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32 Possible Causes for Neuronal Loss and Gliosis in the Inferior Olives, Nystagmus

  • Olivopontocerebellar Atrophy

    There was no pathologic nystagmus or saccadic dysmetria.[ncbi.nlm.nih.gov] There is neuronal loss and gliosis in the inferior olives, pons, cerebellum, substantia nigra, locus ceruleus, striatum and the intermediolateral column of the spinal cord[dizziness-and-balance.com] […] uptake deficiency on single photon emission computed tomography scans had poorer performances on three of the four subscores (static equilibrium, dynamic equilibrium and nystagmus[ncbi.nlm.nih.gov]

  • Spinocerebellar Ataxia Type 13

    loss and gliosis.[link.springer.com] Spinocerebellar ataxia type 13 (SCA13) is a rare autosomal dominant disorder, which, like other types of SCA, is characterized by dysarthria, nystagmus, and ataxia of gait[en.wikipedia.org] Spinocerebellar ataxia type 13 (SCA13) is a rare autosomal dominant disorder, which, like other types of SCA , is characterized by dysarthria , nystagmus , and ataxia of gait[ipfs.io]

  • Hereditary Cerebellar Degeneration

    Microscopic examination of these structures reveals neuronal loss, axon and myelin degeneration, and gliosis.[neuropathology-web.org] […] the cases reported by Bouchard had a horizontal nystagmus and occasionally a more irregular vertical nystagmus.[collections.lib.utah.edu] […] positional down-beat nystagmus).[orpha.net]

  • Friedreich Ataxia

    Microscopic examination of these structures reveals neuronal loss, axon and myelin degeneration, and gliosis.[neuropathology-web.org] The clinical picture consisted of progressive spastic gait, truncal and limb ataxia, dysarthria, nystagmus, hyperreflexia with knee and ankle clonus and extensor plantar response[ncbi.nlm.nih.gov] Differential Diagnosis Ataxia-telengiectasia - autosomal dominant, click HERE for a video of the nystagmus seen in this disorder.[pedclerk.bsd.uchicago.edu]

  • Creutzfeldt Jakob Disease

    & neuronal loss involving medial dorsal & anterior ventral thalamic nuclei & inferior olive; spongiform degeneration is minimal & focal VPSPr Median 70, 79 SD 9, 79 range[doi.org] The authors report a case of 66-year-old male patient with sporadic CJD who had dizziness, gaze-evoked nystagmus (GEN), and other central eye signs (impaired smooth pursuit[ncbi.nlm.nih.gov] […] examinations accurately discriminate central from peripheral lesions in those with new, acute, continuous vertigo/dizziness with nausea/vomiting, gait unsteadiness, and nystagmus[ncbi.nlm.nih.gov]

  • Ataxia

    Microscopic examination of these structures reveals neuronal loss, axon and myelin degeneration, and gliosis.[neuropathology-web.org] Jittery eye movements - nystagmus . Sensory (Proprioceptive) Ataxia This results from dysfunction to position sensing (proprioceptive) nerve inputs.[mult-sclerosis.org] In addition, mild secondary neuronal cell loss with gliosis was noted in the dentate nucleus and inferior olive.[doi.org]

  • Autosomal Recessive Spinocerebellar Ataxia 8

    Microscopic examination of these structures reveals neuronal loss, axon and myelin degeneration, and gliosis.[neuropathology-web.org] Findings on examination include spastic and ataxic dysarthria, gaze-evoked nystagmus, limb and gait ataxia, limb spasticity, and diminished vibratory sensation.[ataxia.uchicago.edu] Other features of ARCA1 include abnormal eye movements (nystagmus) and problems following the movements of objects with the eyes.[ghr.nlm.nih.gov]

  • Cerebellar Ataxia

    Microscopic examination of these structures reveals neuronal loss, axon and myelin degeneration, and gliosis.[neuropathology-web.org] A 54-year-old woman with adenocarcinoma of the lung and lymph node metastasis experienced nystagmus and cerebellar ataxia 2 weeks after initiating nivolumab therapy.[ncbi.nlm.nih.gov] Vestibular function testing showed severely reduced horizontal nystagmus in response to bithermal caloric stimulation.[ncbi.nlm.nih.gov]

  • Spinocerebellar Ataxia Type 5

    loss and gliosis.[link.springer.com] The phenotype is characterized by a purely cerebellar syndrome with a downbeat nystagmus occurring prior to the development of other features.[ncbi.nlm.nih.gov] […] a novel SPTBN2 mutation (transition C T at nucleotide position 1438), the proband having a much more severe phenotype with global developmental delay, hypotonia, tremor, nystagmus[ncbi.nlm.nih.gov]

  • Autosomal Recessive Spinocerebellar Ataxia

    Microscopic examination of these structures reveals neuronal loss, axon and myelin degeneration, and gliosis.[neuropathology-web.org] Spinocerebellar Ataxia 18 Clinical Characteristics Ocular Features: Ocular signs in SCAR18 include nystagmus, oculomotor apraxia, and optic atrophy.[disorders.eyes.arizona.edu] Additionally, patients may show dysarthria, nystagmus, spasticity of the lower limbs, and mild peripheral sensory neuropathy.[uniprot.org]

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