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16 Possible Causes for Neurologic Crises with Coma

  • Addison's Disease

    Hypoglycemic crises resulting in convulsions can lead to coma or death if untreated and recurrent hypolglycemia may lead to neurological sequelae (i.e. learning disabilities[orpha.net]

  • Diabetic Coma

    There are multiple reports of patients with hyperglycaemic crises and focal neurologic damage, most commonly due to cerebrovascular accidents (CVA).[cancertherapyadvisor.com] CVA may be the precipitating factor for development of hyperosmolar coma and the hyperosmolar state may also predispose to thrombotic CVA.[cancertherapyadvisor.com]

  • Insulin Overdose

    Abstract Three types of diabetic crises occur: insulin overdose, diabetic ketoacidosis, and hyperosmolar coma.[ncbi.nlm.nih.gov] Neurologic signs may accompany each of these syndromes, and each must be differentiated quickly by the emergency clinician so that an appropriate treatment plan can be initiated[ncbi.nlm.nih.gov]

  • Metabolic Disease

    The brain and muscles are generally affected first, which can cause developmental delay, neurological crises — including episodes of coma, stroke-like events, and seizures[encyclopedia.com]

  • HMG-CoA Lyase Deficiency

    Hypoglycemic crises are strikingly similar to severe stages of Reye's syndrome, and can lead to irreversible neurological sequelae (psychomotor retardation, epilepsy), cardiomyopathy[symptoma.com] Nausea, vomiting, lethargy and hypotonia are most important symptoms, whereas respiratory distress and coma are reported in severe cases.[symptoma.com]

  • Maple Syrup Urine Disease

    Affected children can develop metabolic crises that result in seizures, coma, brain damage, and, in rare cases, life-threatening neurological complications.[rarediseases.org]

  • Lysinuric Protein Intolerance

    […] with overt neurologic manifestations (vomiting, drowsiness, coma) and of respiratory involvement (cough, dyspnea, recurrent lower respiratory tract infections) Neurologic[ncbi.nlm.nih.gov] […] individual diagnosed with lysinuric protein intolerance, the following evaluations are recommended if they have not already been completed: History for evidence of hyperammonemic crises[ncbi.nlm.nih.gov]

  • Lysinemia

    […] with overt neurologic manifestations (vomiting, drowsiness, coma) and of respiratory involvement (cough, dyspnea, recurrent lower respiratory tract infections) Neurologic[ncbi.nlm.nih.gov] […] individual diagnosed with lysinuric protein intolerance, the following evaluations are recommended if they have not already been completed: History for evidence of hyperammonemic crises[ncbi.nlm.nih.gov]

  • Glutaric Aciduria

    Urine Ketone bodies, pH Vital signs Heart rate, blood pressure, temperature, diuresis; Glasgow Coma Scale if reduced consciousness; assessment for neurological signs (hypotonia[ncbi.nlm.nih.gov] , irritability, rigor, dystonia) Emergency treatment after age 6 years Although encephalopathic crises are extremely rare if they occur at all after age 6 years (Bjugstad[ncbi.nlm.nih.gov]

  • Disorders of Pyruvate Metabolism and Gluconeogenesis

    The brain and muscles are generally affected first, which can cause developmental delay, neurological crises — including episodes of coma, stroke-like events, and seizures[encyclopedia.com]

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