Create issue ticket

27 Possible Causes for Neuronal Loss and Gliosis in Caudate and Putamen

  • Huntington's Disease

    Microscopically, there is loss of medium size spiny, enkephalin-containing internuncial neurons in the caudate nucleus and putamen, loss of cortical neurons, and gliosis.[neuropathology-web.org] The neostriatum showed marked atrophy, with severe neuron loss and gliosis of the caudate, putamen and globus pallidus.[dx.doi.org] Degeneration begins in the caudal portions of the caudate and putamne and advances rostrally. Cortical atrophy is also present in advanced cases.[neuropathology-web.org]

  • McLeod Neuroacanthocytosis Syndrome

    Necropsy shows loss of neurons and gliosis in the caudate and globus pallidus. Thalamus, substantia nigra, and putamen also show similar changes.[xpertdox.com] There is neuronal loss with secondary gliosis in the caudate and globus pallidus . Similar changes may also be seen in the thalamus , substantia nigra and putamen.[radiopaedia.org] Necropsy shows loss of neurons and gliosis in the caudate and globus pallidus. Similar changes may also be seen in the thalamus, substantia nigra, and putamen.[en.wikipedia.org]

  • Hemiballismus

    As well as the typical neuropathological findings of ALS (marked upper and lower motor neuron loss), post‐mortem examination showed prominent neuronal loss and gliosis in[doi.org] No abnormalities were found in the caudate, putamen, and thalamus. No defects were found in the SOD1, HD, and DRPLA genes.[doi.org]

  • Cerebellar Hemorrhage

    (0/5) 0% (0/2) 0% NA Occipital cortex - gliosis (0/5) 0% (0/2) 0% NA Putamenneuronal loss (1/18) 6% (2/24) 8% 1.0 Putamengliosis (1/18) 6% (2/24) 8% 1.0 Caudateneuronal[actaneurocomms.biomedcentral.com] The CHI and control groups showed no significant difference in the incidence of neuronal loss or gliosis in the frontal, parietal, temporal, and occipital cortices, putamen[actaneurocomms.biomedcentral.com] , caudate, globus pallidus, thalamus, hypothalamus, hippocampus (except subiculum) and spinal cord (Table 2 ).[actaneurocomms.biomedcentral.com]

  • Motor Neuron Disease

    Interestingly, the caudate, putamen, and thalamus were normal. Rare ubiquitin-positive skeinlike inclusions were found in the motor neurons.[jamanetwork.com] In another pathological report of a patient with familial ALS who had chorea and ballism, postmortem examination revealed prominent neuronal loss and gliosis in the subthalamus[jamanetwork.com]

  • Huntington Disease-Like 3

    Neuroradiologically, findings include progressive striatal atrophy with a maximum in the caudate head. [65] Postmortem examinations have shown a neuronal loss and gliosis[movementdisorders.org] Microscopically, there was severe bilateral neuronal loss and marked reactive gliosis (increase in the number and size of astrocytes, and increase in the number of oligodendrocytes[journals.sagepub.com] […] predominantly affecting the caudate nucleus, putamen, globus pallidus, thalamus, and substantia nigra.[movementdisorders.org]

  • Classic Progressive Supranuclear Palsy Syndrome

    It causes atrophy of the caudate nucleus and putamen. Nuclei show an extensive neuronal loss and marked gliosis.[lecturio.com] The substantia nigra and locus ceruleus show loss of pigmented neurons and argyrophilic inclusions.[lecturio.com]

  • Superficial Siderosis of the Central Nervous System

    loss & Gliosis Locations: Caudate, Putamen, Pallidum & Substantia nigra PNS Motor Distal wasting Anterior horn cell loss Tendon reflexes: Reduced or Absent Laboratory EMG[neuromuscular.wustl.edu] Oro-facial-lingual dyskinesia Chorea Limbs, especially legs Frequent but not all patients Parkinsonism Cortical: Dementia; Personality disorders; Seizures (50%) Pathology Neuronal[neuromuscular.wustl.edu]

  • Huntington Disease-Like 1

    Neuroradiologically, findings include progressive striatal atrophy with a maximum in the caudate head. [65] Postmortem examinations have shown a neuronal loss and gliosis[movementdisorders.org] […] predominantly affecting the caudate nucleus, putamen, globus pallidus, thalamus, and substantia nigra.[movementdisorders.org]

  • Striatonigral Degeneration

    There is neuronal loss in caudate nucleus and globus pallidus. GCIs are more abundant in grade II than grade III SNC and putamen.[ncbi.nlm.nih.gov] The subthalamicus nuclei showed loss of neurons and gliosis. The thalamus was unchanged.[dokumen.tips] SND grade II is characterized by neuronal loss, astrogliosis and presence of GCIs in SNC and posterior/dorsolateral putamen.[ncbi.nlm.nih.gov]

Further symptoms