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10 Possible Causes for Neuronal Loss and Gliosis in the Inferior Olives, Slow Pulse

  • Shy Drager Syndrome

    Catecholamine increases in the pheochromocytoma patient were accompanied by a rise in blood pressure, bradycardia, and an acute up-regulation of beta-adrenoceptors.[ncbi.nlm.nih.gov] loss, gliosis, and microvacuolation in the involved neuronal systems.[emedicine.medscape.com] […] by his neurologist due to a poor response to levodopa/carbidopa and episodes of severe unprovoked orthostatic hypotension, constipation, urinary retention and symptomatic bradycardia[casereports.in]

  • Lethal Infantile Mitochondrial Myopathy

    The patient died with bradycardia and hypotension at four months of age.[pediatricneurologybriefs.com] EMG: Myopathic features Pathology: Neuronal loss in dentate, inferior olive, substantia nigra, gliosis in the cerebellar cortex, and degeneration of the posterior column.[slideplayer.com] Symptoms: Seizures, apnea, bradycardia, vomiting, lethargy, coma, enlarged liver, limb weakness, myoglobin in the urine, Reye-like symptoms triggered by fasting.[umdf.org]

  • Ataxia

    The symptoms of bradycardia are palpitations, dizziness, and loss of consiousness.[lacaf.org] Microscopic examination of these structures reveals neuronal loss, axon and myelin degeneration, and gliosis.[neuropathology-web.org] Fatal bradycardia after intentional overdose of cimetidine and diazepam. Lancet 2: 982, 1982 PubMed Google Scholar Hofer P, Scollo-Lavizzari G.[doi.org]

  • Severe Neonatal-Onset Encephalopathy with Microcephaly

    […] consanguineous Arab-Muslim parents who presented in early infancy with myoclonic seizures, hypertonia and contractures, arrested head growth, inability to swallow, and bouts of apnea-bradycardia[childnervoussystem.blogspot.com] Postmortem examination of the brain in one child disclosed severe neuronal loss in the inferior olives and the pontine nuclei.[link.springer.com] The first report described two unrelated Amish infants with lethal, multifocal seizures, hypertonia, microcephaly, apnea, and bradycardia. [2] After this report, few other[jcnonweb.com]

  • Myopathic Carnitine Deficiency

    • A 7-day-old girl with congenital hypotonia and unexplained episodes of bradycardia had a broad spectrum of similar skeletal muscle and myocardial degenerative ultrastructural[jamanetwork.com] loss in the dentate, inferior olive Diffuse gliosis in cerebellar white matter and brain Differential Diagnosis of MERRF Unverricht-Lundborg disease (Baltic myoclonus): AR-chromosome[neurodiffdx.com] […] on cause Normal or elevated Myopathic MUAPs‡ with or without fibrillation potentials Usually normal Thyroid hormone (hypothyroidism) Proximal 30 to 49 years Menorrhagia; bradycardia[aafp.org]

  • Spinocerebellar Ataxia Type 5

    Slow saccade represents loss of excitatory burst neuronal function, whose neurons initiate the pulse sequence of saccadic eye movement [ 21 ].[bmcneurol.biomedcentral.com] loss and gliosis.[link.springer.com] Pronounced neuronal loss was identified in the Purkinje cell layer of the rostal vermis, the dentate nuclei and inferior olives; the surrounding white matter showed myelin[link.springer.com]

  • Friedreich Ataxia

    The symptoms of bradycardia are palpitations, dizziness, and loss of consiousness.[lacaf.org] Microscopic examination of these structures reveals neuronal loss, axon and myelin degeneration, and gliosis.[neuropathology-web.org] Arrhythmias can be diagnosed by electrocardiography and are of two types : bradycardia, which is a slow cardiac rhythm, due most of the time to an illness of the sinus node[lacaf.org]

  • Shy-Drager Syndrome

    Patients suffer from orthostatic hypotension, bradycardia, anhidrosis, failure of accommodation, sialoporia, low tears secretion, gastrointestinal dysmotility and incomplete[ncbi.nlm.nih.gov] Neuronal loss and gliosis in the cerebral cortex, putamen, caudate nucleus, external pallidum, substantia nigra, locus coeruleus, pontine nuclei, inferior olives, cerebellar[academic.oup.com]

  • Autosomal Dominant Sensory Ataxia

    Note: Vital signs correlating with increased intracranial tension include bradycardia, hypertension, and abnormal respiration, while fever correlates with infections.[lecturio.com] Microscopic examination of these structures reveals neuronal loss, axon and myelin degeneration, and gliosis.[neuropathology-web.org] Neuropathological examination reveals loss of normal pigmentation in the substantia nigra, OPCA (atrophy of the cerebellum, basis pontis, and inferior olives), and atrophy[neuropathology-web.org]

  • Chorea Acanthocytosis Syndrome

    Autonomic nervous system dysfunction with orthostatic hypotension and bradycardia has been described 40, 41 and is attributed to peripheral post-ganglionic sympathetic denervation[tremorjournal.org] From a neuropathological perspective, marked neuronal loss and astrocytic gliosis were frequently observed, especially in the caudate nucleus ( Ishida et al., 2009 ).[journal.frontiersin.org] […] hypersensitivity to norepinephrine may cause fatal arrhythmias and may account for reports of sudden death. 42 Pacemaker implantation has been useful in the treatment of sustained bradycardia[tremorjournal.org]

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