Neurologic Involvement: Causes & Reasons

Possible Causes for Neurologic Involvement

Long COVID or long-haul COVID (also known as post-COVID-19 syndrome, post-COVID-19 condition,[1][2] post-acute sequelae of COVID-19 (PASC), or chronic COVID syndrome (CCS)[3][4][5]) is a condition characterized by long-term health problems persisting or appearing after the typical recovery period of COVID-19.[…] [en.wikipedia.org]

Gaucher Disease Type 2

These types are determined by the absence or presence and severity of neurological involvement. [themedicalbiochemistrypage.org]

Type 3 Gaucher disease also has neurological involvement but not as severe as Type 2 Gaucher. [huffingtonpost.co.uk]

There are several subtypes based on the presence and severity of neurological involvement. [hon.ch]

Neurologic Manifestation of Whipple Disease

[…] of intestinal involvement, and neurologic relapse of previously treated WD. [asmscience.org]

Although previously considered a late manifestation of Whipple disease, neurological involvement is now frequently the initial clinical manifestation and represents the greatest [ncbi.nlm.nih.gov]

It has been suggested that neurological involvement will eventually occur in all patients with Whipple disease. [radiopaedia.org]

Niemann-Pick Disease Type B

NPD type B is a rare inborn error of metabolism, with a benign course and prognosis, while types A and C are always associated with severe neurological involvement. [ncbi.nlm.nih.gov]

Survival into adulthood and absence of gross neurological involvement suggests Niemann-Pick disease type B. [ncbi.nlm.nih.gov]

It appears that the lack of neurological involvement in type B patients cannot be due to an obvious presence of significant lysosomal sphingomyelinase activity in brain. [ncbi.nlm.nih.gov]

Cerebrotendinous Xanthomatosis

involvement. [ncbi.nlm.nih.gov]

Cerebrotendinous xanthomatosis without neurological involvement. J Intern Med. 2021b;290:1039–47. [ncbi.nlm.nih.gov]

CLINICAL FEATURES Patients with CTX present diverse manifestations with multi-organ involvement and a broad range of neurological and non-neurological symptoms (Table 1). [ncbi.nlm.nih.gov]

Spondyloenchondrodysplasia

Manifestation of the disorder may include neurological involvement (spasticity, intracranial calcifications and mental retardation) and immune dysfunction. [ncbi.nlm.nih.gov]

involvement and variable immune dysfunction. [ncbi.nlm.nih.gov]

The clinical spectrum of SPENCD includes neurological involvement and immune dysfunction, such as systemic lupus erythematosus (SLE). [ncbi.nlm.nih.gov]

Gaucher Disease

Type A is a lethal infantile form with marked progressive neurologic involvement. [accessmedicine.mhmedical.com]

lungs and kidneys may also be involved, but the CNS is spared type 2 (acute neuropathic form or infantile form): severe progressive neurological involvement with death by [radiopaedia.org]

We report a case of recurrent cholelithiasis and liver failure in a patient with type 2 Gaucher disease who showed severe progressive neurological involvement. [ncbi.nlm.nih.gov]

Niemann-Pick Disease

Type B Niemann-Pick disease is a less severe form with milder neurological involvement, characterized by hepatosplenomegaly, hyperlipidemia, and pulmonary involvement; most [ncbi.nlm.nih.gov]

Survival into adulthood and absence of gross neurological involvement suggests Niemann-Pick disease type B. [ncbi.nlm.nih.gov]

NPB is characterised by hepatosplenomegaly, thrombocytopenia, interstitial lung disease and dyslipidaemia with most patients having little or no neurological involvement. [patient.info]

Behçet Disease

Neurological manifestations are present in 5-10%, and gastrointestinal tract involvement in 10-15% of cases. [ncbi.nlm.nih.gov]

It is not known whether this is the consequence of mucosal involvement or neurologic involvement. [ncbi.nlm.nih.gov]

Our study included 14 individuals with BD with neurological involvement (neuroBehçet syndrome - NBS), 16 individuals with BD without neurological involvement and 18 healthy [ncbi.nlm.nih.gov]

Perinatal Lethal Gaucher Disease

If born, neurologic involvement begins in the first week and leads to death within 3 months. [newmedicalterms.com]

This is caused by neurologic involvement leading to uncoordinated movements of the pharynx. [childrensgaucher.org]

Neurological involvement occurs very early on in the disease process, resulting in severe degeneration and death in infancy or early childhood. [epostersonline.com]

Transient Sarcoidosis

Over time, skin, eye, and neurologic involvement seem more apparent. [what-when-how.com]

Neurosarcoidosis generally occurs only in cases of sarcoidosis with substantial systemic involvement, and signs of neurologic involvement usually are seen in patients known [emedicine.medscape.com]

Bell's palsy and lymphocytic meningitis are common manifestations of neurological involvement but diabetes insipidus is also seen. [patient.info]

Transcobalamin 2 Deficiency

A case of hereditary transcobalamin II deficiency with neurological involvement is described. [ncbi.nlm.nih.gov]

Neurological involvement in hereditary transcobalamin II deficiency. [jnnp.bmj.com]

Thomas PD, Hoffbrand AV, Smith IS (1982) Neurologic involvement in hereditary transcobalamin II deficiency. [link.springer.com]

Sea-blue histiocytosis

It is characterized by childhood onset of hepatosplenomegaly, lack of neurological involvement and diminished sphingomyelinase activity. [ncbi.nlm.nih.gov]

It seems clear that chronic Niemann-Pick disease without neurological involvement is associated with sea blue histiocytosis. [ncbi.nlm.nih.gov]

NPD type B is a rare inborn error of metabolism, with a benign course and prognosis, while types A and C are always associated with severe neurological involvement. [ncbi.nlm.nih.gov]

Mucopolysaccharidosis Type 2

In patients with neurologic involvement, intelligence is impaired, and death usually occurs in the second decade of life, whereas those patients with minimal or no neurologic [pediatrics.aappublications.org]

involvement. [pediatrics.aappublications.org]

involvement may survive into adulthood with normal intellectual development. [pediatrics.aappublications.org]

Cerebral Angiitis

Neurology 39:167–173 PubMed Google Scholar 16. Nishino H, Rubino FA, DeRemee RA et al. (1993) Neurological involvement in Wegener’s granulomatosis. [link.springer.com]

Conclusions Neurological involvement in rheumatic disease is associated with high morbidity and, in some cases, can be life-threatening. [jmedicalcasereports.biomedcentral.com]

Akman-Demir G, Serdaroglu P, Tasci B (1999) Clinical patterns of neurological involvement in Behcet’s disease: evaluation of 200 patients. The Neuro-Behcet Study Group. [link.springer.com]

Transcobalamin 1 Deficiency

Neurological involvement in hereditary transcobalamin II deficiency. [jnnp.bmj.com]

Diseases in children cover all specialties encountered in adulthood, and neurology involves a particularly large area, ranging from the brain to the striated muscle, the generation [books.google.com]

Pernicious anaemia and other macrocytic anaemias with neurological involvement, initially 1 mg on alternate days until no further improvement, then 1 mg every 2 months. [patient.info]

Omsk Hemorrhagic Fever

involvement. [medbox.iiab.me]

[…] uterus, and lungs, a papulovesicular rash on the soft palate, cervical lymphadenopathy (it occurs in the neck which that enlarges the lymph glandular tissue), and occasional neurological [medbox.iiab.me]

Hemolytic Uremic Syndrome

Neurologic involvement is the most threatening complication of diarrhea-associated hemolytic uremic syndrome (D+HUS). [ncbi.nlm.nih.gov]

Severe neurologic involvement is not rare in D+HUS. [doi.org]

Neurologic involvement is frequent but often reversible. [ncbi.nlm.nih.gov]

Farber Disease

However, allogeneic hematopoietic stem cell transplantation provides a promising approach for patients with limited neurological involvement. [orpha.net]

Evaluation of neurological involvement is difficult as movement causes extreme pain in afflicted infants. [themedicalbiochemistrypage.org]

In addition the neurologic involvement is much more mild than in type 1. Type 4 is referred to as the "neonatal-visceral" form of the disease. [themedicalbiochemistrypage.org]

Bloch Sulzberger Syndrome

Extracutaneous manifestations (~75%) 1: neurologic involvement has been correlated with the neonatal scalp lesions in the first months of life, suggesting a non-progressive [radiopaedia.org]

Prognosis:Individuals without significant ophthalmologic or neurologic involvement have excellent prognosis and a normal life expectancy.For patients with brain or ocular [dailyrounds.org]

Neurological involvement necessitates a pediatric neurologist, whereas developmental screening and additional complementary therapy may be recommended in cases with developmental [orpha.net]

Whipple Disease

involvement and to add a high dose of sulfamethoxazole or sulfadiazine only in patients with neurological involvement. [jac.oxfordjournals.org]

Neurological involvement has been recognised in 40% of patients, either as initial manifestations or during the course of the disease. [ncbi.nlm.nih.gov]

[…] of intestinal involvement, and neurologic relapse of previously treated WD. [asmscience.org]

Neurosyphilis

involvement and 23 controls (noninfectious intracranial disease) before, 3 and 12 months after treatment with high dose penicillin.Results showed that there was no significant [ncbi.nlm.nih.gov]

involvement, sometimes asymptomatic. [ncbi.nlm.nih.gov]

INTRODUCTION: Neurological involvement is one of the most important clinical manifestations of syphilis and neurological disease occurs in both early and late syphilis. [ncbi.nlm.nih.gov]

Lyme Meningoencephalitis

Compared to published data from the same population in 2000–2005 Lyme incidence has doubled while the rate of hospital admission and neurological involvement has remained [jnnp.bmj.com]

ABSTRACT Neurological involvement in Lyme disease has been reported to include meningitis, cranial neuropathy and radiculoneuritis. [scielo.br]

Clinical patterns of neurological involvement in Behçet's disease: evaluation of 200 patients. The Neuro-Behçet Study Group. [elsevier.es]

Tertiary Syphilis

The investigation for cardiovascular and neurological involvement was negative in both patients. [ncbi.nlm.nih.gov]

[…] occurs in up to 10 percent of patients with untreated syphilis. 14 Neurosyphilis should be considered in patients with signs or symptoms of neurologic involvement at any [aafp.org]

We recall the necessity of ruling out neurological and cardiac involvement in this stage of syphilis. [ncbi.nlm.nih.gov]

Chédiak-Higashi Syndrome

involvement. [clinicaladvisor.com]

Chediak-Higashi syndrome is characterized by varying degrees of oculocutaneous albinism, recurrent infections, bleeding disorders and variable neurological involvement. [ncbi.nlm.nih.gov]

Patients who have survived into their third decade after HSCT develop neurologic involvement with weakness, ataxia, sensory deficit and progressive neurodegeneration. [clinicaladvisor.com]

CINCA Syndrome

Neurological involvement can evolve over childhood and its delayed onset or absence as in our case has been reported in other patients(8). [indianpediatrics.net]

involvement. [worldwidejournals.com]

Abstract CINCA syndrome is a genetic disorder characterized by early onset of recurrent fever, rash, progressive articular and neurological involvement. [ncbi.nlm.nih.gov]

IFAP Syndrome with or without BRESHEK Syndrome

Christopher Griffiths, Jonathan Barker, Tanya Bleiker, Robert Chalmers, Daniel Creamer Wiley, ٢٩‏/٠٢‏/٢٠١٦ - 4992 من الصفحات 2017 PROSE Award Winner - Multivolume Reference/Science The world's number 1 dermatology information resource Universally respected, Rook's Textbook of Dermatology is the most comprehensive,[…] [books.google.com]

Autoimmune Vasculitis

Neurological involvement with peripheral neuropathy or mononeuritis multiplex is less common at presentation but can be detected (often subclinically) with time. [thermofisher.com]

A, Lamloum M, et al. (2013) Rectrospective CNS involvement PubMed Neurological complications of Behçet’s syndrome Kidd D (2012) Review CNS involvement and treatments PubMed [ncbi.nlm.nih.gov]

PubMed Neurologic involvement in scleroderma: a systematic review Amaral TN, Peres FA, Lapa AT, Marques-Neto JF and Appenzeller S (2013) Systematic review CNS + PNS involvement [ncbi.nlm.nih.gov]

Gaucher Disease Type 3

involvement leading to death at an age of 12.5 years. [ncbi.nlm.nih.gov]

Combined audiological tests may provide information on the severity of the neurological involvement and should therefore be part of a standard assessment for the diagnosis [ncbi.nlm.nih.gov]

There are several subtypes based on the presence and severity of neurological involvement. [hon.ch]

Griscelli Syndrome

However, neurological involvement at onset in GS2 and treatment has rarely been described. [bmcpediatr.biomedcentral.com]

A kindred with Griscelli disease: spectrum of neurological involvement. Eur J Pediatr. 1993 ;152: 402 - 405. [journals.sagepub.com]

We report a 20-year-old female patient with classical features of GS along with circumscribed pigment loss (vitiligo-like lesions) and neurological involvement. [escholarship.org]