Neurologic Involvement: Causes & Reasons

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Possible Causes for Neurologic Involvement

Gaucher Disease Type 2

These types are determined by the absence or presence and severity of neurological involvement. [themedicalbiochemistrypage.org]

lungs and kidneys may also be involved, but the CNS is spared type II (acute neuropathic form or infantile form): severe progressive neurological involvement with death [radiopaedia.org]

Type 3 Gaucher disease also has neurological involvement but not as severe as Type 2 Gaucher. [huffingtonpost.co.uk]

Niemann-Pick Disease Type B

NPD type B is a rare inborn error of metabolism, with a benign course and prognosis, while types A and C are always associated with severe neurological involvement. [ncbi.nlm.nih.gov]

Survival into adulthood and absence of gross neurological involvement suggests Niemann-Pick disease type B. [ncbi.nlm.nih.gov]

It appears that the lack of neurological involvement in type B patients cannot be due to an obvious presence of significant lysosomal sphingomyelinase activity in brain. [ncbi.nlm.nih.gov]

Gaucher Disease

Type A is a lethal infantile form with marked progressive neurologic involvement. [accessmedicine.mhmedical.com]

We report a case of recurrent cholelithiasis and liver failure in a patient with type 2 Gaucher disease who showed severe progressive neurological involvement. [ncbi.nlm.nih.gov]

Three distinct GD subtypes have been described with varying clinical features based on the presence or absence of neurologic involvement. [ncbi.nlm.nih.gov]

Niemann-Pick Disease

Type B Niemann-Pick disease is a less severe form with milder neurological involvement, characterized by hepatosplenomegaly, hyperlipidemia, and pulmonary involvement; most [ncbi.nlm.nih.gov]

Survival into adulthood and absence of gross neurological involvement suggests Niemann-Pick disease type B. [ncbi.nlm.nih.gov]

Some may show neurological involvement, poor co-ordination and impaired intellectual capacity In severe cases, liver involvement is marked with cirrhosis and ascites. [epainassist.com]

Neurologic Manifestation of Whipple Disease

Although previously considered a late manifestation of Whipple disease, neurological involvement is now frequently the initial clinical manifestation and represents the greatest [ncbi.nlm.nih.gov]

[…] of intestinal involvement, and neurologic relapse of previously treated WD. [asmscience.org]

It has been suggested that neurological involvement will eventually occur in all patients with Whipple disease. [radiopaedia.org]

Transient Sarcoidosis

Over time, skin, eye, and neurologic involvement seem more apparent. [what-when-how.com]

Neurosarcoidosis generally occurs only in cases of sarcoidosis with substantial systemic involvement, and signs of neurologic involvement usually are seen in patients known [emedicine.medscape.com]

Bell's palsy and lymphocytic meningitis are common manifestations of neurological involvement but diabetes insipidus is also seen. [patient.info]

Behçet Disease

It is not known whether this is the consequence of mucosal involvement or neurologic involvement. [ncbi.nlm.nih.gov]

Our study included 14 individuals with BD with neurological involvement (neuroBehçet syndrome - NBS), 16 individuals with BD without neurological involvement and 18 healthy [ncbi.nlm.nih.gov]

Neurological involvement or neuro-Behçet disease is not common, but typically affects young men at its onset between the ages of 20 and 40 with significant long-term morbidity [ncbi.nlm.nih.gov]

Spondyloenchondrodysplasia

Manifestation of the disorder may include neurological involvement (spasticity, intracranial calcifications and mental retardation) and immune dysfunction. [ncbi.nlm.nih.gov]

The clinical spectrum of SPENCD includes neurological involvement and immune dysfunction, such as systemic lupus erythematosus (SLE). [ncbi.nlm.nih.gov]

involvement and variable immune dysfunction. [ncbi.nlm.nih.gov]

Omsk Hemorrhagic Fever

involvement. [en.wikipedia.org]

[…] uterus, and lungs, a papulovesicular rash on the soft palate, cervical lymphadenopathy (it occurs in the neck which that enlarges the lymph glandular tissue), and occasional neurological [en.wikipedia.org]

Acute Sarcoidosis

Given the wide a range of neurologic involvement, patients may present with virtually any neurologic complaint. [emedicine.medscape.com]

[…] findings Neurologic manifestations include cranial nerve VII involvement (unilaterally or bilaterally), Bell palsy, basal granulomatous meningitis (ie, aseptic meningitis [emedicine.medscape.com]

Systemic immunosuppressive agents are indicated in patients who are dependent on or intolerant of corticosteroids. [4] Neurologic care Patients who have CNS involvement may [emedicine.medscape.com]

Sea-blue histiocytosis

It is characterized by childhood onset of hepatosplenomegaly, lack of neurological involvement and diminished sphingomyelinase activity. [ncbi.nlm.nih.gov]

It seems clear that chronic Niemann-Pick disease without neurological involvement is associated with sea blue histiocytosis. [ncbi.nlm.nih.gov]

NPD type B is a rare inborn error of metabolism, with a benign course and prognosis, while types A and C are always associated with severe neurological involvement. [ncbi.nlm.nih.gov]

Farber Disease

Evaluation of neurological involvement is difficult as movement causes extreme pain in afflicted infants. [themedicalbiochemistrypage.org]

However, allogeneic hematopoietic stem cell transplantation provides a promising approach for patients with limited neurological involvement. [orpha.net]

In addition the neurologic involvement is much more mild than in type 1. Type 4 is referred to as the "neonatal-visceral" form of the disease. [themedicalbiochemistrypage.org]

Mucopolysaccharidosis Type 2

In patients with neurologic involvement, intelligence is impaired, and death usually occurs in the second decade of life, whereas those patients with minimal or no neurologic [pediatrics.aappublications.org]

involvement. [pediatrics.aappublications.org]

involvement may survive into adulthood with normal intellectual development. [pediatrics.aappublications.org]

Perinatal Lethal Gaucher Disease

If born, neurologic involvement begins in the first week and leads to death within 3 months. [newmedicalterms.com]

This is caused by neurologic involvement leading to uncoordinated movements of the pharynx. [childrensgaucher.org]

Neurological involvement occurs very early on in the disease process, resulting in severe degeneration and death in infancy or early childhood. [epostersonline.com]

Cerebral Angiitis

Neurology 39:167–173 PubMed Google Scholar 16. Nishino H, Rubino FA, DeRemee RA et al. (1993) Neurological involvement in Wegener’s granulomatosis. [link.springer.com]

Conclusions Neurological involvement in rheumatic disease is associated with high morbidity and, in some cases, can be life-threatening. [jmedicalcasereports.biomedcentral.com]

Akman-Demir G, Serdaroglu P, Tasci B (1999) Clinical patterns of neurological involvement in Behcet’s disease: evaluation of 200 patients. The Neuro-Behcet Study Group. [link.springer.com]

Bloch Sulzberger Syndrome

Prognosis:Individuals without significant ophthalmologic or neurologic involvement have excellent prognosis and a normal life expectancy.For patients with brain or ocular [dailyrounds.org]

Neurological involvement necessitates a pediatric neurologist, whereas developmental screening and additional complementary therapy may be recommended in cases with developmental [orpha.net]

Whipple Disease

involvement and to add a high dose of sulfamethoxazole or sulfadiazine only in patients with neurological involvement. [jac.oxfordjournals.org]

[…] of intestinal involvement, and neurologic relapse of previously treated WD. [asmscience.org]

Neurological involvement has been recognised in 40% of patients, either as initial manifestations or during the course of the disease. [ncbi.nlm.nih.gov]

Hemolytic Uremic Syndrome

Neurologic involvement is frequent but often reversible. [ncbi.nlm.nih.gov]

Neurologic involvement is the most threatening complication of diarrhea-associated hemolytic uremic syndrome (D+HUS). [ncbi.nlm.nih.gov]

Severe neurologic involvement is not rare in D+HUS. [doi.org]

Tertiary Syphilis

The investigation for cardiovascular and neurological involvement was negative in both patients. [ncbi.nlm.nih.gov]

[…] occurs in up to 10 percent of patients with untreated syphilis. 14 Neurosyphilis should be considered in patients with signs or symptoms of neurologic involvement at any [aafp.org]

We recall the necessity of ruling out neurological and cardiac involvement in this stage of syphilis. [ncbi.nlm.nih.gov]

CINCA Syndrome

Abstract CINCA syndrome is a genetic disorder characterized by early onset of recurrent fever, rash, progressive articular and neurological involvement. [ncbi.nlm.nih.gov]

involvement. [worldwidejournals.com]

Similarly, symptoms related to neurological involvement can become obvious in patients with increasing age. [printo.it]

Chédiak-Higashi Syndrome

Chediak-Higashi syndrome is characterized by varying degrees of oculocutaneous albinism, recurrent infections, bleeding disorders and variable neurological involvement. [ncbi.nlm.nih.gov]

Neurologic involvement is variable, but often includes peripheral neuropathy. [ncbi.nlm.nih.gov]

involvement. [clinicaladvisor.com]

Pulmonary Lymphomatoid Granulomatosis

Nine had lymphomatoid granulomatosis characterized by necrotic atypical lymphoreticular infiltrates and frequent cutaneous and neurologic involvement, usually fatal despite [annals.org]

In the involved peripheral nerves there is demyelination and lymphoid cell infiltration. Neurologic involvement tends to indicate a worse prognosis. [neurology.org]

Fifteen patients had Wegener's granulomatosis characterized by necrotizing granulomatous inflammation of lung, frequent upper airway and renal involvement, and responsiveness [annals.org]

Neurosyphilis

involvement, sometimes asymptomatic. [ncbi.nlm.nih.gov]

The overwhelming majority of early syphilis cases in patients with HIV in Warsaw had neurological involvement, Polish investigators report in HIV Medicine. [aidsmap.com]

INTRODUCTION: Neurological involvement is one of the most important clinical manifestations of syphilis and neurological disease occurs in both early and late syphilis. [ncbi.nlm.nih.gov]

Lymphomatoid Granulomatosis

He was treated with steroid and cyclophosphamide but succumbed by neurologic involvement. [ncbi.nlm.nih.gov]

Nine had lymphomatoid granulomatosis characterized by necrotic atypical lymphoreticular infiltrates and frequent cutaneous and neurologic involvement, usually fatal despite [ncbi.nlm.nih.gov]

Nine had lymphomatoid granulomatosis characterized by necrotic atypical lymphoreticular infiltrates and frequent cutaneous and neurologic involvement… CONTINUE READING [semanticscholar.org]

Sturge-Weber Syndrome

Abstract The primary neurologic involvement in both von Hippel-Lindau (VHL) disease and Sturge-Weber syndrome (SWS) is vascular tumor/vascular malformation, but molecular [ncbi.nlm.nih.gov]

Glaucoma also may occur without neurologic involvement (Type II, Roach Scale). [emedicine.medscape.com]

Author information 1 Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA, United States. [ncbi.nlm.nih.gov]

Mononeuritis

We excluded the patients with neurological involvement such as nerve entrapment syndromes, mononeuritis multiplex, and atlantoaxial subluxation. [medical-dictionary.thefreedictionary.com]

Garzoni et al [5] did a systematic review of all HSP cases with neurological involvement who presented between 1969- 2009. [elynsgroup.com]

“The Clinical Spectrum of the Neurological Involvement in Vasculitides”. Journal of Neurological Sciences. vol. 285. 2009 Oct 15. pp. 13-21. [clinicaladvisor.com]

Mucopolysaccharidosis Type 1S

Patients with MPS1S may have little or no neurological involvement, normal stature and life span, but present development of joints stiffness, mild hepatosplenomegaly, aortic [uniprot.org]

Thus, brain and spinal MR imaging are valuable tools for the assessment of neurologic involvement, and there is evidence that they might be reliable markers demonstrating [ajnr.org]

involvement. [1], [2] All these syndromes are autosomal recessive, with the exception of the X-linked recessive Hunter syndrome. [jcor.in]

Transcobalamin 2 Deficiency

Neurological involvement in hereditary transcobalamin II deficiency. [jnnp.bmj.com]

A case of hereditary transcobalamin II deficiency with neurological involvement is described. [ncbi.nlm.nih.gov]

Thomas PD, Hoffbrand AV, Smith IS (1982) Neurologic involvement in hereditary transcobalamin II deficiency. [link.springer.com]

Niemann-Pick Disease Type C

Abstract Niemann-Pick disease type C, an autosomal recessive lysosomal storage disorder, can present with severe visceral and neurologic involvement and is associated with [ncbi.nlm.nih.gov]

NPC is clinically characterized by a wide spectrum of manifestations with progressive visceral and neurological involvement, including dysphagia. [ncbi.nlm.nih.gov]

CONCLUSIONS: This Bulgarian NP-C cohort showed wide variability in terms of NPC1 mutations and predominant forms of neurological involvement. [ncbi.nlm.nih.gov]

Lyme Meningoencephalitis

ABSTRACT Neurological involvement in Lyme disease has been reported to include meningitis, cranial neuropathy and radiculoneuritis. [scielo.br]

In children, indications of neurological involvement include behaviour changes, learning difficulties and headaches. [lymediseaseaction.org.uk]

Weder B, Wiedersheim P, Matter L, Steck A, Otto F (1987) Chronic progressive neurological involvement in Borrelia burgdorferi infection. [link.springer.com]