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12 Possible Causes for Neuronal Loss and Gliosis in the Inferior Olives, REM Sleep Behavior Disorder

  • Olivopontocerebellar Atrophy

    Patients with OPCA are prone to a number of sleep disturbance disorders such as rapid eye movement (REM) sleep behavior disorder RBD.[symptoma.com] There is neuronal loss and gliosis in the inferior olives, pons, cerebellum, substantia nigra, locus ceruleus, striatum and the intermediolateral column of the spinal cord[dizziness-and-balance.com] Respiratory disturbances (sleep apnea, stridor and inspiratory sighs) and night time sleep disturbances, including rapid eye movement (REM) sleep behavior disorder (RBD) and[orpha.net]

  • Striatonigral Degeneration

    sleep behavior disorder (RBD).[brainsupportnetwork.org] There is neuronal loss and gliosis in the inferior olives, pons, cerebellum, substantia nigra, locus ceruleus, striatum and the intermediolateral column of the spinal cord[dizziness-and-balance.com] Inferior olives and dentate nucleus were well outlined.[dokumen.tips]

  • Shy Drager Syndrome

    Patients are often unaware of REM sleep behavior disorder.[merckmanuals.com] loss, gliosis, and microvacuolation in the involved neuronal systems.[emedicine.medscape.com] Sleep problems such as REM sleep behavior disorder can be treated with medicines including clonazepam, melatonin, or some antidepressants.[ninds.nih.gov]

  • Hereditary Cerebellar Degeneration

    Respiratory disturbances (sleep apnea, stridor and inspiratory sighs) and night time sleep disturbances, including rapid eye movement (REM) sleep behavior disorder (RBD) and[orpha.net] Microscopic examination of these structures reveals neuronal loss, axon and myelin degeneration, and gliosis.[neuropathology-web.org] Neuropathological examination reveals loss of normal pigmentation in the substantia nigra, OPCA (atrophy of the cerebellum, basis pontis, and inferior olives), and atrophy[neuropathology-web.org]

  • Parkinsonian Disorder

    Abstract We report longitudinal data on a group of 29 male patients 50 years of age or older who were initially diagnosed as having idiopathic REM sleep behavior disorder[ncbi.nlm.nih.gov] loss, gliosis, and microvacuolation in the involved neuronal systems.[emedicine.medscape.com] Patients with MSA-C primarily have shrinkage of the cerebellum, middle cerebellar peduncles, inferior olives, and basis pontis. [14] Histopathologic findings include neuronal[emedicine.medscape.com]

  • Fatal Familial Insomnia

    sleep behavioral disorder, REM rapid eye movement, RWA rapid eye movement sleep without atonia, VPSG video-polysomnography.[journals.lww.com] Neuronal loss and gliosis are most conspicuous and frequent in inferior olives and minor in other nuclei ( Manetto et al ., 1992 ; Gambetti et al ., 1995 ; Reder et al .,[brain.oxfordjournals.org] Prominent motor overactivation during rapid eye movement (REM) sleep sometimes leads to misinterpretation of FFI as an REM sleep behavioral disorder (RBD).[journals.lww.com]

  • Creutzfeldt Jakob Disease

    behavior disorder.[ncbi.nlm.nih.gov] & neuronal loss involving medial dorsal & anterior ventral thalamic nuclei & inferior olive; spongiform degeneration is minimal & focal VPSPr Median 70, 79 SD 9, 79 range[doi.org] The inferior olives also show similar lesions. Other brain regions are less affected.[doi.org]

  • Shy-Drager Syndrome

    Patients with REM sleep behavior disorder typically act out their dreams or shout in their sleep.[mdedge.com] Neuronal loss and gliosis in the cerebral cortex, putamen, caudate nucleus, external pallidum, substantia nigra, locus coeruleus, pontine nuclei, inferior olives, cerebellar[academic.oup.com] Additional sleep disorders such as REM sleep behavior disorder (RBD) occur in many individuals with MSA, but RBD is also common, but less so, in PD.[rarediseases.org]

  • Cognitive Impairment with or without Cerebellar Ataxia

    REM Behavior Disorder Screening The REM Sleep Behavior Disorder Screening Questionnaire (RBDSQ) contains a set of questions that are related to symptoms of RBD.[jcsm.aasm.org] Microscopic examination of these structures reveals neuronal loss, axon and myelin degeneration, and gliosis.[neuropathology-web.org] Disordered REM sleep, known as REM behavior disorder, or RBD, affects up to 90 percent of MSA patients and may occur before motor symptoms show up.[multiplesystematrophy.org]

  • Chorea Acanthocytosis Syndrome

    "REM sleep behavior disorder in patients with DJ-1 mutations and parkinsonism-dementia-ALS complex". Movement Disorders. 24 (10): 1555–1556. doi : 10.1002/mds.22629.[en.wikipedia.org] From a neuropathological perspective, marked neuronal loss and astrocytic gliosis were frequently observed, especially in the caudate nucleus ( Ishida et al., 2009 ).[journal.frontiersin.org] olives, and other brain regions ( Hardie et al., 1991 ; Henkel et al., 2006 ).[journal.frontiersin.org]

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