Neurologic Involvement: Causes & Reasons

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Possible Causes for Neurologic Involvement

Gaucher Disease Type 2

These types are determined by the absence or presence and severity of neurological involvement. [themedicalbiochemistrypage.org]

lungs and kidneys may also be involved, but the CNS is spared type II (acute neuropathic form or infantile form): severe progressive neurological involvement with death [radiopaedia.org]

Type 3 Gaucher disease also has neurological involvement but not as severe as Type 2 Gaucher. [huffingtonpost.co.uk]

Niemann-Pick Disease Type B

NPD type B is a rare inborn error of metabolism, with a benign course and prognosis, while types A and C are always associated with severe neurological involvement. [ncbi.nlm.nih.gov]

Survival into adulthood and absence of gross neurological involvement suggests Niemann-Pick disease type B. [ncbi.nlm.nih.gov]

It appears that the lack of neurological involvement in type B patients cannot be due to an obvious presence of significant lysosomal sphingomyelinase activity in brain. [ncbi.nlm.nih.gov]

Niemann-Pick Disease

Type B Niemann-Pick disease is a less severe form with milder neurological involvement, characterized by hepatosplenomegaly, hyperlipidemia, and pulmonary involvement; most [ncbi.nlm.nih.gov]

Survival into adulthood and absence of gross neurological involvement suggests Niemann-Pick disease type B. [ncbi.nlm.nih.gov]

Some may show neurological involvement, poor co-ordination and impaired intellectual capacity In severe cases, liver involvement is marked with cirrhosis and ascites. [epainassist.com]

Neurologic Manifestation of Whipple Disease

Although previously considered a late manifestation of Whipple disease, neurological involvement is now frequently the initial clinical manifestation and represents the greatest [ncbi.nlm.nih.gov]

[…] of intestinal involvement, and neurologic relapse of previously treated WD. [asmscience.org]

It has been suggested that neurological involvement will eventually occur in all patients with Whipple disease. [radiopaedia.org]

Gaucher Disease

Type A is a lethal infantile form with marked progressive neurologic involvement. [accessmedicine.mhmedical.com]

We report a case of recurrent cholelithiasis and liver failure in a patient with type 2 Gaucher disease who showed severe progressive neurological involvement. [ncbi.nlm.nih.gov]

Three distinct GD subtypes have been described with varying clinical features based on the presence or absence of neurologic involvement. [ncbi.nlm.nih.gov]

Spondyloenchondrodysplasia

Manifestation of the disorder may include neurological involvement (spasticity, intracranial calcifications and mental retardation) and immune dysfunction. [ncbi.nlm.nih.gov]

The clinical spectrum of SPENCD includes neurological involvement and immune dysfunction, such as systemic lupus erythematosus (SLE). [ncbi.nlm.nih.gov]

[…] or immunologic involvement. [ncbi.nlm.nih.gov]

Transcobalamin 2 Deficiency

A case of hereditary transcobalamin II deficiency with neurological involvement is described. [ncbi.nlm.nih.gov]

Neurological involvement in hereditary transcobalamin II deficiency. [jnnp.bmj.com]

Thomas PD, Hoffbrand AV, Smith IS (1982) Neurologic involvement in hereditary transcobalamin II deficiency. [link.springer.com]

Behçet Disease

Neurological manifestations are present in 5-10%, and gastrointestinal tract involvement in 10-15% of cases. [ncbi.nlm.nih.gov]

It is not known whether this is the consequence of mucosal involvement or neurologic involvement. [ncbi.nlm.nih.gov]

Our study included 14 individuals with BD with neurological involvement (neuroBehçet syndrome - NBS), 16 individuals with BD without neurological involvement and 18 healthy [ncbi.nlm.nih.gov]

Omsk Hemorrhagic Fever

involvement. [en.wikipedia.org]

[…] uterus, and lungs, a papulovesicular rash on the soft palate, cervical lymphadenopathy (it occurs in the neck which that enlarges the lymph glandular tissue), and occasional neurological [en.wikipedia.org]

Transient Sarcoidosis

Over time, skin, eye, and neurologic involvement seem more apparent. [what-when-how.com]

Neurosarcoidosis generally occurs only in cases of sarcoidosis with substantial systemic involvement, and signs of neurologic involvement usually are seen in patients known [emedicine.medscape.com]

Bell's palsy and lymphocytic meningitis are common manifestations of neurological involvement but diabetes insipidus is also seen. [patient.info]

Sea-blue histiocytosis

It is characterized by childhood onset of hepatosplenomegaly, lack of neurological involvement and diminished sphingomyelinase activity. [ncbi.nlm.nih.gov]

It seems clear that chronic Niemann-Pick disease without neurological involvement is associated with sea blue histiocytosis. [ncbi.nlm.nih.gov]

NPD type B is a rare inborn error of metabolism, with a benign course and prognosis, while types A and C are always associated with severe neurological involvement. [ncbi.nlm.nih.gov]

Perinatal Lethal Gaucher Disease

If born, neurologic involvement begins in the first week and leads to death within 3 months. [newmedicalterms.com]

This is caused by neurologic involvement leading to uncoordinated movements of the pharynx. [childrensgaucher.org]

Neurological involvement occurs very early on in the disease process, resulting in severe degeneration and death in infancy or early childhood. [epostersonline.com]

Farber Disease

Evaluation of neurological involvement is difficult as movement causes extreme pain in afflicted infants. [themedicalbiochemistrypage.org]

However, allogeneic hematopoietic stem cell transplantation provides a promising approach for patients with limited neurological involvement. [orpha.net]

In addition the neurologic involvement is much more mild than in type 1. Type 4 is referred to as the "neonatal-visceral" form of the disease. [themedicalbiochemistrypage.org]

Acute Sarcoidosis

Given the wide a range of neurologic involvement, patients may present with virtually any neurologic complaint. [emedicine.medscape.com]

[…] findings Neurologic manifestations include cranial nerve VII involvement (unilaterally or bilaterally), Bell palsy, basal granulomatous meningitis (ie, aseptic meningitis [emedicine.medscape.com]

Systemic immunosuppressive agents are indicated in patients who are dependent on or intolerant of corticosteroids. [4] Neurologic care Patients who have CNS involvement may [emedicine.medscape.com]

Mucopolysaccharidosis Type 2

In patients with neurologic involvement, intelligence is impaired, and death usually occurs in the second decade of life, whereas those patients with minimal or no neurologic [pediatrics.aappublications.org]

involvement. [pediatrics.aappublications.org]

involvement may survive into adulthood with normal intellectual development. [pediatrics.aappublications.org]

Hemolytic Uremic Syndrome

Neurologic involvement is the most threatening complication of diarrhea-associated hemolytic uremic syndrome (D+HUS). [ncbi.nlm.nih.gov]

Severe neurologic involvement is not rare in D+HUS. [doi.org]

Neurologic involvement is frequent but often reversible. [ncbi.nlm.nih.gov]

Cerebral Angiitis

Neurology 39:167–173 PubMed Google Scholar 16. Nishino H, Rubino FA, DeRemee RA et al. (1993) Neurological involvement in Wegener’s granulomatosis. [link.springer.com]

Conclusions Neurological involvement in rheumatic disease is associated with high morbidity and, in some cases, can be life-threatening. [jmedicalcasereports.biomedcentral.com]

Akman-Demir G, Serdaroglu P, Tasci B (1999) Clinical patterns of neurological involvement in Behcet’s disease: evaluation of 200 patients. The Neuro-Behcet Study Group. [link.springer.com]

Bloch Sulzberger Syndrome

Prognosis:Individuals without significant ophthalmologic or neurologic involvement have excellent prognosis and a normal life expectancy.For patients with brain or ocular [dailyrounds.org]

Neurological involvement necessitates a pediatric neurologist, whereas developmental screening and additional complementary therapy may be recommended in cases with developmental [orpha.net]

Eosinophilic Synovitis

Neurological involvement with peripheral neuropathy or mononeuritis multiplex is less common at presentation but can be detected (often subclinically) with time. [thermofisher.com]

IFAP Syndrome with or without BRESHEK Syndrome

Clinical Characteristics Ocular Features: The eyelashes and eyebrow hair is sparse or completely absent. Keratitis with secondary photophobia is often seen during infancy and progresses to corneal vascularization and scarring, sometimes resembling trachomatous disease. Cataracts do not seem to be part of this[…] [disorders.eyes.arizona.edu]

Endosteal Hyperostosis

Report of a Spanish family with neurological involvement J A Perez-Vicente et al. Clin Genet. 1987 Mar. [pubmed.ncbi.nlm.nih.gov]

Report of a Spanish family with neurological involvement, Corresponding Author Departments of Neurology and Radiology, Hospital Provincial, Madrid, Spain 2 Department of Neurology [onlinelibrary.wiley.com]

Ades LC, Morris LL, Burns R, Haan EA: Neurological involvement in Worth type endosteal hyperostosis: report of a family. [jmedicalcasereports.biomedcentral.com]

Autoimmune Vasculitis

Neurological involvement with peripheral neuropathy or mononeuritis multiplex is less common at presentation but can be detected (often subclinically) with time. [thermofisher.com]

A, Lamloum M, et al. (2013) Rectrospective CNS involvement PubMed Neurological complications of Behçet’s syndrome Kidd D (2012) Review CNS involvement and treatments PubMed [ncbi.nlm.nih.gov]

PubMed Neurologic involvement in scleroderma: a systematic review Amaral TN, Peres FA, Lapa AT, Marques-Neto JF and Appenzeller S (2013) Systematic review CNS + PNS involvement [ncbi.nlm.nih.gov]

Gaucher Disease Type 3

involvement leading to death at an age of 12.5 years. [ncbi.nlm.nih.gov]

There are several subtypes based on the presence and severity of neurological involvement. [hon.ch]

In addition to organomegaly and bony involvement, individuals with type 3 disease have neurologic involvement, most often including slowing of the horizontal saccadic eye [emedicine.medscape.com]

Congenital Disorder of Glycosylation Type 2C

It is characterized by neurological involvement that may be associated with multivisceral involvement and it is estimated that the frequency is 1/50,000-1/100,000. [tellmegen.com]

Most CDG are multisystem disorders with predominant neurological involvement. [nature.com]

Clinical manifestations Given the ubiquitous presence of glycosylation pathways, virtually any organ system may be involved in CDG, although most cases involve neurologic [ncbi.nlm.nih.gov]

Griscelli Syndrome

A kindred with Griscelli disease: spectrum of neurological involvement. Eur J Pediatr. 1993 ;152: 402 - 405. [journals.sagepub.com]

We report a 20-year-old female patient with classical features of GS along with circumscribed pigment loss (vitiligo-like lesions) and neurological involvement. [escholarship.org]

involvement and no immunodeficiency.1 Commonest complication of GS is hemophagocytic lymphohistiocystosis which carries high mortality in absence of bone marrow transplantation [academic.oup.com]

Congenital Disorder of Glycosylation Type 1L

[…] progressive neurological involvement after her first years of life. [ncbi.nlm.nih.gov]

Nevertheless, patient 2 was born with a severe liver involvement and recurrent neonatal infections that lead to an unfortunate early death; however, patient 1 developed a [ncbi.nlm.nih.gov]

Congenital Disorder of Glycosylation Type 1J

It is characterized by neurological involvement that may be associated with multivisceral involvement and it is estimated that the frequency is 1/50,000-1/100,000. [tellmegen.com]

neurological involvement that can be associated with mild or no visceral disorders [8],[9]. [ojrd.biomedcentral.com]

Clinical manifestations Given the ubiquitous presence of glycosylation pathways, virtually any organ system may be involved in CDG, although most cases involve neurologic [ncbi.nlm.nih.gov]

Whipple Disease

involvement and to add a high dose of sulfamethoxazole or sulfadiazine only in patients with neurological involvement. [jac.oxfordjournals.org]

[…] of intestinal involvement, and neurologic relapse of previously treated WD. [asmscience.org]

Neurological involvement has been recognised in 40% of patients, either as initial manifestations or during the course of the disease. [ncbi.nlm.nih.gov]

Congenital Disorder of Glycosylation Type 1P

It is characterized by neurological involvement that may be associated with multivisceral involvement and it is estimated that the frequency is 1/50,000-1/100,000. [tellmegen.com]

Despite the wide variety in presentation, many types of CDG have a significant neurological component involving the brain and/or spine (central nervous system). [rarediseases.org]

Common neurological symptoms include diminished muscle tone (hypotonia), seizures, deficits in attaining developmental milestones (developmental disability), varying degrees [rarediseases.org]

Neuroectodermal Melanolysosomal Disease

Isolated neurological deterioration without hematological involvement has been rarely described [ 4 - 6 ]. [casereports.in]

Absence of hypopigmentation of the covered body parts and an accelerated neurological involvement leading to sudden death in the patient are interesting features. [ijdvl.com]

Involvement without Hematologic Manifestations.JCR 2017;7:139-142 Akunuri S, Jain A, Narwal V, Alam SUnusual Presentation of Griscelli Syndrome: Neurological Involvement [casereports.in]