalitic Syndrome

The brain regions affected contain neurofibrillary tangles, similar to those seen in Alzheimer's disease. [en.wikipedia.org]

tangles in residual neurons in many subcortical nuclei. [alzheimer-europe.org]

Neuropathology: multisystem neuronal degeneration and cell loss, with gliosisin many brainstem nuclei, in particular substantia nigra, locus ceruleus, and others with globous neurofibrillary [alzheimer-europe.org]

Familial Progressive Vestibulocochlear Dysfunction

tangles and neuropil threads to a lesser extent.[33, 39] Much like Alzheimer disease, PSP is characterized by neurofibrillary tangles causing nerve cell loss, gliosis, and [eyewiki.aao.org]

Postmortem examination demonstrated neurofibrillary tangles (NFTs) and gliosis without prominent senile plaques, the same pathology that was observed in the sporadic cases [emedicine.medscape.com]

tangles. [eyewiki.aao.org]

Prion Disease

Tau-positive pathologic structures including neurofibrillary tangles, neuropil threads, and dystrophic neurites around the plaques were abundant in the brain of Patient 2. [ncbi.nlm.nih.gov]

Abstract Patients with pathogenic truncating mutations in the prion gene (PRNP) usually present with prolonged disease courses with severe neurofibrillary tangle and cerebral [ncbi.nlm.nih.gov]

Neuropathological findings are also relatively diverse, partly overlapping with those found in Alzheimer's disease, especially the presence of neurofibrillary tangles (NFTs [ncbi.nlm.nih.gov]

Degenerative Disorder

In this video he explains the plaques and tangles behind Alzheimer’s Disease. Neurofibrillary tangles in the brain may foreshadow trouble. [brainfacts.org]

tangles in this disease and other tauopathies. [neuroscience.cam.ac.uk]

In Alzheimer's disease, work done in Cambridge was the first to show that the microtubule-associated protein tau is the major component of the filaments that form the neurofibrillary [neuroscience.cam.ac.uk]

Binswanger Disease

Cerebral vascular amyloid deposits, senile plaques and neurofibrillary tangles have been found in subcortical arteriosclerotic encephalopathy (Binswanger disease). [ncbi.nlm.nih.gov]

Abnormally phosphorylated tau that accumulates intraneuronally forming neurofibrillary tangles (NFTs). [librepathology.org]

AD is characterized by two abnormalities in the brain: amyloid plaques and neurofibrillary tangles. [alzheimersweekly.com]

Pelvic Declination

Recent investigations point to a greater participation of neurofibrillary tangles (NFTs) than that of senile plaques, as responsible for cognitive impairment in AD and normal [urotoday.com]

Primary Progressive Aphasia

When Alzheimer pathology is detected, the neurofibrillary tangles show lower entorhinal-to-neocortical ratios and greater leftward asymmetry in PPA than in the typical amnestic [neurology.org]

Neuropathological examination revealed the typical pathology of PSP: loss of neurons, gliosis, occurrence of neurofibrillary tangles, oligodendroglial coiled bodies, and tuft-shaped [ncbi.nlm.nih.gov]

[…] the leftward asymmetry of the atrophy, and where neurofibrillary tangles show a greater density in memory than language areas despite the predominantly aphasic phenotype. [ncbi.nlm.nih.gov]

Beta-Propeller Protein-Associated Neurodegeneration

There was extensive hyperphosphorylated-tau deposition in the form of neurofibrillary tangles, pre-tangles and neuropil threads. [ncbi.nlm.nih.gov]

Tau-positive neurofibrillary tangles and alpha-synuclein–positive Lewy bodies may be found in cortical and subcortical regions in patients with a prolonged clinical course [emedicine.medscape.com]

Numerous tau-positive neurofibrillary tangles were seen in several regions; no beta-amyloid plaques or Lewy bodies were observed [ Hayflick et al 2013 ]. [ncbi.nlm.nih.gov]

Pick Disease of The Brain

ABBREVIATIONS: ICV intracranial volume NFT neurofibrillary tangle NPC Niemann-Pick disease type C NUCOG Neuropsychiatry Unit Cognitive Assessment Tool VBM voxel-based morphometry [ajnr.org]

Neurofibrillary tangles are damaged proteins (tau proteins) that collect into "tangles," which cause improper functioning of nerve cells, leading them to disintegrate. [onhealth.com]

In addition, the presence of neurofibrillary tangles that are a hallmark of Alzheimer’s can be stained with antibodies to basic fibroblast growth factor, amyloid P, and heparan [en.wikipedia.org]